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Circulation Research, ISSN 0009-7330, 06/2010, Volume 106, Issue 11, pp. 1675 - 1680
Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program. During... 
TGF | Endothelin | Scarring | PDGF | Fibrosis | CARDIAC & CARDIOVASCULAR SYSTEMS | scarring | GENE-REGULATION | FIBROTIC PHENOTYPE | MATRIX CONTRACTION | endothelin | GROWTH-FACTOR-BETA | MYOCARDIAL FIBROSIS | IN-VIVO | PERIPHERAL VASCULAR DISEASE | fibrosis | SMOOTH-MUSCLE-CELLS | DERMAL FIBROBLASTS | TGF beta | MICE LACKING SMAD3 | HEMATOLOGY | MYOFIBROBLAST DIFFERENTIATION
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2015, Volume 74, Issue 7, pp. 1408 - 1416
ObjectivesWe have previously described the antifibrotic role of the soluble guanylate cyclase (sGC). The mode of action, however, remained elusive. In the... 
GROWTH-FACTOR-BETA | TRANS-DIFFERENTIATION | FIBROTIC DISORDERS | DISEASE | KINASE | EXPERIMENTAL DERMAL FIBROSIS | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | HYPERTENSION | INDUCED FIBROBLAST ACTIVATION | MAP Kinase Signaling System - physiology | Receptors, Cytoplasmic and Nuclear - deficiency | Skin - metabolism | Humans | Scleroderma, Systemic - pathology | Fibrosis - metabolism | Case-Control Studies | Scleroderma, Systemic - physiopathology | Transforming Growth Factor beta - antagonists & inhibitors | Fibrosis - prevention & control | Skin - pathology | Disease Models, Animal | Fibroblasts - metabolism | Pyrazoles - pharmacology | Scleroderma, Systemic - metabolism | Cells, Cultured | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - agonists | Fibroblasts - pathology | Mice, Knockout | Collagen - metabolism | Guanylate Cyclase - deficiency | Animals | MAP Kinase Signaling System - drug effects | Cyclic GMP - metabolism | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Pyridines - pharmacology | In Vitro Techniques | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
Journal Article