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by Kim, SY and Baek, KH
CELLULAR AND MOLECULAR LIFE SCIENCES, ISSN 1420-682X, 02/2019, Volume 76, Issue 4, pp. 653 - 665
Journal Article
Chemical Communications, ISSN 1359-7345, 01/2014, Volume 50, Issue 2, pp. 216 - 218
We report a new class of deubiquitinating enzyme (DUB) probes that resemble the native diubiquitin with a same linkage size and contain a Michael addition... 
DEUBIQUITYLATING ENZYMES | POLYUBIQUITIN | STRUCTURAL BASIS | UBIQUITIN | SUBSTRATE | CHEMISTRY | CHAINS | CHEMISTRY, MULTIDISCIPLINARY | PROTEOMICS | REVEALS | Ubiquitin-Specific Proteases - chemistry | Catalytic Domain | Molecular Probe Techniques | Molecular Probes - chemistry | Animals | Electrophoresis, Polyacrylamide Gel | Humans | Models, Molecular | Index Medicus
Journal Article
Chemical Science, ISSN 2041-6520, 2018, Volume 9, Issue 40, pp. 7859 - 7865
Ubiquitination is an essential eukaryotic post-translational modification that regulates various cellular processes. The removal of ubiquitin from its target... 
YEAST | DEUBIQUITYLATING ENZYMES | PCNA | UBIQUITYLATION | DIUBIQUITIN PROBES | ENABLES | DI-UBIQUITIN | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2001, Volume 20, Issue 18, pp. 5187 - 5196
A C‐terminally modified ubiquitin (Ub) derivative, ubiquitin vinyl sulfone (UbVS), was synthesized as an active site‐directed probe that irreversibly modifies... 
proteasome | active site‐directed probe | deubiquitylating enzyme | ubiquitin | vinyl sulfone | Ubiquitin | Active site-directed prob | Vinyl sulfone | Deubiquitylating enzyme | Proteasome | active site-directed probe | BIOCHEMISTRY & MOLECULAR BIOLOGY | 26S PROTEASOME | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | DEUBIQUITINATING ENZYMES | CELL BIOLOGY | YEAST | SUBSTRATE-BINDING | UBIQUITIN-LIKE DOMAIN | DNA-REPAIR | REGULATORY COMPLEX | CARBOXYL-TERMINAL HYDROLASE | Iodine Radioisotopes | Ubiquitins - chemistry | Yeasts - enzymology | Proteasome Endopeptidase Complex | Sulfones - pharmacology | Ubiquitins - analogs & derivatives | Sulfones - chemistry | Gene Deletion | Thiolester Hydrolases - analysis | Binding Sites | Ubiquitins - metabolism | Peptide Hydrolases - metabolism | Sulfones - chemical synthesis | Cell Line | Endopeptidases - metabolism | Enzyme Inhibitors - pharmacology | Cell Extracts - chemistry | Fungal Proteins - genetics | Ubiquitins - chemical synthesis | Macromolecular Substances | Fungal Proteins - analysis | Animals | Saccharomyces cerevisiae Proteins | Mice | Oligopeptides - pharmacology | Ubiquitin Thiolesterase | 3T3 Cells | Ubp12 protein | USP14 gene | Ubp2 protein | Ubp6 protein | hydrolase | proteasomes | Yuh1 protein | ubiquitin vinyl sulfone | Ubp1 protein | Ubp15 protein | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2019, Volume 29, Issue 2, pp. 204 - 211
Promiscuous inhibitors of tyrosine protein kinases, proteases and phosphatases are useful reagents for probing regulatory pathways and stabilizing lysates as... 
USP9 | Mdm2 | USP7 | Bcr Abl | Activity profiling | APOPTOSIS | CELLS | STRUCTURE-GUIDED DEVELOPMENT | CHEMISTRY, MEDICINAL | CURCUMIN | CHEMISTRY, ORGANIC | IDENTIFICATION | CANCER | DISCOVERY | DEUBIQUITYLATING ENZYMES | SELECTIVITY | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2017, Volume 130, Issue 19, pp. 3336 - 3346
The consecutive actions of the ubiquitin-selective segregase Cdc48 and the ubiquitin shuttle factor Rad23 result in the delivery of ubiquitylated proteins at... 
Degradation | Ubiquitin | Yeast | Deubiquitylating enzyme | Rad23 | Ubiquitin shuttle factor | Proteasome | ATPASE | UBL DOMAIN | PROTEOLYSIS | BINDING PROTEIN | CELL BIOLOGY | UBIQUITIN CHAINS | PROTEIN-DEGRADATION | PATHWAY | DNA-REPAIR | Biodegradation | Enzymes | Stabilization | Saccharomyces | DNA repair | Substrates | Proteins | Protein folding | Lysine | Proteolysis | Proteasomes | Saccharomyces cerevisiae | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
FRONTIERS IN CHEMISTRY, ISSN 2296-2646, 08/2019, Volume 7
Enzymes that bind and process ubiquitin, a small 76-amino-acid protein, have been recognized as pharmacological targets in oncology, immunological disorders,... 
ubiquitin specific proteases | PROTEIN | proteomics | SPECIFICITY | UBIQUITIN | isoforms | deubiquitylating enzymes | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | ACTIVITY-BASED PROBES | chemical biology | SMALL-MOLECULE INHIBITORS | CHEMISTRY | mass spectrometry | FUNCTIONAL PROTEOMICS
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 09/2016, Volume 1449, pp. 411 - 419
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 05/2012, Volume 10, Issue 17, pp. 3379 - 3383
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4280 - 4289
Purpose: The ubiquitin proteasome pathway is a validated therapeutic target in multiple myeloma. Deubiquitylating enzyme USP1 participates in DNA damage... 
TARGET | OVERCOMES BORTEZOMIB RESISTANCE | ONCOLOGY | ID PROTEINS | BONE-MARROW | RECEPTOR | HOMOLOGOUS RECOMBINATION | DIFFERENTIATION | CANCER STEM-CELLS | SMALL-MOLECULE INHIBITOR | DEUBIQUITINATING ENZYMES | DNA Damage - drug effects | Cell Survival - drug effects | DNA Repair - drug effects | Ubiquitin-Specific Proteases - genetics | Ubiquitin-Specific Proteases - antagonists & inhibitors | Apoptosis - drug effects | Humans | DNA-Binding Proteins - drug effects | Thalidomide - administration & dosage | DNA-Binding Proteins - genetics | Neoplasm Proteins - drug effects | Drug Synergism | Xenograft Model Antitumor Assays | Thalidomide - analogs & derivatives | Drug Resistance, Neoplasm - genetics | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Bortezomib - administration & dosage | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Multiple Myeloma - genetics | Ubiquitin | Biotechnology | Plasma | Toxicity | Homologous recombination | DNA damage | Multiple myeloma | Cytotoxicity | Homology | DNA repair | Caspase-3 | Proteins | DNA-binding protein | Enzymatic activity | Bone marrow | Repair | Deoxyribonucleic acid--DNA | Enzymes | Bortezomib | Cell survival | Anemia | Tumor cells | Caspase | siRNA | Tumor cell lines | Fanconi syndrome | Studies | Caspase-8 | Inhibitors | Experimental design | Cell lines | Stem cells | Caspase-9 | Plasma cells | Viability | Apoptosis | Cancer | Index Medicus | Pre-clinical study | USP1 | Deubiquitylating enzymes | Multiple Myeloma
Journal Article