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Bioscience Reports, ISSN 0144-8463, 12/2012, Volume 32, Issue 6, pp. 631 - 639
Miller syndrome is a recessive inherited disorder characterized by postaxial acrofacial dysostosis. It is caused by dysfunction of the DHODH (dihydroorotate... 
Mitochondrion | Miller syndrome | Protein stability | Dihydro-orotate dehydrogenase (DHODH) | Missense mutation | MITOCHONDRIAL-DNA MUTATIONS | METHOTREXATE | protein stability | missense mutation | mitochondrion | CELL BIOLOGY | SYNTHASE | GENE | BIOSYNTHESIS | DISEASE | dihydro-orotate dehydrogenase (DHODH) | NEURAL CREST | INHIBITOR | LEFLUNOMIDE | Abnormalities, Multiple - metabolism | Limb Deformities, Congenital - enzymology | Limb Deformities, Congenital - genetics | Mitochondria - enzymology | Electron Transport Complex III - metabolism | Humans | Micrognathism - genetics | Limb Deformities, Congenital - metabolism | Micrognathism - enzymology | Ubiquinone - metabolism | Mitochondria - metabolism | Mutation, Missense | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Micrognathism - metabolism | Mandibulofacial Dysostosis - genetics | Oxidoreductases Acting on CH-CH Group Donors - analysis | Mandibulofacial Dysostosis - enzymology | Abnormalities, Multiple - enzymology | Oxidoreductases Acting on CH-CH Group Donors - genetics | Succinate Dehydrogenase - metabolism | HeLa Cells | Mandibulofacial Dysostosis - metabolism | Protein Stability | Abnormalities, Multiple - genetics | anti-HA, anti-haemagglutinin | DCPIP, dichlorophenolindophenol | LFN, leflunomide | UMPS, UMP synthase | CHX, cycloheximide | DHODH-HA, DHODH with a C-terminal HA tag | FBS, fetal bovine serum | Original Paper | DHFR, dihydrofolate reductase | DHO, dihydroorotate | DOX, doxycycline | DMEM, Dulbecco’s modified Eagle’s medium | OXPHOS, oxidative phosphorylation | DHODH, dihydro-orotate dehydrogenase | TFAM, mitochondrial transcription factor A
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2018, Volume 66, Issue 3, pp. 239 - 242
Helicobacter pylori (H. pylori) infection is the world's most common bacterial infection, affecting approximately 50% of the global population. H. pylori is... 
Journal Article
Science, ISSN 0036-8075, 4/2010, Volume 328, Issue 5978, pp. 636 - 639
Journal Article
ACS Catalysis, ISSN 2155-5435, 02/2016, Volume 6, Issue 2, pp. 1024 - 1027
A copper-catalyzed novel carbene/alkyne metathesis cascade reaction with alkyne-tethered diazo compounds is described. The whole transformation features a... 
quinoline | diazo compound | alkyne functionalization | cascade reaction | azide | carbene/alkyne metathesis | INSERTION | CASCADE REACTIONS | CHEMISTRY, PHYSICAL | DIHYDROOROTATE DEHYDROGENASE DHODH | C-H FUNCTIONALIZATION | FORMAL 3+2 CYCLOADDITION | METAL CARBENE | CONSTRUCTION | SITE-SELECTIVITY | INHIBITORS | DERIVATIVES
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2011, Volume 11, Issue 10, pp. 1226 - 1254
Journal Article
Molecular and Biochemical Parasitology, ISSN 0166-6851, 2013, Volume 190, Issue 1, pp. 6 - 15
1-Hydroxyquinolones as for example 1-hydroxy-2-dodecyl-4(1)quinolone (HDQ) are effective growthinhibitors for Toxoplasma gondii. These compounds were shown to... 
Toxoplasma gondii | Hdq | Dihydroorotate dehydrogenase (dhodh) | 1-Hydroxyquinolone | Drug resistance
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 10/2019, Volume 118, p. 109305
Foot-and-mouth disease virus (FMDV) is an important pathogen that affects livestock breeding and causes huge economic losses worldwide. Currently, the... 
IMPDH | In vivo | FMDV | Antiviral activity | DHODH | MEDICINE, RESEARCH & EXPERIMENTAL | INOSINE MONOPHOSPHATE DEHYDROGENASE | REPLICATION | PHARMACOLOGY & PHARMACY | INFECTION | AVN944 | TERIFLUNOMIDE
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2019, Volume 183, p. 111681
Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms, such as , and , that are able to impact upon human health.... 
Schistosoma mansoni | Trypanosoma | Malaria | Teriflunomide | Bioisosterism | Theileria equi | Leflunomide | Plasmodium falciparum | Plasmodium vivax | Helicobacter pilory | Toxoplasma gondii | Dihydroorotate dehydrogenase (DHODH) inhibitors | Leishmania | Antiviral | Pseudomonas aeruginosa | Brequinar | Babesia bovis | Aspergillus fumigatus | hDHODH | Babesia caballi
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2016, Volume 7, Issue 12, pp. 1112 - 1117
Homeobox transcription factor A9 (HoxA9) is overexpressed in 70% of patients diagnosed with acute myeloid leukemia (AML), whereas only a small subset of AML... 
AML | HoxA9 | ML390 | DHODH | CHEMISTRY, MEDICINAL | DIHYDROOROTATE DEHYDROGENASE | MODE | RANDOMIZED-TRIAL | THERAPY | HEMATOPOIESIS | BREQUINAR | GENES | AGENTS | EXPRESSION | BINDING
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, pp. 2559 - 2564
Clinically relevant inhibitors of dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis, have strong antiviral... 
Pyrimidine processing inhibitors | De novo pyrimidine synthesis | Uridine | High-throughput screening | GSK983 | Pyrimidine salvage | Uridine-cytidine kinase | DHODH inhibitor | TARGET | CELLS | CHEMISTRY, MEDICINAL | VIRUS | ANALOG | CHEMISTRY, ORGANIC | METABOLISM | BLOCKS | DERIVATIVES | Nucleosides | Antiviral agents | Pyrimidines
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 68, pp. 112354 - 112370
Malignant melanoma (MM) is one of the most malignant tumors and has a very poor prognosis. However, there are no effective drugs to treat this disease. As a... 
BCL-2 | Dihydroorotate dehydrogenase (DHODH) | Leflunomide | Autophagy | Melanoma | PATHWAYS | leflunomide | APOPTOSIS | autophagy | PROTEIN | DIHYDROOROTATE DEHYDROGENASE | PHOSPHORYLATION | melanoma | CANCER | CELL BIOLOGY | BCL2 FAMILY | dihydroorotate dehydrogenase (DHODH) | INHIBITION | GROWTH
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2017, Volume 8, Issue 4, pp. 438 - 442
Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of... 
BRD7539 | BRD9185 | Plasmodium falciparum | malaria | diversity-oriented synthesis | DHODH | CHEMISTRY, MEDICINAL | BRD918S | LEAD OPTIMIZATION | MEDICINES | POTENT | ARTEMISININ RESISTANCE | BRD7S39 | TARGETS | ORIENTED SYNTHESIS YIELDS
Journal Article