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1. Full Text Isoxazole-tethered diarylheptanoid analogs: Discovery of a new drug-like PAR2 antagonist
by Bhuniya, Debnath and Bhosale, Sandeep and Reddy, Satyanarayana B and Reddy, Sudharshan N
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 13, pp. 2285 - 2288
Stereo-conserved synthesis | Protease-activated receptor-2 (PAR2) antagonist | Diarylheptanoid | Isoxazole tether | Isoxazoles - pharmacokinetics | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Calcium - metabolism | Stereoisomerism | Humans | Microsomes, Liver - metabolism | Isoxazoles - chemistry | Isoxazoles - chemical synthesis | Hep G2 Cells | Isoxazoles - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Diarylheptanoids - chemical synthesis | Diarylheptanoids - pharmacokinetics | HEK293 Cells | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Trypsin | Drug discovery | Permeability | Glucose | Proteases | Dextrose | Index Medicus
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2. Full Text Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa
by Ilic-Tomic, Tatjana and Sokovic, Marina and Vojnovic, Sandra and Ciric, Ana and Veljic, Milan and Nikodinovic-Runic, Jasmina and Novakovic, Miroslav
Planta medica, ISSN 0032-0943, 01/2017, Volume 83, Issue 1/02, pp. 117 - 125
Natural Product Chemistry and Analytical Studies | diarylheptanoids | quorum sensing | Alnus glutinosa | Pseudomonas aeruginosa | Alnus viridis ssp. viridis | Betulaceae | acyl homoserine lactone | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Quorum Sensing - drug effects | Plant Extracts - pharmacology | Chromobacterium - metabolism | Humans | Pseudomonas aeruginosa - drug effects | Plant Bark - chemistry | Pyocyanine - metabolism | Diarylheptanoids - metabolism | Indoles - metabolism | Alnus - chemistry | Pseudomonas aeruginosa - metabolism | Diarylheptanoids - isolation & purification | Acyl-Butyrolactones - metabolism | Anti-Bacterial Agents - pharmacology | Chromobacterium - drug effects | Catechols - metabolism | Alder | Pseudomonas aeruginosa infections | Care and treatment | Quorum sensing | Research | Properties | Health aspects | Materia medica, Vegetable | Plant extracts
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3. Full Text Quali-quantitative analysis of the phenolic fraction of the flowers of Corylus avellana, source of the Italian PGI product “Nocciola di Giffoni”: Isolation of antioxidant diarylheptanoids
by Masullo, Milena and Mari, Angela and Cerulli, Antonietta and Bottone, Alfredo and Kontek, Bogdan and Olas, Beata and Pizza, Cosimo and Piacente, Sonia
Phytochemistry (Oxford), ISSN 0031-9422, 10/2016, Volume 130, pp. 273 - 281
Multiple Reaction Monitoring | Diarylheptanoids | Antioxidant activity | Hazelnut | Corylus avellana | LC-ESI(QqQ)MS | Flowers | Betulaceae | Plant Leaves - chemistry | Diarylheptanoids - chemistry | Antioxidants - chemistry | Diarylheptanoids - pharmacology | Humans | Hydrogen Peroxide - pharmacology | Flowers - chemistry | Diarylheptanoids - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Italy | Phenols - chemistry | Corylus - chemistry | Lipid Peroxidation | Antioxidants | Nuclear magnetic resonance spectroscopy | Drug discovery | Index Medicus
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4. Full Text Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds
by Akter, Jesmin and Hossain, Md. Amzad and Takara, Kensaku and Islam, Md. Zahorul and Hou, De-Xing
Comparative biochemistry and physiology. Toxicology & pharmacology, ISSN 1532-0456, 01/2019, Volume 215, pp. 9 - 17
Turmeric | Phenolic | Ryudai gold | Active compound | Antioxidant | Flavonoid | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Toxicology | Life Sciences & Biomedicine | Zoology | Science & Technology | Free Radical Scavengers - pharmacology | Plant Extracts - chemistry | Curcumin - analogs & derivatives | Diarylheptanoids - chemistry | Antioxidants - chemistry | Species Specificity | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Curcumin - chemistry | Diarylheptanoids - analysis | Spices - analysis | Osmolar Concentration | Rhizome - chemistry | Curcumin - analysis | Free Radical Scavengers - analysis | Molecular Structure | Methanol - chemistry | Antioxidants - analysis | Phytochemicals - chemistry | Diarylheptanoids - pharmacology | Oxidation-Reduction | Phytochemicals - analysis | Japan | Curcumin - pharmacology | Deoxyribose - chemistry | Curcumin - isolation & purification | Plant Breeding | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Drug Discovery | Free Radical Scavengers - isolation & purification | Curcuma - growth & development | Phytochemicals - isolation & purification | Rhizome - growth & development | Antioxidants - isolation & purification | Diarylheptanoids - isolation & purification | Phytochemicals - pharmacology | Curcuma - chemistry | Antioxidants | Hydroxides | Chemical properties | Mass spectrometry | High performance liquid chromatography | Sugars | Isoflavones | Monosaccharides | Index Medicus
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5. Full Text Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells
by Novaković, Miroslav and Pešić, Milica and Trifunović, Snežana and Vučković, Ivan and Todorović, Nina and Podolski-Renić, Ana and Dinić, Jelena and Stojković, Sonja and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan
Phytochemistry (Oxford), ISSN 0031-9422, 01/2014, Volume 97, pp. 46 - 54
Multi-drug resistance | HPLC-DAD | Black alder | Diarylheptanoids | NMR analysis | Anti-cancer activity | Cell Survival - drug effects | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Heptanes - pharmacology | Ilex - chemistry | Small Cell Lung Carcinoma | Antineoplastic Agents, Phytogenic - chemistry | Catechols - chemistry | Plant Bark - chemistry | Alnus - chemistry | Diarylheptanoids - isolation & purification | Catechols - pharmacology | Glycosides | Nuclear Magnetic Resonance, Biomolecular | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Drug resistance | Lung cancer, Non-small cell | Index Medicus
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6. Full Text Pharmacokinetics and Tissue Distribution of Alnustone in Rats after Intravenous Administration by Liquid Chromatography-Mass Spectrometry
by Song, Yang and Zhou, Yu and Yan, Xiao-Ting and Bi, Jing-Bo and Qiu, Xin and Bian, Yu and Wang, Ke-Fei and Zhang, Yuan and Feng, Xue-Song
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 17, p. 3183
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Diarylheptanoids - chemistry | Limit of Detection | Reproducibility of Results | Male | Calibration | Rats, Sprague-Dawley | Tissue Distribution | Diarylheptanoids - administration & dosage | Administration, Intravenous | Reference Standards | Animals | Caffeine - chemistry | Diarylheptanoids - pharmacokinetics | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Diarylheptanoids - blood | Intravenous administration | Seeds | Ions | Mass spectroscopy | Liquid chromatography | Regression analysis | Optimization | Chromatography | Proteins | Accuracy | Paracetamol | Efficiency | Formic acid | Stable isotopes | Acetonitrile | Scientific imaging | Precipitators | Pharmacokinetics | Mass spectrometry | Methods | Caffeine | Quantitative analysis | Index Medicus | pharmacokinetics | LC-MS/MS | rats | tissue distribution | alnustone
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7. Full Text A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples
by Yoon, Alexander J and Wu, Haiqiang and Pan, Roy D and Teter, Bruce and Cipolla, Jack and Chang, Edwin and Avila, Luis Z and Basak, Saroj K and Srivatsan, Eri S and Wang, Marilene B and Cole, Greg M and Frautschy, Sally A and Hampton, Phillip D and Faull, Kym F
Analytical biochemistry, ISSN 0003-2697, 05/2020, Volume 596, pp. 113636 - 113636
Curcumin | Liquid chromatography coupled mass spectrometry (LCMS) | Boron trifluoride (BF3) | Pharmacokinetics | Curcuminoids | Boron trifluoride (BF | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Diarylheptanoids - chemistry | Animals | Humans | Mass Spectrometry | Boranes - chemistry | Diarylheptanoids - isolation & purification | Chromatography, Liquid | Mice | Molecular Structure | Healthy Volunteers | Diarylheptanoids - blood | Index Medicus
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8. Full Text Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure–activity relationship studies
by Motiur Rahman, A F. M and Lu, Yang and Lee, Hwa-Jong and Jo, Hyunji and Yin, Wencui and Alam, Mohammad Sayed and Cha, Hyochang and Kadi, Adnan A and Kwon, Youngjoo and Jahng, Yurngdong
Archives of pharmacal research, ISSN 0253-6269, 12/2018, Volume 41, Issue 12, pp. 1131 - 1148
Linear diarylheptanoids | Topoisomerase-IIα | Topoisomerase-I | Antiproliferative activity | Pharmacology/Toxicology | Pharmacy | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Gram-Positive Bacteria - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Gram-Negative Bacteria - drug effects | Diarylheptanoids - chemical synthesis | Anti-Bacterial Agents - chemistry | Gram-Negative Bacteria - growth & development | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Gram-Positive Bacteria - growth & development | Drug Screening Assays, Antitumor | Gastrointestinal agents | Microbiota (Symbiotic organisms) | Therapeutics | Drugstores | Plants | Antibacterial agents | Homeopathy | Materia medica and therapeutics | Index Medicus
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9. Full Text Giffonins J–P, Highly Hydroxylated Cyclized Diarylheptanoids from the Leaves of Corylus avellana Cultivar “Tonda di Giffoni”
by Masullo, Milena and Cantone, Vincenza and Cerulli, Antonietta and Lauro, Gianluigi and Messano, Francesco and Russo, Gian Luigi and Pizza, Cosimo and Bifulco, Giuseppe and Piacente, Sonia
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 12/2015, Volume 78, Issue 12, pp. 2975 - 2982
Plant Leaves - chemistry | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Diarylheptanoids - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Italy | Molecular Structure | Corylus - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text Cyclic diarylheptanoids deoxycymodienol and isotedarene A from Zostera marina (Zosteraceae)
by Li, Yan and Mangoni, Alfonso and Shulha, Oleksandr and Çiçek, Serhat Sezai and Zidorn, Christian
Tetrahedron letters, ISSN 0040-4039, 08/2019, Volume 60, Issue 32, p. 150930
Seagrasses | Marine natural products | Diarylheptanoids | Alismatales
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11. Full Text A comprehensive investigation of anti-inflammatory diarylheptanoids from the leaves of Alnus formosana
by Lai, Yi-Chun and Chen, Chien-Kuang and Lin, Wan-Wan and Lee, Shoei-Sheng
Phytochemistry (Oxford), ISSN 0031-9422, 2012, Volume 73, Issue 1, pp. 84 - 94
Alnus formosana | HPLC-SPE-NMR | Anti-inflammatory | Diarylheptanoids | Betulaceae | Plant Leaves - chemistry | Nitric Oxide - biosynthesis | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Anti-Inflammatory Agents - pharmacology | Chromatography, High Pressure Liquid | Animals | Anti-Inflammatory Agents - chemistry | Alnus - chemistry | Diarylheptanoids - isolation & purification | Lipopolysaccharides - pharmacology | Taiwan | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Anti-inflammatory drugs | Investigations | Index Medicus
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12. Full Text Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies
by Gagandeep and Kumar, Prince and Kandi, Shamseer Kulangara and Mukhopadhyay, Kasturi and Rawat, Diwan S
European journal of medicinal chemistry, ISSN 0223-5234, 06/2020, Volume 195, pp. 112276 - 112276
Curcumin | Antibacterial | S. aureus | Curcuminoids | MRSA | Methicillin-Resistant Staphylococcus aureus - physiology | Diarylheptanoids - chemistry | Chemistry Techniques, Synthetic | Diarylheptanoids - pharmacology | Microbial Viability - drug effects | Methicillin-Resistant Staphylococcus aureus - drug effects | Anti-Bacterial Agents - chemical synthesis | Animals | Diarylheptanoids - chemical synthesis | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Mice | 3T3 Cells | Index Medicus
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13. Full Text New Taste-Active 3‑(O‑β‑d‑Glucosyl)-2-oxoindole-3-acetic Acids and Diarylheptanoids in Cimiciato-Infected Hazelnuts
by Singldinger, Barbara and Dunkel, Andreas and Bahmann, Dominic and Bahmann, Claudia and Kadow, Daniel and Bisping, Bernward and Hofmann, Thomas
Journal of agricultural and food chemistry, ISSN 0021-8561, 05/2018, Volume 66, Issue 18, pp. 4660 - 4673
diarylheptanoids | asadanin | taste | Cimiciato | hazelnuts | Corylus avellana L | giffonin P | bitter | Diarylheptanoids - chemistry | Humans | Nuts - metabolism | Flavoring Agents - metabolism | Male | Chromatography, High Pressure Liquid | Young Adult | Tandem Mass Spectrometry | Diarylheptanoids - metabolism | Corylus - metabolism | Flavoring Agents - chemistry | Nuts - chemistry | Adult | Female | Taste | Corylus - chemistry | Index Medicus
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14. Full Text Anti-adipogenic activity of a new cyclic diarylheptanoid isolated from Alnus japonica on 3T3-L1 cells via modulation of PPARγ, C/EBPα and SREBP1c signaling
by Sung, Sang Hyun and Lee, Mina
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 10/2015, Volume 25, Issue 20, pp. 4648 - 4651
Obesity | 3T3-L1 cells | Diarylheptanoids | Alnus japonica | Adipocyte differentiation | Betulaceae | Adipogenesis | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Fruit - chemistry | Adipogenesis - drug effects | RNA, Messenger - genetics | Signal Transduction - genetics | Structure-Activity Relationship | 3T3-L1 Cells | Down-Regulation - drug effects | PPAR gamma - metabolism | Dose-Response Relationship, Drug | Animals | Alnus - chemistry | Signal Transduction - drug effects | Sterol Regulatory Element Binding Protein 1 - genetics | Diarylheptanoids - isolation & purification | CCAAT-Enhancer-Binding Protein-alpha - genetics | Mice | Molecular Structure | Adipogenesis - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Index Medicus
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