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Isoxazole-tethered diarylheptanoid analogs: Discovery of a new drug-like PAR2 antagonist
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 13, pp. 2285 - 2288
Stereo-conserved synthesis | Protease-activated receptor-2 (PAR2) antagonist | Diarylheptanoid | Isoxazole tether | Isoxazoles - pharmacokinetics | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Calcium - metabolism | Stereoisomerism | Humans | Microsomes, Liver - metabolism | Isoxazoles - chemistry | Isoxazoles - chemical synthesis | Hep G2 Cells | Isoxazoles - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Diarylheptanoids - chemical synthesis | Diarylheptanoids - pharmacokinetics | HEK293 Cells | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Trypsin | Drug discovery | Permeability | Glucose | Proteases | Dextrose | Index Medicus
Journal Article
Planta medica, ISSN 0032-0943, 01/2017, Volume 83, Issue 1/02, pp. 117 - 125
Natural Product Chemistry and Analytical Studies | diarylheptanoids | quorum sensing | Alnus glutinosa | Pseudomonas aeruginosa | Alnus viridis ssp. viridis | Betulaceae | acyl homoserine lactone | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Quorum Sensing - drug effects | Plant Extracts - pharmacology | Chromobacterium - metabolism | Humans | Pseudomonas aeruginosa - drug effects | Plant Bark - chemistry | Pyocyanine - metabolism | Diarylheptanoids - metabolism | Indoles - metabolism | Alnus - chemistry | Pseudomonas aeruginosa - metabolism | Diarylheptanoids - isolation & purification | Acyl-Butyrolactones - metabolism | Anti-Bacterial Agents - pharmacology | Chromobacterium - drug effects | Catechols - metabolism | Alder | Pseudomonas aeruginosa infections | Care and treatment | Quorum sensing | Research | Properties | Health aspects | Materia medica, Vegetable | Plant extracts
Journal Article
Phytochemistry (Oxford), ISSN 0031-9422, 10/2016, Volume 130, pp. 273 - 281
Multiple Reaction Monitoring | Diarylheptanoids | Antioxidant activity | Hazelnut | Corylus avellana | LC-ESI(QqQ)MS | Flowers | Betulaceae | Plant Leaves - chemistry | Diarylheptanoids - chemistry | Antioxidants - chemistry | Diarylheptanoids - pharmacology | Humans | Hydrogen Peroxide - pharmacology | Flowers - chemistry | Diarylheptanoids - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Italy | Phenols - chemistry | Corylus - chemistry | Lipid Peroxidation | Antioxidants | Nuclear magnetic resonance spectroscopy | Drug discovery | Index Medicus
Journal Article
Comparative biochemistry and physiology. Toxicology & pharmacology, ISSN 1532-0456, 01/2019, Volume 215, pp. 9 - 17
Turmeric | Phenolic | Ryudai gold | Active compound | Antioxidant | Flavonoid | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Toxicology | Life Sciences & Biomedicine | Zoology | Science & Technology | Free Radical Scavengers - pharmacology | Plant Extracts - chemistry | Curcumin - analogs & derivatives | Diarylheptanoids - chemistry | Antioxidants - chemistry | Species Specificity | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Curcumin - chemistry | Diarylheptanoids - analysis | Spices - analysis | Osmolar Concentration | Rhizome - chemistry | Curcumin - analysis | Free Radical Scavengers - analysis | Molecular Structure | Methanol - chemistry | Antioxidants - analysis | Phytochemicals - chemistry | Diarylheptanoids - pharmacology | Oxidation-Reduction | Phytochemicals - analysis | Japan | Curcumin - pharmacology | Deoxyribose - chemistry | Curcumin - isolation & purification | Plant Breeding | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Drug Discovery | Free Radical Scavengers - isolation & purification | Curcuma - growth & development | Phytochemicals - isolation & purification | Rhizome - growth & development | Antioxidants - isolation & purification | Diarylheptanoids - isolation & purification | Phytochemicals - pharmacology | Curcuma - chemistry | Antioxidants | Hydroxides | Chemical properties | Mass spectrometry | High performance liquid chromatography | Sugars | Isoflavones | Monosaccharides | Index Medicus
Journal Article
Phytochemistry (Oxford), ISSN 0031-9422, 01/2014, Volume 97, pp. 46 - 54
Multi-drug resistance | HPLC-DAD | Black alder | Diarylheptanoids | NMR analysis | Anti-cancer activity | Cell Survival - drug effects | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Heptanes - pharmacology | Ilex - chemistry | Small Cell Lung Carcinoma | Antineoplastic Agents, Phytogenic - chemistry | Catechols - chemistry | Plant Bark - chemistry | Alnus - chemistry | Diarylheptanoids - isolation & purification | Catechols - pharmacology | Glycosides | Nuclear Magnetic Resonance, Biomolecular | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Drug resistance | Lung cancer, Non-small cell | Index Medicus
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 17, p. 3183
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Diarylheptanoids - chemistry | Limit of Detection | Reproducibility of Results | Male | Calibration | Rats, Sprague-Dawley | Tissue Distribution | Diarylheptanoids - administration & dosage | Administration, Intravenous | Reference Standards | Animals | Caffeine - chemistry | Diarylheptanoids - pharmacokinetics | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Diarylheptanoids - blood | Intravenous administration | Seeds | Ions | Mass spectroscopy | Liquid chromatography | Regression analysis | Optimization | Chromatography | Proteins | Accuracy | Paracetamol | Efficiency | Formic acid | Stable isotopes | Acetonitrile | Scientific imaging | Precipitators | Pharmacokinetics | Mass spectrometry | Methods | Caffeine | Quantitative analysis | Index Medicus | pharmacokinetics | LC-MS/MS | rats | tissue distribution | alnustone
Journal Article
Analytical biochemistry, ISSN 0003-2697, 05/2020, Volume 596, pp. 113636 - 113636
Curcumin | Liquid chromatography coupled mass spectrometry (LCMS) | Boron trifluoride (BF3) | Pharmacokinetics | Curcuminoids | Boron trifluoride (BF | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Diarylheptanoids - chemistry | Animals | Humans | Mass Spectrometry | Boranes - chemistry | Diarylheptanoids - isolation & purification | Chromatography, Liquid | Mice | Molecular Structure | Healthy Volunteers | Diarylheptanoids - blood | Index Medicus
Journal Article
Archives of pharmacal research, ISSN 0253-6269, 12/2018, Volume 41, Issue 12, pp. 1131 - 1148
Linear diarylheptanoids | Topoisomerase-IIα | Topoisomerase-I | Antiproliferative activity | Pharmacology/Toxicology | Pharmacy | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Gram-Positive Bacteria - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Gram-Negative Bacteria - drug effects | Diarylheptanoids - chemical synthesis | Anti-Bacterial Agents - chemistry | Gram-Negative Bacteria - growth & development | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Gram-Positive Bacteria - growth & development | Drug Screening Assays, Antitumor | Gastrointestinal agents | Microbiota (Symbiotic organisms) | Therapeutics | Drugstores | Plants | Antibacterial agents | Homeopathy | Materia medica and therapeutics | Index Medicus
Journal Article
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 12/2015, Volume 78, Issue 12, pp. 2975 - 2982
Plant Leaves - chemistry | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Diarylheptanoids - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Italy | Molecular Structure | Corylus - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Tetrahedron letters, ISSN 0040-4039, 08/2019, Volume 60, Issue 32, p. 150930
Journal Article
Phytochemistry (Oxford), ISSN 0031-9422, 2012, Volume 73, Issue 1, pp. 84 - 94
Alnus formosana | HPLC-SPE-NMR | Anti-inflammatory | Diarylheptanoids | Betulaceae | Plant Leaves - chemistry | Nitric Oxide - biosynthesis | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Anti-Inflammatory Agents - pharmacology | Chromatography, High Pressure Liquid | Animals | Anti-Inflammatory Agents - chemistry | Alnus - chemistry | Diarylheptanoids - isolation & purification | Lipopolysaccharides - pharmacology | Taiwan | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Anti-inflammatory drugs | Investigations | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 06/2020, Volume 195, pp. 112276 - 112276
Curcumin | Antibacterial | S. aureus | Curcuminoids | MRSA | Methicillin-Resistant Staphylococcus aureus - physiology | Diarylheptanoids - chemistry | Chemistry Techniques, Synthetic | Diarylheptanoids - pharmacology | Microbial Viability - drug effects | Methicillin-Resistant Staphylococcus aureus - drug effects | Anti-Bacterial Agents - chemical synthesis | Animals | Diarylheptanoids - chemical synthesis | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Mice | 3T3 Cells | Index Medicus
Journal Article
Journal of agricultural and food chemistry, ISSN 0021-8561, 05/2018, Volume 66, Issue 18, pp. 4660 - 4673
diarylheptanoids | asadanin | taste | Cimiciato | hazelnuts | Corylus avellana L | giffonin P | bitter | Diarylheptanoids - chemistry | Humans | Nuts - metabolism | Flavoring Agents - metabolism | Male | Chromatography, High Pressure Liquid | Young Adult | Tandem Mass Spectrometry | Diarylheptanoids - metabolism | Corylus - metabolism | Flavoring Agents - chemistry | Nuts - chemistry | Adult | Female | Taste | Corylus - chemistry | Index Medicus
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 10/2015, Volume 25, Issue 20, pp. 4648 - 4651
Obesity | 3T3-L1 cells | Diarylheptanoids | Alnus japonica | Adipocyte differentiation | Betulaceae | Adipogenesis | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Diarylheptanoids - chemistry | Diarylheptanoids - pharmacology | Fruit - chemistry | Adipogenesis - drug effects | RNA, Messenger - genetics | Signal Transduction - genetics | Structure-Activity Relationship | 3T3-L1 Cells | Down-Regulation - drug effects | PPAR gamma - metabolism | Dose-Response Relationship, Drug | Animals | Alnus - chemistry | Signal Transduction - drug effects | Sterol Regulatory Element Binding Protein 1 - genetics | Diarylheptanoids - isolation & purification | CCAAT-Enhancer-Binding Protein-alpha - genetics | Mice | Molecular Structure | Adipogenesis - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Index Medicus
Journal Article