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Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 22, pp. 2792 - 2795
Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more... 
DESIGN | METAL-ORGANIC FRAMEWORKS | CHEMISTRY | TUMOR | COLLOIDAL STABILITY | DICHLOROACETATE | ENDOCYTOSIS | CANCER | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 09/2019, Volume 20, Issue 9, pp. 1281 - 1289
Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK) that has been shown to reverse the Warburg effect and cause tumor cell death.... 
hypoxia | dichloroacetate | pyruvate | mitochondria | Cancer | VITRO | APOPTOSIS | DICHLOROACETATE DCA | MECHANISMS | PYRUVATE-DEHYDROGENASE COMPLEX | BREAST-CANCER CELLS | METABOLISM | ONCOLOGY | ADAPTATION | LACTIC-ACIDOSIS | PROGRESSION
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2015, Volume 14, Issue 9, pp. 1389 - 1402
Rhadomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS cells resemble fetal myoblasts but are unable to complete myogenic... 
differentiation therapy | metabolism and cancer | miR-206 | Rhabdomyosarcoma | Differentiation therapy | MiR-206 | Metabolism and cancer | HMT, Histone MethylTransferase | PPP, Pentose Phosphate Pathway | MYOBLAST DIFFERENTIATION | MREs, MicroRNA Responsive Elements | DHEA, Dehydroepiandrosterone | DCA, Dichloroacetate | MRFs, Myogenic Regulatory Factors | DICHLOROACETATE DCA | CYCLIN D1 | G6PD, Glucose 6 Phosphate Dehydrogenase | myomiRs, muscle-specific microRNAs | MIR-206 | PDK, Pyruvate Dehydrogenase Kinase | CELL BIOLOGY | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE | TARGET GENES | RMS, Rhabdomyosarcoma | ALVEOLAR RHABDOMYOSARCOMA | SKELETAL | TCA cycle, TriCarboxylic Acid cycle | PDH, Pyruvate Dehydrogenase | EXPRESSION | SMYD1, SET and MYND domain-containing protein 1 | HISTONE METHYLTRANSFERASE | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | DNA-Binding Proteins - metabolism | Rhabdomyosarcoma, Embryonal - genetics | Transfection | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | Muscle Proteins - metabolism | Rhabdomyosarcoma, Alveolar - pathology | Transcription, Genetic | Rhabdomyosarcoma, Embryonal - pathology | Rhabdomyosarcoma, Alveolar - drug therapy | Rhabdomyosarcoma, Alveolar - genetics | Rhabdomyosarcoma, Embryonal - enzymology | Signal Transduction | Rhabdomyosarcoma, Embryonal - drug therapy | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Myoblasts - pathology | Cell Transformation, Neoplastic - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Phenotype | Muscle Development - drug effects | Energy Metabolism | Rhabdomyosarcoma, Alveolar - enzymology | Cell Differentiation - drug effects | Dichloroacetic Acid - pharmacology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Glucosephosphate Dehydrogenase - metabolism | MicroRNAs - genetics | Glucosephosphate Dehydrogenase - genetics | Cell Transformation, Neoplastic - pathology | Myoblasts - enzymology | Muscle Fibers, Skeletal - enzymology
Journal Article
World Journal of Clinical Oncology, ISSN 2218-4333, 08/2017, Volume 8, Issue 4, pp. 371 - 377
Sodium dichloroacetate (DCA) has been studied as a metabolic cancer therapy since 2007, based on a publication from Bonnet et al demonstrating that DCA can... 
Dichloroacetate | BRAF | Cytostatic | Melanoma | Cancer | Case Report
Journal Article
The Journal of Physiology, ISSN 0022-3751, 08/2018, Volume 596, Issue 15, pp. 2957 - 2958
Metabolic flexibility is compromised during myocardial hypoxia and the development of heart failure. This article is protected by copyright. All rights... 
pyruvate dehydrogenase | cardiac metabolism | dichloroacetate | NEUROSCIENCES | PHYSIOLOGY | Hypoxia | Dichloroacetic acid
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2015, Volume 125, Issue 1, pp. 194 - 207
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2015, Volume 22, Issue 4, pp. 577 - 589
Journal Article