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BMC bioinformatics, ISSN 1471-2105, 2016, Volume 17, Issue 1
The advent of high throughput RNA-seq at the single-cell level has opened up new opportunities to elucidate the heterogeneity of gene expression... 
Transcriptional bursting model | Stochastic gene expression | Software | Differential gene expression | Single-cell RNA-seq | RNA sequencing | Gene expression | Research
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2014, Volume 124, Issue 7, pp. 3003 - 3015
The majority of non-small cell lung cancer (NSCLC) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase... 
CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | BREAST-CANCER | TARGETED THERAPY | MEDICINE, RESEARCH & EXPERIMENTAL | FACTOR-RECEPTOR GENE | DIFFERENTIAL IMMUNOHISTOCHEMICAL DETECTION | ACQUIRED-RESISTANCE | E-CADHERIN | MESENCHYMAL TRANSITION | GEFITINIB RESISTANCE | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Epithelial-Mesenchymal Transition | src-Family Kinases - metabolism | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Intercellular Signaling Peptides and Proteins - genetics | GPI-Linked Proteins - metabolism | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Genes, erbB-1 | Animals | Mice, Nude | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Quinazolines - pharmacology | GPI-Linked Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Care and treatment | Gene mutations | Genetic aspects | Properties | Drug resistance | Lung cancer, Non-small cell | Growth factors | Identification and classification | Proteins | Studies | Medical research | Lung cancer | Mortality | Cell cycle | Kinases | Cancer therapies | Tumors
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 5, pp. 1201 - 1215
...) in the livers of ob/ob mice using an adenoviral vector. GRP78 overexpression reduced ER stress markers and inhibited SREBP-1c cleavage and the expression of SREBP-lc and SREBP-2 target genes... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLUCOSE-HOMEOSTASIS | FATTY-ACID SYNTHESIS | ELEMENT-BINDING PROTEIN-1C | ENZYME GENES | LIPOGENIC GENE-EXPRESSION | ENDOPLASMIC-RETICULUM STRESS | COPII PROTEINS | TRANSCRIPTION FACTOR | DIFFERENTIAL REGULATION | LIVER-X-RECEPTOR | Molecular Chaperones - metabolism | Gene Expression - drug effects | Rats, Wistar | Fatty Liver - pathology | Gene Expression - genetics | Endoplasmic Reticulum - metabolism | Fatty Liver - therapy | Male | Hepatocytes - metabolism | Insulin Receptor Substrate Proteins - metabolism | Heat-Shock Proteins - genetics | Insulin Resistance - physiology | Endoplasmic Reticulum - drug effects | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Nuclear Proteins - genetics | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Insulin - pharmacology | Fatty Liver - metabolism | Heat-Shock Proteins - metabolism | Liver - metabolism | Molecular Chaperones - genetics | Rats | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Obesity - metabolism | Rats, Zucker | Transcription Factors - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Models, Biological | Glucose - metabolism | Thapsigargin - pharmacology | Mice, Obese | Mice | Care and treatment | Liver diseases | Physiological aspects | Heat shock proteins | Insulin resistance | Genetic aspects | Research | Endoplasmic reticulum | Health aspects | Risk factors
Journal Article
Journal Article
Human pathology, ISSN 0046-8177, 2017, Volume 60, pp. 82 - 85
Journal Article
Genome biology, ISSN 1474-760X, 2018, Volume 19, Issue 1, pp. 1 - 5
Journal Article
GenomeBiology.com, ISSN 1465-6906, 2011, Volume 12, Issue 3, pp. R22 - R22
.... This non-uniformity must be accounted for when estimating expression levels, and we show how to perform the needed corrections using a likelihood based approach... 
GENE-EXPRESSION | SPLICE JUNCTIONS | DIFFERENTIAL EXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | REVEALS | Sequence Analysis, RNA - methods | Reproducibility of Results | Gene Library | Quality Improvement | Bias | Humans | Gene Expression Profiling | Method
Journal Article
2010, 1, ISBN 9780470581599, xix, 372
An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational... 
Bioinformatics
Book