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hedyotis diffusa willd (36) 36
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by Lin, JM and Chen, YQ and Wei, LH and Chen, XZ and Xu, W and Hong, ZF and Sferra, TJ and Peng, J
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 11/2010, Volume 37, Issue 5, pp. 1331 - 1338
Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer. However,... 
1ST-LINE TREATMENT | MULTICENTER RANDOMIZED-TRIAL | colorectal cancer | mitochondria | apoptosis | CHANNEL-FORMING ACTIVITY | DEATH | Hedyotis Diffusa Willd | RELEASE | METASTATIC COLORECTAL-CANCER | FAMILY | CYTOCHROME-C | BCL-2 | ONCOLOGY | HT-29 cells | BAX | herbal medicine
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 11/2011, Volume 4, Issue 6, pp. 1283 - 1288
Journal Article
Oncology Letters, ISSN 1792-1074, 12/2017, Volume 14, Issue 6, pp. 7923 - 7930
Hedyotis diffusa Willd (HDW) is a widely used traditional Chinese medicine in clinical therapy to treat various types of cancer, including colorectal cancer... 
Extracellular-signal-regulated kinase | Protein kinase B | Proliferation | Colorectal cancer | Apoptosis | Hedyotis diffusa willd | URSOLIC ACID | colorectal cancer | extracellular-signal-regulated kinase | proliferation | ONCOLOGY | GROWTH | apoptosis | Hedyotis diffusa Willd | OLEANOLIC ACID | protein kinase B | PROMOTES APOPTOSIS
Journal Article
Oncology Letters, ISSN 1792-1074, 12/2017, Volume 14, Issue 6, pp. 8197 - 8205
The development of colorectal cancer (CRC) is strongly associated with the imbalance of various intracellular signal transduction cascades, including protein... 
Signaling pathway | Colorectal cancer | Cytokine | Hedyotis diffusa willd | cytokine | ACTIVATION | colorectal cancer | NATURAL-PRODUCTS | STAT3 | signaling pathway | CYCLE ARREST | Hedyotis diffusa Willd | DRUG-RESISTANCE | SIGNALING INDUCES APOPTOSIS | BARBATA D. DON | INHIBITION | COLITIS | ONCOLOGY | COLON-CARCINOMA CELL
Journal Article
In Vivo, ISSN 0258-851X, 07/2015, Volume 29, Issue 4, pp. 453 - 460
Numerous clinical anticancer drugs are obtained from natural plants and Hedyotis diffusa Willd (EEHDW) has been used as a major component in Traditional... 
Normal BALB/c mice | Natural killer cells | Ethanol extract of Hedyotis diffusa Willd | Phagocytosis | Macrophage | ethanol extract of Hedyotis diffusa Willd | MEDICINE, RESEARCH & EXPERIMENTAL | phagocytosis | APOPTOSIS | ANGIOGENESIS | NATURAL-PRODUCTS | CYCLE ARREST | macrophage | PROLIFERATION | CANCER | INHIBITION | PATHWAY | DISEASE | LEUKEMIA WEHI-3 CELLS | normal BALB/c mice | Plant Extracts - chemistry | Plant Extracts - pharmacology | Blood Cells - metabolism | Body Weight - drug effects | Male | Hedyotis - chemistry | Immunity - drug effects | Plant Extracts - administration & dosage | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Antigens, Surface - metabolism | Killer Cells, Natural - immunology | Blood Cells - drug effects | Cytotoxicity, Immunologic - drug effects | B-Lymphocytes - metabolism | Macrophages - immunology | Phagocytosis - drug effects | Immunologic Factors - administration & dosage | Phagocytosis - immunology | B-Lymphocytes - drug effects | Macrophages - metabolism | Organ Size - drug effects | Animals | B-Lymphocytes - immunology | Lymphocyte Activation - drug effects | Immune System - drug effects | Biomarkers | Macrophages - drug effects | T-Lymphocytes - immunology | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Immunologic Factors - pharmacology | Index Medicus
Journal Article
Environmental Toxicology, ISSN 1520-4081, 09/2015, Volume 30, Issue 10, pp. 1162 - 1177
Journal Article
Oncology Reports, ISSN 1021-335X, 8/2012, Volume 28, Issue 2, pp. 742 - 748
Hedyotis Diffusa Willd (HDW), a Chinese herbal medicine, has been widely used as an adjuvant therapy against various cancers, including hepatocellular... 
E2F1 | 5-fluorouracil | Hedyotis Diffusa Willd | hepatocellular carcinoma | CDK2 | Hepatocellular carcinoma | ADVANCED HEPATOCELLULAR-CARCINOMA | INTRAARTERIAL | CYCLOPHOSPHAMIDE | ARTERIAL INFUSION CHEMOTHERAPY | FLUOROURACIL | CISPLATIN | ONCOLOGY | METASTATIC BREAST-CANCER | TRANSCRIPTION FACTOR | EXPRESSION | CYCLE | Plant Extracts - chemistry | Plant Extracts - pharmacology | Humans | Hedyotis - chemistry | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Plant Extracts - administration & dosage | RNA, Messenger - biosynthesis | Carcinoma, Hepatocellular - drug therapy | Fluorouracil - administration & dosage | Carcinoma, Hepatocellular - genetics | Water - chemistry | Female | Liver Neoplasms - pathology | E2F1 Transcription Factor - antagonists & inhibitors | Cyclin-Dependent Kinase 2 - metabolism | Liver Neoplasms - genetics | Cell Growth Processes - drug effects | RNA, Messenger - genetics | Liver Neoplasms - drug therapy | Cyclin-Dependent Kinase 2 - genetics | E2F1 Transcription Factor - metabolism | Hep G2 Cells | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Resting Phase, Cell Cycle - drug effects | Fluorouracil - pharmacology | Mice | Mice, Inbred BALB C | S Phase - drug effects | E2F1 Transcription Factor - genetics | G1 Phase Cell Cycle Checkpoints - drug effects | Carcinoma, Hepatocellular - metabolism | Chinese medicine | Cell growth | Kinases | Rodents | Cyclin-dependent kinases | Index Medicus
Journal Article
Experimental and Therapeutic Medicine, ISSN 1792-0981, 06/2017, Volume 13, Issue 6, pp. 3388 - 3396
Arsenic trioxide (ATO) is clinically used to treat acute promyelocytic leukemia (APL); however, the therapeutic dose of ATO may prompt critical cardiac side... 
Arsenic trioxide | Hedyotis diffusa Willd | Acute promyelocytic leukemia | Death receptor | Apoptosis | PROSTATE | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | arsenic trioxide | TUMOR | apoptosis | PROLIFERATION | PROLONGATION | CANCER | acute promyelocytic leukemia | PATHWAY | HUMAN HEPATOCELLULAR-CARCINOMA | AS2O3 | death receptor
Journal Article
Experimental and Therapeutic Medicine, ISSN 1792-0981, 08/2012, Volume 4, Issue 2, pp. 307 - 310
Hedyotis diffusa Willd (HDW) has long been used as an important component in several Chinese medicine formulae to clinically treat various types of cancer,... 
Chinese herbal medicine | Proliferation | Cell cycle | Colorectal cancer | Hedyotis diffusa willd | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | colorectal cancer | proliferation | cell cycle | Hedyotis diffusa Willd | CHEMOPREVENTION | CANCER | EXPRESSION | DEPENDENT KINASE INHIBITORS
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2017, Volume 28, Issue 12, pp. 5280 - 5284
To establish a method for qualification and quantification of gallic acid in Hedyotis diffusa Willd. and to investigate its proapoptotic mechanism on lung... 
NCI-H460 cell | Hedyotis diffusa Willd | Gallic acid | HPLC | MEDICINE, RESEARCH & EXPERIMENTAL | SURVIVIN | LIVIN
Journal Article
In Vivo, ISSN 0258-851X, 07/2011, Volume 25, Issue 4, pp. 633 - 640
Journal Article
African Journal of Biotechnology, ISSN 1684-5315, 08/2011, Volume 10, Issue 46, pp. 9445 - 9453
Hedyotis diffusa (H. diffusa) Willd. is known to induce apoptosis in cancer cells. However, the molecular mechanism of its anti-cancer activity has not been... 
Caspase | THP-1 | Hedyotis diffusa Willd | Apoptosis | SMAC/DIABLO | apoptosis | MECHANISMS | CANCER | caspase | THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CASPASES | IAP | INHIBITORS | ACTIVATED PROTEIN-KINASES | EXPRESSION
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 05/2012, Volume 141, Issue 1, pp. 273 - 281
Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. The current study is an attempt to evaluate the... 
Aspirin | Turnera diffusa Willd. ex Schult | Ethanol | Cytokines | Arbutin | Gastroprotective activities | ANTIOXIDANT ACTIVITY | CHEMISTRY, MEDICINAL | ASSAY | PROTECTION | PROPERTY | INVOLVEMENT | INJURY | NEUTROPHILS | PLANT SCIENCES | GASTRIC-ULCER | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | EXTRACTS | Tumor Necrosis Factor-alpha - metabolism | Liver - pathology | Proton Pump Inhibitors - pharmacology | Plant Extracts - toxicity | Plant Extracts - pharmacology | Humans | Stomach Ulcer - pathology | Gastric Mucosa - pathology | Male | Gastric Mucosa - metabolism | Arbutin - pharmacology | Turnera - chemistry | Liver - drug effects | Gastric Mucosa - drug effects | Lipid Peroxidation - drug effects | Interleukin-10 - metabolism | Anti-Ulcer Agents - pharmacology | Female | Mucus - metabolism | Omeprazole - pharmacology | Phytotherapy | Anti-Ulcer Agents - toxicity | Interleukin-6 - metabolism | Stomach Ulcer - prevention & control | Cytoprotection | Disease Models, Animal | Stomach Ulcer - chemically induced | Cell Line | Stomach Ulcer - metabolism | Rats | Arbutin - isolation & purification | Plant Extracts - isolation & purification | Thiobarbituric Acid Reactive Substances - metabolism | Antioxidants - pharmacology | Rats, Sprague-Dawley | Gastric Mucosa - immunology | Animals | Anti-Ulcer Agents - isolation & purification | Gastric Acid - metabolism | Nitric Oxide - metabolism | Immunologic Factors - pharmacology | Plants, Medicinal | Hydrogen-Ion Concentration | Stomach Ulcer - immunology | Universities and colleges | Index Medicus
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 11/2016, Volume 192, pp. 132 - 139
willd (HDW) is a widely used medicinal herb in China. It processed various medicinal properties including antioxidative, anti-inflamatory and anti-cancer... 
Bioactive phytochemicals | Migration | Hedyotis diffusa willd | Ovarian cancer | Apoptosis | CHEMISTRY, MEDICINAL | HERBAL MEDICINE | KAEMPFEROL | PLANT SCIENCES | IN-VITRO | INHIBITION | PATHWAY | INTEGRATIVE & COMPLEMENTARY MEDICINE | GROWTH | PHARMACOLOGY & PHARMACY | FLAVONOID QUERCETIN | EXPRESSION | EXTRACT | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Ovarian Neoplasms - pathology | Chromatography, High Pressure Liquid | Hedyotis - chemistry | Dose-Response Relationship, Drug | Matrix Metalloproteinase 9 - metabolism | Mass Spectrometry | Female | Flavonoids - pharmacology | Ovarian Neoplasms - metabolism | Phytotherapy | Ovarian Neoplasms - drug therapy | Cell Survival - drug effects | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Anthraquinones - isolation & purification | Plant Extracts - isolation & purification | Apoptosis Regulatory Proteins - metabolism | Phytochemicals - isolation & purification | Cell Movement - drug effects | Cell Line, Tumor | Anthraquinones - pharmacology | Flavonoids - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Phytochemicals - pharmacology | Plants, Medicinal | Antineoplastic Agents, Phytogenic - isolation & purification | Medicinal plants | Medicine, Herbal | Medicine, Botanic | Cancer cells | Yuan (China) | Analysis | Index Medicus
Journal Article