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difluorination (95) 95
chemistry, organic (77) 77
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chemistry, multidisciplinary (41) 41
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Organic Letters, ISSN 1523-7060, 12/2018, Volume 20, Issue 24, pp. 8073 - 8076
A geminal difluorination of alkenes based on I­(I)/I­(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally... 
CHEMISTRY, ORGANIC | ALKENES | OLEFINS | DESIGN | VICINAL DIFLUORINATION | PHARMACEUTICALS
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2018, Volume 57, Issue 50, pp. 16431 - 16435
The enantioselective, catalytic vicinal difluorination of alkenes is reported by II/IIII catalysis using a novel, C2‐symmetric resorcinol derivative. Catalyst... 
enantioselectivity | organocatalysis | Brønsted acid | iodine | difluorination | FUNCTIONALIZATION | Bronsted acid | GEMINAL DIFLUORINATION | FLUORINATION | CHEMISTRY, MULTIDISCIPLINARY | Amines | Drug discovery | Catalysis | Enantiomers | Olefins | Alkenes | Styrenes | Oxidation | Acidity | Selectivity | Orthogonality | Resorcinol
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 04/2019, Volume 2019, Issue 13, pp. 2409 - 2413
We have successfully accomplished gem‐difluorination of triazole alkyl functionalized amino pyrazoles in the presence of Selectfluor under dry condition and... 
C–H halogenation | Electrophilic substitution | Triazoles | Selectfluor | Gem‐difluorination | Gem-difluorination | C-H halogenation | BIOLOGICAL EVALUATION | CHEMISTRY | CHEMISTRY, ORGANIC | FLUORINE | DERIVATIVES | BROMIDES | Bisphenol-A | Schiff bases
Journal Article
Chemical Society reviews, ISSN 0306-0012, 11/2016, Volume 45, Issue 22, pp. 6270 - 6288
The fluorination of organic molecules is a rapidly evolving and exciting field in synthesis, which still poses huge challenges despite the advances made in the... 
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2018, Volume 57, Issue 31, pp. 9896 - 9900
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2016, Volume 138, Issue 42, pp. 13858 - 13861
The enantioselective synthesis of 4-fluoroisochromanones via chiral aryl iodide-catalyzed fluorolactonization is reported. This methodology uses HF-pyridine as... 
MEDICINAL CHEMISTRY | ALKENES | PHASE-TRANSFER | AMINOFLUORINATION | ELECTROPHILIC FLUOROCYCLIZATION | ALPHA-FLUORINATION | AMMONIUM-SALTS | CHEMISTRY, MULTIDISCIPLINARY | CARBOXYLIC-ACIDS | ALLYL SILANES | DIFLUORINATION | Chemical reactions | Usage | Pyridine | Chemical properties | Nucleophiles
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 01/2019, Volume 84, Issue 1, pp. 458 - 462
Lewis/Bronsted acid activation plays a key role in hypervalent iodine reagent-mediated reactions. In addition to generally accepted cis-activation or... 
DENSITY FUNCTIONALS | REAGENT | ALKENES | AMINOFLUORINATION | THERMOCHEMISTRY | DISPERSION | CHEMISTRY, ORGANIC | NONCOVALENT INTERACTIONS | FLUORINATION | ENERGIES | DIFLUORINATION
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2017, Volume 139, Issue 12, pp. 4354 - 4357
An enantioselective catalytic vicinal diamination of styrenes is reported, which proceeds under entirely intermolecular reaction control. It relies on a... 
OXIDATION | BIOLOGICAL SIGNIFICANCE | ALKENE DIAMINATION | HYPERVALENT IODINE(III) REAGENTS | CONJUGATED DIENES | OLEFINS | ALPHA,BETA-DIAMINO ACIDS | TRIENE | CHEMISTRY, MULTIDISCIPLINARY | DIFLUORINATION | Benzoic acid | Chemical reactions | Usage | Catalysis | Chemical properties | Styrene
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 11/2016, Volume 45, Issue 22, pp. 627 - 6288
Journal Article
Organic Letters, ISSN 1523-7060, 10/2017, Volume 19, Issue 19, pp. 5300 - 5303
The first ring-contraction monofluorination reaction mediated by a hypervalent iodine reagent is reported, and the use of the reaction for the synthesis of... 
ALKENES | TRIACETATES | BORON-TRIFLUORIDE | REAGENTS | CHEMISTRY | CHEMISTRY, ORGANIC | OXIDATIVE FLUORINATION | 2-OXAZOLINES | DIFLUORINATION
Journal Article
Chemical Communications, ISSN 1359-7345, 2009, Issue 16, pp. 2073 - 2085
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 12/2019, Volume 55, Issue 98, pp. 14821 - 14824
A chemoselective fluorinative ring expansion has been realized using the hypervalent iodine (HVI) reagent p-TolIF(2), which delivers beta,beta-difluoroalkyl... 
CATALYZED FLUORINATION | ALKENES | BORON-TRIFLUORIDE | HYPERVALENT | REAGENTS | CONTRACTION | P-IODOTOLUENE DIFLUORIDE | GEMINAL DIFLUORINATION | CHEMISTRY, MULTIDISCIPLINARY | FLUORIDE
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 07/2018, Volume 51, Issue 7, pp. 1701 - 1710
Journal Article
by Xu, K and Yang, RQ and Yang, S and Jiang, C and Ding, ZH
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 10/2019, Volume 17, Issue 40, pp. 8977 - 8981
A hypervalent iodane reagent used for the intramolecular cyclization of N-acetyl enamines and intermolecular cyclocondensation of enamines and nitriles was... 
ALKENES | CYCLOADDITION | PALLADIUM | CARBONYLATION | CHEMISTRY, ORGANIC | OXIDATIVE CYCLIZATION | GEMINAL DIFLUORINATION | FLUORINATION | OXYFLUORINATION | IODINE REAGENTS | ENAMIDES
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, p. 15913
Amines are a fundamentally important class of biologically active compounds and the ability to manipulate their physicochemical properties through the... 
FLUORINATION | MULTIDISCIPLINARY SCIENCES | DISCOVERY | TRIFLUOROMETHYLATION | DIFLUORINATION | Oxygen | Construction | Amines | Catalysts | Fluorine | Moisture | Glassware | Selectivity | Aldehydes | Cores | Chemistry | Trifluoroacetic acid | Construction methods | Reagents | Fluorination | Chemical synthesis | Physicochemical properties
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2018, Volume 140, Issue 40, pp. 13034 - 13041
Despite ample evidence for the unique reactivity offered by hypervalent F-iodanes, mechanistic investigations fall far behind. In order to shed light on the... 
METAL-FREE SYNTHESIS | FLUOROIODANE REAGENT | MEDICINAL CHEMISTRY | ALKENES | ACID | OLEFINS | GEMINAL DIFLUORINATION | CHEMISTRY, MULTIDISCIPLINARY | HYPERVALENT IODINE REAGENTS | ATOM-TRANSFER REACTIONS | TRIFLUOROMETHYLATION
Journal Article