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difluorocarbene (314) 314
chemistry, organic (203) 203
chemistry, multidisciplinary (88) 88
fluorine (87) 87
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chemistry (71) 71
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JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 05/2019, Volume 84, Issue 9, pp. 5524 - 5534
A synthesis of the proposed structure of lineariifolianone has been achieved in eight steps and 9% overall yield starting from (+)-valencene, leading to a... 
DIFLUOROCARBENE | CHEMISTRY, ORGANIC | DERIVATIVES
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 2017, Volume 56, Issue 33, pp. 9971 - 9975
A new method for the on-site preparation of tetrafluoroethylene (TFE) and a procedure for its efficient use in pentafluoroethylation by fluoride addition were... 
pentafluoroethylation | copper | tetrafluoroethylation | difluorocarbene | tetrafluoroethylene
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2019, Volume 75, Issue 31, pp. 4167 - 4173
A method for the first direct insertion of difluorcarbene, generated from TMSCF , into diselenides and disulfides is disclosed, producing novel difluoromethyl... 
Insertion | Diselenides | TMSCF3 | Disulfides | Difluorocarbene
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2018, Volume 59, Issue 28, pp. 2752 - 2754
A simple and efficient protocol for the direct -difluoromethylation of imidazoles and pyrazoles has been developed. The reaction makes use of commercially... 
Benzimidazoles | Imidazoles | Pyrazoles | Difluoromethylation | Difluorocarbene
Journal Article
Organic Letters, ISSN 1523-7060, 05/2018, Volume 20, Issue 10, pp. 3061 - 3064
An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols... 
CHEMISTRY, ORGANIC | FLUORINE | DIFLUOROCARBENE | APPEL REACTION
Journal Article
ORGANOMETALLICS, ISSN 0276-7333, 08/2019, Volume 38, Issue 16, pp. 3169 - 3173
The air-stable [fac-(MeCN)(3)Co(C2F5)(3)] (1) was prepared through the reaction of cobalt(II) bromide with [Me3SiC2F5] and AgF. Upon reaction of 1 with wet... 
DIFLUOROCARBENE | CHEMISTRY, ORGANIC | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 02/2020, Volume 230, p. 109437
A large number of trifluoromethylthiolation methods have been developed, but a trifluoromethylthiolation reagent usually has to be used in these methods.... 
Copper | Fluorine | Terminal alkynes | Trifluoromethylthiolation | Difluorocarbene
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 3/2017, Volume 56, Issue 12, pp. 3196 - 3200
We discovered trifluoromethylthiolation occurred through sulfuration of difluorocarbene with elemental sulfur for the first time, which overrides our putative... 
trifluoromethylthiolation | 18F labeling | sulfuration | Difluorocarbene | fluorine
Journal Article
Synthetic Communications, ISSN 0039-7911, 01/2018, Volume 48, Issue 1, pp. 91 - 96
A simple and efficient protocol for difluoromethylation of isoflavones, flavonoids, and coumarins has been developed. The protocol uses readily available,... 
Coumarins | difluoromethylation | isoflavones | difluorocarbene | flavonoids | ETHERS | ACID | ARENES | CHEMISTRY, ORGANIC | DIFLUOROCARBENE PRECURSOR
Journal Article
Organic Letters, ISSN 1523-7060, 08/2016, Volume 18, Issue 15, pp. 3686 - 3689
The combination of difluoroiodomethane and zinc dust or diethylzinc can readily lead to (difluoromethyl)zinc reagents. Therefore, the first copper-catalyzed... 
HALIDES | PERFLUOROALKYL | MEDIATED DIFLUOROMETHYLATION | TRIFLUOROMETHYL | DIFLUOROCARBENE | ACIDS | ARENES | CHEMISTRY, ORGANIC | SYNTHETIC APPLICATION | BROMIDES
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2019, Volume 55, Issue 52, pp. 7446 - 7449
A facile and practical approach for the difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt was developed. A wide variety of... 
FLUORINE | ETHERS | O-DIFLUOROMETHYLATION | ACID | DIFLUOROCARBENE REAGENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
The Journal of organic chemistry, ISSN 0022-3263, 02/2019, Volume 84, Issue 4, pp. 2061 - 2071
A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed... 
CHEMISTRY, ORGANIC | ORGANIC HALIDES | FLUORINATION | DECARBOXYLATIVE TRIFLUOROMETHYLATION | DIFLUOROCARBENE | TEBUFENPYRAD ANALOGS
Journal Article
Organic Letters, ISSN 1523-7060, 08/2016, Volume 18, Issue 15, pp. 3690 - 3693
The palladium-catalyzed Negishi cross-coupling reaction of aryl iodides and bromides with (difluoromethyl)zinc reagent bearing a diamine such as TMEDA is... 
IODIDES | PERFLUOROALKYL | DIFLUOROCARBENE | COPPER-MEDIATED DIFLUOROMETHYLATION | CONSTRUCTION | CHEMISTRY, ORGANIC | SYNTHETIC APPLICATION | CENTERS | BROMIDES
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2013, Volume 52, Issue 7, pp. 2092 - 2095
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2017, Volume 139, Issue 34, pp. 11662 - 11665
This Communication describes studies of Ph–RF (RF = CF3 or CF2CF3) coupling at Pd complexes of general structure (P t Bu3)­PdII(Ph)­(RF). The CF3 analogue... 
FLUOROCARBENE | DIFLUOROCARBENE | STABILITY | REACTIVITY | CHEMISTRY | LIGAND | ARYLPALLADIUM(II) HALIDE-COMPLEXES | REDUCTIVE ELIMINATION | CHEMISTRY, MULTIDISCIPLINARY | TRIFLUOROMETHYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 10/2013, Volume 15, Issue 19, pp. 5036 - 5039
A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes... 
REAGENT | KETONES | ETHERS | DIFLUOROCARBENE | ACIDS | CATALYZED SYNTHESIS | CHEMISTRY, ORGANIC | FLUORINE | ARYL | THIOETHERS | TRIFLUOROMETHYLATION
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2018, Volume 360, Issue 21, pp. 4030 - 4030
The inside cover picture, provided by Pavel Nosik, Sergey Ryabukhin, Dmitriy Volochnyuk, and Oleksandr Grygorenko illustrates difluorocyclopropanation of... 
Cycloaddition | Cycloalkanes | Ruppert−Prakash reagent | Spiro compounds | Difluorocarbene
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 03/2019, Volume 30, Issue 3, pp. 714 - 716
As trifluoromethylthiolation has received increasing attention recently, many CF S-reagents and trifluoromethylthiolation methods have been developed. Herein... 
Thiocarbonyl fluoride | Fluorine | Alkyl halides | Trifluoromethylthiolation | Difluorocarbene
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 08/2019, Volume 30, Issue 8, pp. 1515 - 1518
A facile and highly efficient approach for selective -difluoromethylation of 1,3-diones with -(difluoromethyl)sulfonium salt was developed, and a wide variety... 
S-(Difluoromethy)sulfonium salt | 1,3-Diones | Difluoromethyl enol ethers | O-Difluoromethylation | Difluorocarbene | ALCOHOLS | ETHERS | FLUORINE | DIFLUOROCARBENE REAGENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 12/2012, Volume 2012, Issue 34, pp. 6679 - 6687
Development of transition‐metal‐catalyzed trifluoromethylation of arene substrates under mild reaction conditions has attracted great attention in the past few... 
Arenes | Trifluoromethylation | Copper | Fluorine | CATALYZED OXIDATIVE TRIFLUOROMETHYLATION | DIFLUOROCARBENE | CONVENIENT METHOD | CHEMISTRY, ORGANIC | REDUCTIVE ELIMINATION | SELECTIVE TRIFLUOROMETHYLATION | BORONIC ACIDS | ORGANIC HALIDES | ARYL IODIDES | BOND-FORMATION
Journal Article
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