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difluorocarbene (164) 164
chemistry, organic (113) 113
chemistry, multidisciplinary (61) 61
fluorine (61) 61
reagent (44) 44
derivatives (40) 40
chemistry (36) 36
difluoromethylation (36) 36
trifluoromethylation (35) 35
reagents (34) 34
chemistry, inorganic & nuclear (31) 31
fluorides (23) 23
index medicus (22) 22
organic chemistry (22) 22
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ethers (20) 20
thioethers (20) 20
fluor (19) 19
medicinal chemistry (19) 19
reactivity (18) 18
trifluoromethylthiolation (17) 17
acid (15) 15
alpha-fluorinated ethers (15) 15
arenes (15) 15
catalysis (15) 15
ketones (15) 15
alcohols (14) 14
alkenes (14) 14
amines (14) 14
chemical tests and reagents (14) 14
copper (14) 14
efficient synthesis (14) 14
aldehydes (13) 13
fluorination (13) 13
synthetic methods (13) 13
halides (12) 12
o-difluoromethylation (12) 12
copper-mediated difluoromethylation (11) 11
cycloaddition (11) 11
difluorocarbene precursor (11) 11
fluoroalkylation (11) 11
hydrocarbons, fluorinated - chemistry (11) 11
iodides (11) 11
organic halides (11) 11
ruppert-prakash reagent (11) 11
aromatic compounds (10) 10
difluorocarbene reagent (10) 10
esters (10) 10
gem-difluorocyclopropanes (10) 10
generation (10) 10
molecular structure (10) 10
reaction-condition (10) 10
reaktionsbedingung (10) 10
synthesis (10) 10
chemical properties (9) 9
chemical synthesis (9) 9
chemistry, applied (9) 9
complexes (9) 9
nucleophiles (9) 9
nucleophilic trifluoromethylation (9) 9
organozinc reagents (9) 9
salts (9) 9
alkynes (8) 8
analysis (8) 8
aryl halides (8) 8
aryl iodides (8) 8
bromides (8) 8
carbenes (8) 8
cyclopropanes (8) 8
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funktionelle gruppe (8) 8
radicals (8) 8
acids (7) 7
activation (7) 7
aryl boronic acids (7) 7
c-nucleophiles (7) 7
direct difluoromethylation (7) 7
functional groups (7) 7
hydrocarbons, fluorinated - chemical synthesis (7) 7
nucleophilic difluoromethylation (7) 7
olefins (7) 7
photoredox catalysis (7) 7
route (7) 7
terminal alkynes (7) 7
trimethylchlorosilan (7) 7
trimethylchlorosilane (7) 7
alkene (6) 6
anions (6) 6
arylboronic acids (6) 6
building-blocks (6) 6
carbon (6) 6
chemisches reaktionsvermögen (6) 6
copper-catalyzed trifluoromethylation (6) 6
cyclization (6) 6
disulfides (6) 6
fluoroform (6) 6
gem-difluoroolefination (6) 6
heterocycles (6) 6
inhibitors (6) 6
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Angewandte Chemie International Edition, ISSN 1433-7851, 04/2016, Volume 55, Issue 15, pp. 4790 - 4793
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 1900, Volume 137, Issue 33, pp. 10547 - 10553
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2016, Volume 55, Issue 51, pp. 15807 - 15811
A new shelf‐stable and easily scalable difluoromethylthiolating reagent S‐(difluoromethyl) benzenesulfonothioate (PhSO2SCF2H) was developed. PhSO2SCF2H is a... 
reaction mechanisms | decarboxylation | radicals | synthetic methods | fluorine | DIFLUOROCARBENE | C-NUCLEOPHILES | CHEMISTRY, MULTIDISCIPLINARY | MEDICINAL CHEMISTRY | DIFLUOROMETHYLATION | ETHERS | TRIFLUOROMETHYLTHIOLATION | HETEROCYCLES | ARYL | ALIPHATIC CARBOXYLIC-ACIDS | THIOETHERS | Chemical tests and reagents | Fluorides
Journal Article
Chinese Journal of Chemistry, ISSN 1001-604X, 02/2020, Volume 38, Issue 2, pp. 202 - 212
Summary Methyl fluorosulfonyldifluoroacetate (FSO2CF2CO2Me or MFSDA), often called “Chen's reagent”, is commonly used to synthesize trifluoromethylated and... 
ACID | DIFLUOROCARBENE | DIFLUORODIIODOMETHANE | METHYL FLUOROSULFONYLDIFLUOROACETATE | ARYL HALIDES | FLUOROALKYLATION | FLUORINE | COPPER | ORGANOFLUORINE CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | IN-SITU
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 01/2017, Volume 23, Issue 6, pp. 1219 - 1230
Journal Article
Organic Letters, ISSN 1523-7060, 07/2016, Volume 18, Issue 14, pp. 3354 - 3357
Siladifluoromethylations and difluoromethylations on sp3, sp2, and sp carbons of lithiated carbamates, arenes, and terminal alkynes, respectively, have been... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | FUNCTIONALIZATION | SP CARBON | DIFLUOROCARBENE | COPPER-MEDIATED DIFLUOROMETHYLATION | DEOXYFLUORINATION | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | BOND ACTIVATION | ARYL | FLUORINATION
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2016, Volume 57, Issue 13, pp. 1397 - 1409
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 10/2015, Volume 17, Issue 19, pp. 4882 - 4885
Difluoromethylation on sp(3) carbon of various nitrile compounds with lithium base and fluoroform (CF3H), which is an ideal difluoromethylating reagent, is... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | EFFICIENT PRECURSOR | ACTIVATION | DIFLUOROCARBENE | IMINES | COPPER-MEDIATED DIFLUOROMETHYLATION | CONSTRUCTION | CHEMISTRY, ORGANIC | ARYL | ALDEHYDES
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 12/2015, Volume 180, pp. 186 - 191
Journal Article
Organic Letters, ISSN 1523-7060, 08/2016, Volume 18, Issue 15, pp. 3690 - 3693
The palladium-catalyzed Negishi cross-coupling reaction of aryl iodides and bromides with (difluoromethyl)zinc reagent bearing a diamine such as TMEDA is... 
IODIDES | PERFLUOROALKYL | DIFLUOROCARBENE | COPPER-MEDIATED DIFLUOROMETHYLATION | CONSTRUCTION | CHEMISTRY, ORGANIC | SYNTHETIC APPLICATION | CENTERS | BROMIDES
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2017, Volume 56, Issue 12, pp. 3206 - 3210
A general method for the efficient difluoromethylation of alcohols using commercially available TMSCF2Br (TMS=trimethylsilyl) as a unique and practical... 
alcohols | difluorocarbene | synthetic methods | difluoromethyl ethers | fluorine | MEDICINAL CHEMISTRY | AMINES | ALPHA-FLUORINATED ETHERS | BOND | ORGANOFLUORINE COMPOUNDS | THIOETHERS | CHEMISTRY, MULTIDISCIPLINARY | Fluorides | Drinking of alcoholic beverages | Alcohols | Alcohol
Journal Article
Organic Letters, ISSN 1523-7060, 05/2009, Volume 11, Issue 10, pp. 2109 - 2112
The first α-difluoromethyl sulfoximine compound, 2, was successfully prepared by using the copper(II)-catalyzed nitrene transfer reaction. Compound 2 was found... 
MEDICINAL CHEMISTRY | SULFOXIMINES | ALLYLIC ALCOHOLS | PHENYL SULFONE | FLUOROALKYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | DIFLUOROCARBENE PRECURSOR | DERIVATIVES | RADICAL (PHENYLSULFONYL)DIFLUOROMETHYLATION | EQUIVALENT
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 03/2015, Volume 171, pp. 97 - 101
Assembling of gem-difluorinated compounds from organozinc reagents, potassium bromodifluoroacetate and electrophiles is described. •Synthesis of... 
gem-Difluorinated compounds | Organozinc reagents | Potassium bromodifluoroacetate | Difluorocarbene | (TRIFLUOROMETHYL)COPPER | HALIDES | INSERTION | TRIFLUOROMETHYL IODIDE | CHEMISTRY, ORGANIC | COPPER | CHEMISTRY, INORGANIC & NUCLEAR | CHEMISTRY | BOND | DIFLUOROMETHYLENE | Chemical tests and reagents
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 06/2017, Volume 198, pp. 67 - 75
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 10/2019, Volume 21, Issue 20, pp. 8244 - 8249
We report a general and efficient approach to construct achiral and chiral gem-difluoroallylic amines from a masked difluorodiazo reagent (PhSO2CF2CHN2) and... 
ASYMMETRIC MANNICH REACTION | DIFLUOROOLEFINATION | ANION | DIFLUOROCARBENE | CATALYZED REACTIONS | ALKYLATION | IMINES | CHEMISTRY, ORGANIC | GENERATION | ALPHA-DIAZOMETHYLPHOSPHONATES | C-F
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2014, Volume 55, Issue 50, pp. 6839 - 6843
[Display omitted] The bromodifluoromethylation of aromatic Grignard reagents having electron-withdrawing groups with dibromodifluoromethane (CF2Br2) was... 
Bromodifluoromethylation | Organofluorine compounds | Dibromodifluoromethane | Aromatic Grignard reagents | Difluorocarbene | Grignard reagents | Aromatic | EXCHANGE-REACTION | EFFICIENT SYNTHESIS | REACTIVITY | CHEMISTRY, ORGANIC
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2016, Volume 81, Issue 19, pp. 9455 - 9460
A new fluorinated silicon reagent bearing a functionalized tetrafluoroethylene fragment was prepared from two CF2 building blocks: ethyl bromodifluoroacetate... 
KETONES | DIFLUOROCARBENE | DIFLUOROHOMOLOGATION | MESOGENIC CORE STRUCTURE | LIQUID-CRYSTALS | CHEMISTRY, ORGANIC | FLUORINE | FLUOROALKYLATION REACTIONS | DERIVATIVES | EQUIVALENT | TRIFLUOROMETHYLATION | Silicon compounds | Chemical bonds | Chemical properties | Analysis | Methyl groups
Journal Article
ORGANIC PROCESS RESEARCH & DEVELOPMENT, ISSN 1083-6160, 08/2019, Volume 23, Issue 8, pp. 1695 - 1702
We report a safe and readily prepared reagent [1,1'-biphenyl]-4-y1 2-bromo-2,2-difluoroacetate (BBDFA) for Cu-catalyzed trifluoromethylation of allylic or... 
process safety | DIFLUOROCARBENE | ANALOGS | CHEMISTRY, ORGANIC | thermal stability | RC1 calorimetry | copper catalysis | COPPER-CATALYZED TRIFLUOROMETHYLATION | DECARBOXYLATIVE TRIFLUOROMETHYLATION | FLUORINE | trifluoromethylation | ORGANIC HALIDES | CHEMISTRY, APPLIED | DERIVATIVES
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 11/2016, Volume 191, pp. 143 - 148
[Display omitted] Copper-catalyzed or light-promoted coupling of gem-difluorinated organozinc reagents with disulfides is described. •Reactions of fluorinated... 
Organozinc reagents | Disulfides | Difluorinated compounds | Difluorocarbene | HALIDES | ORGANIC-SYNTHESIS | CATALYSIS | FLUOROALKYLATION | CHEMISTRY, ORGANIC | DISULFIDE | CHEMISTRY, INORGANIC & NUCLEAR | ARYL IODIDES | RADICALS | BOND | PHOTOLYSIS | Chemical tests and reagents | Copper | Sulfur compounds
Journal Article