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chemistry, organic (192) 192
fluorine (93) 93
chemistry, multidisciplinary (72) 72
difluoromethyl (60) 60
chemistry, inorganic & nuclear (48) 48
trifluoromethylation (47) 47
carbonyl-compounds (45) 45
derivatives (41) 41
medicinal chemistry (39) 39
functionalized difluoromethyl bromides (35) 35
aldehydes (33) 33
alcohols (30) 30
animals (30) 30
index medicus (30) 30
aryl boronic acids (29) 29
difluoromethyl phenyl sulfone (28) 28
fluorination (28) 28
chemistry (27) 27
difluoromethylation (27) 27
stereoselective-synthesis (27) 27
ketones (26) 26
reagents (25) 25
alkenes (24) 24
herbicides (24) 24
plant sciences (24) 24
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catalysis (22) 22
research (22) 22
asymmetric-synthesis (21) 21
copper (21) 21
organic chemistry (21) 21
difluorocarbene (20) 20
difluoromethyl thioethers (20) 20
equivalent (19) 19
copper-mediated difluoromethylation (18) 18
inhibitors (18) 18
difluoroalkylation (17) 17
synthetic methods (17) 17
trifluoromethyl (17) 17
amines (15) 15
biochemistry & molecular biology (15) 15
c-h difluoroalkylation (15) 15
enantioselective synthesis (15) 15
ethers (15) 15
humans (15) 15
nucleophilic difluoromethylation (15) 15
ornithine decarboxylase (15) 15
polyamines (15) 15
reagent (15) 15
acids (14) 14
analogs (14) 14
arylboronic acids (14) 14
difluoromethyl group (14) 14
fluorides (14) 14
light photoredox catalysis (14) 14
weed control (14) 14
carboxylic-acids (13) 13
chemistry, applied (13) 13
difluoromethyl 2-pyridyl sulfone (13) 13
eflornithine - pharmacology (13) 13
fluorinated sulfones (13) 13
fluoroalkylation (13) 13
heterocycles (13) 13
inhibition (13) 13
photoredox catalysis (13) 13
radicals (13) 13
rats (13) 13
agriculture (12) 12
agronomy (12) 12
alkyl-halides (12) 12
alkynes (12) 12
chemical properties (12) 12
chemical synthesis (12) 12
difluoromethyl ornithine (12) 12
fluor (12) 12
molecular structure (12) 12
palladium (12) 12
stereoisomerism (12) 12
trifluoromethyl ketones (12) 12
zinc reagent (12) 12
analysis (11) 11
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difluoromethyl diazomethane (11) 11
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one-pot synthesis (11) 11
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convenient synthesis (10) 10
diazo-compounds (10) 10
facile synthesis (10) 10
hydrazones (10) 10
iodides (10) 10
organic-synthesis (10) 10
pharmacology & pharmacy (10) 10
plants (10) 10
arenes (9) 9
aryl halides (9) 9
catalysts (9) 9
chemical tests and reagents (9) 9
ethyl bromodifluoroacetate (9) 9
letter (9) 9
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Chemistry – A European Journal, ISSN 0947-6539, 06/2019, Volume 25, Issue 31, pp. 7405 - 7405
Under catalyst‐free conditions, decarboxylative fluorination of lithium 2‐pyridylacetates easily occurs. An electrophilic fluorinating reagent dramatically... 
fluorination | pyridine | difluoromethyl group | decarboxylation | methyl ester
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2015, Volume 137, Issue 45, pp. 14496 - 14501
A new olefination protocol for transition-metal-free cross-coupling of two carbene fragments arising from two different sources, namely, a nonfluorinated... 
NUCLEOPHILES | INSERTION | DIFLUOROALKENES | BIOLOGICAL-ACTIVITY | BONDS | DIFLUOROMETHYL 2-PYRIDYL SULFONE | CATALYZED REACTION | CYCLOPROPANES | CHEMISTRY, MULTIDISCIPLINARY | CYCLIZATION | SSR182289A
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 03/2019, Volume 17, Issue 9, pp. 2502 - 2507
In contrast to many other water-soluble peptide arrangements, the formation of a triple helix in collagen proceeds inside out: polar glycyl residues form the... 
MIMETIC PEPTIDES | CHEMISTRY, ORGANIC | DESIGN | TRIFLUOROMETHYL | DIFLUOROMETHYL DIAZOMETHANE | CARBOXYLIC-ACIDS
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 11/2015, Volume 179, pp. 175 - 178
Improved, efficient, grams scale synthesis of α-(difluoromethyl)styrene (DFMST) based on nucleophilic difluoromethylation process using difluoromethylphenyl... 
α-(Difluoromethyl)styrene | Grams scale monomer synthesis | Nucleophilic fluoroalkylation | Difluoromethylphenyl sulfone | Functional fluorinated polymers | ALCOHOLS | AMINES | FLUOROALKYLATION | CHEMISTRY, ORGANIC | DIFLUOROMETHYL PHENYL SULFONE | alpha-(Difluoromethyl)styrene | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Steroids, ISSN 0039-128X, 11/2019, Volume 151, p. 108469
The DAF-12 receptor is a ligand-activated transcription factor that in its ligand-bound form allows the expression of target genes needed to support the... 
Caenorhabditis elegans | DAF-12 receptor | Difluoromethyl group | Oxysterol
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 07/2018, Volume 211, pp. 119 - 123
Journal Article
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 8, pp. 1598 - 1601
A mild, versatile and efficient method for the silver(I)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade... 
ARYL BORONIC ACIDS | PHENANTHRIDINE DERIVATIVES | DIFLUOROMETHYL | PHOTOREDOX | ISOCYANIDES | DIFLUOROALKYLATION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIZATION | CARBOXYLIC-ACIDS | BENZOIC-ACIDS | TRIFLUOROMETHYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 03/2016, Volume 18, Issue 5, pp. 996 - 999
gem-Difluorinated phosphonium salts, which are readily obtained from aldehydes and difluoromethylene phosphobetaine, can serve as a source of radicals under... 
ORGANOZINC REAGENTS | VISIBLE-LIGHT | ALKENES | DIFLUOROCARBENE | BROMODIFLUOROMETHYLATION | DIFLUOROMETHYL | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | TRANSFER RADICAL-ADDITION | PHOTOREDOX CATALYSIS | TRIFLUOROMETHYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 08/2011, Volume 13, Issue 15, pp. 3826 - 3829
A highly enantioselective Strecker reaction of difluoromethyl and trifluoromethyl ketoimines was developed. Remarkable fluorine effect on the reactivity and... 
ALPHA-DIFLUOROMETHYL AMINES | ALCOHOLS | CATALYSIS | KETONES | ENANTIOSELECTIVE SYNTHESIS | ACIDS | CHEMISTRY, ORGANIC | STEREOSELECTIVE-SYNTHESIS | KETIMINES | NUCLEOPHILIC-ADDITION | CENTERS
Journal Article
Organic Letters, ISSN 1523-7060, 10/2016, Volume 18, Issue 19, pp. 5130 - 5133
A new application of trifluoromethylating reagent, methyl fluorosulfonyldifluoroacetate (FO2SCF2CO2Me, Chen’s reagent), as the carbomethoxydifluoromethylating... 
MEDICINAL CHEMISTRY | VISIBLE-LIGHT | CHEMISTRY, ORGANIC | AROMATIC-SUBSTITUTION | DIFLUOROALKYLATION | FUNCTIONALIZED DIFLUOROMETHYL BROMIDES | ACCESS | UNACTIVATED ALKENES | FLUOROALKYLSULFONYL CHLORIDES | CARBOXYLIC-ACIDS | TRIFLUOROMETHYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 11/2016, Volume 18, Issue 22, pp. 5912 - 5915
An atom-economical method for radical (phenylsulfonyl)­difluoromethylation of isocyanides with PhSO2CF2H under transition-metal-free conditions has been... 
MEDICINAL CHEMISTRY | MEDIATED TRIFLUOROMETHYLATION | ARENES | CATALYZED TRIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | FLUORINE | NUCLEOPHILIC DIFLUOROMETHYLATION | ISONITRILES | DIFLUOROMETHYL PHENYL SULFONE | UNACTIVATED ALKENES | EQUIVALENT
Journal Article
Organic Letters, ISSN 1523-7060, 08/2017, Volume 19, Issue 16, pp. 4187 - 4190
A general and facile synthetic method for C­(sp2)–H difluoroalkylations and perfluoroalkylations of alkenes and (hetero)­arenes with commercially available... 
PALLADIUM | HETEROARENES | ARYL BORONIC ACIDS | HECK-TYPE REACTION | PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION | ARENES | CHEMISTRY, ORGANIC | BOND FORMATION | FUNCTIONALIZED DIFLUOROMETHYL BROMIDES | ACCESS | PHOTOREDOX CATALYSIS
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 11/2016, Volume 22, Issue 47, pp. 16733 - 16748
In recent years, much interest has been paid to difluoromethylthiolated molecules as the "SCF2" moiety is a key motif in drug and agrochemical research.... 
REAGENT | difluoromethylthiolation | S-DIFLUOROMETHYLATION | C-NUCLEOPHILES | DIFLUOROCARBENE PRECURSOR | CHEMISTRY, MULTIDISCIPLINARY | MEDICINAL CHEMISTRY | DIFLUOROMETHYL ETHERS | TRIFLUOROMETHYLTHIOLATION | sulfur | ALPHA-FLUORINATED ETHERS | difluoromethylation | ARYL | THIOETHERS | synthetic methods | fluorine
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 02/2018, Volume 51, Issue 2, pp. 484 - 495
Conspectus The chemistry of hydrazones has gained great momentum due to their involvement throughout the evolution of organic synthesis. Herein, we discuss the... 
VISIBLE-LIGHT | PYRAZOLES | ALKYLATION | LIGHT PHOTOREDOX CATALYSIS | N,N-DIALKYLHYDRAZONES | N BOND FORMATION | DIRECTING-GROUP | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZED DIFLUOROMETHYL BROMIDES | DEHYDROGENATIVE CYCLIZATION | TRIFLUOROMETHYLATION
Journal Article
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