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difluoromethylation (349) 349
chemistry, organic (335) 335
fluorine (242) 242
chemistry, multidisciplinary (194) 194
trifluoromethylation (185) 185
copper-mediated difluoromethylation (128) 128
catalysis (102) 102
alkenes (97) 97
medicinal chemistry (97) 97
difluorocarbene (85) 85
carbonyl-compounds (82) 82
index medicus (80) 80
reagents (76) 76
derivatives (73) 73
aryl (72) 72
iodides (69) 69
nucleophilic difluoromethylation (68) 68
reagent (68) 68
fluoroalkylation (67) 67
fluorination (59) 59
aryl boronic acids (57) 57
difluoroalkylation (54) 54
chemistry, inorganic & nuclear (53) 53
palladium (52) 52
ketones (49) 49
chemistry (47) 47
copper (46) 46
aldehydes (43) 43
arenes (43) 43
fluor (40) 40
synthetic methods (40) 40
arylboronic acids (39) 39
organic chemistry (39) 39
photoredox catalysis (39) 39
bromides (38) 38
fluorides (37) 37
aromatic compounds (36) 36
cyclization (36) 36
acids (35) 35
halides (34) 34
molecular structure (34) 34
synthesis (34) 34
alcohols (33) 33
activation (32) 32
functionalization (32) 32
heterocycles (32) 32
inhibitors (32) 32
radicals (32) 32
ethers (31) 31
alkynes (27) 27
functional groups (27) 27
phenyl sulfone (27) 27
chlorides (26) 26
ethyl bromodifluoroacetate (26) 26
amines (25) 25
chemical synthesis (25) 25
functional-group (25) 25
funktionelle gruppe (25) 25
alkylation (24) 24
alpha,beta-unsaturated carboxylic-acids (24) 24
carboxylic-acids (24) 24
stereoselective-synthesis (24) 24
access (23) 23
efficient (23) 23
hydrocarbons, fluorinated - chemistry (23) 23
olefins (23) 23
unactivated alkenes (23) 23
aryl halides (22) 22
chemical properties (22) 22
direct difluoromethylation (22) 22
fluorinated sulfones (22) 22
regioselectivity (22) 22
room-temperature (22) 22
chemical sciences (21) 21
chemistry, applied (21) 21
heteroarenes (21) 21
monofluoromethylation (21) 21
salts (21) 21
asymmetric-synthesis (20) 20
complexes (20) 20
methylation (20) 20
perfluoroalkylation (20) 20
thioethers (20) 20
chemical tests and reagents (19) 19
nucleophilic trifluoromethylation (19) 19
o-difluoromethylation (19) 19
oxidative trifluoromethylation (19) 19
amides (18) 18
analysis (18) 18
c-h functionalization (18) 18
esters (18) 18
fluoroalkylation reactions (18) 18
generation (18) 18
ligands (18) 18
substrates (18) 18
sulfones (18) 18
alkyl-halides (17) 17
alpha-arylation (17) 17
catalysts (17) 17
construction (17) 17
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Current Organic Chemistry, ISSN 1385-2728, 07/2015, Volume 19, Issue 16, pp. 1638 - 1650
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 2017, Volume 2017, Issue 2, pp. 266 - 270
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 12/2017, Volume 23, Issue 72, pp. 18125 - 18128
Journal Article
Synthesis, ISSN 0039-7881, 08/2017, Volume 49, Issue 15, pp. 3394 - 3406
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2018, Volume 59, Issue 28, pp. 2752 - 2754
A simple and efficient protocol for the direct -difluoromethylation of imidazoles and pyrazoles has been developed. The reaction makes use of commercially... 
Benzimidazoles | Imidazoles | Pyrazoles | Difluoromethylation | Difluorocarbene
Journal Article
Acta Chimica Sinica, ISSN 0567-7351, 02/2015, Volume 73, Issue 2, pp. 90 - 115
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2018, Volume 74, Issue 32, pp. 4295 - 4297
The high demand for the biologically active CF H-molecules has stimulated significant efforts to develop efficient methods for the installation of CF H... 
Nucleophilic | Imines | Aldehydes | Decarboxylative | Difluoromethylation | DIFLUOROCARBENE | PHENYL SULFONE | COPPER-MEDIATED DIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ALCOHOLS | IODIDES | CATALYZED DIFLUOROMETHYLATION | ARYL | CARBOXYLIC-ACIDS | TRIFLUOROMETHYLATION | Schiff bases
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 12/2019, Volume 228, p. 109391
CF H-containing oxindoles were obtained visible-light-promoted difluoromethylation/cyclization of -arylacrylamides. A photocatalytic... 
Acrylamides | Oxindole | Photoredox | Radical | Difluoromethylation
Journal Article
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 11/2016, Volume 22, Issue 47, pp. 16733 - 16748
In recent years, much interest has been paid to difluoromethylthiolated molecules as the "SCF2" moiety is a key motif in drug and agrochemical research.... 
REAGENT | difluoromethylthiolation | S-DIFLUOROMETHYLATION | C-NUCLEOPHILES | DIFLUOROCARBENE PRECURSOR | CHEMISTRY, MULTIDISCIPLINARY | MEDICINAL CHEMISTRY | DIFLUOROMETHYL ETHERS | TRIFLUOROMETHYLTHIOLATION | sulfur | ALPHA-FLUORINATED ETHERS | difluoromethylation | ARYL | THIOETHERS | synthetic methods | fluorine
Journal Article
Organic Letters, ISSN 1523-7060, 10/2018, Volume 20, Issue 20, pp. 6407 - 6410
A one-pot strategy for the diversified synthesis of 3-difluoromethyl benzoxazole-2-thiones is reported. The reaction of 2-aminophenol, sodium... 
REAGENTS | DIFLUOROCARBENE | COPPER-MEDIATED DIFLUOROMETHYLATION | CATALYZED DIFLUOROMETHYLATION | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | ARYL | IMIDAZOLES | DERIVATIVES | DEHYDROXYTRIFLUOROMETHYLTHIOLATION | TRIFLUOROMETHYLATION
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2005, Volume 46, Issue 48, pp. 8273 - 8277
A new nucleophilic difluoromethylation chemistry using fluoride-induced (phenylsulfonyl)difluoromethylation with TMSCF SO Ph followed by the... 
Fluorine | Difluoromethylation | Magnesium | Desulfonylation
Journal Article
Organic Letters, ISSN 1523-7060, 03/2019, Volume 21, Issue 5, pp. 1350 - 1353
A method for the room temperature Wdeoxyfluorination of benzaldehydes and alpha-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of... 
IODIDES | PALLADIUM-CATALYZED DIFLUOROMETHYLATION | COPPER-MEDIATED DIFLUOROMETHYLATION | ARYL HALIDES | CHLORIDES | CHEMISTRY, ORGANIC | BROMIDES
Journal Article
Synthesis, ISSN 0039-7881, 04/2014, Volume 46, Issue 7, pp. 842 - 863
Journal Article
Tetrahedron, ISSN 0040-4020, 02/2019, Volume 75, Issue 7, pp. 868 - 873
A facile synthesis of 2-difluoromethylated quinolines DBU-promoted cascade Michael addition/cyclization between functionalized 2-aminobenzonitriles and methyl... 
Quinoline | Heterocycle synthesis | Difluoromethylation | REAGENT | ROUTE | CATALYZED DIFLUOROMETHYLATION | ARYL HALIDES | CHEMISTRY, ORGANIC | FLUORINE | BROMIDES
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 08/2018, Volume 54, Issue 64, pp. 8881 - 8884
The highly C-selective difluoromethylation of -ketoesters was achieved by combining TMSCF2Br/LiOH/N,N,N-trimethylhexadecan-1-ammonium bromide. Compared to... 
BETA-KETOESTERS | ALKYLATION | O-DIFLUOROMETHYLATION | DIAZO-COMPOUNDS | SOFT ACIDS | INHIBITORS | FLUOROALKYLATION REACTIONS | DIFLUOROCARBENE REAGENT | EFFICIENT DIFLUOROMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY | 1,3-DIONES
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2018, Volume 140, Issue 37, pp. 11613 - 11617
The difluoromethyl group (CF2H) is of great interest in the area of medicinal chemistry. However, the investigation of molecular scaffolds containing this... 
MEDICINAL CHEMISTRY | IODIDES | ARYL BORONIC ACIDS | PALLADIUM-CATALYZED DIFLUOROMETHYLATION | COPPER-MEDIATED DIFLUOROMETHYLATION | ARENES | (DIFLUOROMETHYL)ZINC REAGENT | FLUORINE | CARBON-HYDROGEN BONDS | CHEMISTRY, MULTIDISCIPLINARY | TRIFLUOROMETHYLATION
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 03/2012, Volume 135, pp. 45 - 58
A series of sulfur-, selenium- and tellurium-containing (phenylchalcogen)difluoromethylation reagents PhSCF H (1a), PhSeCF H (1b), and PhTeCF H (1c) were... 
Nucleophilic fluoroalkylation | Fluorine | Difluoromethylation | (Phenylchalcogen)difluoromethylation | Diastereoselectivity
Journal Article
Chemical Communications, ISSN 1359-7345, 04/2014, Volume 50, Issue 31, pp. 4108 - 4111
A Pd(0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed. This reaction provides a new... 
MEDICINAL CHEMISTRY | H FUNCTIONALIZATION | OXINDOLES BEARING | ROOM-TEMPERATURE | ALPHA,BETA-UNSATURATED CARBOXYLIC-ACIDS | PHENYL SULFONE | COPPER-MEDIATED DIFLUOROMETHYLATION | NUCLEOPHILIC DIFLUOROMETHYLATION | FLUOROALKYL IODIDES | CHEMISTRY, MULTIDISCIPLINARY | HECK-TYPE REACTIONS | Alkenes | Cascades | Construction methods | Radicals
Journal Article
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