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dihydrodiol dehydrogenase (323) 323
biochemistry & molecular biology (183) 183
humans (169) 169
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index medicus (115) 115
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aldehyde reductase (79) 79
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expression (73) 73
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3-alpha-hydroxysteroid dehydrogenase (67) 67
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ortho-quinones (22) 22
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Steroids, ISSN 0039-128X, 2004, Volume 69, Issue 13, pp. 795 - 801
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2004, Volume 279, Issue 11, pp. 10784 - 10795
The source of NADPH-dependent cytosolic 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activity is unknown to date. This important reaction leads e. g. to the... 
HYDROXYSTEROID DEHYDROGENASES | SUBSTRATE-SPECIFICITY | HUMAN 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | HUMAN PROSTATE | HUMAN BRAIN | MALE RATS | ANDROGEN METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROACTIVE STEROIDS | SITE-DIRECTED MUTAGENESIS | DIHYDRODIOL DEHYDROGENASE
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2017, Volume 491, Issue 2, pp. 403 - 408
Journal Article
Biochemistry, ISSN 0006-2960, 10/2006, Volume 45, Issue 43, pp. 13054 - 13063
Human type 3 3α-hydroxysteroid dehydrogenase, or aldo-keto reductase (AKR) 1C2, eliminates the androgen signal in human prostate by reducing... 
STEROID-HORMONE ACTION | HYDROXYSTEROID DEHYDROGENASES | XYLOSE REDUCTASE | MECHANISM | TESTOSTERONE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-SITE | SUPERFAMILY | ALDO-KETO REDUCTASE | DIHYDRODIOL DEHYDROGENASE
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This... 
DIHYDRODIOL DEHYDROGENASE ISOFORMS | QUINONE REDUCTASE | HUMAN CARBONYL REDUCTASE | ENZYMES | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ALDEHYDE REDUCTASE | SINGLE NUCLEOTIDE POLYMORPHISMS | PROSTAGLANDIN-F SYNTHASE | Aldehyde Reductase - genetics | Humans | Polymorphism, Single Nucleotide - physiology | Mitochondrial Proteins - genetics | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Recombinant Proteins - isolation & purification | Mitochondrial Proteins - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Glyceraldehyde - metabolism | Phenanthrenes - metabolism | Recombinant Proteins - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Biocatalysis | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Frequency | Indans - metabolism | Models, Molecular | Alcohol Oxidoreductases - metabolism | Recombinant Proteins - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductases | Vitamin K 3 - metabolism | Aldo-Keto Reductase Family 1 Member C3 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 3, pp. 335 - 344
Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level.... 
Aldo-keto reductase (AKR) | Retinaldehyde | Proliferation | Retinoic acid | Retinol | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | proliferation | BIOCHEMISTRY & MOLECULAR BIOLOGY | aldo-keto reductase (AKR) | retinaldehyde | STEROID-HORMONE | DIHYDRODIOL DEHYDROGENASE | retinol | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | BREAST-CANCER CELLS | retinoic acid | METABOLISM | REVEALS ROLES | MCF-7 CELLS | PROSTAGLANDIN-F SYNTHASE | Vitamin A - pharmacology | Vitamin A - chemistry | Cell Proliferation | Hydroxysteroid Dehydrogenases - chemistry | Humans | Transcriptional Activation | 20-Hydroxysteroid Dehydrogenases - chemistry | Retinaldehyde - chemistry | Substrate Specificity | Hydroxyprostaglandin Dehydrogenases - metabolism | Oxidoreductases - chemistry | 3-Hydroxysteroid Dehydrogenases - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Retinaldehyde - physiology | Hydroxyprostaglandin Dehydrogenases - chemistry | Binding Sites | Mutagenesis, Site-Directed | Oxidoreductases - metabolism | Models, Molecular | Receptors, Retinoic Acid - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Vitamin A - physiology | Retinaldehyde - pharmacology | Cell Line, Tumor | Protein Binding | 3-Hydroxysteroid Dehydrogenases - chemistry | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Amino Acid Substitution
Journal Article