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dihydroorotate dehydrogenase (486) 486
animals (332) 332
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biochemistry & molecular biology (197) 197
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malaria (131) 131
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oxidoreductases acting on ch-ch group donors - metabolism (75) 75
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human dihydroorotate dehydrogenase (47) 47
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plasmodium falciparum - enzymology (44) 44
oxidoreductases - metabolism (42) 42
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oxidoreductases acting on ch-ch group donors (41) 41
oxidoreductases acting on ch-ch group donors - chemistry (41) 41
cancer (40) 40
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dihydroorotate dehydrogenase inhibitors (38) 38
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brequinar (31) 31
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mitochondria - enzymology (27) 27
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Infectious Disorders - Drug Targets, ISSN 1871-5265, 2010, Volume 10, Issue 3, pp. 226 - 239
Malaria remains a globally prevalent infectious disease that leads to significant morbidity and mortality. While there are a number of drugs approved for its... 
Plasmodium | Drug discovery | Malaria | Pyrimidine biosynthesis | Dihydroorotate dehydrogenase
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 68, pp. 112354 - 112370
Malignant melanoma (MM) is one of the most malignant tumors and has a very poor prognosis. However, there are no effective drugs to treat this disease. As a... 
BCL-2 | Dihydroorotate dehydrogenase (DHODH) | Leflunomide | Autophagy | Melanoma | PATHWAYS | leflunomide | APOPTOSIS | autophagy | PROTEIN | DIHYDROOROTATE DEHYDROGENASE | PHOSPHORYLATION | melanoma | CANCER | CELL BIOLOGY | BCL2 FAMILY | dihydroorotate dehydrogenase (DHODH) | INHIBITION | GROWTH
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 45, pp. 12809 - 12814
There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening... 
Antifungal drug | Aspergillus fumigatus | Mechanism of action | Dihydroorotate dehydrogenase | dihydroorotate dehydrogenase | ASPERGILLUS-FUMIGATUS | PATHOGEN | MULTIDISCIPLINARY SCIENCES | mechanism of action | EXTRA COPIES | VIRULENCE | URACIL | CANDIDA-ALBICANS | GENE | AZOLE RESISTANCE | GROWTH | antifungal drug | EXPRESSION | Biological Sciences
Journal Article
Chemistry : a European journal, ISSN 0947-6539, 2017, Volume 23, Issue 56, pp. 13875 - 13878
Brequinar, a potent dihydroorotate dehydrogenase (DHODH) inhibitor, has been evaluated in multiple clinical trials as a potential treatment for cancer. To... 
triphenylphosphonium | brequinar | PROTAC | DHODH | PROTEIN | ACID | CHEMISTRY, MULTIDISCIPLINARY | SMALL-MOLECULE PROTACS | NSC-368390 | DEGRADATION | VHL | HUMAN DIHYDROOROTATE DEHYDROGENASE | LIGASE | Medical research | Mitochondria | Synthesis | Toxicity | Clinical trials | Cytotoxicity | Inhibition | Probes | Dihydroorotate dehydrogenase | Cancer
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 1107 - 14
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2013, Volume 9, Issue 10, p. e1003678
Journal Article
Journal Article
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2018, Volume 66, Issue 3, pp. 239 - 242
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 5822 - 5880
The electronic properties and relatively small size of fluorine endow it with considerable versatility as a bioisostere and it has found application as a... 
PEPTIDASE-IV INHIBITOR | CHEMISTRY, MEDICINAL | MECHANISM-BASED INHIBITION | HUMAN CATHEPSIN-L | KINASE BTK INHIBITOR | SMALL-MOLECULE INHIBITORS | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | PROTEIN KSP INHIBITORS | HUMAN LIVER-MICROSOMES | GENERATION DOPAMINERGIC AGENTS | ORTHOGONAL MULTIPOLAR INTERACTIONS
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, p. 19141
Journal Article
Journal of fluorine chemistry, ISSN 0022-1139, 2012, Volume 143, pp. 57 - 93
Synthesis, reactivity and biological properties of SF5-substituted organic molecules are reviewed in this article, with an emphasis on the work published in... 
Biological properties | Synthesis | Review | Pentafluorosulphanyl group | VICARIOUS NUCLEOPHILIC-SUBSTITUTION | SULFUR CHLORIDE PENTAFLUORIDE | TRIFLUOROMETHYL | LEAD OPTIMIZATION | CHEMISTRY, ORGANIC | SALTS | CHEMISTRY, INORGANIC & NUCLEAR | FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | FLUORINE | INHIBITORS | FACILE PREPARATION | DERIVATIVES
Journal Article