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Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7327, pp. 1067 - 1073
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 1900, Volume 137, Issue 28, pp. 8892 - 8895
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2015, Volume 746, pp. 233 - 244
Multidrug resistance (MDR) caused by P-glycoprotein (P-gp, ABCB1, MDR-1) transporter over-expression in cancer cells substantially limits the effectiveness of... 
P-glycoprotein | Cytotoxicity | 1,4-Dihydropyridine(CID104822) | Multidrug resistance | Rhodamine 123(CID65217) | DIHYDROPYRIDINE | Rhodamine 123 (CID 65217) | MECHANISMS | DRUG-RESISTANCE | EFFLUX | HANTZSCH 1,4-DIHYDROPYRIDINES | VINCRISTINE | PHARMACOLOGY & PHARMACY | INHIBITORS | ACCUMULATION | DERIVATIVES | 1,4-Dihydropyridine (CID 104822) | Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | Calcium Channels - metabolism | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Drug Resistance, Multiple - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | Structure-Activity Relationship | Neoplasm Proteins - metabolism | Dihydropyridines - adverse effects | Antineoplastic Agents - adverse effects | Drug Design | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Doxorubicin - metabolism | Molecular Structure | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Dihydropyridines - chemistry | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Dihydropyridines - chemical synthesis | Calcium Channels - chemistry | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Dihydropyridines - pharmacology | Antibiotics, Antineoplastic - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug resistance in microorganisms | Chemotherapy | Anthracyclines | Calcium channels | Cancer cells | Cancer
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2009, Volume 52, Issue 9, pp. 2724 - 2732
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2005, Volume 127, Issue 1, pp. 32 - 33
The first enantioselective organocatalytic hydride reduction has been accomplished. The use of iminium catalysis has provided a new organocatalytic strategy... 
CHEMISTRY | CATALYSIS | DIHYDROPYRIDINES | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 09/2012, Volume 19, Issue 25, pp. 4306 - 4323
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 878 - 886
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are driver mutations in acute myeloid leukemia (AML) and other cancers. We report the development of... 
ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | PROGENITOR CELLS | DNA METHYLATION | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-IMPLICATIONS | KINASE INHIBITORS | CELL-DIFFERENTIATION | MYELODYSPLASTIC SYNDROMES | ACUTE PROMYELOCYTIC LEUKEMIA | Neoplastic Stem Cells - drug effects | Allosteric Regulation | Humans | Crystallography, X-Ray | Male | Isocitrate Dehydrogenase - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - enzymology | Pyrazoles - chemistry | Enzyme Inhibitors - pharmacokinetics | Granulocytes - drug effects | Cytosine - metabolism | Dihydropyridines - pharmacokinetics | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Granulocytes - pathology | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Dihydropyridines - chemistry | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Models, Molecular | Isocitrate Dehydrogenase - genetics | Cytosine - chemistry | Granulocytes - enzymology | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Isocitrate Dehydrogenase - chemistry | Allosteric Site | Cell Line, Tumor | CpG Islands | Dihydropyridines - pharmacology | Protein Binding | Isocitrate Dehydrogenase - metabolism | Mice | Kinetics | Mutation | Primary Cell Culture | DNA Methylation - drug effects | Neoplastic Stem Cells - enzymology | Leukemia, Myeloid, Acute - genetics
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1251 - 1254
Journal Article