X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry, medicinal (92) 92
index medicus (85) 85
humans (80) 80
hiv integrase inhibitors - chemistry (64) 64
diketo acid (62) 62
hiv integrase inhibitors - pharmacology (58) 58
active-site (55) 55
models, molecular (54) 54
hiv (53) 53
hiv integrase - metabolism (53) 53
catalytic domain (51) 51
biochemistry & molecular biology (50) 50
structure-activity relationship (49) 49
hiv-1 - enzymology (47) 47
pharmacology & pharmacy (45) 45
design (42) 42
drug design (42) 42
hiv-1 - drug effects (42) 42
hiv integrase - chemistry (40) 40
integrase (40) 40
in-vitro (39) 39
hiv-1 integrase (38) 38
replication (38) 38
strand transfer (38) 38
chemistry, organic (37) 37
chemistry, multidisciplinary (36) 36
molecular structure (36) 36
anti-hiv agents - pharmacology (35) 35
diketo acid-derivatives (35) 35
reverse-transcriptase (32) 32
immunodeficiency-virus type-1 (30) 30
anti-hiv agents - chemistry (29) 29
derivatives (29) 29
inhibitors (29) 29
ribonuclease-h (27) 27
beta-diketo acids (26) 26
binding (26) 26
diketo acids (26) 26
antiviral agents (25) 25
hiv-1 (25) 25
hiv integrase inhibitors - chemical synthesis (24) 24
mechanism (24) 24
dual inhibitors (23) 23
human-immunodeficiency-virus (23) 23
chemistry (22) 22
resistance (22) 22
biological evaluation (21) 21
dna (21) 21
hiv infections - drug therapy (21) 21
raltegravir (21) 21
aids (20) 20
analysis (20) 20
crystal-structure (20) 20
hiv-1 integrase inhibitors (20) 20
article (19) 19
discovery (19) 19
integrase inhibitors (19) 19
ribonuclease h (19) 19
animals (18) 18
hiv integrase - genetics (18) 18
hiv reverse transcriptase - antagonists & inhibitors (18) 18
protein binding (18) 18
reverse transcriptase inhibitors - pharmacology (18) 18
binding sites (17) 17
reverse transcriptase (17) 17
ribonuclease h - antagonists & inhibitors (17) 17
type-1 integrase (17) 17
virology (17) 17
virus type-1 integrase (17) 17
cells (16) 16
diketo acid pharmacophore (16) 16
drug resistance (16) 16
hiv integrase inhibitors - metabolism (16) 16
reverse transcriptase inhibitors - chemistry (16) 16
cell line (15) 15
keto acids - chemistry (15) 15
domain (14) 14
identification (14) 14
keto acids - pharmacology (14) 14
viral replication (14) 14
catalysis (13) 13
diketo-pyrrolo-pyrrole (13) 13
dna polymerases (13) 13
enzyme inhibitors - pharmacology (13) 13
enzymes (13) 13
hiv integrase inhibitors - therapeutic use (13) 13
hiv-1 - genetics (13) 13
potent (13) 13
protein (13) 13
anti-hiv agents - chemical synthesis (12) 12
crystallography (12) 12
crystallography, x-ray (12) 12
drug discovery (12) 12
hiv reverse transcriptase - metabolism (12) 12
inhibitory concentration 50 (12) 12
protein conformation (12) 12
ribonuclease (12) 12
rnase-h (12) 12
viral-dna (12) 12
analogs (11) 11
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 3, pp. 1212 - 1228
Substitution of β-diketo acid moiety onto the phenanthridinone and analogous polycyclic aromatic systems provided new potent HIV integrase (IN) inhibitors. The... 
Polycyclic aromatic diketo acids | HIV integrase inhibitors | Phenanthridinones | Peripheral blood mononuclear cells | Selectivity | Inhibition of HIV replication | Phenanthridinone diketo acid | selectivity | peripheral blood mononuclear cells | DESIGN | CHEMISTRY, MEDICINAL | INVITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | phenanthridinones | CHEMISTRY, ORGANIC | ANTIRETROVIRAL THERAPY | phenanthridinone diketo acid | IN-VITRO | 3'-AZIDO-3'-DEOXYTHYMIDINE | REPLICATION | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | polycyclic aromatic diketo acids | CELL-CULTURE | DERIVATIVES | inhibition of HIV replication | HIV Integrase Inhibitors - pharmacology | Phenanthridines - chemical synthesis | Phenanthridines - chemistry | Butyrates - pharmacology | Humans | Keto Acids - chemistry | Cercopithecus aethiops | Crystallography, X-Ray | Structure-Activity Relationship | HIV Integrase - metabolism | Phenanthridines - pharmacology | Phenanthrenes - chemistry | Leukemia, Lymphoid - metabolism | HIV Integrase Inhibitors - chemistry | Molecular Structure | Magnesium | Keto Acids - chemical synthesis | Virus Replication - drug effects | Leukocytes, Mononuclear - drug effects | HIV-1 - drug effects | Cells, Cultured | Models, Molecular | HIV Integrase - chemistry | Leukemia, Lymphoid - virology | Butyrates - chemical synthesis | Phenanthrenes - pharmacology | Animals | Phenanthrenes - chemical synthesis | Leukemia, Lymphoid - drug therapy | Vero Cells - drug effects | Butyrates - chemistry | Keto Acids - pharmacology | Cell Proliferation - drug effects | HIV Integrase Inhibitors - chemical synthesis
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 12/2016, Volume 81, Issue 24, pp. 12532 - 12539
A new synthesis of functionalized (Z)-6-hetaryl-2,4-dioxo-5-hexenoic acids based on acid-catalyzed alkenylation of indoles and pyrroles with derivatives of... 
NONNUCLEOSIDE INHIBITORS | HIV-1 INTEGRASE | REVERSE-TRANSCRIPTASE | OXO KETENE DITHIOACETALS | 6-(TRIFLUOROMETHYL)COMANIC ACID | REGIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | DIKETO ACID | DUAL INHIBITORS | C-H | RIBONUCLEASE-H | Usage | Chemical properties | Chemical synthesis | Olefins | Indole | Pyrrole
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 21, pp. 8588 - 8598
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 67 - 82
A series of diketo esters and their pertinent bioisosteres were designed and synthesized as potent antibacterial agents by targeting methionine amino... 
Cytotoxicity | Methionine aminopeptidase | Diketo acids | Antibacterial | Galleria mellonella | Bioisosteres | IN-VITRO | CHEMISTRY, MEDICINAL | INHIBITION | ANALOGS | GROWTH | DISCOVERY | Index Medicus
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2017, Volume 27, Issue 8, pp. 1640 - 1643
Journal Article
Journal Article
Letters in Drug Design and Discovery, ISSN 1570-1808, 2014, Volume 11, Issue 5, pp. 618 - 627
Herein, we present a validated predictive QSAR model to provide more insight into the relationship between the molecular properties of diketo acid and... 
Carboxamide | GFA | Integrase inhibitor | Diketo acid | 2D-QSAR | DESIGN | CHEMISTRY, MEDICINAL | 3D-QSAR | AIDS | CALCIUM-CHANNEL ANTAGONISTS | VARIABLE SELECTION | DISCOVERY | carboxamide | REPLICATION | INFECTED-CELLS | PHARMACOPHORE | PNEUMOCYSTIS-CARINII PNEUMONIA
Journal Article