Pharmacological Research, ISSN 1043-6618, 12/2015, Volume 102, pp. 138 - 157
Diminazene aceturate (C H N .2C H NO ) is an aromatic diamidine that was developed more than six decades ago and has been marketed until today for the control...
Diminazene aceturate | Diamidine | Antitrypanosomal activity | Trypanosomiasis | Pharmacological properties | CONVERTING ENZYME 2 | PNEUMOCYSTIS-CARINII-PNEUMONIA | TRYPANOSOMA-EVANSI INFECTION | SENSING ION CHANNELS | ENDOTOXIN-INDUCED UVEITIS | DNA TOPOISOMERASE-I | RENIN-ANGIOTENSIN SYSTEM | S-ADENOSYLMETHIONINE DECARBOXYLASE | L-METHIONINE DECARBOXYLASE | PHARMACOLOGY & PHARMACY | BABESIA-GIBSONI | Trypanosomiasis - drug therapy | Antiparasitic Agents - therapeutic use | Diminazene - pharmacology | Animals | Humans | Antiparasitic Agents - pharmacology | Diminazene - analogs & derivatives | Diminazene - therapeutic use | Therapeutics | Homeopathy | Materia medica and therapeutics
Diminazene aceturate | Diamidine | Antitrypanosomal activity | Trypanosomiasis | Pharmacological properties | CONVERTING ENZYME 2 | PNEUMOCYSTIS-CARINII-PNEUMONIA | TRYPANOSOMA-EVANSI INFECTION | SENSING ION CHANNELS | ENDOTOXIN-INDUCED UVEITIS | DNA TOPOISOMERASE-I | RENIN-ANGIOTENSIN SYSTEM | S-ADENOSYLMETHIONINE DECARBOXYLASE | L-METHIONINE DECARBOXYLASE | PHARMACOLOGY & PHARMACY | BABESIA-GIBSONI | Trypanosomiasis - drug therapy | Antiparasitic Agents - therapeutic use | Diminazene - pharmacology | Animals | Humans | Antiparasitic Agents - pharmacology | Diminazene - analogs & derivatives | Diminazene - therapeutic use | Therapeutics | Homeopathy | Materia medica and therapeutics
Journal Article
Experimental Parasitology, ISSN 0014-4894, 12/2017, Volume 183, pp. 92 - 98
The mechanism of the development of diminazene aceturate (DA) resistance in is still unknown even though DA-resistant isolate was previously developed . To...
Babesia gibsoni | Diminazene aceturate-resistance | Diminazene aceturate content | Adenosine incorporation | Glucose consumption | HIGH-K | INFECTIONS | TRANSPORTER | VARIANTS | BERENIL | INHIBITION | ERYTHROCYTES | GROWTH | TRYPANOSOMA-BRUCEI-BRUCEI | STRAIN | PARASITOLOGY | Incorporation | Glucose | Muscle proteins | Dextrose
Babesia gibsoni | Diminazene aceturate-resistance | Diminazene aceturate content | Adenosine incorporation | Glucose consumption | HIGH-K | INFECTIONS | TRANSPORTER | VARIANTS | BERENIL | INHIBITION | ERYTHROCYTES | GROWTH | TRYPANOSOMA-BRUCEI-BRUCEI | STRAIN | PARASITOLOGY | Incorporation | Glucose | Muscle proteins | Dextrose
Journal Article
Life Sciences, ISSN 0024-3205, 06/2016, Volume 155, pp. 63 - 69
Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin-angiotensin system. Recent studies have shown that diminazene aceturate (DIZE) acts as...
Diminazene aceturate | Cardiac hypertrophy | ACE2 activation | Angiotensin-converting enzyme 2 | Angiotensin-(1–7) | Cardiac function | Angiotensin-(1-7) | FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | RENIN | ANGIOTENSIN-CONVERTING ENZYME | LEFT-VENTRICULAR HYPERTROPHY | BLOOD-PRESSURE | INDUCED CARDIAC DYSFUNCTION | IMPROVES | PHARMACOLOGY & PHARMACY | HYPERTENSION | EXPRESSION | Heart - physiopathology | Diminazene - pharmacology | Animals | Rats, Wistar | Hypertrophy, Left Ventricular - prevention & control | Heart - drug effects | Rats | Male | Cardiotonic Agents - pharmacology | Diminazene - analogs & derivatives | In Vitro Techniques | Angiotensin
Diminazene aceturate | Cardiac hypertrophy | ACE2 activation | Angiotensin-converting enzyme 2 | Angiotensin-(1–7) | Cardiac function | Angiotensin-(1-7) | FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | RENIN | ANGIOTENSIN-CONVERTING ENZYME | LEFT-VENTRICULAR HYPERTROPHY | BLOOD-PRESSURE | INDUCED CARDIAC DYSFUNCTION | IMPROVES | PHARMACOLOGY & PHARMACY | HYPERTENSION | EXPRESSION | Heart - physiopathology | Diminazene - pharmacology | Animals | Rats, Wistar | Hypertrophy, Left Ventricular - prevention & control | Heart - drug effects | Rats | Male | Cardiotonic Agents - pharmacology | Diminazene - analogs & derivatives | In Vitro Techniques | Angiotensin
Journal Article
International Immunopharmacology, ISSN 1567-5769, 08/2014, Volume 21, Issue 2, pp. 342 - 345
Diminazene aceturate or Berenil has been the drug of choice for treatment of animal trypanosomiasis. Although the compound has been in the market since 1955,...
Diminazene aceturate (Berenil) | Anti-inflammatory agent | Immunomodulation | African trypanosomiasis | Management of chronic inflammatory conditions | CONVERTING ENZYME 2 | DRUG | TRYPANOSOMA-CONGOLENSE | KINETOPLAST DNA | BOS-INDICUS CATTLE | IMMUNOLOGY | DISPOSITION | P38 MAP KINASE | SELECTIVE INHIBITOR | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | BINDING | Transcription Factors - metabolism | Diminazene - pharmacology | Inflammation - metabolism | Animals | Cytokines - metabolism | Signal Transduction - drug effects | Inflammation - drug therapy | Humans | Diminazene - analogs & derivatives | Diminazene - therapeutic use | Proteins
Diminazene aceturate (Berenil) | Anti-inflammatory agent | Immunomodulation | African trypanosomiasis | Management of chronic inflammatory conditions | CONVERTING ENZYME 2 | DRUG | TRYPANOSOMA-CONGOLENSE | KINETOPLAST DNA | BOS-INDICUS CATTLE | IMMUNOLOGY | DISPOSITION | P38 MAP KINASE | SELECTIVE INHIBITOR | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | BINDING | Transcription Factors - metabolism | Diminazene - pharmacology | Inflammation - metabolism | Animals | Cytokines - metabolism | Signal Transduction - drug effects | Inflammation - drug therapy | Humans | Diminazene - analogs & derivatives | Diminazene - therapeutic use | Proteins
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2016, Volume 112, pp. 50 - 59
The angiotensin (Ang) II converting enzyme (ACE II) pathway has recently been shown to be associated with several beneficial effects in various organisms,...
Gastroprotection | Healing | Antioxidant | Anti-inflammatory | Collagen | SYSTEM | MAS-RECEPTOR | ANTIULCEROGENIC ACTIVITY | ACETIC-ACID ULCER | PEPTIC-ULCER DISEASE | ATP PATHWAY | RAT STOMACH | INFLAMMATION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | Proto-Oncogene Proteins - metabolism | Stomach Ulcer - chemically induced | Diminazene - pharmacology | Peptide Fragments - metabolism | Stomach Ulcer - metabolism | Receptors, G-Protein-Coupled - metabolism | Acetic Acid - administration & dosage | Ethanol - administration & dosage | Stomach Ulcer - pathology | Gastric Mucosa - pathology | Male | Diminazene - analogs & derivatives | Angiotensin I - metabolism | Gastric Mucosa - metabolism | Animals | Signal Transduction - drug effects | Gastric Mucosa - drug effects | Peptidyl-Dipeptidase A - metabolism | Female | Renin-Angiotensin System - drug effects | Mice | Stomach Ulcer - prevention & control | Diminazene - therapeutic use | Disease Models, Animal | Enzymes | ACE inhibitors | Angiotensin
Gastroprotection | Healing | Antioxidant | Anti-inflammatory | Collagen | SYSTEM | MAS-RECEPTOR | ANTIULCEROGENIC ACTIVITY | ACETIC-ACID ULCER | PEPTIC-ULCER DISEASE | ATP PATHWAY | RAT STOMACH | INFLAMMATION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | Proto-Oncogene Proteins - metabolism | Stomach Ulcer - chemically induced | Diminazene - pharmacology | Peptide Fragments - metabolism | Stomach Ulcer - metabolism | Receptors, G-Protein-Coupled - metabolism | Acetic Acid - administration & dosage | Ethanol - administration & dosage | Stomach Ulcer - pathology | Gastric Mucosa - pathology | Male | Diminazene - analogs & derivatives | Angiotensin I - metabolism | Gastric Mucosa - metabolism | Animals | Signal Transduction - drug effects | Gastric Mucosa - drug effects | Peptidyl-Dipeptidase A - metabolism | Female | Renin-Angiotensin System - drug effects | Mice | Stomach Ulcer - prevention & control | Diminazene - therapeutic use | Disease Models, Animal | Enzymes | ACE inhibitors | Angiotensin
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e48696
Background: Trypanosoma congolense are extracellular and intravascular blood parasites that cause debilitating acute or chronic disease in cattle and other...
GAMMA | ANTIBODIES | EXPERIMENTAL AFRICAN TRYPANOSOMIASIS | KINETOPLAST DNA | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | RESISTANCE | MEDIATED PHAGOCYTOSIS | DIFFER | T-CELLS | SUSCEPTIBLE MICE | Trypanosomiasis, African - drug therapy | Trypanosomiasis, African - complications | Immunity, Cellular - drug effects | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | Inflammation - drug therapy | Female | Kupffer Cells - metabolism | Cytokines - blood | Diminazene - pharmacology | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Spleen - cytology | Diminazene - analogs & derivatives | Inflammation - etiology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Spleen - metabolism | Trypanosoma congolense | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Diminazene - therapeutic use | Kupffer Cells - immunology | Infection | Chemotherapy | Cattle | Liver | Chronic diseases | Septic shock | Livestock | T cells | Enzyme-linked immunosorbent assay | Cancer | Disease | Lymphocytes T | Infections | Parasites | Macrophages | Cattle industry | Domestic animals | Lipopolysaccharides | Interleukin 6 | Reduction | Immunology | Lymphocytes | CD25 antigen | Foxp3 protein | Blood pressure | Parasitemia | Trypanosomiasis | Deoxyribonucleic acid--DNA | Immune system | Vector-borne diseases | Spleen | CD11b antigen | Immune response | Cytokines | Medical treatment | Interleukin 12 | CD4 antigen | Serum levels | Studies | Blood parasites | Tumor necrosis factor | γ-Interferon | Interferon | Deoxyribonucleic acid | DNA
GAMMA | ANTIBODIES | EXPERIMENTAL AFRICAN TRYPANOSOMIASIS | KINETOPLAST DNA | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | RESISTANCE | MEDIATED PHAGOCYTOSIS | DIFFER | T-CELLS | SUSCEPTIBLE MICE | Trypanosomiasis, African - drug therapy | Trypanosomiasis, African - complications | Immunity, Cellular - drug effects | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | Inflammation - drug therapy | Female | Kupffer Cells - metabolism | Cytokines - blood | Diminazene - pharmacology | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Spleen - cytology | Diminazene - analogs & derivatives | Inflammation - etiology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Spleen - metabolism | Trypanosoma congolense | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Diminazene - therapeutic use | Kupffer Cells - immunology | Infection | Chemotherapy | Cattle | Liver | Chronic diseases | Septic shock | Livestock | T cells | Enzyme-linked immunosorbent assay | Cancer | Disease | Lymphocytes T | Infections | Parasites | Macrophages | Cattle industry | Domestic animals | Lipopolysaccharides | Interleukin 6 | Reduction | Immunology | Lymphocytes | CD25 antigen | Foxp3 protein | Blood pressure | Parasitemia | Trypanosomiasis | Deoxyribonucleic acid--DNA | Immune system | Vector-borne diseases | Spleen | CD11b antigen | Immune response | Cytokines | Medical treatment | Interleukin 12 | CD4 antigen | Serum levels | Studies | Blood parasites | Tumor necrosis factor | γ-Interferon | Interferon | Deoxyribonucleic acid | DNA
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 02/2016, Volume 13, Issue 1, p. 35
Background: Retinal inflammation is a devastating pathological process in ocular diseases. Functional impairment of retinal pigment epithelium (RPE) is...
Diminazene aceturate | NF-ΚB | Inflammation | Angiotensin-converting enzyme 2 | MAPK | CELLS | AQUEOUS-HUMOR | RECEPTOR | IMMUNOLOGY | ENDOTOXIN-INDUCED UVEITIS | NEUROSCIENCES | ALDOSTERONE SYSTEM | ACE2 | NF-kappa B | CYTOKINE PRODUCTION | EXPRESSION | MOLECULAR-MECHANISMS | AXIS | Enzyme Activators - pharmacology | Cell Survival - drug effects | Diminazene - pharmacology | RNA, Small Interfering - genetics | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Humans | Cells, Cultured | NF-kappa B - metabolism | Signal Transduction - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Peptidyl-Dipeptidase A - genetics | Retina - cytology | Signal Transduction - drug effects | Time Factors | Lipopolysaccharides - pharmacology | Peptidyl-Dipeptidase A - metabolism | Cytokines - genetics | RNA, Small Interfering - metabolism | Retinal Pigment Epithelium - drug effects
Diminazene aceturate | NF-ΚB | Inflammation | Angiotensin-converting enzyme 2 | MAPK | CELLS | AQUEOUS-HUMOR | RECEPTOR | IMMUNOLOGY | ENDOTOXIN-INDUCED UVEITIS | NEUROSCIENCES | ALDOSTERONE SYSTEM | ACE2 | NF-kappa B | CYTOKINE PRODUCTION | EXPRESSION | MOLECULAR-MECHANISMS | AXIS | Enzyme Activators - pharmacology | Cell Survival - drug effects | Diminazene - pharmacology | RNA, Small Interfering - genetics | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Humans | Cells, Cultured | NF-kappa B - metabolism | Signal Transduction - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Peptidyl-Dipeptidase A - genetics | Retina - cytology | Signal Transduction - drug effects | Time Factors | Lipopolysaccharides - pharmacology | Peptidyl-Dipeptidase A - metabolism | Cytokines - genetics | RNA, Small Interfering - metabolism | Retinal Pigment Epithelium - drug effects
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 06/2014, Volume 55, Issue 6, pp. 3809 - 3818
PURPOSE. Uveitis is a common cause of vision loss. The renin angiotensin system (RAS), which plays a vital role in cardiovascular system, is a potent mediator...
MACROPHAGES | uveitis | renin angiotensin system | CELL-DEATH | INFILTRATION | EIU | TELMISARTAN | INHIBITION | 1-7/MAS RECEPTOR | INFLAMMATION | PHARMACOLOGY | IN-VIVO | OPHTHALMOLOGY | angiotensin-converting enzyme 2 | NF-KAPPA-B | diminazene aceturate | Uveitis - enzymology | Follow-Up Studies | Uveitis - drug therapy | Renin-Angiotensin System - physiology | Peptidyl-Dipeptidase A - drug effects | Anterior Eye Segment - pathology | Diminazene - analogs & derivatives | Enzyme Activation - drug effects | Anterior Eye Segment - metabolism | Animals | Diminazene - administration & dosage | Intercalating Agents - administration & dosage | Peptidyl-Dipeptidase A - metabolism | Ophthalmic Solutions | Anterior Eye Segment - drug effects | Female | Renin-Angiotensin System - drug effects | Mice | Mice, Inbred BALB C | Uveitis - chemically induced | Disease Models, Animal
MACROPHAGES | uveitis | renin angiotensin system | CELL-DEATH | INFILTRATION | EIU | TELMISARTAN | INHIBITION | 1-7/MAS RECEPTOR | INFLAMMATION | PHARMACOLOGY | IN-VIVO | OPHTHALMOLOGY | angiotensin-converting enzyme 2 | NF-KAPPA-B | diminazene aceturate | Uveitis - enzymology | Follow-Up Studies | Uveitis - drug therapy | Renin-Angiotensin System - physiology | Peptidyl-Dipeptidase A - drug effects | Anterior Eye Segment - pathology | Diminazene - analogs & derivatives | Enzyme Activation - drug effects | Anterior Eye Segment - metabolism | Animals | Diminazene - administration & dosage | Intercalating Agents - administration & dosage | Peptidyl-Dipeptidase A - metabolism | Ophthalmic Solutions | Anterior Eye Segment - drug effects | Female | Renin-Angiotensin System - drug effects | Mice | Mice, Inbred BALB C | Uveitis - chemically induced | Disease Models, Animal
Journal Article
Hypertension, ISSN 0194-911X, 08/2013, Volume 62, Issue 4, pp. 746 - 752
Angiotensin-converting enzyme 2 (ACE2) plays a critical role against myocardial infarction (MI). We hypothesized that activation of intrinsic ACE2 would be...
stem cells | diminazene | MYOCARDIAL-INFARCTION | PULMONARY-HYPERTENSION | RAT | PROTECTION | myocardial infarction | HEART-FAILURE | CAPTOPRIL | OVEREXPRESSION | macrophages | CARBOXYPEPTIDASE | PERIPHERAL VASCULAR DISEASE | angiotensin-converting enzyme 2 | INFECTION | EXPRESSION | Heart - physiopathology | Diminazene - pharmacology | Apoptosis - drug effects | Myocardial Ischemia - prevention & control | Rats | Renin-Angiotensin System - physiology | Myocardial Ischemia - enzymology | Diminazene - analogs & derivatives | Rats, Sprague-Dawley | Myocardium - enzymology | Animals | Receptor, Angiotensin, Type 1 - metabolism | Peptidyl-Dipeptidase A - metabolism | Heart - drug effects | Myocardial Ischemia - physiopathology | Stem Cells - drug effects | Macrophages - drug effects | Myocardial Infarction - physiopathology | Renin-Angiotensin System - drug effects | Hemodynamics - drug effects | Myocardial Infarction - prevention & control | Diminazene - therapeutic use | Myocardial Infarction - enzymology
stem cells | diminazene | MYOCARDIAL-INFARCTION | PULMONARY-HYPERTENSION | RAT | PROTECTION | myocardial infarction | HEART-FAILURE | CAPTOPRIL | OVEREXPRESSION | macrophages | CARBOXYPEPTIDASE | PERIPHERAL VASCULAR DISEASE | angiotensin-converting enzyme 2 | INFECTION | EXPRESSION | Heart - physiopathology | Diminazene - pharmacology | Apoptosis - drug effects | Myocardial Ischemia - prevention & control | Rats | Renin-Angiotensin System - physiology | Myocardial Ischemia - enzymology | Diminazene - analogs & derivatives | Rats, Sprague-Dawley | Myocardium - enzymology | Animals | Receptor, Angiotensin, Type 1 - metabolism | Peptidyl-Dipeptidase A - metabolism | Heart - drug effects | Myocardial Ischemia - physiopathology | Stem Cells - drug effects | Macrophages - drug effects | Myocardial Infarction - physiopathology | Renin-Angiotensin System - drug effects | Hemodynamics - drug effects | Myocardial Infarction - prevention & control | Diminazene - therapeutic use | Myocardial Infarction - enzymology
Journal Article
Theriogenology, ISSN 0093-691X, 09/2011, Volume 76, Issue 4, pp. 721 - 728
Thirty red fronted gazelles ( ) were used to assess the genital lesions associated with trypanosomosis and the efficacy of melarsamine hydrochloride...
Diminazene aceturate (Berenil®) | Melarsamine hydrochloride (Cymelarsan®) | Genital lesions | Red fronted gazelles (Gazella rufifrons) | Trypanosomosis | Diminazene aceturate (Berenil) | Melarsamine hydrochloride (Cymelarsan) | REPRODUCTIVE BIOLOGY | Melarsamine hydrochloride (Cymelarsan (R)) | VIVAX | RATS | BULLS | VETERINARY SCIENCES | CONGOLENSE INFECTIONS | Diminazene aceturate (Berenil (R)) | Diminazene - pharmacology | Trypanosomiasis, African - drug therapy | Arsenicals - pharmacology | Genital Diseases, Male - parasitology | Trypanosomiasis, African - veterinary | Parasitemia - veterinary | Male | Histocytochemistry - veterinary | Parasitemia - drug therapy | Diminazene - analogs & derivatives | Body Temperature - physiology | Trypanosomiasis, African - parasitology | Animals | Antelopes - parasitology | Hematocrit - veterinary | Trypanocidal Agents - pharmacology | Genital Diseases, Male - veterinary | Semen - parasitology | Genital Diseases, Male - drug therapy | Parasitemia - parasitology | Trypanosoma brucei brucei - growth & development | Universities and colleges
Diminazene aceturate (Berenil®) | Melarsamine hydrochloride (Cymelarsan®) | Genital lesions | Red fronted gazelles (Gazella rufifrons) | Trypanosomosis | Diminazene aceturate (Berenil) | Melarsamine hydrochloride (Cymelarsan) | REPRODUCTIVE BIOLOGY | Melarsamine hydrochloride (Cymelarsan (R)) | VIVAX | RATS | BULLS | VETERINARY SCIENCES | CONGOLENSE INFECTIONS | Diminazene aceturate (Berenil (R)) | Diminazene - pharmacology | Trypanosomiasis, African - drug therapy | Arsenicals - pharmacology | Genital Diseases, Male - parasitology | Trypanosomiasis, African - veterinary | Parasitemia - veterinary | Male | Histocytochemistry - veterinary | Parasitemia - drug therapy | Diminazene - analogs & derivatives | Body Temperature - physiology | Trypanosomiasis, African - parasitology | Animals | Antelopes - parasitology | Hematocrit - veterinary | Trypanocidal Agents - pharmacology | Genital Diseases, Male - veterinary | Semen - parasitology | Genital Diseases, Male - drug therapy | Parasitemia - parasitology | Trypanosoma brucei brucei - growth & development | Universities and colleges
Journal Article
Immunologic Research, ISSN 0257-277X, 2/2019, Volume 67, Issue 1, pp. 84 - 92
Diminazene aceturate (Berenil) is the most commonly used trypanolytic agent in livestock. We previously showed that Berenil downregulates Trypanosoma...
Allergology | Immunology | Medicine & Public Health | STAT1 | Internal Medicine | Diminazene aceturate (Berenil) | Proinflammatory cytokines | Macrophages | MAPK | Medicine/Public Health, general | Trypanosome | PATHWAYS | INFECTIONS | EXPERIMENTAL AFRICAN TRYPANOSOMIASIS | ANTIBODY | ALPHA | IMMUNOLOGY | MEDIATED PHAGOCYTOSIS | MACROPHAGE ACTIVATION | RESPONSES | RESISTANCE | EXPRESSION | Medical colleges | Livestock | Cytokines | Mitogens | Protein kinases | Phosphorylation | Transcription | Stat3 protein | MAP kinase | Inflammation | Kinases | Proteins | Molecular modelling | Protein kinase | In vivo methods and tests | Pretreatment | Stat1 protein
Allergology | Immunology | Medicine & Public Health | STAT1 | Internal Medicine | Diminazene aceturate (Berenil) | Proinflammatory cytokines | Macrophages | MAPK | Medicine/Public Health, general | Trypanosome | PATHWAYS | INFECTIONS | EXPERIMENTAL AFRICAN TRYPANOSOMIASIS | ANTIBODY | ALPHA | IMMUNOLOGY | MEDIATED PHAGOCYTOSIS | MACROPHAGE ACTIVATION | RESPONSES | RESISTANCE | EXPRESSION | Medical colleges | Livestock | Cytokines | Mitogens | Protein kinases | Phosphorylation | Transcription | Stat3 protein | MAP kinase | Inflammation | Kinases | Proteins | Molecular modelling | Protein kinase | In vivo methods and tests | Pretreatment | Stat1 protein
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 11/2018, Volume 107, pp. 212 - 218
Diminazene aceturate (DIZE) has been reported to enhance the catalytic efficiency of ACE-2 and presumably increases angiotensin 1–7 generation, interfering...
Diminazene | Myocardial infarction | Heart | Diastolic function | Fibrosis | CONVERTING ENZYME 2 | MEDICINE, RESEARCH & EXPERIMENTAL | HEART-FAILURE | CARDIAC DYSFUNCTION | ANGIOTENSIN-II | HYPERTROPHY | STIFFNESS | PHARMACOLOGY & PHARMACY | SALT INTAKE | HYPERTENSIVE-RATS | EXPRESSION | Enzyme Activators - pharmacology | Rats, Wistar | Enzyme Activators - therapeutic use | Ventricular Dysfunction - drug therapy | Cardiomegaly - pathology | Male | Ventricular Dysfunction - etiology | Myocardial Infarction - pathology | Peptidyl-Dipeptidase A - metabolism | Myocardial Infarction - physiopathology | Diastole - drug effects | Ventricular Dysfunction - physiopathology | Ventricular Function - drug effects | Diminazene - pharmacology | Ventricular Dysfunction - pathology | Cardiomegaly - physiopathology | Diminazene - analogs & derivatives | Collagen - metabolism | Myocardial Infarction - complications | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Hemodynamics - drug effects | Diminazene - therapeutic use | Prevention | Health aspects | Collagen | Heart attack | Angiotensin
Diminazene | Myocardial infarction | Heart | Diastolic function | Fibrosis | CONVERTING ENZYME 2 | MEDICINE, RESEARCH & EXPERIMENTAL | HEART-FAILURE | CARDIAC DYSFUNCTION | ANGIOTENSIN-II | HYPERTROPHY | STIFFNESS | PHARMACOLOGY & PHARMACY | SALT INTAKE | HYPERTENSIVE-RATS | EXPRESSION | Enzyme Activators - pharmacology | Rats, Wistar | Enzyme Activators - therapeutic use | Ventricular Dysfunction - drug therapy | Cardiomegaly - pathology | Male | Ventricular Dysfunction - etiology | Myocardial Infarction - pathology | Peptidyl-Dipeptidase A - metabolism | Myocardial Infarction - physiopathology | Diastole - drug effects | Ventricular Dysfunction - physiopathology | Ventricular Function - drug effects | Diminazene - pharmacology | Ventricular Dysfunction - pathology | Cardiomegaly - physiopathology | Diminazene - analogs & derivatives | Collagen - metabolism | Myocardial Infarction - complications | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Hemodynamics - drug effects | Diminazene - therapeutic use | Prevention | Health aspects | Collagen | Heart attack | Angiotensin
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2013, Volume 713, Issue 1-3, pp. 89 - 93
We have previously demonstrated that diminazene aceturate (DIZE), a putative angiotensin 1–7 converting enzyme activator, protects rats from monocrotaline...
Diminazene | ACE2 | Autonomic nervous system | Pulmonary hypertension | INTERVAL | SYSTEM | ARTERIAL-PRESSURE | HEART-RATE-VARIABILITY | PHARMACOLOGY & PHARMACY | FAILURE | BLOOD-PRESSURE | Diminazene - pharmacology | Antihypertensive Agents - pharmacology | Autonomic Nervous System - drug effects | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Monocrotaline - pharmacology | Rats | Male | Diminazene - analogs & derivatives | Antihypertensive Agents - therapeutic use | Hypertension, Pulmonary - chemically induced | Rats, Sprague-Dawley | Heart Rate - drug effects | Animals | Diminazene - administration & dosage | Arterial Pressure - drug effects | Peptidyl-Dipeptidase A - metabolism | Hypertension, Pulmonary - drug therapy | Diminazene - therapeutic use
Diminazene | ACE2 | Autonomic nervous system | Pulmonary hypertension | INTERVAL | SYSTEM | ARTERIAL-PRESSURE | HEART-RATE-VARIABILITY | PHARMACOLOGY & PHARMACY | FAILURE | BLOOD-PRESSURE | Diminazene - pharmacology | Antihypertensive Agents - pharmacology | Autonomic Nervous System - drug effects | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Monocrotaline - pharmacology | Rats | Male | Diminazene - analogs & derivatives | Antihypertensive Agents - therapeutic use | Hypertension, Pulmonary - chemically induced | Rats, Sprague-Dawley | Heart Rate - drug effects | Animals | Diminazene - administration & dosage | Arterial Pressure - drug effects | Peptidyl-Dipeptidase A - metabolism | Hypertension, Pulmonary - drug therapy | Diminazene - therapeutic use
Journal Article
Journal of Parasitic Diseases, ISSN 0971-7196, 6/2019, Volume 43, Issue 2, pp. 329 - 332
The blood glucose levels of rats were assessed following experimental Trypanosoma brucei infection and diminazene aceturate treatment. Ten adult female albino...
Diminazene aceturate | Fasting blood glucose levels | Medicine & Public Health | Relapse infection | Health Promotion and Disease Prevention | Rats | Infectious Diseases | Trypanosoma brucei | Medicine/Public Health, general | Medicine, Experimental | Medical research | Albinism | Blood sugar | Health aspects
Diminazene aceturate | Fasting blood glucose levels | Medicine & Public Health | Relapse infection | Health Promotion and Disease Prevention | Rats | Infectious Diseases | Trypanosoma brucei | Medicine/Public Health, general | Medicine, Experimental | Medical research | Albinism | Blood sugar | Health aspects
Journal Article