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Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 248 - 255
Dipeptidyl peptidase (DPP) IV inhibitors are probably beneficial for preventing diabetic complication and modulating glucagon-like peptide-1 receptor (GLP-1R)... 
FIBROSIS | GROWTH-FACTOR-BETA | TGF-BETA | GLP-1 | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE-METABOLISM | BETA-CELL APOPTOSIS | RECEPTOR EXPRESSION | IMPROVES | PHARMACOLOGY & PHARMACY | NEPHROPATHY | Diabetes Mellitus, Experimental - drug therapy | Dipeptidyl Peptidase 4 - metabolism | Gene Expression - drug effects | Kidney - pathology | Gene Expression - genetics | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Glycated Hemoglobin A - metabolism | Transforming Growth Factor beta1 - metabolism | Caspase 3 - metabolism | Body Weight - drug effects | Diabetic Nephropathies - drug therapy | Pyrrolidines - administration & dosage | Glucagon-Like Peptide 1 - blood | Male | Insulin - blood | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Kidney - metabolism | Diabetic Nephropathies - physiopathology | Glomerular Basement Membrane - pathology | Adamantane - therapeutic use | Diabetes Mellitus, Experimental - complications | Adamantane - administration & dosage | Cyclic AMP - urine | Deoxyguanosine - analogs & derivatives | Kidney - physiopathology | Adamantane - analogs & derivatives | Diabetes Mellitus, Experimental - physiopathology | Receptors, Glucagon - genetics | Adamantane - pharmacology | Diabetic Nephropathies - pathology | Kidney - drug effects | Deoxyguanosine - urine | Diabetic Nephropathies - metabolism | Rats | Receptors, Glucagon - metabolism | Rats, Sprague-Dawley | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Blood Glucose - drug effects | Eating - drug effects | Glomerular Basement Membrane - drug effects | Animals | Glucagon-Like Peptide-1 Receptor | Diabetes Mellitus, Experimental - pathology | Blood Glucose - metabolism
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2014, Volume 36, Issue 12, pp. 2072 - 2079
Abstract Purpose Although recent reports suggest an association between saxagliptin and an increased risk of admissions for heart failure, it is not clear... 
Internal Medicine | Medical Education | DPP-IV inhibition | cardiovascular disease | heart failure | type 2 diabetes | Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) | Vildagliptin in Ventricular Dysfunction Diabetes Trial (VIVIDD) | Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus–Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 trial | Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 trial | MYOCARDIAL-INFARCTION | SAXAGLIPTIN | HUMANS | Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 trial | IMPACT | CLINICAL-TRIALS | IMPROVES | PHARMACOLOGY & PHARMACY | TYPE-2 DIABETES-MELLITUS | CARDIOVASCULAR RISK | Dipeptides - therapeutic use | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Dipeptides - adverse effects | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Pyrrolidines - adverse effects | Uracil - therapeutic use | Hospitalization | Pyrrolidines - therapeutic use | Uracil - adverse effects | Piperidines - therapeutic use | Piperidines - adverse effects | Adamantane - therapeutic use | Sitagliptin Phosphate - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Nitriles - adverse effects | Heart Failure - chemically induced | Adamantane - adverse effects | Adamantane - analogs & derivatives | Nitriles - therapeutic use | Sitagliptin Phosphate - adverse effects | Uracil - analogs & derivatives | Heart failure | Regulatory agencies | Heart attacks | Peptides | Mortality | Cardiovascular disease | FDA approval | Patients | Data bases | Studies | Diabetes | Drug therapy | Acute coronary syndromes
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2005, Volume 48, Issue 1, pp. 141 - 151
Journal Article