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chemistry, organic (27) 27
chemistry, multidisciplinary (24) 24
direct difluoromethylation (22) 22
carbonyl-compounds (16) 16
fluorine (14) 14
catalysis (13) 13
direct nucleophilic difluoromethylation (13) 13
reagents (12) 12
difluorocarbene (11) 11
difluoromethylation (11) 11
derivatives (10) 10
organic chemistry (10) 10
chemistry (9) 9
trifluoromethylation (9) 9
aryl (8) 8
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activation (7) 7
alkenes (7) 7
palladium (7) 7
arenes (6) 6
aryl boronic acids (6) 6
copper-mediated difluoromethylation (6) 6
cross-coupling reactions (6) 6
difluoroalkylation (6) 6
direct arylation (6) 6
inhibitors (6) 6
iodides (6) 6
photoredox catalysis (6) 6
arylboronic acids (5) 5
c-h activation (5) 5
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chemistry, applied (5) 5
complexes (5) 5
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fluorination (5) 5
fluoroalkylation reactions (5) 5
fluoroform (5) 5
functionalisation (5) 5
funktionalisierung (5) 5
index medicus (5) 5
n-arylacrylamides (5) 5
nucleophilic difluoromethylation (5) 5
photocatalysis (5) 5
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radicals (5) 5
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substrates (5) 5
thioethers (5) 5
unactivated alkenes (5) 5
access (4) 4
alkylation (4) 4
alpha-fluorinated ethers (4) 4
aromatic compounds (4) 4
building-blocks (4) 4
catalyzed direct difluoromethylation (4) 4
c−h activation (4) 4
fluorides (4) 4
generation (4) 4
heteroarenes (4) 4
ligand (4) 4
nucleophilic trifluoromethylation (4) 4
reactivity (4) 4
ruppert-prakash reagent (4) 4
ruthenium (4) 4
sulfones (4) 4
synthesis (4) 4
aryl halides (3) 3
biological evaluation (3) 3
chemistry, inorganic & nuclear (3) 3
cucf3 (3) 3
efficient (3) 3
ethyl bromodifluoroacetate (3) 3
functional groups (3) 3
gem-difluoroolefination (3) 3
halides (3) 3
heterocycles (3) 3
heterocyclic compounds (3) 3
light photoredox catalysis (3) 3
nucleophiles (3) 3
ortho-metalation strategy (3) 3
oxidative trifluoromethylation (3) 3
photoredox (3) 3
reductive elimination (3) 3
transformations (3) 3
übergangsmetalle (3) 3
acids (2) 2
acyclic or carbocyclic compounds (2) 2
adhesives (2) 2
agrochemical (2) 2
agrochemikalie (2) 2
aldehydes (2) 2
alkene (2) 2
alkyl-halides (2) 2
alkynes (2) 2
alpha,beta-unsaturated carboxylic-acids (2) 2
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2019, Volume 141, Issue 29, pp. 11398 - 11403
We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues.... 
ALKENES | REAGENTS | DIRECT NUCLEOPHILIC DIFLUOROMETHYLATION | FLUORINE | ARYL | REDOX-ACTIVE ESTERS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 07/2015, Volume 19, Issue 16, pp. 1638 - 1650
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1189 - 10
Transition-metal-catalyzed direct site-selective functionalization of arene C-H bonds has emerged as an innovative approach for building the core structure of... 
BENZENE-DERIVATIVES | FUNCTIONALIZATION | ACTIVATION | DIRECT ARYLATION | BROMINATION | ALKYLATION | MULTIDISCIPLINARY SCIENCES | ARENES | ORTHO-METALATION STRATEGY | FLUORINE | CARBON-HYDROGEN BONDS | Complex compounds | Ruthenium | Heterocyclic compounds | Aromatic compounds | Chelation | Derivatives | Drug discovery | Fluorination | Substrates | Ruthenium compounds
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2017, Volume 56, Issue 8, pp. 2045 - 2049
Ruthenium(II)‐catalyzed meta‐selective C−H (di)fluoromethylation was accomplished by phosphine and carboxylate cooperation. The remote C−H functionalization... 
ruthenium | phosphine | C−H activation | meta-selectivity | fluorine | ACTIVATION | ARENES | CATALYZED DIRECT ARYLATIONS | CARBON-HYDROGEN BONDS | CHEMISTRY, MULTIDISCIPLINARY | PHENOL DERIVATIVES | ALKYL-HALIDES | FUNCTIONALIZATION | C-H activation | RECENT PROGRESS | LIGAND | ARYL CHLORIDES | Ruthenium | Fluorides | Cooperation | Phosphine | Ruthenium compounds
Journal Article
Organic Letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 15, pp. 3802 - 3805
The difluoromethylation of terminal alkynes through the use of fluoroform as a source of difluorocabene is described. The choice of solvents and bases was... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | EFFICIENT PRECURSOR | DIRECT CUPRATION | ENANTIOSELECTIVE FLUORINATION | BOND-FORMING REACTIONS | ELECTROGENERATED BASE | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | CUCF3 | C-NUCLEOPHILES | ALDEHYDES
Journal Article
Synthesis, ISSN 0039-7881, 08/2017, Volume 49, Issue 15, pp. 3394 - 3406
Journal Article
by Wang, WQ and Yu, QW and Zhang, Q and Li, JW and Hui, F and Yang, JM and Lu, J
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 07/2018, Volume 38, Issue 7, pp. 1569 - 1585
Journal Article
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 07/2018, Volume 38, Issue 7, pp. 1569 - 1585
Journal Article
Organic Letters, ISSN 1523-7060, 10/2017, Volume 19, Issue 19, pp. 5304 - 5307
A one-step protocol for the difluoromethylation of carboxylic acids is described. The reaction involves the interaction of intermediate acyl chlorides with in... 
IODIDES | GEM-DIFLUOROOLEFINATION | COPPER-MEDIATED DIFLUOROMETHYLATION | DIRECT NUCLEOPHILIC DIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ARYL | FLUOROALKYLATION REACTIONS | PERFLUOROALKYLATION REACTIONS | PHOTOREDOX CATALYSIS | TRIFLUOROMETHYLATION
Journal Article
Chemical Communications: Chem Comm, ISSN 1359-7345, 02/2016, Volume 52, Issue 18, pp. 3657 - 3660
A new method for the generation of the "PhSO sub(2)CF sub(2)Cu" species from readily available difluoromethyl phenyl sulfone (PhSO sub(2)CF sub(2)H) has been... 
Phenyls | Sulfones | Reagents
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 08/2018, Volume 59, Issue 33, pp. 3184 - 3187
A novel decarboxylative difluoromethylation reaction of PhSO CF COOK with aldehydes under metal- and ligand-free conditions has been developed. The reaction is... 
Potassium phenylsulfonyldifluoroacetate | Addition | Difluoromethyl alcohol | Decarboxylative difluoromethylation | HALF THIOESTERS | ENANTIOSELECTIVE SYNTHESIS | PHENYL SULFONE | DIRECT NUCLEOPHILIC DIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | BETA-KETOACIDS | KETONES | ALDOL REACTION | STEREOSELECTIVE-SYNTHESIS | EQUIVALENT
Journal Article
Arkivoc, ISSN 1551-7004, 03/2017, Volume 2017, Issue 1, pp. 67 - 83
Recent development in the trifluoromethylation and difluoromethylation of organic compounds employing fluoroform is reviewed. Eight approaches to... 
Fluoroform | Trifluoromethylation | CuCF | Difluoromethylation | NUCLEOPHILIC TRIFLUOROMETHYLATION | DIRECT CUPRATION | MEDIATED TRIFLUOROMETHYLATION | RUPPERT-PRAKASH REAGENT | SODIUM TRIFLINATE | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ARYLBORONIC ACIDS | EFFICIENT PRECURSOR | MEDICINAL CHEMISTRY | fluoroform | CuCF3 | difluoromethylation
Journal Article
ISSN 0306-0012, 10/2016, Volume 45, Issue 2, pp. 5441 - 5454
Fluoroalkylation reaction, featuring the transfer of a fluoroalkyl group to a substrate, is a straightforward and efficient method for the synthesis of... 
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 10/2016, Volume 45, Issue 20, pp. 5441 - 5454
Fluoroalkylation reaction, featuring the transfer of a fluoroalkyl group to a substrate, is a straightforward and efficient method for the synthesis of... 
MEDICINAL CHEMISTRY | ACTIVATION | HETEROARENES | RESOLUTION | DIRECT NUCLEOPHILIC DIFLUOROMETHYLATION | CATALYZED TRIFLUOROMETHYLATION | CARBONYL-COMPOUNDS | GENERATION | C-F BOND | FLUOROFORM | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 01/2017, Volume 2017, Issue 2, pp. 266 - 270
CF2H‐substituted pyrazolines were synthesized by [3+2] cycloaddition between in situ generated CF2HCHN2 and electron‐deficient alkenes. The representative... 
Cycloaddition | Alkenes | Fluorine | Pyrazoline | Difluoromethylation | REAGENTS | CHEMISTRY, ORGANIC | ALKYNES | DISCOVERY | DIRECT DIFLUOROMETHYLATION | OPTIMIZATION | GENERATION | INHIBITORS | ANTAGONISTS | DERIVATIVES | IN-SITU | Olefins
Journal Article
Russian Chemical Reviews, ISSN 0036-021X, 2019, Volume 88, Issue 5, pp. 425 - 569
Journal Article