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Angewandte Chemie International Edition, ISSN 1433-7851, 02/2016, Volume 55, Issue 9, pp. 3153 - 3157
The C−H alkylation of aniline derivatives with both primary and secondary alkyl halides was achieved with a versatile nickel catalyst of a vicinal diamine ligand. Step... 
reaction mechanisms | nickel | alkylation | C−H activation | anilines | C-H activation | HALIDES | C(SP)-H BONDS | ACTIVATION | DIRECT ARYLATION | CARBON-HYDROGEN BONDS | CHEMISTRY, MULTIDISCIPLINARY | BIDENTATE-CHELATION ASSISTANCE | UNACTIVATED C(SP)-H BONDS | COUPLING REACTIONS | AROMATIC AMIDES | DIRECTED ALKYLATION | Aniline | Nickel | Drugs | Antitumor agents | Catalysts | Halides | Alkylation
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2015, Volume 137, Issue 1, pp. 531 - 539
We report a method for the monoselective alkylation of ortho-C–H bonds of N-quinolyl benzamides with both primary and secondary alkyl halides under palladium catalysis... 
FUNCTIONALIZATION | HALIDES | PALLADIUM | ACTIVATION | DIRECT ARYLATION | INTRAMOLECULAR AMINATION | COPPER | OXIDATIVE ADDITION | CHEMISTRY, MULTIDISCIPLINARY | METHYLENE C(SP)-H BONDS | DIRECTED ALKYLATION | Palladium | Chemical properties | Hydrogen | Carbon compounds
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2007, Volume 104, Issue 2, pp. 491 - 494
Journal Article
Organic Letters, ISSN 1523-7060, 07/2012, Volume 14, Issue 14, pp. 3796 - 3799
The alkylation of aryl sulfamates and carbamates using iron catalysis is reported... 
ALKYL-GRIGNARD-REAGENTS | HALIDES | CROSS-COUPLING REACTIONS | DIRECTED ORTHO-METALATION | COMPLEXES | ARENES | CHEMISTRY, ORGANIC | ALKENYL | ORTHO-ARYLATION
Journal Article
Journal of Coordination Chemistry, ISSN 0095-8972, 10/2016, Volume 69, Issue 19, pp. 2807 - 2818
... toward metal fragments has been exploited in the synthesis of multimetallic aggregates [3-11]. Alkylation reactions of 1 with mild electrophiles were realized... 
platinum complexes | mass spectrometry | alkylation | Real-time analysis | boronic acid | COORDINATION CHEMISTRY | PRESSURIZED SAMPLE INFUSION | COMPLEXES | PT-2(PPH3)(MU-S) | SULFUR | SULFIDE | CHEMISTRY, INORGANIC & NUCLEAR | METALLOLIGAND | SPECTROMETRY-DIRECTED SURVEY | ARYL HALIDES | PT-2(MU-S)(PPH3) | Infrared spectroscopy | Infusion | X rays | Equivalence | Ionization | Derivatives | NMR spectroscopy | Alkylation
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0170719 - e0170719
.... Here, we investigated the role and biological function of TLS polymerase ImuC (former DnaE2), generally present in bacteria lacking DNA polymerase V, and TLS polymerase DinB in response to DNA alkylation damage in Pseudomonas aeruginosa and P... 
STATIONARY-PHASE MUTAGENESIS | REPAIR | GRAM-NEGATIVE BACTERIA | REPLICATION | SOS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | AGENTS | ADAPTIVE RESPONSE | GENE-PRODUCT | Temperature | DNA, Bacterial - metabolism | Species Specificity | DNA Repair - genetics | DNA-Directed DNA Polymerase - deficiency | Recombinant Fusion Proteins - metabolism | Alkylation | DNA Adducts - metabolism | DNA-Directed DNA Polymerase - genetics | DNA Glycosylases - deficiency | Methylnitronitrosoguanidine - pharmacology | Pseudomonas aeruginosa - enzymology | Pseudomonas putida - drug effects | Drug Resistance, Bacterial - genetics | DNA Glycosylases - metabolism | Genes, Reporter | Promoter Regions, Genetic | Pseudomonas putida - genetics | Bacterial Proteins - genetics | Mutagens - pharmacology | Pseudomonas putida - enzymology | Pseudomonas aeruginosa - drug effects | Bacterial Proteins - physiology | Phenotype | DNA, Bacterial - genetics | Rifamycins - pharmacology | Pseudomonas aeruginosa - genetics | Recombinant Fusion Proteins - genetics | DNA-Directed DNA Polymerase - physiology | DNA Damage | Mutation | Methyl Methanesulfonate - pharmacology | Lac Operon | DNA damage | DNA polymerases | DNA synthesis | Pseudomonas aeruginosa | Genetic aspects | Research | Pseudomonas putida | N-Methyl-N'-nitro-N-nitrosoguanidine | DNA polymerase | Toxicity | Cytotoxicity | Biochemistry | Biology | Methyl methanesulfonate | DNA repair | Base excision repair | Damage tolerance | Proteins | E coli | DNA methylation | Bacteria | Genetics | Chemical synthesis | Deoxyribonucleic acid--DNA | Low temperature | Cell survival | Survival | Mutants | DNA biosynthesis | Polymerase | Tuberculosis | Mutagenesis | Methylation | DNA-directed DNA polymerase | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2015, Volume 137, Issue 34, pp. 10950 - 10953
Pd­(II)-catalyzed ortho-alkylation of benzoic acids with both terminal and internal epoxides affords 3,4-dihydroisocoumarins in one step... 
ACTIVATION | AMINO-ACIDS | ARYL HALIDES | ARYLATION | ELECTRON-DEFICIENT ARENES | CHEMISTRY, MULTIDISCIPLINARY | METHYLENE C(SP)-H BONDS | DIRECTED ALKYLATION | PALLADIUM-CATALYZED ALKYLATION | BENZOIC-ACIDS
Journal Article
Organic letters, ISSN 1523-7060, 01/2019, Volume 21, Issue 2, pp. 571 - 574
Low-valent manganese-catalyzed C–H alkylation of pyridine derivatives with both primary and challenging secondary alkyl halides was established by amide assistance... 
OXIDATIVE OLEFINATION | HALIDES | PALLADIUM | ACTIVATION | DIRECT ARYLATION | QUINOLINES | CHEMISTRY, ORGANIC | CARBOXAMIDES | CATALYZED DIRECTED ALKYLATION | C(SP)-H | BOND
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2013, Volume 23, Issue 8, pp. 2395 - 2398
.... The photolysis of a quaternary amine yields a tertiary amine and has allowed us to temporally control aziridinium formation and subsequent alkylation of a colorimetric nucleophilic reporter molecule... 
Bioconjugation | Ring closure | Alkylation | Photochemistry | Nucleophilic addition | CHEMISTRY, MEDICINAL | CROSS-LINKING | CHEMISTRY, ORGANIC | MOLECULES | DNA | DYNAMICS | DIRECTED TOSYL CHEMISTRY | RECEPTORS | Aziridines - chemistry | Photochemical Processes
Journal Article
Journal Article
Frontiers of Chemical Science and Engineering, ISSN 2095-0179, 6/2016, Volume 10, Issue 2, pp. 213 - 221
Biological application of conjugates derived from oligonucleotides and quinone methides have previously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic acids... 
bioconjugation | Chemistry | target-directed modification of nucleic acids | quione methide | DNA alkylation | Industrial Chemistry/Chemical Engineering | Nanotechnology | reversible covalent reaction | OXIDATION | REACTIVITY | ADDUCTS | DUPLEX DNA | ENGINEERING, CHEMICAL | CROSS-LINKING AGENT | CYTOPROTECTION | OXIDE-DONATING ASPIRIN | GENERATION | SELECTIVITY | HYBRID DRUGS
Journal Article