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1. The Effects of Disc1 on Neurodevelopment in the Mouse
by Lee, Frankie Hang Fung
06/2013
Over the past decade, a combination of genetic, biological and imaging approaches have identified Disrupted-in-Schizophrenia-1 (DISC1) as a strong... 
Schizophrenia | DISC1 | 0317
Dissertation
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2. Full Text DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca 2+ Transfer through the MAM
by Park, Sung Jin and Lee, Su Been and Suh, Yeongjun and Kim, Su-Jeong and Lee, Namgyu and Hong, Ji-Ho and Park, Cana and Woo, Youngsik and Ishizuka, Koko and Kim, Joung-Hun and Berggren, Per-Olof and Sawa, Akira and Park, Sang Ki
Cell Reports, ISSN 2211-1247, 12/2017, Volume 21, Issue 10, pp. 2748 - 2759
A wide range of Ca -mediated functions are enabled by the dynamic properties of Ca , all of which are dependent on the endoplasmic reticulum (ER) and... 
MAM | DISC1 | mitochondria | oxidative stress
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3. Full Text Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics
by Tomoda, Toshifumi and Hikida, Takatoshi and Sakurai, Takeshi
Neurotherapeutics, ISSN 1933-7213, 7/2017, Volume 14, Issue 3, pp. 623 - 629
Disrupted-in-schizophrenia 1 (DISC1) was initially identified as a gene disrupted by a translocation mutation co-segregating with a variety of psychotic and... 
Neurology | Cargo | Neurosciences | Biomedicine | Interactome | Trafficking | Neurobiology | Schizophrenia | Neurosurgery | DISC1 | COMPLEX | PROTEIN | MITOCHONDRIA | SYNAPSE | DISRUPTED-IN-SCHIZOPHRENIA-1 DISC1 | MODEL | NEUROSCIENCES | CLINICAL NEUROLOGY | TRANSPORT | SCHIZOPHRENIA 1 DISC1 | PHARMACOLOGY & PHARMACY | SPINES | PLASTICITY | Nerve Tissue Proteins - metabolism | Mental Disorders - genetics | Animals | Humans | Mental Disorders - metabolism | Protein Transport - physiology | Neurons - metabolism | Nerve Tissue Proteins - genetics | Animal models | Mood | Mental disorders | Pedigree | Cognition | Mental depression | Motor task performance | Disc1 protein | Review
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4. Full Text Association of DISC1 Polymorphisms with Late-Onset Alzheimer’s Disease in Northern Han Chinese
by Zhang, Xiao-Yan and Wang, Hui-Fu and Tan, Meng-Shan and Wan, Yu and Kong, Ling-Li and Zheng, Zhan-Jie and Tan, Chen-Chen and Zhang, Wei and Wang, Zi-Xuan and Tan, Lin and Jiang, Teng and Tan, Lan and Yu, Jin-Tai
Molecular Neurobiology, ISSN 0893-7648, 05/2017, Volume 54, Issue 4, pp. 2922 - 2927
Association | Alzheimer’s disease | DISC1 | Polymorphism
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5. Animal Models of Prophylaxis and Prevention of Schizophrenia: Prenatal Seasonal Influenza Vaccine and Postnatal Valproate
by Doucet, Jean-Sebastien
11/2012
Schizophrenia is a mental illness with early adult onset. Prophylactic treatments would be clinically important and therefore we investigated the effect of two... 
influenza | cortex | postnatal | MIA | Disc1 L100P | morphology | VPA | pregnancy | Schizophrenia | IL-6 | Valproate | mouse | vaccine | Disc1 | neurodevelopment | prenatal | pyramidal neuron | maternal immune activation | behaviour | 0419 | Valproic Acid | 0317
Dissertation
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6. Full Text The Genetics and Biology of Disc1—An Emerging Role in Psychosis and Cognition
by Porteous, David J and Thomson, Pippa and Brandon, Nicholas J and Millar, J. Kirsty
Biological Psychiatry, ISSN 0006-3223, 2006, Volume 60, Issue 2, pp. 123 - 131
In the developing field of biological psychiatry, DISC1 stands out by virtue of there being credible evidence, both genetic and biological, for a role in... 
Bipolar affective disorder | PDE4B | schizophrenia | cognition | DISC1 | NUDEL | NEURONAL MIGRATION | TRANSLOCATION BREAKPOINT | PSYCHIATRY | VISUAL WORKING-MEMORY | SCHIZOAFFECTIVE DISORDER | DISRUPTED-IN-SCHIZOPHRENIA-1 DISC1 | BIPOLAR AFFECTIVE-DISORDER | NEUROSCIENCES | GENOME SCAN | NEUROCOGNITIVE FUNCTION | SCHIZOPHRENIA-1 DISC1 | SUSCEPTIBILITY LOCUS | bipolar affective disorder | Translocation, Genetic | Psychotic Disorders - genetics | Humans | Cloning, Molecular | Cognition - physiology | Cytogenetics | Signal Transduction - physiology | Cognition Disorders - genetics | Nerve Tissue Proteins - genetics | Proteins | Drugs and athletes | Depression, Mental | Medical genetics | Schizophrenia | Bipolar disorder | Cyclic adenylic acid | Adenylic acid
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7. Full Text DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis
by Ye, Fei and Kang, Eunchai and Yu, Chuan and Yu, Cong and Qian, Xuyu and Jacob, Fadi and Mao, Mao and Poon, Randy Y.C and Kim, Jieun and Song, Hongjun and Ming, Guo-li and Zhang, Mingjie
Neuron, ISSN 0896-6273, 12/2017, Volume 96, Issue 5, pp. 1204 - 1204
(Neuron 96, 1041-1054; December 6, 2017) During the production process of the original article, the term “Nde1l” was inadvertently italicized instead of... 
NEUROSCIENCES | Cell division | Errors | Mitosis | Neurogenesis | Disc1 protein
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8. Full Text Effects of genetic and environmental risk for schizophrenia on hippocampal activity and psychosis-like behavior in mice
by Scott, Daniel and Tamminga, Carol A
Behavioural Brain Research, ISSN 0166-4328, 02/2018, Volume 339, pp. 114 - 123
Schizophrenia is a serious mental illness most notably characterized by psychotic symptoms. In humans, psychotic disorders are associated with specific... 
Psychosis | Disc1 | Maternal deprivation | Hippocampus | REPEATED MATERNAL SEPARATION | EARLY-LIFE | PREPULSE INHIBITION | DISRUPTED-IN-SCHIZOPHRENIA-1 DISC1 | MUTANT DISC1 | NEUROSCIENCES | MOUSE MODELS | DENDRITIC SPINES | BEHAVIORAL SCIENCES | DENTATE GYRUS | ADULT MALE | WORKING-MEMORY | Animals, Newborn | Behavior, Animal - physiology | Mice, Transgenic | Risk | Hippocampus - metabolism | Maternal Deprivation | Animals | Schizophrenia - genetics | Schizophrenia - physiopathology | Social Behavior | Psychotic Disorders | Hippocampus - physiopathology | Disease Models, Animal | Medical research | Animal behavior | Schizophrenia | Genetic research | Medicine, Experimental | Genetic engineering | Risk factors
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9. Full Text TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD
by Endo, Ryo and Takashima, Noriko and Nekooki-Machida, Yoko and Komi, Yusuke and Hui, Kelvin Kai-Wan and Takao, Masaki and Akatsu, Hiroyasu and Murayama, Shigeo and Sawa, Akira and Tanaka, Motomasa
Biological psychiatry, ISSN 0006-3223, 10/2018, Volume 84, Issue 7, pp. 509 - 521
co-aggregation | TDP-43 | FTLD | psychiatric behaviors | DISC1 | local translation
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10. Full Text Association between variations in the disrupted in schizophrenia 1 gene and schizophrenia: A meta-analysis
by Xu, Yiliang and Ren, Jun and Ye, Haihong
Gene, ISSN 0378-1119, 04/2018, Volume 651, pp. 94 - 99
Schizophrenia is a severe psychiatric disorder. Genetic and functional studies have strongly implicated the gene ( ) as a candidate susceptibility gene for... 
Schizophrenia | DISC1 | Polymorphisms | Meta-analysis | SCOTTISH POPULATION | BIPOLAR DISORDER | CHINESE POPULATION | DISC1 GENE | RISK-FACTOR | MAJOR MENTAL-ILLNESS | JAPANESE POPULATION | GENETICS & HEREDITY | IMMUNE ACTIVATION | PSYCHIATRIC GENETICS | HAN CHINESE
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11. Full Text Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice
by Hikida, Takatoshi and Morita, Makiko and Kuroiwa, Mahomi and Macpherson, Tom and Shuto, Takahide and Sotogaku, Naoki and Niwa, Minae and Sawa, Akira and Nishi, Akinori
Neuroscience Research, ISSN 0168-0102, 2019
Development of drug addictive behaviors is modulated by both genetic and environmental risk factors. However, the molecular mechanisms remain unknown. To... 
Nucleus accumbens | Adolescent stress | Gene-environmental interaction | Addiction | DISC1 | Phosphodiesterase
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12. Full Text Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders
by Segal-Gavish, Hadar and Barzilay, Ran and Rimoni, Ofri and Offen, Daniel
The World Journal of Biological Psychiatry, ISSN 1562-2975, 03/2019, Volume 20, Issue 3, pp. 243 - 252
Objectives: Physical exercise has gained increasing interest as a treatment modality that improves prognosis in psychiatric patients. The disrupted in... 
neurogenesis | exercise | DISC1 | animal model | recognition memory | ADULT NEUROGENESIS | EXONS 2 | PSYCHIATRY | CELL-PROLIFERATION | PHYSICAL-EXERCISE | MUTANT MICE | SCHIZOPHRENIA-1 DISC1 | CA2 REGION | SPATIAL MEMORY | BRAIN
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13. Full Text Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse
by Kuroda, Keisuke and Yamada, Shinnosuke and Tanaka, Motoki and Iizuka, Michiro and Yano, Hisashi and Mori, Daisuke and Tsuboi, Daisuke and Nishioka, Tomoki and Namba, Takashi and Iizuka, Yukihiko and Kubota, Shimpei and Nagai, Taku and Ibi, Daisuke and Wang, Rui and Enomoto, Atsushi and Isotani-Sakakibara, Mayu and Asai, Naoya and Kimura, Kazushi and Kiyonari, Hiroshi and Abe, Takaya and Mizoguchi, Akira and Sokabe, Masahiro and Takahashi, Masahide and Yamada, Kiyofumi and Kaibuchi, Kozo
Human Molecular Genetics, ISSN 0964-6906, 12/2011, Volume 20, Issue 23, pp. 4666 - 4683
Disrupted-In-Schizophrenia 1 (DISC1) is a promising candidate gene for susceptibility to psychiatric disorders, including schizophrenia. DISC1 appears to be... 
ADULT BRAIN | NEURITE OUTGROWTH | SCHIZOPHRENIA-1 DISC1 | MIGRATION DEFECTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | DISRUPTED-IN-SCHIZOPHRENIA-1 DISC1 | D-SERINE LEVELS | DENTATE GYRUS | SYNAPTIC PLASTICITY | MICE LACKING | PREFRONTAL CORTEX | Immunohistochemistry | Neurons - pathology | Aging - drug effects | Astrocytes - pathology | Neuronal Plasticity - drug effects | Clozapine - pharmacology | Time Factors | Antibodies - immunology | Behavior, Animal - drug effects | Hippocampus - ultrastructure | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | Hippocampus - growth & development | Astrocytes - drug effects | Gene Targeting | Nerve Tissue Proteins - immunology | Gene Expression Regulation, Developmental - drug effects | Exons - genetics | Hippocampus - pathology | Maze Learning - drug effects | Mice, Inbred Strains | Amines - metabolism | Nerve Tissue Proteins - genetics | Aging - pathology | Hippocampus - metabolism | Phenotype | Animals | Mice | Astrocytes - metabolism
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14. Full Text Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion
by Ma, T.M and Abazyan, S and Abazyan, B and Nomura, J and Yang, C and Seshadri, S and Sawa, A and Snyder, S.H and Pletnikov, M.V
Molecular Psychiatry, ISSN 1359-4184, 05/2013, Volume 18, Issue 5, pp. 557 - 567
Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia... 
serine racemase | MK-801 | D-serine | astrocytes | schizophrenia | DISC1 | MOUSE-BRAIN | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISC1 PROTEIN | D-ASPARTATE RECEPTOR | NEUROSCIENCES | TARGETED DISRUPTION | GLUTAMATE NEUROTRANSMISSION | MICE | MENTAL-ILLNESS | RAT-BRAIN | GLIA | INDUCIBLE EXPRESSION | Neuroprotective Agents - therapeutic use | Glial Fibrillary Acidic Protein - genetics | Humans | Nerve Tissue Proteins - deficiency | Male | Reflex, Startle - genetics | Schizophrenia - pathology | Dopamine Agents - therapeutic use | Glial Fibrillary Acidic Protein - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Exploratory Behavior - physiology | Racemases and Epimerases - metabolism | Schizophrenia - genetics | Transfection | Schizophrenia - physiopathology | Protein Binding - drug effects | Acoustic Stimulation - adverse effects | Dizocilpine Maleate - therapeutic use | Female | Disease Models, Animal | Inhibition (Psychology) | Astrocytes - drug effects | Amphetamine - therapeutic use | Mice, Inbred C57BL | Mice, Transgenic | Mutation - genetics | Cycloheximide - pharmacology | Brain - drug effects | Animals | Leupeptins | Maze Learning | Analysis of Variance | Serine - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Mice | Schizophrenia - drug therapy | Cell Line, Transformed | Astrocytes - metabolism | Physiology, Pathological | Serine | Schizophrenia | Physiological aspects | Research | Health aspects | Protein binding
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15. Full Text Association on DISC1 SNPs with schizophrenia risk: A meta-analysis
by Ma, Jia-Hui and Sun, Xiao-Yu and Guo, Tong-Jun and Barot, Emily and Wang, Dong-Fang and Yan, Lai-Lai and Ni, Da-Wei and Huang, Ning-Hua and Xie, Qing and Zeng, Jing and Ou-Yang, Li and Liu, Ya-Qiong and Lu, Qing-Bin
Psychiatry Research, ISSN 0165-1781, 12/2018, Volume 270, pp. 306 - 309
Schizophrenia is a major psychiatric disorder with complex genetic, environmental, and psychological etiologies. Although gene has been shown as a risk factor... 
SNPs | Schizophrenia risk | DISC1 | POLYMORPHISMS | GENE | VARIANTS | PSYCHIATRY | SUSCEPTIBILITY | DISRUPTED-IN-SCHIZOPHRENIA-1 DISC1 | Genetic Predisposition to Disease | Schizophrenia - genetics | Humans | Alleles | Genotype | Polymorphism, Single Nucleotide | Nerve Tissue Proteins - genetics | Schizophrenia | Single nucleotide polymorphisms | Genomics | Risk factors
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16. Full Text DISC1-dependent regulation of mitochondrial dynamics controls the morphogenesis of complex neuronal dendrites
by Norkett, Rosalind and Modi, Souvik and Birsa, Nicol and Atkin, Talia A and Ivankovic, Davor and Pathania, Manav and Trossbach, Svenja V and Korth, Carsten and Hirst, Warren D and Kittler, Josef T
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 2, pp. 613 - 629
The DISC1 protein is implicated in major mental illnesses including schizophrenia, depression, bipolar disorder, and autism. Aberrant mitochondrial dynamics... 
TRANSPORT | PROTEIN | FUSION | KINESIN | MITOFUSIN 2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGENITOR PROLIFERATION | TRAFFICKING | SCHIZOPHRENIA | ENDOPLASMIC-RETICULUM | DISC1 | Mitochondrial Dynamics | Dendrites - metabolism | Mitochondrial Membrane Transport Proteins - metabolism | Schizophrenia - metabolism | Humans | Axons - metabolism | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Mitochondria - metabolism | Structure-Activity Relationship | Recombinant Fusion Proteins - metabolism | Morphogenesis | Nerve Tissue Proteins - metabolism | Nerve Tissue Proteins - chemistry | Animals | Biological Transport | Protein Binding | COS Cells | mitochondria | Neurobiology | dendrite | endoplasmic reticulum (ER) | schizophrenia | trafficking | Miro | mitofusin | DISC1-Boymaw fusion protein
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17. Full Text Association of the Ser704Cys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding
by Di Giorgio, Annabella and Blasi, Giuseppe and Sambataro, Fabio and Rampino, Antonio and Papazacharias, Apostolos and Gambi, Francesco and Romano, Raffaella and Caforio, Grazia and Rizzo, Miriam and Latorre, Valeria and Popolizio, Teresa and Kolachana, Bhaskar and Callicott, Joseph H and Nardini, Marcello and Weinberger, Daniel R and