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1. Full Text Cytokine-producing B lymphocytes — key regulators of immunity
by Lund, Frances E
Current Opinion in Immunology, ISSN 0952-7915, 2008, Volume 20, Issue 3, pp. 332 - 338
The successful use of B cell depletion therapy for the treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators of... 
Allergy and Immunology | ACTIVATION | IFN-GAMMA PRODUCTION | INTERFERON-GAMMA | LUPUS MICE | DISTINCT | CPG-OLIGODEOXYNUCLEOTIDES | CD40 LIGAND | RECEPTOR | IMMUNOLOGY | T-CELLS | IL-10 | Autoimmunity | Models, Immunological | Animals | Humans | B-Lymphocyte Subsets - immunology | Immunologic Memory | Mice | Cytokines - biosynthesis | Cytokines - physiology
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2. Full Text Diverse Cytokine Production by NKT Cell Subsets and Identification of an IL-17: Producing CD4⁻NK1.1⁻ NKT Cell Population
by Jonathan M. Coquet and Sumone Chakravarti and Konstantinos Kyparissoudis and Finlay W. McNab and Lauren A. Pitt and Brent S. McKenzie and Stuart P. Berzins and Mark J. Smyth and Dale I. Godfrey
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2008, Volume 105, Issue 32, pp. 11287 - 11292
NKT cell subsets can be divided based on CD4 and NK1.1 expression and tissue of origin, but the developmental and functional relationships between the... 
T lymphocytes | Spleen | Cell mediated immunity | Cytokines | Natural killer T cells | Liver | Cell lines | Cultured cells | Cells | Tumors | CD1d | T cell | Thymus | thymus | ACTIVATION | PRECURSOR | MULTIDISCIPLINARY SCIENCES | MATURATION | ARTHRITIS | FUNCTIONALLY DISTINCT | IN-VIVO | KILLER T-CELLS | cytokines | MICE | DIFFERENTIATION | SELECTION | Inflammation Mediators - immunology | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | CD4-Positive T-Lymphocytes - cytology | Interleukin-17 - immunology | Organ Specificity - immunology | CD4-Positive T-Lymphocytes - immunology | Killer Cells, Natural - cytology | Lymphocyte Activation - immunology | Animals | Time Factors | Killer Cells, Natural - immunology | Mice | Biological Sciences
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3. Full Text Profile of Th17 cytokines (IL-17, TGF-β, IL-6) and Th1 cytokine (IFN-γ) in patients with immune thrombocytopenic purpura
by Ma, Daoxin and Zhu, Xiaojuan and Zhao, Ping and Zhao, Chunhong and Li, Xiaofang and Zhu, Yuanyuan and Li, Lizhen and Sun, Jianzhi and Peng, Jun and Ji, Chunyan and Hou, Ming
Annals of Hematology, ISSN 0939-5555, 11/2008, Volume 87, Issue 11, pp. 899 - 904
The data on polarization of the immune system towards T helper 1 (Th1) or T helper 2 (Th2) cells in immune thrombocytopenic purpura (ITP) are limited and... 
IFN-γ | Medicine & Public Health | Hematology | ITP | TGF-ß | IL-17 | Oncology | IL-6 | TGF-β | T-CELL SUBSETS | AUTOIMMUNE INFLAMMATION | DISTINCT | REACTIVITY | SUPPRESSION | TGF-beta | IFN-gamma | INTERLEUKIN-17 | MEGAKARYOCYTES | TYPE-1 | HEMATOLOGY | LYMPHOCYTES | Purpura, Thrombocytopenic, Idiopathic - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Humans | Middle Aged | Male | Interferon-gamma - metabolism | Case-Control Studies | Interleukin-17 - metabolism | T-Lymphocyte Subsets - metabolism | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interleukin-6 - metabolism | Transforming Growth Factor beta - metabolism | Thrombocytopenic purpura | Care and treatment | Interleukins | Analysis | Interferon | Transforming growth factors | Enzyme-linked immunosorbent assay
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4. Full Text Development, cytokine profile and function of human interleukin 17-producing helper T cells
by Wilson, Nicholas J and Boniface, Katia and Chan, Jason R and McKenzie, Brent S and Blumenschein, Wendy M and Mattson, Jeanine D and Basham, Beth and Smith, Kathleen and Chen, Taiying and Morel, Franck and Lecron, Jean-Claude and Kastelein, Robert A and Cua, Daniel J and McClanahan, Terrill K and Bowman, Edward P and Malefyt, Rene de Waal
Nature Immunology, ISSN 1529-2908, 09/2007, Volume 8, Issue 9, pp. 950 - 957
T-H-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T-H-17 lineage is... 
AUTOIMMUNE INFLAMMATION | DISTINCT | HOST-DEFENSE | BETA-DEFENSINS | ANTIMICROBIAL PEPTIDES | DIFFERENTIATION | IMMUNOLOGY | IL-23 | EXPRESSION | HUMAN KERATINOCYTES | PSORIASIS | Immunohistochemistry | Psoriasis - immunology | T-Lymphocyte Subsets - immunology | Enzyme-Linked Immunosorbent Assay | T-Lymphocyte Subsets - cytology | Humans | Antimicrobial Cationic Peptides - biosynthesis | Cells, Cultured | Interleukin-17 - biosynthesis | Cell Differentiation - immunology | Flow Cytometry | Interleukin-23 - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Epithelial Cells - immunology | Polymerase Chain Reaction | T-Lymphocytes, Helper-Inducer - cytology | Cytokines - immunology | Regulation | Immune response | Research | Interleukins | T cells | Parasitic diseases
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5. Full Text T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
by Hirota, Keiji and Hashimoto, Motomu and Yoshitomi, Hiroyuki and Tanaka, Satoshi and Nomura, Takashi and Yamaguchi, Tomoyuki and Iwakura, Yoichiro and Sakaguchi, Noriko and Sakaguchi, Shimon
Journal of Experimental Medicine, ISSN 0022-1007, 01/2007, Volume 204, Issue 1, pp. 41 - 47
This report shows that highly self-reactive T cells produced in mice as a result of genetically altered thymic T cell selection spontaneously differentiate... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | INFLAMMATION | TOLERANCE | DISTINCT | MICE | DIFFERENTIATION | INDUCTION | IMMUNOLOGY | LINEAGE | TYROSINE-PHOSPHATASE | BETA | Humans | Autoimmune Diseases - etiology | T-Lymphocytes, Regulatory - immunology | Mice, Mutant Strains | T-Lymphocytes, Helper-Inducer - immunology | Arthritis, Experimental - etiology | Cell Differentiation | Interferon-gamma - genetics | Interferon-gamma - deficiency | Cytokines - genetics | Interleukin-6 - metabolism | Cytokines - metabolism | Interleukin-6 - genetics | Autoimmune Diseases - immunology | Interleukin-17 - genetics | Arthritis, Experimental - immunology | Interleukin-17 - deficiency | Interleukin-6 - deficiency | Antigen-Presenting Cells - immunology | Mice, Knockout | Interleukin-17 - metabolism | Animals | Cytokines - deficiency | Mice | Mice, Inbred BALB C | Arthritis, Rheumatoid - immunology | In Vitro Techniques | Transforming Growth Factor beta - metabolism | Brief Definitive Reports
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6. Full Text STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
by Xuexian O. Yang and Athanasia D. Panopoulos and Roza Nurieva and Seon Hee Chang and Demin Wang and Stephanie S. Watowich and Chen Dong
Journal of Biological Chemistry, ISSN 0021-9258, 03/2007, Volume 282, Issue 13, pp. 9358 - 9363
Interleukin-17 (IL-17)-producing helper T (TH) cells, named as TH IL-17 , TH17, or inflammatory TH (THi), have been recently identified as a novel effector... 
INTERLEUKIN-17 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | DISTINCT | RECEPTOR | NEUTROPHILS | MICE | PROLIFERATION | DIFFERENTIATION | LINEAGE | EXPRESSION | T-Lymphocytes, Helper-Inducer - metabolism | Interleukin-6 - genetics | Mice, Inbred C57BL | Interferon-gamma - physiology | Inflammation - immunology | Interleukin-6 - deficiency | Mice, Knockout | Cell Differentiation - genetics | Cell Differentiation - immunology | Inflammation - metabolism | Animals | STAT3 Transcription Factor - physiology | Interleukin-6 - physiology | Inflammation - genetics | Mice | T-Lymphocytes, Helper-Inducer - pathology | Interferon-gamma - genetics | Interferon-gamma - deficiency | STAT3 Transcription Factor - metabolism
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7. Full Text A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures
by Wong, Michael Thomas and Ong, David Eng Hui and Lim, Tony Kiat Hon and Lim, Frances Sheau Huei and Teng, Karen Wei Weng and McGovern, Naomi and Narayanan, Sriram and Ho, Wen Qi and Cerny, Daniela and Tan, Henry Kun Kiaang and Tan, Eng-Huat and Tan, Ern Yu and Tan, Bien Keem and Anicete, Rosslyn and Chan, Jerry Kok Yen and Chan, Chung Yip and Cheow, Peng Chung and Lee, Ser Yee and Takano, Angela and Tam, John Kit Chung and Fink, Katja and Bertoletti, Antonio and Ginhoux, Florent and Curotto de Lafaille, Maria Alicia and Newell, Evan William
Immunity, ISSN 1074-7613, 08/2016, Volume 45, Issue 2, pp. 442 - 456
Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies... 
CHEMOKINE RECEPTOR EXPRESSION | IMMUNITY | TGF-BETA | MASS CYTOMETRY | INTERLEUKIN 22 | DISTINCT | COMPARTMENTALIZATION | DIFFERENTIATION | IMMUNOLOGY | SUBSET | LYMPHOCYTES | Biomarkers - metabolism | T-Lymphocyte Subsets - immunology | Cytokines - metabolism | Lymphocyte Activation | Humans | Blood - immunology | Cells, Cultured | Transcriptome | Receptors, Lymphocyte Homing - metabolism | Biodiversity | Organ Specificity | Lymphoid Tissue - immunology | Cell Lineage | T-Lymphocytes, Helper-Inducer - physiology | Animals | Cell Differentiation | Mice | Mass Spectrometry - methods | Cell Movement | Surgery, Plastic | Cytokines | Surgical clinics | T cells | Analysis | Studies | Spleen | Lymphocytes | Dimensional analysis | T cell receptors | Immune system
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8. Full Text Activated T Cells Secrete an Alternatively Spliced Form of Common γ-Chain that Inhibits Cytokine Signaling and Exacerbates Inflammation
by Hong, Changwan and Luckey, Megan A and Ligons, Davinna L and Waickman, Adam T and Park, Jung-Hyun and Park, Joo-Young and Kim, Grace Y and Keller, Hilary R and Etzensperger, Ruth and Tai, Xuguang and Lazarevic, Vanja and Feigenbaum, Lionel and Catalfamo, Marta and Walsh, Scott T.R
Immunity, ISSN 1074-7613, 06/2014, Volume 40, Issue 6, pp. 910 - 923
The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc-dependent cytokines. Here we report that activated T cells produce an... 
MECHANISM | SOLUBLE FORM | IN-VIVO | DISTINCT | GENERATION | DEFICIENT MICE | DIFFERENTIATION | IMMUNOLOGY | LINEAGE | INTERLEUKIN-7 RECEPTOR | IL-7 | Autoimmunity | Cell Proliferation | Immunoglobulin gamma-Chains - genetics | Interleukin-5 Receptor alpha Subunit - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | RNA, Messenger - biosynthesis | Signal Transduction - immunology | Lymphocyte Activation - immunology | Immunomodulation | Mice, Inbred C57BL | RNA, Messenger - genetics | Inflammation - immunology | Cell Survival - immunology | Protein Binding - immunology | Mice, Knockout | Alternative Splicing - immunology | Cell Differentiation - immunology | Animals | Immunoglobulin gamma-Chains - blood | Immunoglobulin gamma-Chains - immunology | Th17 Cells - immunology | Mice | Protein Isoforms - immunology | Interleukin-2 Receptor beta Subunit - immunology | Protein Isoforms - genetics
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9. Full Text Characteristic Cerebrospinal Fluid Cytokine/Chemokine Profiles in Neuromyelitis Optica, Relapsing Remitting or Primary Progressive Multiple Sclerosis
by Matsushita, Takuya and Tateishi, Takahisa and Isobe, Noriko and Yonekawa, Tomomi and Yamasaki, Ryo and Matsuse, Dai and Murai, Hiroyuki and Kira, Jun-Ichi
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61835
Background: Differences in cytokine/chemokine profiles among patients with neuromyelitis optica (NMO), relapsing remitting multiple sclerosis (RRMS), and... 
RHEUMATOID-ARTHRITIS | CELLS | MESSENGER-RNA | MARKER | INFLAMMATION | MS | MULTIDISCIPLINARY SCIENCES | DISTINCT | T-HELPER TYPE-1 | DIAGNOSTIC-CRITERIA | SYNOVIAL-FLUIDS | Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid | Recurrence | Aquaporin 4 - immunology | Chemokines - cerebrospinal fluid | Humans | Middle Aged | Male | Granulocyte-Macrophage Colony-Stimulating Factor - cerebrospinal fluid | Cytokines - cerebrospinal fluid | Interleukin-17 - cerebrospinal fluid | Neuromyelitis Optica - cerebrospinal fluid | Adult | Female | Interleukin-6 - cerebrospinal fluid | Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid | Development and progression | Neuromyelitis optica | Interleukins | T cells | Multiplexing | Neuroimaging | Immunoassay | Multiple sclerosis | Spinal cord | Disease | Carbon tetrachloride | Correlation coefficients | Interleukin | Central nervous system | Helper cells | Fluorescence | Lymphocytes T | Cerebrospinal fluid | Macrophages | Interleukin 6 | Proteins | Granulocyte colony-stimulating factor | Lymphocytes | Quality | Measurement methods | Colony-stimulating factor | Differential diagnosis | Growth factors | Immunoglobulins | Medical imaging | Psoriasis | Cytokines | Granulocyte-macrophage colony-stimulating factor | Colonies | Aquaporins | Neutrophils | CCL4 protein | Patients | Microglia | Neurological diseases | Neurology | Overexpression | Neuromyelitis | γ-Interferon | CXCL10 protein | Interferon | Chemokines | Monocyte chemoattractant protein 1
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10. Full Text Expression of interleukin‐12‐related cytokine transcripts in inflammatory bowel disease: Elevated interleukin‐23p19 and interleukin‐27p28 in Crohn's disease but not in ulcerative colitis
by Schmidt, Carsten and Giese, Thomas and Ludwig, Bianca and Mueller‐Molaian, Ina and Marth, Thomas and Zeuzem, Stefan and Meuer, Stefan C and Stallmach, Andreas
Inflammatory Bowel Diseases, ISSN 1078-0998, 01/2005, Volume 11, Issue 1, pp. 16 - 23
Background: It has been suggested that Crohn's disease (CD) is associated with an exaggerated T‐helper 1 cytokine response manifested by increased production... 
interleukin‐23 | Crohn's disease | ulcerative colitis | realtime polymerase chain reaction | interleukin‐27 | Interleukin-27 | Interleukin-23 | Real-time polymerase chain reaction | Ulcerative colitis | PROFILES | PROTEIN | CELL STIMULATORY FACTOR | real-time polymerase chain reaction | DISTINCT | HETERODIMERIC CYTOKINE | LESIONS | interleukin-23 | PATHOGENESIS | RESPONSES | interleukin-27 | RT-PCR | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | Crohn Disease - genetics | Intestinal Mucosa | Up-Regulation | Colitis, Ulcerative - metabolism | Humans | Middle Aged | Colitis, Ulcerative - genetics | Crohn Disease - metabolism | RNA, Messenger - analysis | Male | Interleukin-23 Subunit p19 | Reverse Transcriptase Polymerase Chain Reaction | Case-Control Studies | Interleukins - genetics | RNA, Messenger - biosynthesis | Adolescent | Aged, 80 and over | Adult | Female | Transcription, Genetic | Aged | Interleukins - biosynthesis
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11. Full Text T‐helper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factor‐α) in patients with alopecia areata: association with clinical type and severity
by Atwa, Mona A and Youssef, Nahed and Bayoumy, Nervana M
International Journal of Dermatology, ISSN 0011-9059, 06/2016, Volume 55, Issue 6, pp. 666 - 672
BackgroundAlopecia areata (AA) is an organ-specific autoimmune disease characterized by T-cell infiltrates and cytokine production. T-helper 17 (Th17) cells... 
INFLAMMATION | SERUM-LEVELS | IL-17 | DISTINCT | CELL-DIFFERENTIATION | IL-23 | AUTOIMMUNE-DISEASE | EXPRESSION | LINEAGE | TH17 CELLS | DERMATOLOGY | Interleukin-17 - blood | Severity of Illness Index | Interleukins - blood | Humans | Tumor Necrosis Factor-alpha - blood | Male | Case-Control Studies | Young Adult | Time Factors | Interleukin-6 - blood | Adolescent | Th17 Cells - immunology | Adult | Female | Alopecia Areata - immunology | Care and treatment | Alopecia | Baldness | Interleukins | Tumor necrosis factor | T cells | Tumors | Necrosis
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12. Full Text VHH-based bispecific antibodies targeting cytokine production
by Nosenko, Maxim A and Atretkhany, Kamar-Sulu N and Mokhonov, Vladislav V and Efimov, Grigory A and Kruglov, Andrey A and Tillib, Sergei V and Drutskaya, Marina S and Nedospasov, Sergei A
Frontiers in Immunology, ISSN 1664-3224, 09/2017, Volume 8, p. 1073
Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because... 
Single-chain antibodies | Macrophages | TNF | IL-6 | DISTINCT | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | SINGLE-DOMAIN ANTIBODIES | CD8(+) T-CELLS | macrophages | INHIBITION | SELECTIVE BLOCKADE | VHH | MICE | single-chain antibodies | EXPRESSION
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