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1. Full Text Remarkable impairment of Wnt/β‐catenin signaling in the brains of the mice infected with scrapie agents
by Sun, Jing and Wang, Hui and Chen, Li‐Na and Wang, Jing and Lv, Yan and Yang, Xiao‐Dong and Zhang, Bao‐Yun and Tian, Chan and Shi, Qi and Dong, Xiao‐Ping
Journal of Neurochemistry, ISSN 0022-3042, 02/2016, Volume 136, Issue 4, pp. 731 - 740
Prion diseases are a group of neurodegenerative diseases characterized by neuronal loss and spongiform degeneration, astrogliosis and aggregation of scrapie... 
DKK‐1 | Wnt/β‐catenin signaling | Prion diseases | GSK‐3β | β‐catenin | scrapie | Wnt/β-catenin signaling | GSK-3β | β-catenin | DKK-1
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2. Full Text Selective glucocorticoid receptor modulation maintains bone mineral density in mice
by Thiele, Sylvia and Ziegler, Nicole and Tsourdi, Elena and De Bosscher, Karolien and Tuckermann, Jan P and Hofbauer, Lorenz C and Rauner, Martina
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2012, Volume 27, Issue 11, pp. 2242 - 2250
Glucocorticoids (GCs) are potent anti‐inflammatory drugs, but their use is limited by their adverse effects on the skeleton. Compound A (CpdA) is a novel GC... 
DKK‐1 | COMPOUND A | GLUCOCORTICOID‐INDUCED OSTEOPOROSIS | RANKL | BONE REMODELING | GLUCOCORTICOID-INDUCED OSTEOPOROSIS | DKK-1 | INDUCED OSTEOPOROSIS | CELLS | OSTEOPROTEGERIN | MECHANISMS | PLANT-ORIGIN | INHIBITION | OSTEOBLASTS | ENDOCRINOLOGY & METABOLISM | LIGAND | DIFFERENTIATION | Anti-Inflammatory Agents - pharmacology | Humans | Osteoblasts - drug effects | Osteogenesis - drug effects | Receptors, Glucocorticoid - metabolism | Receptors, Glucocorticoid - agonists | Bone Density - drug effects | Animals | Cell Differentiation - drug effects | Models, Biological | Glucocorticoids - pharmacology | Mice | Osteoblasts - cytology | Osteoblasts - metabolism | Osteoporosis | Corticosteroids | Peptides | Analysis | Genes | Bones | Universities and colleges | Gene expression | Density | Prednisolone | Steroids | Antiinflammatory agents | Glucocorticoids | Spine | Osteocytes | procollagen | Bone turnover | Osteoblasts | Osteoprotegerin | Apposition | Bone histomorphometry | NF- Kappa B protein | Bone marrow | Bone mineral density | Skeleton | Bone loss | Dkk1 protein | TRANCE protein | Osteogenesis
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3. Full Text High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients
by Rachner, Tilman D and Thiele, Stefanie and Göbel, Andy and Browne, Andrew and Fuessel, Susanne and Erdmann, Kati and Wirth, Manfred P and Fröhner, Michael and Todenhöfer, Tilman and Muders, Michael H and Kieslinger, Matthias and Rauner, Martina and Hofbauer, Lorenz C
BMC Cancer, ISSN 1471-2407, 09/2014, Volume 14, Issue 1, p. 649
Background: The Wnt inhibitor Dickkopf-1 (DKK-1) has been linked to the progression of malignant bone disease by impairing osteoblast activity. In addition,... 
DKK-1 | Prostate cancer | Prognosis | MULTIPLE-MYELOMA | DKK 1 | ONCOLOGY | BONE | EXPRESSION | Multivariate Analysis | Prostatic Neoplasms - pathology | Tissue Array Analysis | Humans | Middle Aged | Male | Prostatic Neoplasms - diagnosis | Intercellular Signaling Peptides and Proteins - blood | Biomarkers, Tumor - blood | Survival Analysis | Prostatic Neoplasms - blood | Aged | Complications and side effects | Care and treatment | Cancer patients | Multiple myeloma | Development and progression | Research | Health aspects | Risk factors
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4. Full Text Serum concentrations of Dickkopf‐1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
by Politou, Marianna C and Heath, Deborah J and Rahemtulla, Amin and Szydlo, Richard and Anagnostopoulos, Athanasios and Dimopoulos, Meletios A and Croucher, Peter I and Terpos, Evangelos
International Journal of Cancer, ISSN 0020-7136, 10/2006, Volume 119, Issue 7, pp. 1728 - 1731
Dickkopf‐1 (DKK‐1) protein, a soluble inhibitor of Wnt signalling, has been implicated in the pathogenesis of myeloma bone disease through the suppression of... 
multiple myeloma | osteoblasts | dickkopf‐1 (DKK‐1) | bone disease | autologous stem cell transplantation | Bone disease | Osteoblasts | Autologous stem cell transplantation | Dickkopf-1 (DKK-1) | Multiple myeloma | ONCOLOGY | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | INHIBITOR | BONE-RESORPTION | Multiple Myeloma - diagnosis | Humans | Middle Aged | Male | Transplantation, Autologous | Intercellular Signaling Peptides and Proteins - blood | Biomarkers, Tumor - blood | Stem Cell Transplantation | Aged, 80 and over | Adult | Female | Aged | Neoplasm Staging | Multiple Myeloma - surgery | Multiple Myeloma - blood
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5. Full Text Effect of Recent Spinal Cord Injury on Wnt Signaling Antagonists (Sclerostin and Dkk‐1) and Their Relationship With Bone Loss. A 12‐Month Prospective Study
by Gifre, Laia and Vidal, Joan and Carrasco, Josep L and Filella, Xavier and Ruiz‐Gaspà, Silvia and Muxi, Africa and Portell, Enric and Monegal, Ana and Guañabens, Nuria and Peris, Pilar
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2015, Volume 30, Issue 6, pp. 1014 - 1021
Spinal cord injury (SCI) has been associated with a marked increase in bone loss and bone remodeling, especially short‐term after injury. The absence of... 
DKK‐1 | SPINAL CORD INJURY | SCLEROSTIN | WNT SIGNALING | OSTEOPOROSIS | DKK-1 | MULTIPLE-MYELOMA | INDUCED OSTEOPOROSIS | BIOCHEMICAL MARKERS | FOLLOW-UP | SERUM | CIRCULATING SCLEROSTIN | FRACTURE | MINERAL DENSITY | MEN | ENDOCRINOLOGY & METABOLISM | BED REST | Bone Resorption - etiology | Prospective Studies | Bone Resorption - blood | Follow-Up Studies | Spinal Cord Injuries - complications | Humans | Middle Aged | Male | Bone Morphogenetic Proteins - blood | Biomarkers - blood | Genetic Markers | Intercellular Signaling Peptides and Proteins - blood | Adolescent | Adult | Female | Aged | Spinal Cord Injuries - blood | Wnt Signaling Pathway | Bones | Spinal cord injuries | Density | Analysis
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6. Full Text Dickkopf‐1 (DKK‐1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases
by Thudi, Nanda K and Martin, Chelsea K and Murahari, Sridhar and Shu, Sherry T and Lanigan, Lisa G and Werbeck, Jillian L and Keller, Evan T and McCauley, Laurie K and Pinzone, Joseph J and Rosol, Thomas J
The Prostate, ISSN 0270-4137, 05/2011, Volume 71, Issue 6, pp. 615 - 625
BACKGROUND Osteoblastic bone metastasis is the predominant phenotype observed in prostate cancer patients and is associated with high patient mortality and... 
DKK‐1 | metastasis | prostate cancer | DKK-1 | WNT SIGNALING PATHWAY | MULTIPLE-MYELOMA | CELLS | MECHANISM | SKELETAL COMPLICATIONS | MESSENGER-RNA | GASTRIC-CANCER | MOUSE MODEL | IN-VIVO | ENDOCRINOLOGY & METABOLISM | UROLOGY & NEPHROLOGY | UP-REGULATION | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Osteogenesis - physiology | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Bone Neoplasms - secondary | Cell Growth Processes - physiology | Male | Tomography, X-Ray Computed | Wnt Proteins - metabolism | Bone Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Mice, Nude | Dogs | Histocytochemistry | Statistics, Nonparametric | Cell Line, Tumor | Mice | Wnt Proteins - antagonists & inhibitors | Prostate cancer
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7. Full Text Clinical significance and diagnostic value of serum dickkopf-1 in patients with hepatocellular carcinoma
by Fouad, Yasser M and Mohamed, Hala I and kamal, Enas M and Rasek, Mohamed A
Scandinavian Journal of Gastroenterology, ISSN 0036-5521, 09/2016, Volume 51, Issue 9, pp. 1133 - 1137
Background: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide. It has been widely established that the early detection of HCC... 
HCC | AFP | DKK 1 | hepatitis C | GASTROENTEROLOGY & HEPATOLOGY | CANCER | DKK1 | Multivariate Analysis | Hepatitis C, Chronic - pathology | Prospective Studies | Humans | Middle Aged | Egypt | Linear Models | Male | Liver Cirrhosis - blood | Hepatitis C, Chronic - blood | alpha-Fetoproteins - analysis | Intercellular Signaling Peptides and Proteins - blood | Biomarkers, Tumor - blood | Liver Neoplasms - blood | Sensitivity and Specificity | Liver Cirrhosis - pathology | Adult | Female | ROC Curve | Aged | Carcinoma, Hepatocellular - blood
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8. Full Text Myeloma Bone Disease: Recent Advances in Biology, Diagnosis, and Treatment
by Sezer, Orhan
The Oncologist, ISSN 1083-7159, 03/2009, Volume 14, Issue 3, pp. 276 - 283
Bone disease is a hallmark of multiple myeloma (MM). Occurring in the majority of MM patients, it is associated with bone pain, fractures, and hypercalcemia... 
DKK‐1 | RANKL | ICTP | MIP‐1 | Multiple myeloma | Osteoblast | Osteoclast | Bone | Biochemical markers | Osteoprotegerin | MIP-1 | DKK-1 | OSTEOBLAST DIFFERENTIATION | OSTEOLYTIC LESIONS | UROKINASE PLASMINOGEN-ACTIVATOR | ADVANCED MULTIPLE-MYELOMA | SERUM CONCENTRATIONS | ONCOLOGY | IN-VIVO | RECEPTOR ACTIVATOR | OSTEOCLAST DIFFERENTIATION | KAPPA-B LIGAND | MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA | Osteoblasts - pathology | Multiple Myeloma - pathology | Multiple Myeloma - therapy | Osteoclasts - pathology | Osteolysis - therapy | Multiple Myeloma - diagnosis | Humans | Osteolysis - diagnosis | Osteolysis - pathology
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9. Full Text Dickkopf‐1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
by Hall, Christopher L and Daignault, Stephanie D and Shah, Rajal B and Pienta, Kenneth J and Keller, Evan T
The Prostate, ISSN 0270-4137, 09/2008, Volume 68, Issue 13, pp. 1396 - 1404
BACKGROUND Prostate cancer (PCa) frequently metastasizes to the bone and induces osteoblastic lesions. We previously demonstrated through over‐expression of... 
DKK‐1 | prostate cancer | bone | Wnt | metastasis | DKK-1 | Bone | Metastasis | Prostate cancer | MULTIPLE-MYELOMA | TARGET | CELLS | ANTAGONIST | BONE METASTASES | IDENTIFICATION | DKK1 | GENE | PATHWAY | OSTEOBLASTS | ENDOCRINOLOGY & METABOLISM | UROLOGY & NEPHROLOGY | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Prognosis | Soft Tissue Neoplasms - secondary | Tissue Array Analysis | Humans | Lung Neoplasms - metabolism | Kaplan-Meier Estimate | Bone Neoplasms - secondary | Male | Prostatic Neoplasms - diagnosis | beta Catenin - metabolism | Disease Progression | Bone Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasm Metastasis | Lung Neoplasms - secondary | Biopsy | Liver Neoplasms - metabolism | Biomarkers, Tumor - metabolism | Retrospective Studies | Liver Neoplasms - secondary
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10. Full Text How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow
by GREGORY, CARL A and GUNN, WILLIAM G and REYES, EMIGDIO and SMOLARZ, ANGELA J and MUNOZ, JAMES and SPEES, JEFFREY L and PROCKOP, DARWIN J
Annals of the New York Academy of Sciences, ISSN 0077-8923, 05/2005, Volume 1049, Issue 1, pp. 97 - 106
: Human mesenchymal stem cells (hMSCs) from bone marrow are a source of osteoblast progenitors in vivo, and under appropriate conditions they differentiate... 
Dkk‐1 | bone | cancer | osteogenesis | Wnt | mesenchymal stem cells | Dkk-1 | Bone | Osteogenesis | Cancer | Mesenchymal stem cells | MULTIPLE-MYELOMA | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | ADULT PROGENITOR CELLS | ENGRAFTMENT | GROWTH-FACTORS | GENE FAMILY | OSTEOGENESIS IMPERFECTA | DIFFERENTIATION | STROMAL CELLS | EXPRESSION | Neoplasms - metabolism | Osteogenesis - physiology | Bone Marrow Cells - cytology | Humans | Bone Marrow Cells - physiology | Wnt Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Mesenchymal Stromal Cells - cytology | Animals | Signal Transduction - physiology | Neoplasms - physiopathology | Cell Differentiation - physiology | Mesenchymal Stromal Cells - physiology | Biomedical materials | Inhibitors | Peptides | Bone marrow | Biocompatibility | Bones | Kinases | Repair
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11. Full Text Circulating Dickkopf‐1 in Diabetes Mellitus: Association With Platelet Activation and Effects of Improved Metabolic Control and Low‐Dose Aspirin
by Lattanzio, Stefano and Santilli, Francesca and Liani, Rossella and Vazzana, Natale and Ueland, Thor and Di Fulvio, Patrizia and Formoso, Gloria and Consoli, Agostino and Aukrust, Pål and Davì, Giovanni
Journal of the American Heart Association, ISSN 2047-9980, 08/2014, Volume 3, Issue 4, p. n/a
Background Dickkopf‐1 (DKK‐1) is a major regulator of the Wnt signaling pathway, involved in inflammation, atherogenesis, and the regulation of glucose... 
DKK‐1 | platelet‐derived factor | diabetes mellitus | inflammation | endothelial dysfunction | platelet activation | Endothelial dysfunction | DKK-1 | Inflammation | Platelet activation | Platelet-derived factor | Diabetes mellitus | WNT SIGNALING PATHWAY | CARDIAC & CARDIOVASCULAR SYSTEMS | INVOLVEMENT | PREVENTION | CD40 LIGAND | GLUCOSE | SERUM-LEVELS | DISEASE | platelet-derived factor | CALCIFICATION | TYPE-2 | Hypoglycemic Agents - therapeutic use | Cross-Sectional Studies | CD40 Ligand - blood | Cardiovascular Diseases - prevention & control | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Biomarkers - blood | Thromboxane B2 - analogs & derivatives | Arginine - analogs & derivatives | Case-Control Studies | Intercellular Signaling Peptides and Proteins - blood | Diabetes Mellitus, Type 2 - blood | Platelet Activation | Thromboxane B2 - urine | Arginine - blood | Female | Aged | Aspirin - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Platelet Aggregation Inhibitors - therapeutic use | Wnt Signaling Pathway
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12. Full Text Dickkopf‐1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth
by Takahashi, Nobuyasu and Fukushima, Tsuyoshi and Yorita, Kenji and Tanaka, Hiroyuki and Chijiiwa, Kazuo and Kataoka, Hiroaki
International Journal of Cancer, ISSN 0020-7136, 04/2010, Volume 126, Issue 7, pp. 1611 - 1620
The protein products of the Dickkopf (DKK) genes are antagonists of Wnt glycoproteins, which participate in tumor development and progression by binding to... 
DKK‐1 | ductal adenocarcinoma | pancreatic cancer | wnt signal | Ductal adenocarcinoma | DKK-1 | Wnt signal | Pancreatic cancer | ANTAGONIST | HEPATOBLASTOMAS | GENE-EXPRESSION PROFILES | BETA-CATENIN | TUMORS | FAMILY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | EPIGENETIC INACTIVATION | CANCER BONE METASTASES | Cell Proliferation | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Immunoblotting | Male | RNA, Messenger - metabolism | Immunoenzyme Techniques | Carcinoma, Pancreatic Ductal - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Tumor Cells, Cultured | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Pancreatic Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Blotting, Western | Animals | Mice, Nude | Mice | Mice, Inbred BALB C | Apoptosis | Cell Movement
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13. Full Text Diagnostic investigations of DKK‐1 and PDCD5 expression levels as independent prognostic markers of human chondrosarcoma
by Zarea, Mojtaba and Mohammadian Bajgiran, Amirhossein and Sedaghati, Farnoush and Hatami, Negin and Taheriazam, Afshin and Yahaghi, Emad and Shakeri, Mohammadreza
IUBMB Life, ISSN 1521-6543, 07/2016, Volume 68, Issue 7, pp. 597 - 601
In this study, we investigated the expression levels of Dickkopf‐1 (DKK‐1) and programmed cell death 5 (PDCD5) by using quantitative real‐time PCR and... 
chondrosarcoma | immunohistochemistry | DKK‐1 and PDCD5 | PCR | patients | Immunohistochemistry | Chondrosarcoma | DKK-1 and PDCD5 | Patients | APOPTOSIS | ANTAGONIST | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH 5 | DICKKOPF-1 | TUMORS | CELL BIOLOGY | BREAST-CANCER | GENE | PROSTATE-CANCER | OSTEOSARCOMA | REDUCED EXPRESSION | Apoptosis Regulatory Proteins - biosynthesis | Prognosis | Neoplasm Proteins - biosynthesis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Intercellular Signaling Peptides and Proteins - genetics | Kaplan-Meier Estimate | Intercellular Signaling Peptides and Proteins - biosynthesis | Male | RNA, Messenger - biosynthesis | Apoptosis Regulatory Proteins - genetics | Cell Line, Tumor | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Adult | Female | Aged | Biomarkers, Tumor - genetics | Neoplasm Proteins - genetics | Biomarkers, Tumor - biosynthesis | Investigations
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