X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (57) 57
index medicus (53) 53
dlg motifs (49) 49
biochemistry & molecular biology (44) 44
humans (42) 42
oxidative stress (34) 34
dlg (31) 31
cell biology (27) 27
protein binding (26) 26
proteins (24) 24
nrf2 (23) 23
keap1 (21) 21
mice (21) 21
nf-e2-related factor 2 - metabolism (21) 21
protein (20) 20
intracellular signaling peptides and proteins - metabolism (19) 19
amino acid sequence (18) 18
kelch-like ech-associated protein 1 (17) 17
molecular sequence data (17) 17
binding (16) 16
binding sites (16) 16
domain (14) 14
membrane proteins (14) 14
protein structure, tertiary (14) 14
cancer (13) 13
cul3-based e3 ligase (12) 12
intracellular signaling peptides and proteins - chemistry (12) 12
nf-e2-related factor 2 - chemistry (12) 12
respiratory system (12) 12
ubiquitination (12) 12
cell line (11) 11
cell polarity (11) 11
genetics & heredity (11) 11
models, molecular (11) 11
oncology (11) 11
phosphorylation (11) 11
rats (11) 11
activation (10) 10
adaptor proteins, signal transducing - metabolism (10) 10
article (10) 10
drosophila (10) 10
drosophila proteins - metabolism (10) 10
environment and public health (10) 10
gene expression (10) 10
guanylate kinases (10) 10
mutation (10) 10
protein-protein interaction (10) 10
recognition model (10) 10
transcription factor nrf2 (10) 10
transfection (10) 10
tumor suppressor proteins - metabolism (10) 10
adaptor proteins, signal transducing (9) 9
amino acid motifs (9) 9
cells, cultured (9) 9
chemistry, medicinal (9) 9
disks large homolog 4 protein (9) 9
expression (9) 9
localization (9) 9
membrane proteins - metabolism (9) 9
pathway (9) 9
signal transduction (9) 9
ubiquitin (9) 9
analysis (8) 8
antioxidants (8) 8
complex (8) 8
human homolog (8) 8
induction (8) 8
kelch domain (8) 8
mechanism (8) 8
membrane proteins - genetics (8) 8
multidisciplinary sciences (8) 8
nerve tissue proteins - metabolism (8) 8
neurosciences (8) 8
pdz domains (8) 8
physiological aspects (8) 8
proteasomal degradation (8) 8
recognition (8) 8
research (8) 8
biology (7) 7
biophysics (7) 7
degradation (7) 7
genetic aspects (7) 7
ligases (7) 7
proteins - metabolism (7) 7
sequence homology, amino acid (7) 7
substrate specificity (7) 7
tumor-suppressor protein (7) 7
adaptor proteins, signal transducing - genetics (6) 6
crystallography, x-ray (6) 6
cytoskeletal proteins - metabolism (6) 6
digestive system (6) 6
family (6) 6
hek293 cells (6) 6
nerve tissue proteins - genetics (6) 6
nf-e2-related factor 2 - genetics (6) 6
pdz (6) 6
peptides (6) 6
protein conformation (6) 6
research article (6) 6
structural basis (6) 6
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Physical Chemistry B, ISSN 1520-6106, 06/2018, Volume 122, Issue 22, pp. 5851 - 5859
Nuclear factor erythroid 2 -related factor 2 (Nrf2) is a transcription factor and principal regulator of the antioxidant pathway. The Kelch domain of... 
INTERACTION DATABASE | LIGAND-BINDING | PROTEIN | KELCH DOMAIN | SIGNALING PATHWAY | DLG MOTIFS | SUBSTRATE | CHEMISTRY, PHYSICAL | COMPUTER-SIMULATIONS | MOLECULAR-DYNAMICS SIMULATIONS | OXIDATIVE STRESS-RESPONSE
Journal Article
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, ISSN 1742-7835, 09/2019, Volume 125, Issue 3, pp. 259 - 270
The Keap1-Nrf2-ARE system serves as a premier defence mechanism to curb oxidative stress, which remains as one of the major causes of ageing and pathogenesis... 
Keap1-Nrf2-ARE pathway | MODEL SYSTEM | SMALL-MOLECULE | KEAP1 | esculin | non-covalent interaction | STRUCTURAL BASIS | DLG MOTIFS | DISEASE | PHARMACOLOGY & PHARMACY | protein-protein interaction | TOXICOLOGY | zebrafish | oxidative stress
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 213 - 223
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of... 
OXIDATIVE STRESS | PROTEIN | MECHANISM | CUL3-BASED E3 LIGASE | STRUCTURAL BASIS | DLG MOTIFS | DEGRADATION | MICE | BETA-CELL MASS | INDUCTION | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Liver - pathology | Microtubule-Associated Proteins - genetics | Cytoskeletal Proteins - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Sequestosome-1 Protein | Humans | Oxidative Stress - physiology | Crystallography, X-Ray | Hepatocytes - pathology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Liver - physiopathology | Heat-Shock Proteins - genetics | Mutation - physiology | Transfection | Organ Size - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Inclusion Bodies - metabolism | Kelch-Like ECH-Associated Protein 1 | Cell Line | Binding, Competitive - physiology | Heat-Shock Proteins - metabolism | Liver - metabolism | Models, Molecular | Mice, Transgenic | Cytoskeletal Proteins - chemistry | Mice, Knockout | Protein Interaction Mapping | Autophagy-Related Protein 7 | Animals | Models, Biological | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Calorimetry | Signal Transduction - physiology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Protein Binding - physiology | Autophagy (Cytology) | Care and treatment | Transcription factors | Liver diseases | Physiological aspects | Genetic aspects | Research
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4683 - 4702
The KEAP1-NRF2-mediated cytoprotective response plays a key role in cellular homoeostasis. Insufficient NRF2 signaling during chronic oxidative stress may be... 
CHEMISTRY, MEDICINAL | NRF2 | MOLECULAR RECOGNITION | BARDOXOLONE METHYL | DLG MOTIFS | FRAGMENT | INDUCTION | STRESS | BINDING | DISCOVERY | LIGASE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8088 - 8103
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has a protective effect against oxidative stress and plays a major role in... 
INTERFERENCE COMPOUNDS PAINS | OXIDATIVE STRESS | PEPTIDE INHIBITORS | CHEMISTRY, MEDICINAL | DLG MOTIFS | DRUG DISCOVERY | CNS DELIVERY | ASSAY INTERFERENCE | NRF2-KEAP1 COMPLEX | NRF2 ACTIVATORS | BINDING
Journal Article
Journal Article
by Lu, MC and Jiao, Q and Liu, T and Tan, SJ and Zhou, HS and You, QD and Jiang, ZY
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 01/2018, Volume 143, pp. 1578 - 1589
Directly disrupting Keap1-Nrf2 protein-protein interaction (PPI) has emerged as a novel way to activate Nrf2. Peptide Keap1-Nrf2 PPI inhibitors have been... 
OXIDATIVE STRESS | KEAP1-NRF2-ARE PATHWAY | CHEMISTRY, MEDICINAL | Cyclic peptide | Nrf2 | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | DLG MOTIFS | THERAPEUTIC AGENTS | Keap1 | Protein-protein interaction inhibitors | DYNAMICS | BINDING
Journal Article