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Diabetes, ISSN 0012-1797, 09/2018, Volume 67, Issue 9, pp. 1807 - 1815
Type 2 diabetes mellitus (T2DM) is characterized by the inability of the insulin-producing -cells to overcome insulin resistance. We previously identified an... 
DLK1-GTL2 IMPRINTED DOMAIN | POOR-PROGNOSIS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | HISTONE MODIFICATIONS | IDENTIFICATION | AFFECTS CELL-PROLIFERATION | EXPRESSION | CANCER | NONCODING RNA MEG3 | REGION | Tissue Banks | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | DNA (Cytosine-5-)-Methyltransferase 1 - chemistry | Green Fluorescent Proteins - genetics | Diabetes Mellitus, Type 2 - metabolism | Genetic Loci | Recombinant Fusion Proteins - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | DNA Methylation | DNA (Cytosine-5-)-Methyltransferase 1 - genetics | Islets of Langerhans - metabolism | Membrane Proteins - metabolism | Green Fluorescent Proteins - chemistry | Repressor Proteins - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Repressor Proteins - chemistry | Cytokines - metabolism | Islets of Langerhans - pathology | Membrane Proteins - genetics | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Repressor Proteins - genetics | Locus Control Region | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Homeodomain Proteins - chemistry | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Enhancer Elements, Genetic | Mice | Diabetes Mellitus, Type 2 - pathology | Mutation | Oxidative Stress - drug effects | RNA, Long Noncoding - metabolism | Type 2 diabetes | Diabetics | Care and treatment | Usage | Pancreatic beta cells | Genetic aspects | High-throughput screening (Biochemical assaying) | Research | Health aspects | 0709 | Islet Studies
Journal Article
Journal Article
Epigenetics and Chromatin, ISSN 1756-8935, 05/2014, Volume 7, Issue 1, pp. 9 - 9
Background: Differential distribution of DNA methylation on the parental alleles of imprinted genes distinguishes the alleles from each other and dictates... 
DNA methylation | Epigenetics | Secondary DMR | Dlk1 | Genomic imprinting | PATTERNS | ESTABLISHMENT | MAINTENANCE | GTL2 | EMBRYO | GENES | GENETICS & HEREDITY | SITES | DLK1-GTL2 LOCUS | CLUSTER | EXPRESSION | Epigenetic inheritance | Book publishing | Analysis | Mergers, acquisitions and divestments | Mutation | Chromosomes | Genes
Journal Article
Journal of Molecular Endocrinology, ISSN 0952-5041, 06/2012, Volume 48, Issue 3, pp. R45 - R53
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 09/2018, Volume 27, Issue 18, pp. 3283 - 3292
Abstract Genomic imprinting is a phenomenon that causes parent-origin-specific monoallelic expression of a small subset of genes, known as imprinted genes, by... 
NONCODING RNA | GTL2 | ZFP57 | DNA METHYLATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | DLK1-GTL2 LOCUS | GERM-CELL DEVELOPMENT | EXPRESSION | DELETION | REGION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 42, pp. 18161 - 18166
Journal Article
Journal Article
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2010, Volume 18, Issue 2, pp. 191 - 202
Human developmental disorders caused by chromatin dysfunction often display overlapping clinical manifestations, such as cognitive deficits, but the underlying... 
DNA | HUMDISEASE | DEVBIO | PROTEIN ATRX | RETT-SYNDROME | MENTAL-RETARDATION | DNA METHYLATION | SNF2 FAMILY | DLK1-GTL2 LOCUS | DE-LANGE-SYNDROME | DEVELOPMENTAL BIOLOGY | H19 GENE | X SYNDROME | HUMAN HOMOLOG | CELL BIOLOGY | Chromatin - metabolism | Genomic Imprinting | Humans | Methyl-CpG-Binding Protein 2 - metabolism | Cognition Disorders - metabolism | Male | X-linked Nuclear Protein | Brain - growth & development | Gene Regulatory Networks | RNA, Untranslated - genetics | Methyl-CpG-Binding Protein 2 - genetics | Brain - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | DNA Methylation | Insulin-Like Growth Factor II - genetics | Nuclear Proteins - deficiency | Cell Cycle Proteins - genetics | Female | Nuclear Proteins - genetics | DNA Helicases - genetics | Repressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Gene Silencing | Intercellular Signaling Peptides and Proteins - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Cognition Disorders - genetics | DNA Helicases - deficiency | Insulin-Like Growth Factor II - metabolism | Chromosomal Proteins, Non-Histone - genetics | Mice, Knockout | Proteins - genetics | DNA Helicases - metabolism | Animals | Proteins - metabolism | CCCTC-Binding Factor | RNA, Long Noncoding | Mice | Histones - metabolism | Chromatin - genetics | Chromatin | Anopheles | Genetic engineering | Methylation
Journal Article
DEVELOPMENTAL BIOLOGY, ISSN 0012-1606, 06/2007, Volume 306, Issue 2, pp. 810 - 823
Dlk1 and Gtl2 are reciprocally imprinted neighboring genes located within a 1 Mb imprinted domain on murine distal chromosome 12. The two genes are expressed... 
imprinting | non-coding RNA | INHIBITS ADIPOCYTE DIFFERENTIATION | FETAL ANTIGEN-1 | DEVELOPMENTAL BIOLOGY | Dlk1 | MOUSE GTL2 GENE | Gtl2 | SKELETAL-MUSCLE | GROWTH-HORMONE | EGF-LIKE REPEATS | IGF2 EXPRESSION | DLK1-GTL2 LOCUS | mouse development | EXPRESSION PATTERN | insulator | uniparental disomy
Journal Article
Stem Cell Reviews and Reports, ISSN 1550-8943, 12/2018, Volume 14, Issue 6, pp. 823 - 836
The paternally-imprinted genes insulin-like growth factor 2 (IGF2), H19, delta-like homologue 1 (DLK1), and maternally-expressed gene 3 (MEG3) are expressed... 
Proliferation | Metastasis | 5-azaD | DLK1 | Cell Biology | Teratocarcinoma | Life Sciences | Stem Cells | Biomedical Engineering | Regenerative Medicine/Tissue Engineering | Imprinting | Primordial germ cells | Pluripotency | Embryonal carcinoma | MEDICINE, RESEARCH & EXPERIMENTAL | METHYLATION | 1 HOMOLOG DROSOPHILA | BONE-MARROW | MOUSE | TUMORS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | GROWTH-FACTORS | DLK1-GTL2 LOCUS | DIFFERENTIATION | EXPRESSION | Genomic Imprinting | Carcinoma, Embryonal - pathology | Membrane Proteins - genetics | Humans | Intercellular Signaling Peptides and Proteins - genetics | RNA, Long Noncoding - genetics | Genetic Loci | Carcinoma, Embryonal - metabolism | Neoplasm Proteins - metabolism | RNA, Neoplasm - metabolism | Insulin-Like Growth Factor II - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Carcinoma, Embryonal - therapy | Insulin-Like Growth Factor II - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Carcinoma, Embryonal - genetics | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | RNA, Long Noncoding - metabolism | Embryonic development | Carcinoma | RNA | Analysis | Genes | Stem cells | Genetic research | Genetic aspects | Health aspects | Cancer | Cell proliferation | Germ cells | Therapeutic applications | Tumorigenicity | mRNA | Preadipocyte factor 1 | Insulin | Neurotrophin 2 | Genomic imprinting | Embryogenesis | DNA methyltransferase | Gene loci | Insulin-like growth factor II | Index Medicus
Journal Article
Stem Cell Reviews and Reports, ISSN 1550-8943, 10/2017, Volume 13, Issue 5, pp. 603 - 610
One of the important questions when studying established cancer cell lines is whether such cells contain a subpopulation of primitive cancer stem cells that... 
Life Sciences | Stem Cells | Biomedical Engineering | SSEA4 | Changing phenotype | Regenerative Medicine/Tissue Engineering | Singly sorted cells | Cancer stem cells | NTera2 | Chemotaxis | Cell Biology | CD133 | MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | EMBRYONIC ANTIGEN-4 | MARKER | TUMORS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SUBPOPULATION | DLK1-GTL2 LOCUS | EXPRESSION | Genomic Imprinting | Bone Marrow - immunology | Cell Proliferation | Embryo, Mammalian | Humans | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells - immunology | Gene Expression Profiling | Stage-Specific Embryonic Antigens - genetics | AC133 Antigen - immunology | Pluripotent Stem Cells - pathology | Stage-Specific Embryonic Antigens - metabolism | Flow Cytometry | Neoplastic Stem Cells - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Lung - pathology | AC133 Antigen - genetics | Pluripotent Stem Cells - immunology | Stage-Specific Embryonic Antigens - immunology | Mice, SCID | Pluripotent Stem Cells - metabolism | Phenotype | Animals | AC133 Antigen - metabolism | Bone Marrow - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Biomarkers, Tumor - immunology | Lung - immunology | Cell Movement | Genetic aspects | Research | Oncology, Experimental | Stem cells | Cancer | Antigens | Biotechnology | Subpopulations | Immunodeficiency | Stem cell transplantation | Tumor cell lines | Seeding | Cell surface | Allografts | Lungs | Rodents | Bone marrow | Biomarkers | Expansion | In vitro methods and tests
Journal Article