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The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2011, Volume 365, Issue 7, pp. 620 - 628
Journal Article
Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6054, pp. 376 - 380
Journal Article
Cancer Research, ISSN 0008-5472, 06/2011, Volume 71, Issue 11, pp. 4028 - 4039
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 51, pp. 14745 - 14750
Journal Article
Proceedings of the Royal Society B: Biological Sciences, ISSN 0962-8452, 06/2018, Volume 285, Issue 1881, pp. 20180694 - 20180694
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2017, Volume 7, Issue 3, pp. 277 - 287
Recent studies have identified somatic ESR1 mutations in patients with metastatic breast cancer and found some of them to promote estrogen-independent... 
AZD9496 | THERAPY | MODELS | ONCOLOGY | PHOSPHORYLATION | DNA | METASTATIC BREAST-CANCER | ESTROGEN-RECEPTOR-ALPHA | CONFORMATION | INHIBITOR
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2012, Volume 132, Issue 9, pp. 2255 - 2262
The melanocortin 1 receptor (MC1R), a G protein–coupled receptor, has an important role in human pigmentation. We investigated the regulation of expression and... 
MELANOMA | COUPLED-RECEPTOR KINASES | DESENSITIZATION | DNA-DAMAGE | RISK | MUTATIONS | ULTRAVIOLET-RADIATION | RED HAIR | EXPRESSION | CULTURED HUMAN MELANOCYTES | DERMATOLOGY | Tetradecanoylphorbol Acetate - pharmacology | alpha-MSH - pharmacology | Humans | Receptor, Melanocortin, Type 1 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - analogs & derivatives | Melanocytes - metabolism | Melanocytes - radiation effects | Monophenol Monooxygenase - metabolism | G-Protein-Coupled Receptor Kinases - biosynthesis | Ultraviolet Rays | Melanocytes - drug effects | Protein Kinase C - metabolism | Skin Pigmentation - radiation effects | Skin Pigmentation - physiology | Agouti Signaling Protein - pharmacology | Colforsin - pharmacology | Receptor, Melanocortin, Type 1 - biosynthesis | Cells, Cultured | Adenylyl Cyclases - metabolism | Skin Pigmentation - drug effects | beta-Arrestin 1 | beta-Arrestins | beta-Defensins - pharmacology | Arrestins - biosynthesis | Melanocortins - pharmacology | Receptor, Melanocortin, Type 1 - agonists | Enzymes | Protein kinase C | U.V. radiation | alpha -Melanocyte-stimulating hormone | 12-O-Tetradecanoylphorbol-13-acetate | Cyclic AMP | MC1R gene | Melanocytes | Antagonists | Monophenol monooxygenase | Pigmentation | Membrane proteins | Adenylate cyclase | beta -Arrestin | Defensins | double prime G protein-coupled receptor kinase | Forskolin | Recycling | Genotypes
Journal Article
Nature, ISSN 0028-0836, 09/2016, Volume 538, Issue 7623, pp. 114 - 117
The common participation of oncogenic KRAS proteins in many of the most lethal human cancers, together with the ease of detecting somatic KRAS mutant alleles... 
TARGET | CRM1/XPO1 | ACTIVATION | MODELS | MULTIDISCIPLINARY SCIENCES | KINASE | YAP | MUTATIONS | INHIBITORS | IDENTIFICATION | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Cell Survival - genetics | Lung Neoplasms - pathology | NF-kappa B - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Verteporfin | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Follistatin-Related Proteins - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Genes, Lethal - genetics | NF-KappaB Inhibitor alpha - metabolism | Nuclear Proteins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Nucleus - drug effects | Karyopherins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Guanosine triphosphatase | Lung cancer | Genomics | Genomes | Kinases | Drug resistance | Gene expression | Drug dosages
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2012, Volume 63, Issue 4, pp. 653 - 666
Cannabinoids have been shown to exert neuroprotective effects in a plethora of neurodegenerative conditions. Over the past decade, some studies demonstrate... 
Neuroinflammation | CB2 | CB1 | WIN55212-2 | PPAR-γ | Beta-amyloid | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | NEUROSCIENCES | PPAR-gamma | CELL-DEATH | CASPASE-3 ACTIVATION | CORTICAL-NEURONS | SIGNALING PATHWAY | DNA FRAGMENTATION | IN-VIVO | PHARMACOLOGY & PHARMACY | INFLAMMATORY RESPONSE | NF-KAPPA-B | Receptor, Cannabinoid, CB2 - agonists | Neuroglia - pathology | Injections, Intraventricular | Male | PPAR gamma - metabolism | Alzheimer Disease - pathology | Cannabinoid Receptor Agonists - therapeutic use | Neuroglia - immunology | Nootropic Agents - antagonists & inhibitors | Cannabinoid Receptor Antagonists - pharmacology | Neurons - metabolism | Alzheimer Disease - immunology | Morpholines - therapeutic use | Receptors, Cannabinoid - chemistry | Disease Models, Animal | Benzoxazines - administration & dosage | Nerve Tissue Proteins - agonists | Alzheimer Disease - drug therapy | Rats | Hippocampus - pathology | Random Allocation | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Naphthalenes - therapeutic use | Neurons - pathology | Rats, Wistar | Hippocampus - drug effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - chemistry | Neuroglia - drug effects | Receptors, Cannabinoid - metabolism | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - agonists | Morpholines - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Neurons - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Hippocampus - immunology | Morpholines - administration & dosage | Neurons - immunology | Nootropic Agents - therapeutic use | Cannabinoid Receptor Agonists - administration & dosage | Benzoxazines - therapeutic use | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Nootropic Agents - administration & dosage | Naphthalenes - administration & dosage | Alzheimer Disease - metabolism | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | PPAR gamma - agonists | Neuroglia - metabolism | Naphthalenes - antagonists & inhibitors
Journal Article