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British Journal of Clinical Pharmacology, ISSN 0306-5251, 08/2012, Volume 74, Issue 2, pp. 336 - 345
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In healthy subjects, GSK2248761 was shown to be safe and well tolerated with single doses up to 1200 mg once daily... 
NNRTI | HIV‐1 infection | antiretroviral therapy | drug‐drug interaction | HIV-1 infection | Drug-drug interaction | Antiretroviral therapy | PHARMACOKINETICS | TOLERABILITY | PHARMACOLOGY & PHARMACY | ATAZANAVIR | SIMVASTATIN | drug-drug interaction | PROTEASE INHIBITORS | Fluorobenzenes - pharmacokinetics | Pyrroles - pharmacokinetics | Darunavir | Ethinyl Estradiol - pharmacokinetics | Humans | Pyrrolidinones - pharmacokinetics | Male | Fluorobenzenes - administration & dosage | Indoles - administration & dosage | Lopinavir - pharmacokinetics | Anti-HIV Agents - administration & dosage | Pyrrolidinones - administration & dosage | Tenofovir | Deoxycytidine - pharmacokinetics | Drug Interactions | Pyrroles - administration & dosage | Contraceptives, Oral - administration & dosage | Patient Safety | Atazanavir Sulfate | Contraceptives, Oral - pharmacokinetics | Phosphinic Acids - administration & dosage | Raltegravir Potassium | Emtricitabine | Adenine - analogs & derivatives | Pyridines - administration & dosage | Risk Assessment | Simvastatin - administration & dosage | Deoxycytidine - administration & dosage | Phosphinic Acids - pharmacokinetics | Rosuvastatin Calcium | Adenine - pharmacokinetics | Sulfonamides - pharmacokinetics | Cross-Over Studies | Cytochrome P-450 CYP3A - metabolism | Atorvastatin | Cytochrome P-450 CYP2D6 - metabolism | Least-Squares Analysis | Lopinavir - administration & dosage | Pyrimidines - pharmacokinetics | Oligopeptides - administration & dosage | Deoxycytidine - analogs & derivatives | Sulfonamides - administration & dosage | Cytochrome P-450 CYP2D6 Inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Heptanoic Acids - pharmacokinetics | Pyridines - pharmacokinetics | Reverse Transcriptase Inhibitors - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Reverse Transcriptase Inhibitors - pharmacokinetics | Heptanoic Acids - administration & dosage | Female | Ethinyl Estradiol - administration & dosage | Androstenes - pharmacokinetics | Double-Blind Method | Ritonavir - administration & dosage | Pyrimidines - administration & dosage | Oligopeptides - pharmacokinetics | Linear Models | Simvastatin - pharmacokinetics | Androstenes - administration & dosage | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Cytochrome P-450 CYP3A Inhibitors | Ritonavir - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | Indoles - pharmacokinetics | Drug Combinations | Urine | Simvastatin | Drug interactions | Cytochrome P-450 | HIV (Viruses) | Complications and side effects | Analysis | Electrocardiogram | Electrocardiography | DNA polymerases | Ethinyl estradiol | Dosage and administration | EKG | Antiviral agents | Urinalysis | Ritonavir | tenofovir | Cytochrome P450 | Lopinavir | ethinylestradiol | Blood | Infection | non-nucleoside reverse transcriptase inhibitors | Antiviral activity | Drug interaction | Probes | CYP2D6 protein
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2015, Volume 76, Issue 4, pp. 803 - 811
5-Fluoro-2′-deoxycytidine (FdCyd; NSC48006), a fluoropyrimidine nucleoside inhibitor of DNA methylation, is degraded by cytidine deaminase (CD).... 
Toxicokinetics | Medicine & Public Health | Toxicity | Oncology | Cancer Research | Monkeys | Pharmacology/Toxicology | Tetrahydrouridine | DNA methylation inhibitor | Fluorodeoxycytidine | 5-FLUORODEOXYCYTIDINE | CYTIDINE DEAMINASE INHIBITOR | TETRAHYDROURIDINE THU | PLASMA | METABOLISM | ONCOLOGY | 5-FLUORO-2-DEOXYCYTIDINE | DNA METHYLTRANSFERASE | PHARMACOLOGY & PHARMACY | MICE | METHYLTRANSFERASE INHIBITOR 5-FLUORO-2'-DEOXYCYTIDINE | MYELODYSPLASTIC SYNDROMES | Cytidine Deaminase - antagonists & inhibitors | Antimetabolites, Antineoplastic - pharmacokinetics | Enzyme Inhibitors - blood | Humans | Half-Life | Macaca fascicularis | Biological Availability | Male | Metabolic Clearance Rate | Deoxycytidine - blood | Antimetabolites, Antineoplastic - administration & dosage | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Deoxycytidine - pharmacokinetics | Antimetabolites, Antineoplastic - blood | Enzyme Inhibitors - pharmacokinetics | Biotransformation | Female | Drug Evaluation, Preclinical | Tetrahydrouridine - pharmacokinetics | Administration, Oral | Tetrahydrouridine - blood | Deoxycytidine - administration & dosage | Tetrahydrouridine - administration & dosage | Pilot Projects | Animals | Infusions, Intravenous | Deoxycytidine - analogs & derivatives | Drug Combinations | Cohort Studies | Metabolites | Methylation | Analysis | Index Medicus | toxicity | monkeys | toxicokinetics | fluorodeoxycytidine | tetrahydouridine
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Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 05/2018, Volume 115, pp. 136 - 147
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 1/2018, Volume 57, Issue 1, pp. 21 - 29
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12722 - 12727
Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is... 
Nanoparticles | Gels | Calcium | Hydrogels | Antineoplastics | Fluorescence | Alginates | Polymers | Pharmacokinetics | Tumors | DNA nanotechnology | Targeting | Nanoparticle | Controlled release | Biomaterials | ALGINATE | MULTIDISCIPLINARY SCIENCES | nanoparticle | BIODISTRIBUTION | THERAPEUTIC ANGIOGENESIS | TUMORS | CANCER-THERAPY | NUCLEIC-ACIDS | NANOPARTICLES | targeting | controlled release | L-DNA | PHARMACOKINETICS | IN-VIVO | biomaterials | Doxorubicin - blood | Neoplasm Transplantation | Injections, Intravenous | Humans | Melanoma, Experimental - drug therapy | Hydrogels - pharmacokinetics | Hexuronic Acids - pharmacokinetics | Antibiotics, Antineoplastic - blood | Oligodeoxyribonucleotides - blood | Injections, Intralesional | Tumor Cells, Cultured | Antibiotics, Antineoplastic - pharmacokinetics | Hydrazones - pharmacokinetics | Alginates - pharmacokinetics | Disease Models, Animal | Hydrazones - blood | Hexuronic Acids - blood | Mice, Inbred C57BL | Glucuronic Acid - blood | Glucuronic Acid - pharmacokinetics | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Oligodeoxyribonucleotides - pharmacokinetics | Mice | Drug Delivery Systems - methods | Drugs | Pharmaceutical research | Drug delivery systems | Research | Drug interactions | Vehicles | Biological Sciences | Physical Sciences
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