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1. Full Text Programmable base editing of T to G C in genomic DNA without DNA cleavage
by Gaudelli, Nicole M and Komor, Alexis C and Rees, Holly A and Packer, Michael S and Badran, Ahmed H and Bryson, David I and Liu, David R
Nature (London), ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. 464 - 471
Directed evolution | Fracture mechanics | Disease | Biological evolution | Genomes | Drug resistance | Experiments | Guanine | Efficiency | Bacteria | Cleavage | Evolution | Cytosine | Nuclease | Deoxyribonucleic acid--DNA | Transfer RNA | CRISPR | Protein engineering | Enzymes | Adenosine | Base pairs | Adenine | Ductile-brittle transition | Adenosine deaminase | Ribonucleic acid--RNA | Studies | Antibiotics | Deamination | Mutation | Index Medicus
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2. Full Text Conformational control of DNA target cleavage by CRISPR-Cas9
by Sternberg, Samuel H and Lafrance, Benjamin and Kaplan, Matias and Doudna, Jennifer A
Nature (London), ISSN 0028-0836, 11/2015, Volume 527, Issue 7576, pp. 110 - 113
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR-Associated Proteins - chemistry | Catalytic Domain | RNA, Guide - metabolism | Allosteric Regulation | Bacterial Proteins - chemistry | Models, Molecular | DNA - metabolism | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Endonucleases - chemistry | DNA - chemistry | Genetic Engineering | Base Pairing | RNA, Guide - chemistry | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Fluorescence Resonance Energy Transfer | Bacterial Proteins - metabolism | Streptococcus pyogenes | Binding Sites | DNA Cleavage | Nucleases | Scission (Chemistry) | Genetic research | Research | Properties | Observations | Gene expression | Proteins | Enzymes | Target recognition | Genes | Genomes | Mutation | Deoxyribonucleic acid--DNA | Crystal structure | Index Medicus
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3. Full Text Metal complexes promoting catalytic cleavage of nucleic acids—biochemical tools and therapeutics
by Yu, Zhen and Cowan, JA
Current opinion in chemical biology, ISSN 1367-5931, 04/2018, Volume 43, pp. 37 - 42
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Coordination Complexes - therapeutic use | Hydrolysis | Biocatalysis | Metals - chemistry | Nucleic Acids - chemistry | Oxidation-Reduction | Coordination Complexes - chemistry | Nucleases | Nucleic acids | DNA binding proteins | Therapeutics | Homeopathy | Materia medica and therapeutics | Index Medicus
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4. Full Text Mapping the genomic landscape of CRISPR-Cas9 cleavage
by Cameron, Peter and Fuller, Chris K and Donohoue, Paul D and Jones, Brittnee N and Thompson, Matthew S and Carter, Matthew M and Gradia, Scott and Vidal, Bastien and Garner, Elizabeth and Slorach, Euan M and Lau, Elaine and Banh, Lynda M and Lied, Alexandra M and Edwards, Leslie S and Settle, Alexander H and Capurso, Daniel and Llaca, Victor and Deschamps, Stéphane and Cigan, Mark and Young, Joshua K and May, Andrew P
Nature methods, ISSN 1548-7091, 05/2017, Volume 14, Issue 6, pp. 600 - 606
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | High-Throughput Nucleotide Sequencing | CRISPR-Cas Systems - genetics | Sequence Analysis, DNA | Chromosome Mapping - methods | Genome - genetics | Chromosome mapping | Gene targeting | Nucleotide sequencing | Methods | DNA sequencing | CRISPR | Target recognition | Nucleotide sequence | Genomics | Biochemistry | Mapping | Genomes | Assaying | Ribonucleic acid--RNA | Engineering | Cleavage | Nuclease | Mutation | Gene mapping | Deoxyribonucleic acid--DNA | Index Medicus
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5. Full Text Notch after cleavage
by Bray, Sarah J and Gomez-Lamarca, Maria
Current opinion in cell biology, ISSN 0955-0674, 04/2018, Volume 51, pp. 103 - 109
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Physiological aspects | Epigenetic inheritance | DNA binding proteins | Genetic transcription | Genomics | Analysis | Index Medicus
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6. Full Text Structure, Cytotoxicity, and DNA-Cleavage Properties of the Complex [CuII(pbt)Br2]
by Maheswari, Palanisamy Uma and Ster, Martijn van der and Smulders, Simon and Barends, Sharief and Wezel, Gilles P. van and Massera, Chiara and Roy, Sudeshna and Dulk, Hans den and Gamez, Patrick and Reedijk, Jan
Inorganic chemistry, ISSN 0020-1669, 05/2008, Volume 47, Issue 9, pp. 3719 - 3727
Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Science & Technology | DNA, Viral - drug effects | Leukemia L1210 - drug therapy | Oxidation-Reduction | Pyridines - chemistry | Humans | DNA, Viral - metabolism | Pyridines - chemical synthesis | Crystallography, X-Ray | DNA, Viral - chemistry | Animals | Copper - chemistry | Thiazoles - chemical synthesis | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Female | Organometallic Compounds - chemistry | Thiazoles - chemistry | Mice | Pyridines - pharmacology | Thiazoles - pharmacology | Ovarian Neoplasms - drug therapy | Organometallic Compounds - pharmacology | X-ray crystallography | Optical properties | Analysis | Copper compounds | Chemical properties | Structure | Chemical synthesis | Observations | Polybutylene terephthalates | Reduction | Acetonitrile | Distortion | Activation | Coordination compounds | Dissolution | Lead (metal) | Index Medicus
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7. Full Text Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage
by Gaudelli, Nicole M and Komor, Alexis C and Rees, Holly A and Packer, Michael S and Badran, Ahmed H and Bryson, David I and Liu, David R
Nature (London), ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, p. 464
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Methods | Nucleotide sequencing | DNA sequencing
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8. Full Text Efficient DNA cleavage mediated by mononuclear mixed ligand copper(II) phenolate complexes: The role of co-ligand planarity on DNA binding and cleavage and anticancer activity
by Jaividhya, Paramasivam and Dhivya, Rajkumar and Akbarsha, Mohamad Abdulkadhar and Palaniandavar, Mallayan
Journal of inorganic biochemistry, ISSN 0162-0134, 09/2012, Volume 114, pp. 94 - 105
DNA cleavage | DNA binding | Mixed ligand copper(II) complexes | Anticancer activity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Life Sciences & Biomedicine | Science & Technology | Magnetic Resonance Spectroscopy | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | 2,2'-Dipyridyl - chemistry | Models, Molecular | Quinoxalines - chemistry | Crystallography, X-Ray | DNA Cleavage - drug effects | DNA - chemistry | Copper - chemistry | Phenanthrolines - chemistry | Phenazines - chemistry | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Coordination Complexes - pharmacology | Female | Ligands | Phenols - chemistry | Antineoplastic Agents - pharmacology | Care and treatment | DNA | Crystals | Copper compounds | Chemical properties | Structure | DNA-ligand interactions | Cancer | Index Medicus
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9. Full Text Pt–S Bond‐Mediated Nanoflares for High‐Fidelity Intracellular Applications by Avoiding Thiol Cleavage
by Qing, Zhihe and Luo, Guoyan and Xing, Shuohui and Zou, Zhen and Lei, Yanli and Liu, Juewen and Yang, Ronghua
Angewandte Chemie (International ed.), ISSN 1433-7851, 08/2020, Volume 59, Issue 33, pp. 14044 - 14048
platinum | biosensors | biothiol | gold nanoparticles | aptamers | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Nanoparticles | Gold | Fidelity | Cell culture | Accuracy | Platinum | MicroRNAs | Optical properties | miRNA | Cleavage | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Index Medicus
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10. Full Text Programmable RNA recognition and cleavage by CRISPR/Cas9
by O'Connell, Mitchell R and Oakes, Benjamin L and Sternberg, Samuel H and East-Seletsky, Alexandra and Kaplan, Matias and Doudna, Jennifer A
Nature (London), ISSN 0028-0836, 12/2014, Volume 516, Issue 7530, pp. 263 - 266
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Oligonucleotides - genetics | Oligonucleotides - chemistry | RNA, Guide - genetics | RNA, Messenger - isolation & purification | RNA, Guide - metabolism | Humans | Substrate Specificity | RNA, Messenger - metabolism | RNA - genetics | Nucleotide Motifs | RNA, Guide - chemistry | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | RNA - metabolism | Genetic Engineering - methods | RNA, Messenger - genetics | DNA - metabolism | RNA - chemistry | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - genetics | DNA - genetics | DNA - chemistry | Oligonucleotides - metabolism | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems - physiology | Cell Extracts | HeLa Cells | RNA | Genomics | Genetic research | Research | Nucleotide sequencing | Identification and classification | Methods | <