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Nature Genetics, ISSN 1061-4036, 2006, Volume 38, Issue 8, pp. 917 - 920
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 5, pp. 873 - 886
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 411 - 413
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this issue of , show that TREX1 also safeguards the cell against... 
IMMUNOLOGY | AICARDI-GOUTIERES SYNDROME | DNA | DISEASE | Cytosol - enzymology | Animals | Humans | Exodeoxyribonucleases - metabolism | Hexosyltransferases - metabolism | Membrane Proteins - metabolism | Phosphoproteins - metabolism | Proteins | Inflammation | Mutation | Kinases | Rodents
Journal Article
Journal Article
Nature genetics, ISSN 1061-4036, 2007, Volume 39, Issue 9, pp. 1068 - 1070
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2008, Volume 7, Issue 12, pp. 1718 - 1725
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2011, Volume 286, Issue 37, pp. 32373 - 32382
TREX1 is a potent 3'-->35' exonuclease that degrades single- and double-stranded DNA (ssDNA and dsDNA). TREX1 mutations at amino acid positions Asp-18 and... 
APOPTOSIS | FAMILIAL CHILBLAIN LUPUS | PROTEIN | DNA FRAGMENTATION | NM23-H1 | FORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED CELL-DEATH | AUTOIMMUNE-DISEASE | EXPRESSION | ERYTHEMATOSUS | Enzyme Mechanisms | Molecular Bases of Disease | DNase | Nucleic Acid | Autoimmune Diseases | DNA
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 1047
BackgroundInterferon-alpha (IFNα) pathway has a crucial role in the pathogenesis of SLE. Many genes have been encoding with this pathway and their impaired... 
HuR protein | Lupus | Photosensitivity | Autoantibodies | Statistical analysis | α-Interferon | Exonuclease | Systemic lupus erythematosus | Gene frequency | Ulcers | Mutation | Deoxyribonucleic acid--DNA | Seizures | Apoptosis
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 09/2013, Volume 39, Issue 3, pp. 423 - 425
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of , show that oxidized DNA is resistant to... 
AUTOIMMUNITY | IMMUNOLOGY | Animals | Humans | Exodeoxyribonucleases - metabolism | Membrane Proteins - metabolism | DNA - metabolism | DNA Damage | Phosphoproteins - metabolism | DNA | Lupus | Medical research | Rodents | Homeostasis | Infections | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2015, Volume 112, Issue 16, p. 5117
  The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of lupus-like autoimmune diseases. Most lupus patients develop... 
Lupus | Enzymes | Kidneys | Genes | Rodents | Deoxyribonucleic acid--DNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2014, Volume 289, Issue 16, pp. 11556 - 11565
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 46, pp. 40246 - 40254
Journal Article
Journal Article