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Trends in Cell Biology, ISSN 0962-8924, 05/2019, Volume 29, Issue 5, pp. 428 - 445
The ‘RNA world’, in which RNA molecules stored information and acquired enzymatic properties, has been proposed to have preceded organism life. RNA is now... 
development | RNA surveillance | noncoding RNA | differentiation | developmental disease | RNA processing | NONCODING RNA | CONVERGENT TRANSCRIPTION | CROSS-TALK | MESSENGER-RNA | SUPER-ENHANCERS | DNA EXONUCLEASE TREX1 | BINDING PROTEINS | INTRON RETENTION | GENE-EXPRESSION | TARGETS AID | CELL BIOLOGY | Titration | Biology | Pathways | Surveillance | Ribonucleic acid--RNA
Journal Article
Brain, ISSN 0006-8950, 2016, Volume 139, Issue 11, pp. 2909 - 2922
Journal Article
Advances in Immunology, ISSN 0065-2776, 2016, Volume 133, pp. 121 - 169
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 2009, Volume 37, Issue 3, pp. 535 - 538
The major DNA-specific 3'-5' exonuclease of mammalian cells is TREX1 (3' repair exonuclease 1; previously called DNase III). The human enzyme is encoded by a... 
DNA 3′ exonuclease | DNase III | 3′ repair exonuclease 1 (TREX1) | Aicardi-Goutières syndrome | Chronic checkpoint activation | DNA 3 ' exonuclease | SITE | COMPLEX | Arcardi-Goutieres syndrome | chronic checkpoint activation | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | EXONUCLEASE TREX1 | LUPUS | 3 ' repair exonuclease 1 (TREX1) | MUTATIONS | EXPRESSION | Humans | Protein Multimerization | Brain Diseases - genetics | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Substrate Specificity | Green Fluorescent Proteins - genetics | Phosphoproteins - metabolism | Recombinant Fusion Proteins - metabolism | Phosphoproteins - chemistry | DNA, Single-Stranded - genetics | Cell Nucleus - metabolism | Exodeoxyribonucleases - genetics | Fibroblasts - metabolism | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | DNA, Single-Stranded - metabolism | Brain Diseases - enzymology | Phosphoproteins - genetics | Syndrome | Mice, Knockout | Animals | Brain Diseases - pathology | DNA Replication - physiology | Exodeoxyribonucleases - metabolism | DNA Replication - genetics | Hydrophobic and Hydrophilic Interactions | Inflammation - genetics | Recombinant Fusion Proteins - genetics | Fibroblasts - cytology | Mice | Exodeoxyribonucleases - chemistry | Mutation | Inflammation - enzymology | Microscopy, Fluorescence | Inflammation - physiopathology
Journal Article
Journal Article
Journal Article
Seminars in Immunology, ISSN 1044-5323, 12/2018, Volume 40, Issue C, pp. 6 - 16
Inflamm-aging depicts the progressive activation of the innate immune system that accompanies human aging. Its role as a disease-predisposing condition has... 
Cell-free DNA | Extracellular vesicles | Telomeres | DNA:RNA hybrids | Inflamm-aging | OXIDIZED MITOCHONDRIAL-DNA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | OXIDATIVE DAMAGE | AICARDI-GOUTIERES SYNDROME | IMMUNOLOGY | EXONUCLEASE TREX1 | CYTOSOLIC RNADNA HYBRIDS | SENESCENCE | TELOMERE LENGTH | LIFE | Pyrimidines | Genomes | RNA | Genomics | DNA
Journal Article