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Oncogene, ISSN 0950-9232, 11/2014, Volume 33, Issue 45, pp. 5262 - 5273
Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) enhances tumor cell sensitivity to ionizing radiation. It is not clear how this effect is... 
CYCLIN D1 | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOTIC CATASTROPHE | DOWN-REGULATION | DEPENDENT PROTEIN-KINASE | TUMOR-CELLS | DNA repair | PTEN WILD-TYPE | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | homologous recombination | ONCOLOGY | radiosensitization | PROSTATE-CANCER CELLS | GENETICS & HEREDITY | double-strand break | non-homologous end joining | IGF-1R | IONIZING-RADIATION | Cell Cycle - genetics | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Homologous Recombination - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | DNA End-Joining Repair - radiation effects | Humans | Apoptosis - genetics | DNA Breaks, Double-Stranded | Pyrones - pharmacology | Quinolines - pharmacology | Histones - radiation effects | HEK293 Cells | Recombinational DNA Repair - drug effects | Fibroblasts - metabolism | DNA End-Joining Repair - drug effects | Homologous Recombination - radiation effects | DNA End-Joining Repair - genetics | Recombinational DNA Repair - genetics | Cell Cycle - radiation effects | Morpholines - pharmacology | Pyrimidines - pharmacology | Receptor, IGF Type 1 - genetics | Blotting, Western | Histones - drug effects | Mice, Knockout | Isoxazoles - pharmacology | Radiation Tolerance - drug effects | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Cell Line, Tumor | Homologous Recombination - genetics | Recombinational DNA Repair - radiation effects | Thiazoles - pharmacology | Histones - metabolism | Cell Cycle - drug effects | Cell receptors | Physiological aspects | Genetic research | Genetic aspects | Research | Genetic recombination | Insulin-like growth factor 1 | Proteins | Oncology | Kinases | Index Medicus | non-homologous end-joining
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 4, pp. 671 - 684.e5
Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs) in G1 cells with biphasic kinetics. We show that DSBs repaired with slow... 
non-homologous end joining | DNA double-strand breaks | resection | nucleases | FACILITATES REPAIR | DAMAGE RESPONSE | TUMOR SUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEASE ACTIVITIES | CTIP | DEPENDENT PROTEIN-KINASE | REPAIR PATHWAY CHOICE | CELL-CYCLE | BRCA1 | BINDING | CELL BIOLOGY | Translocation, Genetic | Phosphorylation | DNA End-Joining Repair - radiation effects | Humans | DNA Repair Enzymes - genetics | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Transfection | Time Factors | Cell Nucleus - pathology | Cell Nucleus - radiation effects | BRCA1 Protein - metabolism | Gene Deletion | DNA Repair Enzymes - metabolism | G2 Phase | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | G1 Phase - radiation effects | Endonucleases | Exodeoxyribonucleases - metabolism | HeLa Cells | Kinetics | Biotechnology | Nucleases | Surgery | Genomics | DNA | DNA binding proteins | DNA repair | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2016, Volume 215, Issue 6, pp. 801 - 821
The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA... 
CHROMOSOME | MEIOTIC PROPHASE | ANEMIA-ASSOCIATED NUCLEASE | MEMBRANE PROTEIN | DOUBLE-STRAND BREAKS | STALLED REPLICATION FORKS | C-ELEGANS | DNA-REPAIR | FANCONI-ANEMIA | SUN PROTEIN UNC-84 | CELL BIOLOGY | Hydroxyurea - pharmacology | Homologous Recombination - drug effects | DNA End-Joining Repair - radiation effects | Microtubule-Associated Proteins - metabolism | Germ Cells - drug effects | Humans | Caenorhabditis elegans Proteins - metabolism | Protein Transport - drug effects | Multiprotein Complexes - metabolism | Polymerization - drug effects | Meiosis - drug effects | Microtubules - metabolism | Cell Nucleus - metabolism | Cell Nucleus - radiation effects | Microtubules - drug effects | Protein Binding - drug effects | Protein Binding - radiation effects | Microtubules - radiation effects | Germ Cells - cytology | Membrane Proteins - metabolism | Germ Cells - metabolism | Germ Cells - radiation effects | Radiation, Ionizing | DNA End-Joining Repair - drug effects | Homologous Recombination - radiation effects | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Cross-Linking Reagents - metabolism | Meiosis - radiation effects | Cell Cycle Checkpoints - radiation effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Protein Transport - radiation effects | Cell Proliferation - drug effects | DNA Damage | Cell Nucleus - drug effects | Cell Proliferation - radiation effects | Caenorhabditis elegans | Cellular proteins | Cell research | DNA damage | Microtubules | Physiological aspects | Genetic aspects | Research | Proteins | Cell division | Cellular biology | DNA repair | Genes | Index Medicus
Journal Article
Cell Death and Disease, ISSN 2041-4889, 01/2014, Volume 5, Issue 10, pp. e1437 - e1437
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2016, Volume 61, Issue 3, pp. 419 - 433
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but... 
INCREASED GENOMIC INSTABILITY | CULLIN-RING LIGASES | STRAND BREAK REPAIR | DEFECTIVE-DNA REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DEPENDENT PROTEIN-KINASE | F-BOX PROTEINS | NEDD8-ACTIVATING ENZYME-INHIBITOR | HOMOLOGOUS RECOMBINATION | FBW7 UBIQUITIN LIGASE | CELL BIOLOGY | F-Box-WD Repeat-Containing Protein 7 | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | DNA End-Joining Repair - radiation effects | Humans | Radiation Tolerance | Molecular Sequence Data | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Ubiquitination | Transfection | RNA Interference | Time Factors | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Ubiquitins - metabolism | Polyubiquitin - metabolism | Amino Acid Sequence | F-Box Proteins - metabolism | HCT116 Cells | Pancreatic Neoplasms - pathology | Radiation-Sensitizing Agents - pharmacology | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Pancreatic Neoplasms - enzymology | Ubiquitin-Protein Ligases - metabolism | Pancreatic Neoplasms - radiotherapy | Protein Processing, Post-Translational - radiation effects | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | DNA-Binding Proteins - genetics | Ubiquitin-Activating Enzymes - metabolism | Mice, Knockout | Animals | Lysine | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Ubiquitins - antagonists & inhibitors | Ionizing radiation | Automated teller machines | Ancient Egypt | Ligases | Genomics | Ubiquitin | Medical colleges | DNA damage | Index Medicus
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2018, Volume 39, Issue 3, pp. 912 - 920
The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in non-homologous end-joining (NHEJ) repair. We investigated the mechanism of NU7441, a... 
Nasopharyngeal carcinoma | NU7441 | Irradiation | Double strand break | Non-homologous end-joining | DNA-PK | CATALYTIC SUBUNIT | nasopharyngeal carcinoma | CANCER CELLS | double strand break | DEPENDENT PROTEIN-KINASE | KU AFFECTS | irradiation | DAMAGE | non-homologous end-joining | ONCOLOGY | IN-VIVO | CHECKPOINT | IONIZING-RADIATION | HUMAN TUMOR-CELLS | Nasopharyngeal Neoplasms - genetics | Gamma Rays - adverse effects | Apoptosis - drug effects | Apoptosis - radiation effects | DNA End-Joining Repair - radiation effects | Humans | DNA Breaks, Double-Stranded - radiation effects | Nasopharyngeal Neoplasms - pathology | DNA Breaks, Double-Stranded - drug effects | Carcinoma - pathology | Chromones - pharmacology | DNA End-Joining Repair - drug effects | DNA-Binding Proteins - physiology | Nasopharyngeal Carcinoma | Nasopharyngeal Neoplasms - therapy | Radiation-Sensitizing Agents - pharmacology | Cells, Cultured | Morpholines - pharmacology | DNA-Activated Protein Kinase - physiology | Fibroblasts - pathology | Mice, Knockout | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Carcinoma - genetics | Carcinoma - therapy | Cell Proliferation - drug effects | Mice | Nuclear Proteins - physiology | Cell Proliferation - radiation effects | Care and treatment | DNA damage | Oncology, Experimental | Research | Nasopharyngeal cancer | Radiotherapy | Health aspects | Protein kinases | Cancer | Phosphorylation | Chemotherapy | Medical prognosis | Cell cycle | Ataxia | Radiation therapy | Kinases | Cancer therapies | DNA repair | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article