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Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12300 - 12312
Background: X-ray crystal structures of fluoroquinolone-gyrase-DNA complexes reveal a single drug-binding mode. Results: A ciprofloxacin derivative with a... 
NALIDIXIC-ACID | Enzyme Inhibitors | Antibiotic Action | MECHANISM | Cleaved Complexes | IIA TOPOISOMERASES | Escherichia coli | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA Topoisomerase | ESCHERICHIA-COLI | Mycobacterium smegmatis | CLEAVAGE | Bacterium | IN-VITRO | GENE | Cross-linking | STRUCTURAL BASIS | TOPOISOMERASE IV-QUINOLONE | Resistance Mutations | RESISTANCE-DETERMINING REGION | Bacteria | Fluoroquinolones - chemistry | DNA, Bacterial - metabolism | Escherichia coli - drug effects | Crystallography, X-Ray | DNA, Bacterial - chemistry | Macromolecular Substances - pharmacology | Microbial Sensitivity Tests | Fluoroquinolones - metabolism | Macromolecular Substances - chemistry | Topoisomerase II Inhibitors - chemistry | Anti-Bacterial Agents - chemistry | DNA Topoisomerases, Type II - chemistry | Molecular Structure | Nucleic Acid Conformation | Ciprofloxacin - metabolism | Protein Structure, Tertiary | DNA Topoisomerases, Type II - metabolism | Escherichia coli - enzymology | DNA Gyrase - chemistry | Ciprofloxacin - pharmacology | Models, Molecular | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Topoisomerase II Inhibitors - pharmacology | Topoisomerase II Inhibitors - metabolism | DNA Gyrase - metabolism | DNA, Bacterial - genetics | DNA Gyrase - genetics | Escherichia coli - genetics | Fluoroquinolones - pharmacology | Mycobacterium smegmatis - drug effects | Ciprofloxacin - chemistry | Escherichia coli Proteins - genetics | Protein Binding | DNA Topoisomerases, Type II - genetics | Anti-Bacterial Agents - pharmacology | Mutation | Escherichia coli Proteins - chemistry | Macromolecular Substances - metabolism | Index Medicus | DNA and Chromosomes
Journal Article
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Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 22, pp. 18636 - 18644
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ChemMedChem, ISSN 1860-7179, 01/2018, Volume 13, Issue 2, pp. 186 - 198
ATP‐competitive inhibitors of DNA gyrase and topoisomerase IV are among the most interesting classes of antibacterial drugs that are unrepresented in the... 
GyrB | antibacterials | inhibitors | pyrrolamides | DNA gyrase
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1703, pp. 269 - 281
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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 3, pp. 958 - 962
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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 1, pp. 338 - 349
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