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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15181 - 15186
Toll-like receptor 9 (TLR9) senses microbial DNA and triggers type I IFN responses in plasmacytoid dendritic cells (pDCs). Previous studies suggest the... 
RNA | Dendritic cells | DNA | Cell lines | Antivirals | Antibodies | Small interfering RNA | Innate immunity | Cellular immunity | Sensors | Cytosolic sensor | VIRUS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | CYTOSOLIC DNA | ALPHA | INDUCTION | cytosolic sensor | innate immunity | PATHWAY | INFECTION | ADAPTER PROTEIN | RNA, Small Interfering - genetics | Dendritic Cells - immunology | Humans | Neoplasm Proteins - antagonists & inhibitors | Phylogeny | Neoplasm Proteins - metabolism | DEAD-box RNA Helicases - antagonists & inhibitors | Base Sequence | B-Lymphocytes - virology | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Neoplasm Proteins - genetics | Binding Sites | DEAD-box RNA Helicases - chemistry | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B p50 Subunit - metabolism | Signal Transduction | DNA, Viral - metabolism | Neoplasm Proteins - chemistry | Immunity, Innate | Interferon Regulatory Factor-7 - metabolism | Receptors, Transferrin - metabolism | DEAD-box RNA Helicases - genetics | B-Lymphocytes - immunology | CpG Islands | Myeloid Differentiation Factor 88 - metabolism | Natural immunity | Genetic aspects | Research | Biological response modifiers | Properties | Binding proteins | Human immunogenetics | Biological Sciences
Journal Article
Genes and Development, ISSN 0890-9369, 10/2008, Volume 22, Issue 20, pp. 2767 - 2772
A key cellular response to DNA double-strand breaks ( DSBs) is 5 '-to-3 ' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle... 
DNA damage checkpoint | Exonuclease 1 | DNA resection | DNA repair | RecQ helicases | ATR | RECOMBINATION | RPA | PROTEIN | DEVELOPMENTAL BIOLOGY | DAMAGE CHECKPOINT ACTIVATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | EXONUCLEASE-1 | REPAIR | REPLICATION FORKS | GENETICS & HEREDITY | END RESECTION | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Recombination, Genetic | Bone Neoplasms - genetics | Tumor Cells, Cultured | DNA Helicases - genetics | Osteosarcoma - metabolism | DNA Repair - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | DNA Helicases - metabolism | Plasmids | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - antagonists & inhibitors | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Nucleases | DNA damage | Analysis | Chemical properties | Research | Helicases | Mutation (Biology) | Research Communication
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7520, pp. 102 - 106
The role of long noncoding RNA(lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes... 
MORPHOGENESIS | DOMAIN | CHROMATIN | GENE | RECOGNITION | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | IN-VIVO | TRANSCRIPTION | GROWTH | Chromatin - metabolism | Transcription Factors - chemistry | Humans | Myosin Heavy Chains - genetics | Cardiomegaly - pathology | Cardiomyopathies - prevention & control | Heart Failure - prevention & control | Cardiomyopathies - genetics | Myocardium - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Protein Structure, Tertiary | DNA Helicases - chemistry | Cardiac Myosins - genetics | Chromatin Assembly and Disassembly | Cardiomyopathies - pathology | Heart Failure - genetics | Histone Deacetylases - metabolism | Myocardium - pathology | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | RNA, Long Noncoding - genetics | Heart Failure - pathology | Transcription Factors - genetics | Nuclear Proteins - chemistry | Organ Specificity | Transcription Factors - metabolism | DNA Helicases - metabolism | Feedback, Physiological | Poly(ADP-ribose) Polymerases - metabolism | Animals | Cardiomegaly - prevention & control | Nuclear Proteins - antagonists & inhibitors | Protein Binding | Mice | DNA Helicases - antagonists & inhibitors | Poly (ADP-Ribose) Polymerase-1 | Cardiomegaly - genetics | RNA, Long Noncoding - antagonists & inhibitors | Chromatin - genetics | RNA, Long Noncoding - metabolism | Heart | Physiological aspects | Genetic aspects | RNA | Hypertrophy | Pathology | Cardiomyocytes | RNA polymerase | Ribonucleic acid--RNA | Cardiomyopathy | Rodents
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1525 - 1530
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that... 
Molecules | Cell growth | DNA | DNA damage | Cell nucleus | Cell lines | HeLa cells | Werner syndrome | DNA repair | Apoptosis | Human disease | Genomic instability | POLY(ADP-RIBOSE) POLYMERASE | CELLS | FORK | RECQ HELICASES | human disease | TELOMESTATIN | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | SUBSTRATE-SPECIFICITY | IN-VITRO | REPAIR | DISSOCIATION | genomic instability | Apoptosis - drug effects | DNA Replication - drug effects | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Maleimides - pharmacology | Exodeoxyribonucleases - antagonists & inhibitors | Immunoblotting | RecQ Helicases - genetics | Dose-Response Relationship, Drug | Topoisomerase I Inhibitors - pharmacology | Time Factors | Enzyme Inhibitors - chemistry | Molecular Structure | Stress, Physiological - drug effects | Exodeoxyribonucleases - genetics | DNA Damage - drug effects | Cell Line | Cell Survival - drug effects | Topotecan - pharmacology | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Drug Synergism | Adenosine Triphosphatases - antagonists & inhibitors | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Oxazoles - pharmacology | S Phase - drug effects | HeLa Cells | Histones - metabolism | Maleimides - chemistry | Proliferating Cell Nuclear Antigen - metabolism | DNA replication | Research | Helicases | Biological Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 136 - 139
Journal Article
Cancer Research, ISSN 0008-5472, 09/2015, Volume 75, Issue 18, pp. 3865 - 3878
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2011, Volume 187, Issue 9, pp. 4501 - 4508
The innate immune system is equipped with many molecular sensors for microbial DNA/RNA to quickly mount antimicrobial host immune responses. In this paper, we... 
AIM2 INFLAMMASOME | VIRUS | RECOGNITION | HELICASE-A | RIG-I | ANTIVIRAL ACTIVITY | KAPPA-B | IMMUNOLOGY | FRANCISELLA-TULARENSIS | INNATE IMMUNITY | CYTOPLASMIC DNA | RNA, Small Interfering - antagonists & inhibitors | RNA, Small Interfering - genetics | Protein Binding - genetics | Dendritic Cells - immunology | Humans | Neoplasm Proteins - antagonists & inhibitors | Nucleic Acid Heteroduplexes - pharmacology | Neoplasm Proteins - metabolism | Interferon Type I - biosynthesis | RNA, Viral - antagonists & inhibitors | RNA, Viral - genetics | DEAD-box RNA Helicases - antagonists & inhibitors | Myeloid Cells - immunology | HEK293 Cells | Inflammation Mediators - metabolism | Influenza A virus - immunology | Inflammation Mediators - antagonists & inhibitors | RNA, Double-Stranded - metabolism | RNA, Viral - metabolism | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Neoplasm Proteins - genetics | Dendritic Cells - metabolism | Cell Line | Cells, Cultured | Myeloid Cells - virology | Protein Binding - immunology | DEAD-box RNA Helicases - genetics | Animals | Poly I-C - metabolism | Adaptor Proteins, Signal Transducing - genetics | RNA, Double-Stranded - genetics | Myeloid Cells - metabolism | Mice | Cytokines - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - metabolism | Cytokines - biosynthesis | Interferon Type I - antagonists & inhibitors | RNA, Small Interfering - metabolism
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2019, Volume 20, Issue 1, pp. 18 - 28
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain-binding... 
SYNTHASE | 2ND-MESSENGER | CYCLIC GMP-AMP | IFI16 | GROWTH | INNATE IMMUNE SENSOR | IMMUNOLOGY | Neuroprotective Agents - therapeutic use | RNA Helicases - metabolism | Autoantigens - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | Cytosol - immunology | Humans | Poly-ADP-Ribose Binding Proteins - antagonists & inhibitors | Multiprotein Complexes - metabolism | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Catechin - therapeutic use | RNA Helicases - genetics | RNA Recognition Motif Proteins - antagonists & inhibitors | Exodeoxyribonucleases - genetics | Nucleotidyltransferases - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | RNA Recognition Motif Proteins - metabolism | DNA Helicases - genetics | Disease Models, Animal | DNA - immunology | Poly-ADP-Ribose Binding Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Autoimmune Diseases of the Nervous System - drug therapy | RNA Helicases - antagonists & inhibitors | Mice, Knockout | DNA Helicases - metabolism | Animals | Autoantigens - immunology | Interferons - metabolism | Nervous System Malformations - drug therapy | Protein Binding | Cytosol - metabolism | Catechin - analogs & derivatives | Mice | RNA Recognition Motif Proteins - genetics | DNA Helicases - antagonists & inhibitors | HeLa Cells | Promoters (Genetics) | Research | DNA-ligand interactions | Transferases | AMP | Therapeutic applications | Medical treatment | Epigallocatechin-3-gallate | Activation | Gene expression | Proteins | Epigallocatechin gallate | GTPase-activating protein | Cyclic GMP | Interferon | Inhibition | Autoimmune diseases | Deoxyribonucleic acid--DNA | Guanosinetriphosphatase
Journal Article
Cancer Research, ISSN 0008-5472, 09/2013, Volume 73, Issue 17, pp. 5508 - 5518
The occurrence of inactivating mutations in SWI/SNF chromatin-remodeling genes in common cancers has attracted a great deal of interest. However, mechanistic... 
CELL LUNG-CANCER | ALK | ONCOLOGY | ADENOCARCINOMA | SENESCENCE | MUTATIONS | FUSIONS | DIFFERENTIATION | EXPRESSION | MEDULLOBLASTOMA | LINES | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Cell Proliferation | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Male | Immunoenzyme Techniques | Discoidin Domain Receptors | Cellular Senescence | Aged, 80 and over | Cell Differentiation | DNA Helicases - genetics | Carcinoma, Squamous Cell - therapy | Lung Neoplasms - therapy | Mutation - genetics | Blotting, Western | DNA Helicases - metabolism | Adenocarcinoma - therapy | Mice, Nude | Mice | Mice, Inbred BALB C | Carcinoma, Squamous Cell - genetics | Lung Neoplasms - pathology | Genes, Lethal | Kinesin - genetics | Adult | Female | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Transcription Factors - metabolism | Carcinoma, Non-Small-Cell Lung - therapy | Animals | Cell Cycle | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Nuclear Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Aged | DNA Helicases - antagonists & inhibitors | Neoplasm Staging | Microscopy, Fluorescence | Apoptosis | Receptors, Mitogen - genetics
Journal Article