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Nucleic acids research, ISSN 1362-4962, 2016, Volume 44, Issue 5, pp. 1989 - 2006
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is critical... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer
Journal Article
Nature (London), ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 130 - 134
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 34, pp. 15181 - 15186
... (IRF7)-expressing B-cell lines. CpG-A selectively bound the aspartate-glutamate-any amino acid-aspartate/histidine (DExD/H)-box helicase 36 (DHX36... 
RNA | Dendritic cells | DNA | Cell lines | Antivirals | Antibodies | Small interfering RNA | Innate immunity | Cellular immunity | Sensors | Cytosolic sensor | VIRUS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | CYTOSOLIC DNA | ALPHA | INDUCTION | cytosolic sensor | innate immunity | PATHWAY | INFECTION | ADAPTER PROTEIN | RNA, Small Interfering - genetics | Dendritic Cells - immunology | Humans | Neoplasm Proteins - antagonists & inhibitors | Phylogeny | Neoplasm Proteins - metabolism | DEAD-box RNA Helicases - antagonists & inhibitors | Base Sequence | B-Lymphocytes - virology | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Neoplasm Proteins - genetics | Binding Sites | DEAD-box RNA Helicases - chemistry | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B p50 Subunit - metabolism | Signal Transduction | DNA, Viral - metabolism | Neoplasm Proteins - chemistry | Immunity, Innate | Interferon Regulatory Factor-7 - metabolism | Receptors, Transferrin - metabolism | DEAD-box RNA Helicases - genetics | B-Lymphocytes - immunology | CpG Islands | Myeloid Differentiation Factor 88 - metabolism | Natural immunity | Genetic aspects | Research | Biological response modifiers | Properties | Binding proteins | Human immunogenetics | Biological Sciences
Journal Article
Genes & development, ISSN 0890-9369, 2008, Volume 22, Issue 20, pp. 2767 - 2772
...). Here, we reveal that in the absence of exonuclease Exo1 activity, deletion or mutation of the Saccharomyces cerevisiae RecQ-family helicase, Sgs1, causes pronounced hypersensitivity to DSB-inducing agents... 
DNA damage checkpoint | Exonuclease 1 | DNA resection | DNA repair | RecQ helicases | ATR | DAMAGE CHECKPOINT | RPA | ACTIVATION | COMPLEX | PROTEIN | MRE11 | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | EXONUCLEASE-1 | REPAIR | REPLICATION FORKS | GENETICS & HEREDITY | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Recombination, Genetic | Bone Neoplasms - genetics | Tumor Cells, Cultured | DNA Helicases - genetics | Osteosarcoma - metabolism | DNA Repair - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | DNA Helicases - metabolism | Plasmids | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - antagonists & inhibitors | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Nucleases | DNA damage | Analysis | Chemical properties | Research | Helicases | Mutation (Biology) | Research Communication
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2003, Volume 3, Issue 3, pp. 169 - 178
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating... 
BLOOMS-SYNDROME GENE | TOPOISOMERASE-III-ALPHA | SYNDROME DNA HELICASE | FUNCTIONAL INTERACTION | ONCOLOGY | ROTHMUND-THOMSON-SYNDROME | STALLED REPLICATION FORKS | MISMATCH REPAIR | HOLLIDAY JUNCTIONS | WERNER-SYNDROME PROTEIN | SISTER-CHROMATID EXCHANGES | Species Specificity | Humans | Rothmund-Thomson Syndrome - enzymology | Werner Syndrome Helicase | DNA Repair - physiology | DNA Repair - genetics | Escherichia coli Proteins - physiology | RecQ Helicases | Cell Transformation, Neoplastic - genetics | Werner Syndrome - genetics | DNA Helicases - genetics | Genes, Tumor Suppressor | Protein Structure, Tertiary | Adenosine Triphosphatases - deficiency | Bloom Syndrome - enzymology | DNA Helicases - chemistry | Genetic Predisposition to Disease | Mutagenesis - genetics | DNA Helicases - deficiency | Bloom Syndrome - genetics | Werner Syndrome - enzymology | Mice, Knockout | Protein Interaction Mapping | Rothmund-Thomson Syndrome - genetics | Animals | DNA Replication - physiology | Multienzyme Complexes - physiology | DNA Replication - genetics | Escherichia coli Proteins - genetics | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Mice | Exodeoxyribonucleases | Adenosine Triphosphatases - physiology | DNA Helicases - physiology | Gene mutations | Physiological aspects | Genetic aspects | Research | Health aspects | Helicases | Cancer
Journal Article