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The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 26, pp. 2509 - 2520
Persons with mismatch repair–deficient tumors are more likely than persons with mismatch repair–proficient tumors to benefit from pembrolizumab — which... 
MEDICINE, GENERAL & INTERNAL | COLORECTAL CARCINOMAS | ANTI-PD-L1 ANTIBODY | SAFETY | MICROSATELLITE INSTABILITY | DNA | GERMLINE MUTATIONS | PREDISPOSE | CLINICAL ACTIVITY | CANCER | LYMPHOCYTES | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Colorectal Neoplasms - genetics | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease-Free Survival | Neoplasm Metastasis - genetics | Neoplasm Metastasis - drug therapy | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | DNA Mismatch Repair | Adult | Female | Adenocarcinoma - genetics | Aged | Colorectal Neoplasms - pathology | Antibody diversity | Carcinoma | Genetic disorders | Analysis | Research | Risk factors | Cancer | Tumors | Antigens | Yeast | PD-1 protein | Colorectal carcinoma | Body weight | Colorectal cancer | Autoantigens | DNA repair | Survival | Metastases | Pembrolizumab | Immune checkpoint | Immunogenicity | Mismatch repair | Death | Mutation | Genetic recombination | Cancer therapies | Drug dosages | Immune system | Medical research | Melanoma | Patients | Studies | Hypotheses | Pancreatic cancer | Epigenetics | Biomarkers | Ligands | Index Medicus | Abridged Index Medicus
Journal Article
NATURE GENETICS, ISSN 1061-4036, 12/2017, Volume 49, Issue 12, pp. 1673 - 1674
A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be... 
DNA | MUTATION HOTSPOTS | GENES | GENETICS & HEREDITY | CHROMATIN ORGANIZATION | REVEAL | CANCER GENOMES | Mutation Rate | Mutation | Exons | Introns | DNA Mismatch Repair | Genetic research | Research | Properties | Exon (Molecular genetics) | DNA mismatch repair | Genes | Bias | Genomes | DNA repair | Recruitment | Proteins | Studies | Mismatch repair | Evolution | Repair | Deoxyribonucleic acid--DNA | Cancer | Tumors | Index Medicus
Journal Article
Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Bioindicators | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis | Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2015, Volume 373, Issue 20, pp. 1979 - 1979
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2010, Volume 107, Issue 15, pp. 6982 - 6987
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 147, Issue 6, pp. 1308 - 1316.e1
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2018, Volume 36, Issue 8, pp. 773 - 779
PurposeNivolumab provides clinical benefit (objective response rate [ORR], 31%; 95% CI, 20.8 to 42.9; disease control rate, 69%; 12-month overall survival... 
CRITERIA | MULTICENTER | MELANOMA | SOLID TUMORS | ONCOLOGY | PD-1 BLOCKADE | OPEN-LABEL | QUALITY-OF-LIFE | DEFICIENCY | GUIDELINE | Index Medicus
Journal Article