Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 10/2013, Volume 5, Issue 10, pp. a012609 - a012609
Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky DNA lesions such as those formed by UV light, environmental mutagens, and...
GROUP-A PROTEIN | DAMAGED DNA | CYCLOBUTANE PYRIMIDINE DIMERS | XERODERMA-PIGMENTOSUM | TRICHOTHIODYSTROPHY GROUP-A | GROUP-C PROTEIN | GROUP D HELICASE | HUMAN XPG PROTEIN | DNA-BINDING PROTEIN | COMPLEMENTATION GROUP-A | CELL BIOLOGY | Chromatin - metabolism | Animals | Eukaryota - genetics | DNA Repair | Humans | Chromatin Assembly and Disassembly | Models, Molecular | Substrate Specificity | Models, Genetic | DNA - metabolism | DNA Damage | 011
GROUP-A PROTEIN | DAMAGED DNA | CYCLOBUTANE PYRIMIDINE DIMERS | XERODERMA-PIGMENTOSUM | TRICHOTHIODYSTROPHY GROUP-A | GROUP-C PROTEIN | GROUP D HELICASE | HUMAN XPG PROTEIN | DNA-BINDING PROTEIN | COMPLEMENTATION GROUP-A | CELL BIOLOGY | Chromatin - metabolism | Animals | Eukaryota - genetics | DNA Repair | Humans | Chromatin Assembly and Disassembly | Models, Molecular | Substrate Specificity | Models, Genetic | DNA - metabolism | DNA Damage | 011
Journal Article
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 03/2013, Volume 5, Issue 3, pp. a012591 - a012591
Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their...
UVRABC NUCLEASE | DNA-DAMAGE RECOGNITION | HELICASE-II | UVRB PROTEIN | STRUCTURAL BASIS | (A)BC EXCINUCLEASE | CRYSTAL-STRUCTURE | COUPLING FACTOR | ESCHERICHIA-COLI | C-TERMINAL DOMAIN | CELL BIOLOGY | Multiprotein Complexes - metabolism | Transcription, Genetic - physiology | Prokaryotic Cells - physiology | DNA Repair - physiology | Endodeoxyribonucleases - metabolism | DNA Damage - genetics | Models, Molecular | Escherichia coli Proteins - metabolism | Protein Conformation | Endodeoxyribonucleases - chemistry | Escherichia coli Proteins - chemistry | Nucleotides - metabolism | 011
UVRABC NUCLEASE | DNA-DAMAGE RECOGNITION | HELICASE-II | UVRB PROTEIN | STRUCTURAL BASIS | (A)BC EXCINUCLEASE | CRYSTAL-STRUCTURE | COUPLING FACTOR | ESCHERICHIA-COLI | C-TERMINAL DOMAIN | CELL BIOLOGY | Multiprotein Complexes - metabolism | Transcription, Genetic - physiology | Prokaryotic Cells - physiology | DNA Repair - physiology | Endodeoxyribonucleases - metabolism | DNA Damage - genetics | Models, Molecular | Escherichia coli Proteins - metabolism | Protein Conformation | Endodeoxyribonucleases - chemistry | Escherichia coli Proteins - chemistry | Nucleotides - metabolism | 011
Journal Article
DNA Repair, ISSN 1568-7864, 12/2015, Volume 36, pp. 13 - 18
The demonstration of DNA damage excision and repair replication by Setlow, Howard-Flanders, Hanawalt and their colleagues in the early 1960s, constituted the...
Nucleotide excision repair | Global genome repair | DNA repair | Transcription-coupled repair | RNA | CHROMATIN | RECOGNITION | UV-SENSITIVE SYNDROME | CANCER | XERODERMA-PIGMENTOSUM | UVSSA | GENETICS & HEREDITY | NER | TOXICOLOGY | DNA-REPAIR | Chromatin - metabolism | Transcription, Genetic | DNA - metabolism | DNA Damage | DNA Repair | Humans | Enzymes | Bacteria | Genetic transcription | DNA damage | Genomics | global genome repair | nucleotide excision repair | transcription-coupled repair
Nucleotide excision repair | Global genome repair | DNA repair | Transcription-coupled repair | RNA | CHROMATIN | RECOGNITION | UV-SENSITIVE SYNDROME | CANCER | XERODERMA-PIGMENTOSUM | UVSSA | GENETICS & HEREDITY | NER | TOXICOLOGY | DNA-REPAIR | Chromatin - metabolism | Transcription, Genetic | DNA - metabolism | DNA Damage | DNA Repair | Humans | Enzymes | Bacteria | Genetic transcription | DNA damage | Genomics | global genome repair | nucleotide excision repair | transcription-coupled repair
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 03/2009, Volume 66, Issue 6, pp. 994 - 1009
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 06/2013, Volume 18, Issue 18, pp. 249 - 2419
Significance: Oxidative DNA damage is repaired by multiple, overlapping DNA repair pathways. Accumulating evidence supports the hypothesis that nucleotide...
Forum Review Articles | SYNDROME GROUP-B | XERODERMA-PIGMENTOSUM | UBIQUITIN LIGASE | UV-SENSITIVE SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROUP-C PROTEIN | COCKAYNE-SYNDROME PATIENTS | ENDOCRINOLOGY & METABOLISM | PIGMENTOSUM GROUP-A | TRANSCRIPTION FACTOR IIH | MITOCHONDRIAL-DNA | ELONGATION COMPLEXES | DNA-Binding Proteins - physiology | Animals | Oxidation-Reduction | Xeroderma Pigmentosum - genetics | Xeroderma Pigmentosum - metabolism | Cockayne Syndrome - metabolism | DNA Repair | Humans | Cockayne Syndrome - genetics | Transcription, Genetic | DNA Damage | Xeroderma Pigmentosum Group A Protein - physiology | Physiological aspects | Oxidative stress | DNA | Analysis | Index Medicus | Forum Review
Forum Review Articles | SYNDROME GROUP-B | XERODERMA-PIGMENTOSUM | UBIQUITIN LIGASE | UV-SENSITIVE SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROUP-C PROTEIN | COCKAYNE-SYNDROME PATIENTS | ENDOCRINOLOGY & METABOLISM | PIGMENTOSUM GROUP-A | TRANSCRIPTION FACTOR IIH | MITOCHONDRIAL-DNA | ELONGATION COMPLEXES | DNA-Binding Proteins - physiology | Animals | Oxidation-Reduction | Xeroderma Pigmentosum - genetics | Xeroderma Pigmentosum - metabolism | Cockayne Syndrome - metabolism | DNA Repair | Humans | Cockayne Syndrome - genetics | Transcription, Genetic | DNA Damage | Xeroderma Pigmentosum Group A Protein - physiology | Physiological aspects | Oxidative stress | DNA | Analysis | Index Medicus | Forum Review
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 2014, Volume 15, Issue 7, pp. 465 - 481
Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a multiwise 'cut and patch'-type reaction. The global genome NER...
RNA-POLYMERASE-II | GROUP-B GENE | XERODERMA-PIGMENTOSUM | DNA-DAMAGE RESPONSE | UV-SENSITIVE SYNDROME | GROUP-C PROTEIN | PIGMENTOSUM GROUP-E | COCKAYNE-SYNDROME | FACTORS IN-VIVO | TRANSCRIPTION-COUPLED REPAIR | CELL BIOLOGY | Aging - genetics | Neoplasms - genetics | Models, Biological | Humans | DNA Repair - physiology | DNA Damage | DNA Repair - genetics | Ubiquitin - physiology | Evaluation | Genetic susceptibility | Genetic research | Genetic aspects | Research | DNA repair | Carcinogenesis | Risk factors | Index Medicus
RNA-POLYMERASE-II | GROUP-B GENE | XERODERMA-PIGMENTOSUM | DNA-DAMAGE RESPONSE | UV-SENSITIVE SYNDROME | GROUP-C PROTEIN | PIGMENTOSUM GROUP-E | COCKAYNE-SYNDROME | FACTORS IN-VIVO | TRANSCRIPTION-COUPLED REPAIR | CELL BIOLOGY | Aging - genetics | Neoplasms - genetics | Models, Biological | Humans | DNA Repair - physiology | DNA Damage | DNA Repair - genetics | Ubiquitin - physiology | Evaluation | Genetic susceptibility | Genetic research | Genetic aspects | Research | DNA repair | Carcinogenesis | Risk factors | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2014, Volume 56, Issue 6, pp. 777 - 785
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on...
RECOMBINATION | RNA | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | REPLICATION FORK PROGRESSION | BINDING-PROTEIN | SWITCH REGIONS | HUMAN GENES | SENATAXIN | RNA/DNA HYBRIDS | CELL BIOLOGY | Genomic Instability | Endonucleases - genetics | RNA Replicase - genetics | Saccharomyces cerevisiae - genetics | Humans | RNA Replicase - metabolism | DNA Repair Enzymes - genetics | Nuclear Proteins - metabolism | Endonucleases - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | RNA, Fungal - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | DNA Repair | DNA Repair Enzymes - metabolism | Transcription, Genetic | RNA, Fungal - genetics | DNA Damage | HeLa Cells | Genome, Human | Nuclear Proteins - genetics | DNA damage | Genomics | Physiological aspects | Genetic transcription | DNA repair | Cells | Medical colleges | Chromatin | DNA | Genomes | TC-NER | genome instability | RNA processing | R-loop
RECOMBINATION | RNA | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | REPLICATION FORK PROGRESSION | BINDING-PROTEIN | SWITCH REGIONS | HUMAN GENES | SENATAXIN | RNA/DNA HYBRIDS | CELL BIOLOGY | Genomic Instability | Endonucleases - genetics | RNA Replicase - genetics | Saccharomyces cerevisiae - genetics | Humans | RNA Replicase - metabolism | DNA Repair Enzymes - genetics | Nuclear Proteins - metabolism | Endonucleases - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | RNA, Fungal - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | DNA Repair | DNA Repair Enzymes - metabolism | Transcription, Genetic | RNA, Fungal - genetics | DNA Damage | HeLa Cells | Genome, Human | Nuclear Proteins - genetics | DNA damage | Genomics | Physiological aspects | Genetic transcription | DNA repair | Cells | Medical colleges | Chromatin | DNA | Genomes | TC-NER | genome instability | RNA processing | R-loop
Journal Article
Trends in Genetics, ISSN 0168-9525, 2012, Volume 28, Issue 11, pp. 566 - 573
Nucleotide excision repair (NER) is a major DNA repair pathway that ensures that the genome remains functionally intact and is faithfully transmitted to...
Medical Education | development | cancer | aging | transcription | chromatin | nucleotide excision repair | Aging | Development | Nucleotide excision repair | Chromatin | Transcription | Cancer | RNA-POLYMERASE-II | UBIQUITIN LIGASE | MICE DEFICIENT | UV-SENSITIVE SYNDROME | DNA-DAMAGE RESPONSE | COCKAYNE-SYNDROME | GENOME MAINTENANCE | TRANSCRIPTION-COUPLED REPAIR | FACIO-SKELETAL SYNDROME | XERODERMA-PIGMENTOSUM | GENETICS & HEREDITY | Chromatin - metabolism | Animals | DNA Repair | Humans | Transcription, Genetic | Genetic Pleiotropy | DNA - metabolism | Genome | Ubiquitin | Genetic transcription | DNA repair | Genes | Stem cells | Genomes | Nuclear receptors | Progeny | Signal transduction | Reviews | ubiquitination | Transcription activation | Histones | Nucleosomes
Medical Education | development | cancer | aging | transcription | chromatin | nucleotide excision repair | Aging | Development | Nucleotide excision repair | Chromatin | Transcription | Cancer | RNA-POLYMERASE-II | UBIQUITIN LIGASE | MICE DEFICIENT | UV-SENSITIVE SYNDROME | DNA-DAMAGE RESPONSE | COCKAYNE-SYNDROME | GENOME MAINTENANCE | TRANSCRIPTION-COUPLED REPAIR | FACIO-SKELETAL SYNDROME | XERODERMA-PIGMENTOSUM | GENETICS & HEREDITY | Chromatin - metabolism | Animals | DNA Repair | Humans | Transcription, Genetic | Genetic Pleiotropy | DNA - metabolism | Genome | Ubiquitin | Genetic transcription | DNA repair | Genes | Stem cells | Genomes | Nuclear receptors | Progeny | Signal transduction | Reviews | ubiquitination | Transcription activation | Histones | Nucleosomes
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 265 - 290
Transcription factor IIH (TFIIH) is a multiprotein complex involved in both transcription and DNA repair, revealing a striking functional link between these...
human diseases | transcription | cell cycle | DNA repair | TFIIH | Human diseases | Transcription | Cell cycle | RNA-POLYMERASE-II | CARBOXY-TERMINAL DOMAIN | CDK-ACTIVATING KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COCKAYNE-SYNDROME | PREINITIATION COMPLEX | GENERAL TRANSCRIPTION | XERODERMA-PIGMENTOSUM | STRUCTURAL BASIS | XPD MUTATIONS | DNA-REPAIR | Cell Cycle - genetics | Transcription, Genetic - drug effects | Trichothiodystrophy Syndromes - genetics | Phenylenediamines - therapeutic use | Xeroderma Pigmentosum - genetics | Xeroderma Pigmentosum - metabolism | Transcription Factor TFIIH - antagonists & inhibitors | Humans | Trichothiodystrophy Syndromes - pathology | Molecular Targeted Therapy | Protein Subunits - metabolism | Transcription Factor TFIIH - genetics | Cell Cycle Proteins - antagonists & inhibitors | Xeroderma Pigmentosum - pathology | Cell Cycle Proteins - genetics | Trichothiodystrophy Syndromes - metabolism | Xeroderma Pigmentosum - drug therapy | Spironolactone - therapeutic use | Protein Subunits - genetics | Chromosome Segregation | DNA Repair - drug effects | Cell Cycle Proteins - metabolism | Models, Molecular | DNA - metabolism | DNA - genetics | Trichothiodystrophy Syndromes - drug therapy | Pyrimidines - therapeutic use | Transcription Factor TFIIH - metabolism | Protein Subunits - antagonists & inhibitors | DNA Damage | Mutation | Cell Cycle - drug effects | Genetic transcription | Observations | Genetic regulation
human diseases | transcription | cell cycle | DNA repair | TFIIH | Human diseases | Transcription | Cell cycle | RNA-POLYMERASE-II | CARBOXY-TERMINAL DOMAIN | CDK-ACTIVATING KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COCKAYNE-SYNDROME | PREINITIATION COMPLEX | GENERAL TRANSCRIPTION | XERODERMA-PIGMENTOSUM | STRUCTURAL BASIS | XPD MUTATIONS | DNA-REPAIR | Cell Cycle - genetics | Transcription, Genetic - drug effects | Trichothiodystrophy Syndromes - genetics | Phenylenediamines - therapeutic use | Xeroderma Pigmentosum - genetics | Xeroderma Pigmentosum - metabolism | Transcription Factor TFIIH - antagonists & inhibitors | Humans | Trichothiodystrophy Syndromes - pathology | Molecular Targeted Therapy | Protein Subunits - metabolism | Transcription Factor TFIIH - genetics | Cell Cycle Proteins - antagonists & inhibitors | Xeroderma Pigmentosum - pathology | Cell Cycle Proteins - genetics | Trichothiodystrophy Syndromes - metabolism | Xeroderma Pigmentosum - drug therapy | Spironolactone - therapeutic use | Protein Subunits - genetics | Chromosome Segregation | DNA Repair - drug effects | Cell Cycle Proteins - metabolism | Models, Molecular | DNA - metabolism | DNA - genetics | Trichothiodystrophy Syndromes - drug therapy | Pyrimidines - therapeutic use | Transcription Factor TFIIH - metabolism | Protein Subunits - antagonists & inhibitors | DNA Damage | Mutation | Cell Cycle - drug effects | Genetic transcription | Observations | Genetic regulation
Journal Article