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Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7485, pp. 691 - 695
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2017, Volume 13, Issue 2, pp. e1006602 - e1006602
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2017, Volume 114, Issue 23, pp. E4612 - E4620
Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor effects of several therapies, including radiation and... 
CGAS | Senescence | DNA sensing | DNA damage | Cancer | LIFE-SPAN | CYCLIC GMP-AMP | SECRETORY PHENOTYPE | TUMOR SUPPRESSION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | CYTOSOLIC DNA SENSOR | DAMAGE | PROMOTES SENESCENCE | senescence | IN-VIVO | cGAS | cancer | NF-KAPPA-B | Prognosis | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Mouse Embryonic Stem Cells - cytology | Mouse Embryonic Stem Cells - metabolism | Cellular Senescence - immunology | Nucleotidyltransferases - deficiency | Adenocarcinoma - metabolism | Immunity, Innate - physiology | HEK293 Cells | Adenocarcinoma - genetics | Nucleotidyltransferases - metabolism | Fibroblasts - metabolism | Lung Neoplasms - genetics | Gene Expression | Cells, Cultured | Cellular Senescence - physiology | Mice, Knockout | Phenotype | Animals | Nucleotidyltransferases - genetics | Cytosol - metabolism | Fibroblasts - cytology | Mice | DNA Damage | Adenocarcinoma | Drugs | Chromatin | Mitosis | Lung | Radiation | Innate immunity | Nuclei | Immunity | DNA repair | Anticancer properties | Clonal deletion | Rodents | Cyclic GMP | Fibroblasts | Deletion | Aging | Tumorigenesis | Damage accumulation | Deoxyribonucleic acid--DNA | Cell survival | AMP | Cytokines | Aging (artificial) | Etoposide | Inflammation | Embryo fibroblasts | Embryos | Cells | Damage localization | Immortalization | Fibrosis | Antitumor activity | Aging (natural) | Nuclei (cytology) | Cytoplasm | Radiation damage | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Index Medicus | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 5, pp. 1939 - 1943
Detection of intracellular DNA triggers activation of the stimulator of IFN genes dependent IFN-stimulatory DNA (ISD) pathway, which is essential for antiviral... 
CYCLIC GMP-AMP | INTRACELLULAR DNA | LUPUS | DENDRITIC CELLS | GENE | DNA EXONUCLEASE TREX1 | CYTOSOLIC DNA | INNATE IMMUNE SENSOR | MUTATIONS | IMMUNOLOGY | RETROVIRUSES | Nucleotides, Cyclic - metabolism | Phosphoproteins - immunology | Exodeoxyribonucleases - immunology | Interferon-beta - immunology | Nervous System Malformations - immunology | Gene Expression - drug effects | Autoantibodies - blood | Humans | Immunoblotting | Interferons - immunology | Phosphoproteins - metabolism | Inflammation - metabolism | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Gene Expression - immunology | Interferon-beta - genetics | Exodeoxyribonucleases - genetics | Nucleotidyltransferases - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | Macrophages - immunology | Disease Models, Animal | Fibroblasts - metabolism | Interferons - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Autoimmune Diseases of the Nervous System - immunology | Autoantibodies - immunology | Macrophages - metabolism | Animals | Interferon-beta - metabolism | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Exodeoxyribonucleases - metabolism | Inflammation - genetics | Nucleotidyltransferases - genetics | Fibroblasts - immunology | Macrophages - drug effects | Nucleotidyltransferases - immunology | Nucleotides, Cyclic - immunology | Index Medicus | Abridged Index Medicus
Journal Article