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Nature Structural & Molecular Biology, ISSN 1545-9993, 05/2009, Volume 16, Issue 5, pp. 492 - 498
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2016, Volume 24, Issue 4, pp. 566 - 581
Journal Article
Cell Death and Disease, ISSN 2041-4889, 01/2014, Volume 5, Issue 10, pp. e1437 - e1437
Journal Article
Cell, ISSN 0092-8674, 12/2012, Volume 151, Issue 7, pp. 1474 - 1487
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 7, pp. E1560 - E1569
Journal Article
Cancer Research, ISSN 0008-5472, 06/2010, Volume 70, Issue 12, pp. 4972 - 4981
The median survival for patients with locally advanced pancreatic cancer treated with gemcitabine and radiation is approximately 1 year. To develop improved... 
Protein Kinases - metabolism | Gamma Rays | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Humans | DNA Repair - radiation effects | Protein Kinases - chemistry | Deoxycytidine - pharmacology | Immunoblotting | RNA, Messenger - metabolism | G2 Phase - drug effects | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Flow Cytometry | Urea - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Drug Therapy, Combination | DNA Damage - drug effects | Rad51 Recombinase - metabolism | DNA Repair - drug effects | G2 Phase - radiation effects | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Radiation-Sensitizing Agents - pharmacology | Pancreatic Neoplasms - radiotherapy | Thiophenes - pharmacology | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Blotting, Western | Xenograft Model Antitumor Assays | Animals | Fluorescent Antibody Technique | Cell Line, Tumor | Checkpoint Kinase 2 | Checkpoint Kinase 1 | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Recombination, Genetic - radiation effects | DNA Damage - radiation effects | Deoxycytidine - analogs & derivatives | Recombination, Genetic - drug effects | Urea - pharmacology | Index Medicus | pancreatic cancer | gemcitabine | Chk1 | radiosensitization | homologous recombination repair
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 16, pp. 6492 - 6496
Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs processing involves the Fanconi... 
Enzymes | Cell growth | Fanconi anemia | Genetic vectors | DNA damage | DNA | Homologous recombination | Cell cycle | DNA repair | Chromosome aberrations | Mitomycin C | Endonuclease | Cisplatin | STRUCTURE-SPECIFIC ENDONUCLEASE | mitomycin C | MONOUBIQUITINATED FANCD2 | STRAND BREAK REPAIR | MULTIDISCIPLINARY SCIENCES | STRUCTURE-SPECIFIC NUCLEASES | endonuclease | HOLLIDAY JUNCTION RESOLVASE | GENE | VERTEBRATE CELLS | ERCC1/XPF ENDONUCLEASE | HOMOLOGOUS RECOMBINATION | cisplatin | DNA-REPAIR | Endonucleases - genetics | Recombination, Genetic - physiology | Fanconi Anemia Complementation Group D2 Protein - genetics | Recombinases - genetics | Chromatids - genetics | Cross-Linking Reagents - pharmacology | DNA Repair - physiology | Multiprotein Complexes - genetics | Endonucleases - metabolism | Chromatids - metabolism | Multiprotein Complexes - metabolism | Ubiquitination - drug effects | Cell Death - genetics | Chromosome Aberrations - drug effects | DNA Damage - physiology | Cell Death - drug effects | Ubiquitination - physiology | DNA Damage - drug effects | Cell Line | DNA Repair - drug effects | Recombinases - metabolism | Zinc Fingers | Animals | Fanconi Anemia Complementation Group D2 Protein - metabolism | Chickens | Cell Proliferation - drug effects | Recombination, Genetic - drug effects | Nucleases | Crosslinked polymers | Physiological aspects | Development and progression | Genetic aspects | Research | Health aspects | Protein binding | Fanconi's anemia | Proteins | Eukaryotes | Anemia | Chromosomes | Binding sites | Apoptosis | Index Medicus | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2010, Volume 39, Issue 1, pp. 36 - 47
Journal Article