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Genes & development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Index Medicus | homologous recombination | Research Paper
Journal Article
Nucleic acids research, ISSN 0305-1048, 2015, Volume 43, Issue 21, pp. 10083 - 10101
.... If left unrepaired, such lesions can become fixed in the genome as permanent mutations. Thus, evolution has led to the creation of several highly conserved, partially redundant pathways to repair or mitigate the effects of DNA base damage... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | DNA Breaks, Single-Stranded | Saccharomyces cerevisiae - genetics | DNA Repair | Humans | DNA Repair Enzymes - metabolism | Saccharomyces cerevisiae - enzymology | DNA Damage | Index Medicus | Survey and Summary
Journal Article
Nature (London), ISSN 1476-4687, 04/2014, Volume 508, Issue 7495, pp. 222 - 227
...), a nucleotide pool sanitizing enzyme. Loss-of-function of MTH1 impaired growth of KRAS tumour cells, whereas MTH1 overexpression mitigated sensitivity towards SCH51344... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2016, Volume 36, Issue 4, pp. 524 - 544
Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ubiquitination | Animals | Signal Transduction | DNA Repair | Humans | Ubiquitin - metabolism | DNA Replication | DNA Damage | Ubiquitin-Specific Proteases - metabolism | Index Medicus
Journal Article