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Genes and Development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins:... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | NUCLEASE ACTIVITY | BLOOMS-SYNDROME HELICASE | HUMAN EXONUCLEASE 1 | ESCHERICHIA-COLI | MISMATCH REPAIR | DEVELOPMENTAL BIOLOGY | DOUBLE-STRAND BREAK | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | homologous recombination | GENETICS & HEREDITY | MRE11 NUCLEASE | MITOTIC RECOMBINATION | RECQ HELICASE | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Research Paper
Journal Article
Journal Article
Annual Review of Genomics and Human Genetics, ISSN 1527-8204, 2007, Volume 8, Issue 1, pp. 37 - 55
Each day tens of thousands of DNA single-strand breaks (SSBs) arise in every cell from the attack of deoxyribose and DNA bases by reactive oxygen species and... 
Cancer predisposition | Single-strand break | Neurodegeneration | Double-strand break | TUMOR-SUPPRESSOR GENES | neurodegeneration | cancer predisposition | TELANGIECTASIA-LIKE DISORDER | LIGASE-IV | CELL-FREE-EXTRACTS | DAMAGE RESPONSE | HISTONE H2AX PHOSPHORYLATION | I COVALENT COMPLEXES | single-strand break | GENETICS & HEREDITY | double-strand break | HOMOLOGY-DIRECTED REPAIR | ATAXIA-TELANGIECTASIA | FANCONI-ANEMIA PROTEIN | Microcephaly - genetics | DNA Ligases - genetics | Humans | DNA Repair - physiology | DNA Repair Enzymes - genetics | Genetic Diseases, Inborn - genetics | DNA Breaks, Double-Stranded | Phosphoric Diester Hydrolases - physiology | DNA Breaks, Single-Stranded | MRE11 Homologue Protein | Apraxias - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | DNA Ligases - physiology | Fanconi Anemia - genetics | Nuclear Proteins - genetics | Spinocerebellar Ataxias - genetics | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Phosphoric Diester Hydrolases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Nijmegen Breakage Syndrome - genetics | Syndrome | Severe Combined Immunodeficiency - genetics | Tumor Suppressor Proteins - physiology | Genes, BRCA1 - physiology | Genes, BRCA2 - physiology | Endonucleases | DNA Ligase ATP | Ataxia Telangiectasia - genetics | Nuclear Proteins - physiology | Cell Cycle Proteins - physiology
Journal Article