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1. Full Text Persistent HIV-1 replication maintains the tissue reservoir during therapy
by Lorenzo-Redondo, Ramon and Fryer, Helen R and Bedford, Trevor and Kim, Eun-Young and Archer, John and Kosakovsky Pond, Sergei L and Chung, Yoon-Seok and Penugonda, Sudhir and Chipman, Jeffrey G and Fletcher, Courtney V and Schacker, Timothy W and Malim, Michael H and Rambaut, Andrew and Haase, Ashley T and McLean, Angela R and Wolinsky, Steven M
Nature (London), ISSN 0028-0836, 02/2016, Volume 530, Issue 7588, pp. 51 - 56
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Anti-HIV Agents - pharmacology | Carrier State - blood | Humans | Molecular Sequence Data | Phylogeny | Selection, Genetic - drug effects | Anti-HIV Agents - administration & dosage | HIV-1 - growth & development | Time Factors | HIV-1 - isolation & purification | Haplotypes - drug effects | Anti-HIV Agents - therapeutic use | Lymph Nodes - drug effects | Spatio-Temporal Analysis | HIV Infections - blood | Virus Replication - drug effects | HIV-1 - drug effects | HIV Infections - virology | Lymph Nodes - virology | HIV-1 - genetics | Sequence Analysis, DNA | Carrier State - virology | Models, Biological | Carrier State - drug therapy | Drug Resistance, Viral - drug effects | HIV Infections - drug therapy | Viral Load - drug effects | Infection | Highly active antiretroviral therapy | Care and treatment | Analysis | Patient outcomes | Physiological aspects | Development and progression | HIV (Viruses) | Health aspects | HIV infection | Haplotypes | Antiretroviral drugs | Lymphatic system | Human immunodeficiency virus--HIV | Phylogenetics | Infections | Drug resistance | Tissues | Index Medicus
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2. Full Text Replication fork stability confers chemoresistance in BRCA-deficient cells
by Chaudhuri, Arnab Ray and Callen, Elsa and Ding, Xia and Gogola, Ewa and Duarte, Alexandra A and Lee, Ji-Eun and Wong, Nancy and Lafarga, Vanessa and Calvo, Jennifer A and Panzarino, Nicholas J and John, Sam and Day, Amanda and Crespo, Anna Vidal and Shen, Binghui and Starnes, Linda M and De Ruiter, Julian R and Daniel, Jeremy A and Konstantinopoulos, Panagiotis A and Cortez, David and Cantor, Sharon B and Fernandez-Capetillo, Oscar and Ge, Kai and Jonkers, Jos and Rottenberg, Sven and Sharan, Shyam K and Nussenzweig, André
Nature (London), ISSN 0028-0836, 07/2016, Volume 535, Issue 7612, pp. 382 - 387
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Embryonic Stem Cells - metabolism | DNA Replication - drug effects | Homologous Recombination | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Neoplasms - genetics | Gene Deletion | Nuclear Proteins - deficiency | DNA Repair Enzymes - metabolism | DNA Damage - genetics | Genes, BRCA2 | DNA - biosynthesis | Female | DNA Repair Enzymes - antagonists & inhibitors | Genes, BRCA1 | Nuclear Proteins - genetics | DNA Helicases - genetics | DNA Damage - drug effects | DNA Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Cisplatin - pharmacology | DNA - metabolism | Carrier Proteins - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Poly(ADP-ribose) Polymerases - genetics | DNA Replication - physiology | Embryonic Stem Cells - drug effects | Cell Line, Tumor | Mice | Poly (ADP-Ribose) Polymerase-1 | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Chemotherapy | Replication fork | B cells | DNA damage | Cancer | Proteins | Lymphocytes | Stem cells | Breast cancer | Drug resistance | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
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3. Full Text Replication stress links structural and numerical cancer chromosomal instability
by Burrell, Rebecca A and McClelland, Sarah E and Endesfelder, David and Groth, Petra and Weller, Marie-Christine and Shaikh, Nadeem and Domingo, Enric and Kanu, Nnennaya and Dewhurst, Sally M and Gronroos, Eva and Chew, Su Kit and Rowan, Andrew J and Schenk, Arne and Sheffer, Michal and Howell, Michael and Kschischo, Maik and Behrens, Axel and Helleday, Thomas and Bartek, Jiri and Tomlinson, Ian P and Swanton, Charles
Nature (London), ISSN 0028-0836, 02/2013, Volume 494, Issue 7438, pp. 492 - 496
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | DNA Damage - drug effects | RNA-Binding Proteins - genetics | Chromosomes, Human, Pair 18 - drug effects | DNA Replication - drug effects | Colorectal Neoplasms - genetics | Humans | Gene Silencing | Aneuploidy | Chromosomal Instability - drug effects | DNA Copy Number Variations - genetics | Chromosome Segregation - drug effects | Chromosomal Instability - genetics | Mitosis - drug effects | Gene Deletion | Cell Line, Tumor | DNA Damage - genetics | DNA Replication - genetics | Nucleosides - pharmacology | Chromosomes, Human, Pair 18 - genetics | Colorectal Neoplasms - pathology | Genes, Tumor Suppressor | Phosphotransferases - genetics | Chromosome Segregation - genetics | Chromosome replication | Chromosomal instability syndromes | Colorectal cancer | Development and progression | Genetic aspects | Research | Cancer | Mutation | Cellular biology | Chromosomes | DNA repair | DNA damage | Index Medicus | Medicin och hälsovetenskap
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4. Full Text Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles
by Albulescu, Irina C and Kovacikova, Kristina and Tas, Ali and Snijder, Eric J and van Hemert, Martijn J
Antiviral research, ISSN 0166-3542, 07/2017, Volume 143, pp. 230 - 236
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Virology | Mycophenolic Acid - antagonists & inhibitors | Zika Virus Infection - drug therapy | Cytopathogenic Effect, Viral - drug effects | DNA Replication - drug effects | Cercopithecus aethiops | Glycosylation - drug effects | Virus Internalization - drug effects | Suramin - administration & dosage | Suramin - antagonists & inhibitors | Zika Virus Infection - virology | Time Factors | Flavivirus - drug effects | Mycophenolic Acid - administration & dosage | Vero Cells | Virus Replication - drug effects | Zika Virus - growth & development | RNA, Viral - biosynthesis | Zika Virus - physiology | RNA, Viral - analysis | Zika Virus - drug effects | Virion - drug effects | Virus Attachment - drug effects | Virus Release - drug effects | Animals | RNA, Viral - drug effects | Birth defects | Conjunctivitis | Microbiology | RNA | Guillain-Barre syndrome | Index Medicus
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5. Full Text CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses
by Yamamoto, Makoto and Onogi, Hiroshi and Kii, Isao and Yoshida, Suguru and Iida, Kei and Sakai, Hiroyuki and Abe, Minako and Tsubota, Toshiaki and Ito, Nobutoshi and Hosoya, Takamitsu and Hagiwara, Masatoshi
The Journal of clinical investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3479 - 3488
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Transcription, Genetic - drug effects | Rats, Wistar | Antiviral Agents - toxicity | Pyridines - chemistry | Humans | Drug Resistance, Viral | Host-Pathogen Interactions - drug effects | DNA Viruses - genetics | Herpes Simplex - drug therapy | Herpesvirus 1, Human - physiology | Protein Kinase Inhibitors - chemistry | Piperidines - pharmacology | Antiviral Agents - chemistry | HEK293 Cells | Flavonoids - pharmacology | DNA Viruses - physiology | Cytomegalovirus - physiology | Herpesvirus 2, Human - drug effects | Disease Models, Animal | Virus Replication - drug effects | Antiviral Agents - pharmacology | Acyclovir - pharmacology | Adenoviruses, Human - physiology | Rats | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Transcriptome - drug effects | Mice, Inbred ICR | Herpesvirus 1, Human - drug effects | Herpes Simplex - virology | Animals | Host-Pathogen Interactions - genetics | Pyridines - toxicity | Herpes Simplex - pathology | Adenoviruses, Human - drug effects | Protein Kinase Inhibitors - toxicity | Herpesvirus 2, Human - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | HeLa Cells | DNA Viruses - drug effects | Cytomegalovirus - drug effects | Physiological aspects | Research | DNA viruses | Health aspects | Protein kinases | Medical research | Drug resistance | Kinases | Cell cycle | Index Medicus | Abridged Index Medicus
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6. Full Text HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
by J Buzón, Maria and Massanella, Marta and Llibre, Josep M and Esteve, Anna and Dahl, Viktor and Puertas, Maria C and Gatell, Josep M and Domingo, Pere and Paredes, Roger and Sharkey, Mark and Palmer, Sarah and Stevenson, Mario and Clotet, Bonaventura and Blanco, Juli and Martinez-Picado, Javier
Nature medicine, ISSN 1078-8956, 04/2010, Volume 16, Issue 4, pp. 460 - 465
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | HIV Integrase Inhibitors - pharmacology | Virus Replication - drug effects | HIV-1 - drug effects | HIV Infections - virology | Humans | DNA, Complementary - genetics | Pyrrolidinones - therapeutic use | HIV Long Terminal Repeat - genetics | Antiretroviral Therapy, Highly Active | HIV Infections - immunology | HIV-1 - immunology | HIV-1 - physiology | Pyrrolidinones - pharmacology | Virus Integration - drug effects | HIV Integrase Inhibitors - therapeutic use | Polymerase Chain Reaction | HIV Infections - drug therapy | DNA, Viral - genetics | HIV Long Terminal Repeat - drug effects | Raltegravir Potassium | Virus Replication - physiology | Highly active antiretroviral therapy | Dosage and administration | Research | Drug therapy | HIV infection | Health aspects | Raltegravir | Immunology | Inhibitor drugs | Antiviral drugs | Human immunodeficiency virus--HIV | Deoxyribonucleic acid--DNA | Index Medicus | Medicin och hälsovetenskap
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7. Full Text Excess Mcm2-7 License Dormant Origins of Replication That Can Be Used under Conditions of Replicative Stress
by Anna M. Woodward and Thomas Göhler and M. Gloria Luciani and Maren Oehlmann and Xinquan Ge and Anton Gartner and Dean A. Jackson and J. Julian Blow
The Journal of cell biology, ISSN 0021-9525, 6/2006, Volume 173, Issue 5, pp. 673 - 683
Replication origin | Molecules | Chromatin | Spermatozoa | DNA replication | Gels | Interphase | DNA | Small interfering RNA | Ova | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Cycle Proteins - drug effects | Chromatin - metabolism | Hydroxyurea - pharmacology | DNA Replication - drug effects | Oxidative Stress - physiology | Adenosine Triphosphatases - drug effects | Minichromosome Maintenance Complex Component 7 | Carrier Proteins - drug effects | Minichromosome Maintenance Complex Component 2 | Minichromosome Maintenance Complex Component 3 | Minichromosome Maintenance Complex Component 4 | DNA-Binding Proteins - metabolism | Aphidicolin - pharmacology | Time Factors | Caffeine - pharmacology | Nuclear Proteins - drug effects | Chromatin - drug effects | Cell Survival - drug effects | Xenopus Proteins - drug effects | Caenorhabditis elegans - growth & development | Xenopus laevis | Cell Cycle Proteins - metabolism | DNA-Binding Proteins - drug effects | Adenosine Triphosphatases - metabolism | Nuclear Proteins - metabolism | Animals | Caenorhabditis elegans - drug effects | Carrier Proteins - metabolism | DNA Replication - physiology | Replication Origin | Xenopus Proteins - metabolism | Dormancy (Biology) | Research | Index Medicus
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8. Full Text β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity
by Gutierrez, A and Laureti, L and Crussard, S and Abida, H and Rodríguez-Rojas, A and Blázquez, J and Baharoglu, Z and Mazel, D and Darfeuille, F and Vogel, J and Matic, I
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1610 - 1610
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Reactive Oxygen Species - metabolism | DNA Replication - drug effects | Vibrio cholerae - genetics | Escherichia coli - drug effects | Bacteria - drug effects | Pseudomonas aeruginosa - drug effects | Bacterial Proteins - physiology | Bacteria - genetics | Vibrio cholerae - metabolism | beta-Lactams - pharmacology | Sigma Factor - physiology | DNA Replication - physiology | Mutagenesis | Pseudomonas aeruginosa - genetics | Escherichia coli - genetics | Pseudomonas aeruginosa - metabolism | Escherichia coli - metabolism | Anti-Bacterial Agents - pharmacology | Vibrio cholerae - drug effects | Index Medicus | Life Sciences | Anti-Bacterial Agents | Sigma Factor | Reactive Oxygen Species | Vibrio cholerae | Escherichia coli | Bacteria | DNA Replication | Pseudomonas aeruginosa | beta-Lactams | Bacterial Proteins
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