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1. Full Text Persistent HIV-1 replication maintains the tissue reservoir during therapy
by Lorenzo-Redondo, Ramon and Fryer, Helen R and Bedford, Trevor and Kim, Eun-Young and Archer, John and Kosakovsky Pond, Sergei L and Chung, Yoon-Seok and Penugonda, Sudhir and Chipman, Jeffrey G and Fletcher, Courtney V and Schacker, Timothy W and Malim, Michael H and Rambaut, Andrew and Haase, Ashley T and McLean, Angela R and Wolinsky, Steven M
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7588, pp. 51 - 56
Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in... 
EVOLUTION | SEQUENCE DATA | COMBINATION THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | IN-VIVO | IMMUNODEFICIENCY-VIRUS TYPE-1 | CD4(+) T-CELLS | PERIPHERAL-BLOOD | INFECTION | Anti-HIV Agents - pharmacology | Carrier State - blood | Humans | Molecular Sequence Data | Phylogeny | Selection, Genetic - drug effects | Anti-HIV Agents - administration & dosage | HIV-1 - growth & development | Time Factors | HIV-1 - isolation & purification | Haplotypes - drug effects | Anti-HIV Agents - therapeutic use | Lymph Nodes - drug effects | Spatio-Temporal Analysis | HIV Infections - blood | Virus Replication - drug effects | HIV-1 - drug effects | HIV Infections - virology | Lymph Nodes - virology | HIV-1 - genetics | Sequence Analysis, DNA | Carrier State - virology | Models, Biological | Carrier State - drug therapy | Drug Resistance, Viral - drug effects | HIV Infections - drug therapy | Viral Load - drug effects | Infection | Highly active antiretroviral therapy | Care and treatment | Analysis | Patient outcomes | Physiological aspects | Development and progression | HIV (Viruses) | Health aspects | HIV infection | Haplotypes | Antiretroviral drugs | Tissue | Lymphatic system | Human immunodeficiency virus--HIV | Phylogenetics | Infections | Drug resistance | Index Medicus
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2. Full Text Replication fork stability confers chemoresistance in BRCA-deficient cells
by Chaudhuri, Arnab Ray and Callen, Elsa and Ding, Xia and Gogola, Ewa and Duarte, Alexandra A and Lee, Ji-Eun and Wong, Nancy and Lafarga, Vanessa and Calvo, Jennifer A and Panzarino, Nicholas J and John, Sam and Day, Amanda and Crespo, Anna Vidal and Shen, Binghui and Starnes, Linda M and De Ruiter, Julian R and Daniel, Jeremy A and Konstantinopoulos, Panagiotis A and Cortez, David and Cantor, Sharon B and Fernandez-Capetillo, Oscar and Ge, Kai and Jonkers, Jos and Rottenberg, Sven and Sharan, Shyam K and Nussenzweig, André
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7612, pp. 382 - 387
Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are... 
BREAST-CANCER | RECOMBINATION | LYSINE-4 METHYLTRANSFERASE COMPLEX | MUTANT-CELLS | 53BP1 | MULTIDISCIPLINARY SCIENCES | RESISTANCE | HOMOLOGY-DIRECTED REPAIR | CONDITIONAL MOUSE MODEL | END RESECTION | DNA-REPAIR | Physiological aspects | Chemotherapy | Replication fork | B cells | DNA damage | Cancer | Proteins | Lymphocytes | Stem cells | Breast cancer | Drug resistance | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
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3. Full Text Replication stress links structural and numerical cancer chromosomal instability
by Burrell, Rebecca A and McClelland, Sarah E and Endesfelder, David and Groth, Petra and Weller, Marie-Christine and Shaikh, Nadeem and Domingo, Enric and Kanu, Nnennaya and Dewhurst, Sally M and Gronroos, Eva and Chew, Su Kit and Rowan, Andrew J and Schenk, Arne and Sheffer, Michal and Howell, Michael and Kschischo, Maik and Behrens, Axel and Helleday, Thomas and Bartek, Jiri and Tomlinson, Ian P and Swanton, Charles
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7438, pp. 492 - 496
Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity(1,2).... 
ORIGINS | EVOLUTION | SEGREGATION ERRORS | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | DNA Damage - drug effects | RNA-Binding Proteins - genetics | Chromosomes, Human, Pair 18 - drug effects | DNA Replication - drug effects | Colorectal Neoplasms - genetics | Humans | Gene Silencing | Aneuploidy | Chromosomal Instability - drug effects | DNA Copy Number Variations - genetics | Chromosome Segregation - drug effects | Chromosomal Instability - genetics | Mitosis - drug effects | Gene Deletion | Cell Line, Tumor | DNA Damage - genetics | DNA Replication - genetics | Nucleosides - pharmacology | Chromosomes, Human, Pair 18 - genetics | Colorectal Neoplasms - pathology | Genes, Tumor Suppressor | Phosphotransferases - genetics | Chromosome Segregation - genetics | Chromosome replication | Chromosomal instability syndromes | Colorectal cancer | Development and progression | Genetic aspects | Research | Cancer | Mutation | Cellular biology | Chromosomes | DNA repair | DNA damage | Index Medicus
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4. Full Text HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
by Palmer, Sarah and Esteve, Anna and Martinez-Picado, Javier and Domingo, Pere and Puertas, Maria C and Blanco, Julià and Dahl, Viktor and Paredes, Roger and Sharkey, Mark and Clotet, Bonaventura and J Buzón, Maria and Llibre, Josep M and Gatell, Josep M and Stevenson, Mario and Massanella, Marta
Nature Medicine, ISSN 1078-8956, 04/2010, Volume 16, Issue 4, pp. 460 - 465
Highly active antiretroviral therapy (HAART) results in potent and durable suppression of HIV-1 viremia. However, HIV-1 replication resumes if therapy is... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXTENDED PERIODS | ACTIVATION | ANTIVIRAL THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CD4(+) T-CELLS | CELL BIOLOGY | INFECTED INDIVIDUALS | EVOLUTION | SUSTAINED VIRAL SUPPRESSION | ACTIVE ANTIRETROVIRAL THERAPY | IN-VIVO | IMMUNODEFICIENCY-VIRUS TYPE-1 | HIV Integrase Inhibitors - pharmacology | Virus Replication - drug effects | HIV-1 - drug effects | HIV Infections - virology | Humans | DNA, Complementary - genetics | Pyrrolidinones - therapeutic use | HIV Long Terminal Repeat - genetics | Antiretroviral Therapy, Highly Active | HIV Infections - immunology | HIV-1 - immunology | HIV-1 - physiology | Pyrrolidinones - pharmacology | Virus Integration - drug effects | HIV Integrase Inhibitors - therapeutic use | Polymerase Chain Reaction | HIV Infections - drug therapy | DNA, Viral - genetics | HIV Long Terminal Repeat - drug effects | Raltegravir Potassium | Virus Replication - physiology | Highly active antiretroviral therapy | Dosage and administration | Research | Drug therapy | HIV infection | Health aspects | Raltegravir | Immunology | Inhibitor drugs | Antiviral drugs | Human immunodeficiency virus--HIV | Deoxyribonucleic acid--DNA | Index Medicus
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5. Full Text Topoisomerase i poisoning results in PARP-mediated replication fork reversal
by Ray Chaudhuri, Arnab and Hashimoto, Yoshitami and Herrador, Raquel and Neelsen, Kai J and Fachinetti, Daniele and Bermejo, Rodrigo and Cocito, Andrea and Costanzo, Vincenzo and Lopes, Massimo
Nature Structural and Molecular Biology, ISSN 1545-9993, 04/2012, Volume 19, Issue 4, pp. 417 - 423
Topoisomerase I (Top1) releases torsional stress during DNA replication and transcription and is inhibited by camptothecin and camptothecin-derived cancer... 
POLY(ADP-RIBOSE) POLYMERASE | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | MAMMALIAN-CELLS | CANCER-THERAPY | CELL BIOLOGY | REPAIR | BIOPHYSICS | CAMPTOTHECIN | S-PHASE | INHIBITORS | PROGRESSION | Cell Line | DNA Repair - drug effects | DNA Topoisomerases, Type I - metabolism | DNA Replication - drug effects | Humans | Saccharomyces cerevisiae - drug effects | DNA - metabolism | Nucleic Acid Conformation - drug effects | Saccharomyces cerevisiae - cytology | DNA - chemistry | Poly(ADP-ribose) Polymerases - metabolism | Topoisomerase I Inhibitors - pharmacology | Animals | Xenopus laevis - metabolism | Camptothecin - pharmacology | DNA replication | Chemotherapy | Topoisomerases | Physiological aspects | Genetic aspects | Research | Cancer | Enzymes | Poisons | Yeast | Cellular biology | Toxicity | Chromosomes | Deoxyribonucleic acid--DNA | Index Medicus
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6. Full Text ATR phosphorylates SMARCAL1 to prevent replication fork collapse
by Couch, Frank B and Bansbach, Carol E and Driscoll, Robert and Luzwick, Jessica W and Glick, Gloria G and Bétous, Rémy and Carroll, Clinton M and Jung, Sung Yun and Qin, Jun and Cimprich, Karlene A and Cortez, David
Genes and Development, ISSN 0890-9369, 07/2013, Volume 27, Issue 14, pp. 1610 - 1623
The DNA damage response kinase ataxia telangiectasia and Rad3-related (ATR) coordinates much of the cellular response to replication stress. The exact... 
Cell cycle checkpoint | SMARCAL1 | DNA replication | DNA damage response | HARP | ATR | EARLY EMBRYONIC LETHALITY | PROTEIN | cell cycle checkpoint | DEVELOPMENTAL BIOLOGY | GENOME STABILITY | CELL BIOLOGY | HOLLIDAY JUNCTION RESOLVASE | SWI2/SNF2 ATPASE | GENETICS & HEREDITY | STRAND DNA BREAKS | CHECKPOINT | STRESS | ATAXIA-TELANGIECTASIA | HELICASE | DNA Damage - drug effects | Xenopus | Cell Survival - drug effects | DNA Replication - drug effects | Humans | Cell Cycle Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA, Single-Stranded - genetics | DNA Helicases - metabolism | Animals | DNA Replication - physiology | Cell Line, Tumor | Protein Binding | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Phosphorylation - drug effects | DNA Helicases - genetics | Protein-Serine-Threonine Kinases - metabolism | Prevention | Ataxia telangiectasia | Care and treatment | Analysis | Index Medicus | Research Paper
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7. Full Text β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity
by Gutierrez, A and Laureti, L and Crussard, S and Abida, H and Rodríguez-Rojas, A and Blázquez, J and Baharoglu, Z and Mazel, D and Darfeuille, F and Vogel, J and Matic, I
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1610 - 1610
Regardless of their targets and modes of action, subinhibitory concentrations of antibiotics can have an impact on cell physiology and trigger a large variety... 
SIGMA(S)-DEPENDENT GENES | STREPTOCOCCUS-PNEUMONIAE | ADAPTIVE MUTATION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI K-12 | SIGMA-FACTOR | DNA-POLYMERASE-IV | GENERAL STRESS-RESPONSE | MULTIDRUG-RESISTANCE | SOS RESPONSE | CELL-DEATH | Reactive Oxygen Species - metabolism | DNA Replication - drug effects | Vibrio cholerae - genetics | Escherichia coli - drug effects | Bacteria - drug effects | Pseudomonas aeruginosa - drug effects | Bacterial Proteins - physiology | Bacteria - genetics | Vibrio cholerae - metabolism | beta-Lactams - pharmacology | Sigma Factor - physiology | DNA Replication - physiology | Mutagenesis | Pseudomonas aeruginosa - genetics | Escherichia coli - genetics | Pseudomonas aeruginosa - metabolism | Escherichia coli - metabolism | Anti-Bacterial Agents - pharmacology | Vibrio cholerae - drug effects | Index Medicus | Life Sciences | Anti-Bacterial Agents | Sigma Factor | Reactive Oxygen Species | Vibrio cholerae | Escherichia coli | Bacteria | DNA Replication | Pseudomonas aeruginosa | beta-Lactams | Bacterial Proteins
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8. Full Text The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
by Sacramento, Carolina Q and De Melo, Gabrielle R and De Freitas, Caroline S and Rocha, Natasha and Hoelz, Lucas Villas Bôas and Miranda, Milene and Fintelman-Rodrigues, Natalia and Marttorelli, Andressa and Ferreira, André C and Barbosa-Lima, Giselle and Abrantes, Juliana L and Vieira, Yasmine Rangel and Bastos, Mônica M and De Mello Volotão, Eduardo and Nunes, Estevão Portela and Tschoeke, Diogo A and Leomil, Luciana and Loiola, Erick Correia and Trindade, Pablo and Rehen, Stevens K and Bozza, Fernando A and Bozza, Patrícia T and Boechat, Nubia and Thompson, Fabiano L and De Filippis, Ana M. B and Brüning, Karin and Souza, Thiago Moreno L
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, pp. 40920 - 40920
Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses.... 
DENGUE | CELLS | DEPENDENT-RNA-POLYMERASE | INFECTION | MULTIDISCIPLINARY SCIENCES | Sofosbuvir - therapeutic use | Cell Line | Cell Survival - drug effects | Genome, Viral | Virus Replication - drug effects | Zika Virus Infection - drug therapy | Antiviral Agents - pharmacology | Sofosbuvir - pharmacology | Zika Virus - genetics | DNA-Directed RNA Polymerases - antagonists & inhibitors | Antiviral Agents - therapeutic use | Zika Virus Infection - pathology | Humans | Zika Virus - physiology | Viral Proteins - antagonists & inhibitors | Zika Virus - isolation & purification | Viral Proteins - metabolism | Zika Virus Infection - virology | Mutation | DNA-Directed RNA Polymerases - metabolism | Zika virus | RNA polymerase | Organoids | Dengue | Virology | Index Medicus
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9. Full Text Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria
by Santi, Isabella and Dhar, Neeraj and Bousbaine, Djenet and Wakamoto, Yuichi and McKinney, John D
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2470 - 2470
During the bacterial cell cycle, chromosome replication and cell division must be coordinated with overall cell growth in order to maintain the correct ploidy... 
SMEGMATIS | WAG31 | SIZE CONTROL | COLI | MULTIDISCIPLINARY SCIENCES | GROWTH | DNA-REPLICATION | Green Fluorescent Proteins - metabolism | Mycobacterium smegmatis - metabolism | DNA Replication - drug effects | Cell Size - drug effects | Protein Transport - drug effects | Time-Lapse Imaging | Cell Division - drug effects | Mycobacterium smegmatis - cytology | Chromosomes, Bacterial - metabolism | Single-Cell Analysis - methods | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Homeostasis - drug effects | Cytokinesis - drug effects | Index Medicus
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10. Full Text Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication
by Dong, Chunsheng and Dong, Yuansu and Qu, Liang and Wang, Haoyi and Wei, Lin and Xiong, Sidong
Antiviral Research, ISSN 0166-3542, 06/2015, Volume 118, pp. 110 - 117
Chronic hepatitis B virus (HBV) infection causes liver cirrhosis and hepatocellular carcinoma and remains a serious health problem worldwide. Covalently closed... 
DNA targeting | CRISPR/Cas9 | Viral replication | HBV | CELLS | STRATEGY | ENDONUCLEASE | VIROLOGY | DNA | IN-VIVO | LIVER | EFFECTOR NUCLEASES | SYSTEMS | PHARMACOLOGY & PHARMACY | INFECTION | MICE | Cell Line | Virus Replication - drug effects | Endonucleases - genetics | CRISPR-Associated Proteins - genetics | Humans | DNA, Viral - metabolism | Drug Carriers - administration & dosage | Treatment Outcome | Antiviral Agents - metabolism | Endonucleases - metabolism | Antiviral Agents - administration & dosage | DNA, Circular - metabolism | Hepatitis B virus - physiology | Hepatitis B virus - drug effects | Animals | Hepatitis B, Chronic - drug therapy | CRISPR-Associated Proteins - metabolism | Hepatocytes - virology | Female | Mice, Inbred BALB C | Hepatocytes - drug effects | Plasmids - administration & dosage | Disease Models, Animal | Antiviral agents | Analysis | Hepatitis B | Index Medicus
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