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1. Full Text Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination
by Loc'h, Jérôme and Rosario, Sandrine and Delarue, Marc
Structure (London), ISSN 0969-2126, 09/2016, Volume 24, Issue 9, pp. 1452 - 1463
X-ray crystallography | micro-homology base pair | double-strand-break DNA repair | V(D)J recombination | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Substrate Specificity | Crystallography, X-Ray | DNA-Directed DNA Polymerase - chemistry | DNA Nucleotidylexotransferase - chemistry | DNA-Directed DNA Polymerase - genetics | Nucleotides - chemistry | Base Sequence | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | DNA Nucleotidylexotransferase - genetics | V(D)J Recombination | Models, Molecular | Recombinant Proteins - chemistry | DNA Nucleotidylexotransferase - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Nucleotides - metabolism | DNA - genetics | Sequence Homology, Amino Acid | DNA - chemistry | Sequence Alignment | Protein Conformation, beta-Strand | Protein Binding | DNA-Directed DNA Polymerase - metabolism | Index Medicus | Biochemistry, Molecular Biology | Nucleotides | Recombinant Proteins | Cristallography | Chemical Sciences | Life Sciences | DNA | DNA Nucleotidylexotransferase | DNA-Directed DNA Polymerase
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2. Full Text Mimivirus encodes a multifunctional primase with DNA/RNA polymerase, terminal transferase and translesion synthesis activities
by Gupta, Ankita and Lad, Shailesh B and Ghodke, Pratibha P and Pradeepkumar, P. I and Kondabagil, Kiran
Nucleic acids research, ISSN 0305-1048, 07/2019, Volume 47, Issue 13, pp. 6932 - 6945
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | RNA | DNA Primase - metabolism | DNA-Directed RNA Polymerases - isolation & purification | DNA-Directed DNA Polymerase - chemistry | DNA Nucleotidylexotransferase - chemistry | DNA-Directed DNA Polymerase - genetics | Mimiviridae - enzymology | Mimiviridae - genetics | RNA-Directed DNA Polymerase - isolation & purification | RNA-Directed DNA Polymerase - chemistry | RNA-Directed DNA Polymerase - genetics | Conserved Sequence | DNA Primase - genetics | DNA-Directed RNA Polymerases - chemistry | Dimerization | DNA Primase - chemistry | Amino Acid Sequence | DNA Nucleotidylexotransferase - isolation & purification | DNA-Directed DNA Polymerase - isolation & purification | DNA Primase - isolation & purification | RNA-Directed DNA Polymerase - metabolism | DNA Nucleotidylexotransferase - genetics | DNA Nucleotidylexotransferase - metabolism | DNA-Directed RNA Polymerases - genetics | DNA Primers | Amino Acid Motifs | Sequence Homology, Amino Acid | Sequence Alignment | DNA-Directed DNA Polymerase - metabolism | DNA-Directed RNA Polymerases - metabolism | Index Medicus | Nucleic Acid Enzymes
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3. Full Text Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase capable of DNA bridging and templated synthesis across strands
by Loc'h, Jérôme and Delarue, Marc
Current opinion in structural biology, ISSN 0959-440X, 12/2018, Volume 53, pp. 22 - 31
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | DNA Repair Enzymes - physiology | Animals | DNA Repair | Humans | V(D)J Recombination | DNA Nucleotidylexotransferase - physiology | DNA Nucleotidylexotransferase - metabolism | DNA-Directed DNA Polymerase - chemistry | DNA Nucleotidylexotransferase - chemistry | DNA polymerases | DNA synthesis | Structure | T cells | DNA | Crystals | Index Medicus | Life Sciences | Biochemistry, Molecular Biology
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4. Full Text New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization, and Crystal Structure in Complex with the Target
by Costi, Roberta and Cuzzucoli Crucitti, Giuliana and Pescatori, Luca and Messore, Antonella and Scipione, Luigi and Tortorella, Silvano and Amoroso, Alessandra and Crespan, Emmanuele and Campiglia, Pietro and Maresca, Bruno and Porta, Amalia and Granata, Ilaria and Novellino, Ettore and Gouge, Jérôme and Delarue, Marc and Maga, Giovanni and Di Santo, Roberto
Journal of medicinal chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 18, pp. 7431 - 7441
Binding, Competitive | Deoxyadenine Nucleotides - metabolism | Catalytic Domain | Enzyme Inhibitors - metabolism | Apoptosis - drug effects | DNA, Single-Stranded - metabolism | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | Crystallography, X-Ray | DNA Nucleotidylexotransferase - metabolism | Hexuronic Acids - chemistry | Nucleotides - metabolism | DNA Nucleotidylexotransferase - chemistry | Drug Discovery | DNA, Single-Stranded - chemistry | DNA Nucleotidylexotransferase - antagonists & inhibitors | Dideoxynucleotides - metabolism | Enzyme Inhibitors - chemistry | Cell Line, Tumor | Cell Cycle - drug effects | Hexuronic Acids - metabolism | Hexuronic Acids - pharmacology | Index Medicus | Enzyme Inhibitors | Nucleotides | Hexuronic Acids | Life Sciences | Cell Cycle | Deoxyadenine Nucleotides | DNA Nucleotidylexotransferase | DNA, Single-Stranded | Dideoxynucleotides | Pharmaceutical sciences | Apoptosis
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5. Full Text Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
by Bertocci, Barbara and De Smet, Annie and Weill, Jean-Claude and Reynaud, Claude-Agnès
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2006, Volume 25, Issue 1, pp. 31 - 41
MOLIMMUNO | DNA | Life Sciences & Biomedicine | Immunology | Science & Technology | DNA-Directed DNA Polymerase - deficiency | DNA-Directed DNA Polymerase - genetics | DNA Polymerase beta - deficiency | Cellular Senescence - immunology | Immunoglobulin J-Chains - genetics | Isoenzymes - metabolism | Recombination, Genetic | Base Sequence | RNA Splicing - genetics | Fibroblasts | Cell Differentiation | DNA Polymerase beta - metabolism | DNA Polymerase beta - genetics | Gene Rearrangement, B-Lymphocyte - genetics | B-Lymphocytes - cytology | Cells, Cultured | DNA Nucleotidylexotransferase - classification | Gene Expression Regulation | DNA Nucleotidylexotransferase - metabolism | Mice, Knockout | Sequence Alignment | Animals | B-Lymphocytes - immunology | Immunoglobulin Variable Region - genetics | Mice | DNA-Directed DNA Polymerase - metabolism | Gene Rearrangement - genetics | Competition | Enzymes | Genes | Light | Genomes | DNA repair | Deoxyribonucleic acid--DNA | Index Medicus | Isoenzymes | DNA Polymerase beta | B-Lymphocytes | Cell Aging | Immunoglobulin J-Chains | Life Sciences | RNA Splicing | Gene Rearrangement | DNA Nucleotidylexotransferase | Gene Rearrangement, B-Lymphocyte | Immunoglobulin Variable Region | DNA-Directed DNA Polymerase
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6. Full Text Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism
by Gouge, Jérôme and Rosario, Sandrine and Romain, Félix and Beguin, Pierre and Delarue, Marc
Journal of molecular biology, ISSN 0022-2836, 11/2013, Volume 425, Issue 22, pp. 4334 - 4352
X-ray crystallography | two-metal ion mechanism | DNA translocation | DNA polymerase | structures of intermediates | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Catalytic Domain | Ions - chemistry | Zinc - metabolism | DNA, Single-Stranded - metabolism | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | DNA Nucleotidylexotransferase - metabolism | Ions - metabolism | Zinc - chemistry | DNA Nucleotidylexotransferase - chemistry | DNA, Single-Stranded - chemistry | Cobalt - metabolism | Metals - metabolism | Metals - chemistry | Protein Binding | Ligands | Protein Conformation | Catalysis | Cobalt - chemistry | Zinc compounds | Immunoglobulins | T cells | Analysis | DNA polymerases | Index Medicus | Metals | Biochemistry, Molecular Biology | Ions | Cobalt | Cristallography | Zinc | Chemical Sciences | Life Sciences | DNA Nucleotidylexotransferase | DNA, Single-Stranded
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7. Full Text Terminal deoxynucleotidyl transferase (TdT) expression is associated with FLT3-ITD mutations in Acute Myeloid Leukemia
by De Bellis, Eleonora and Ottone, Tiziana and Mercante, Lisa and Falconi, Giulia and Cugini, Elisa and Consalvo, Maria Irno and Travaglini, Serena and Paterno, Giovangiacinto and Piciocchi, Alfonso and Rossi, Elisa Linnea Lindfors and Gurnari, Carmelo and Maurillo, Luca and Buccisano, Francesco and Arcese, William and Voso, Maria Teresa
Leukemia research, ISSN 0145-2126, 12/2020, Volume 99, pp. 106462 - 106462
overall survival | acute myeloid leukemia | FLT3-ITD mutations | “filler” sequences | terminal deoxynucleotidyl transferase | DNA Nucleotidylexotransferase - genetics | Neoplasm Proteins - biosynthesis | Humans | Middle Aged | Neoplasm Proteins - physiology | Kaplan-Meier Estimate | DNA Replication | Male | DNA Nucleotidylexotransferase - biosynthesis | Leukemia, Myeloid, Acute - mortality | Young Adult | fms-Like Tyrosine Kinase 3 - genetics | Leukemia, Myeloid, Acute - enzymology | Mutagenesis | Aged, 80 and over | Adult | DNA Nucleotidylexotransferase - physiology | Female | Aged | DNA, Neoplasm - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Leukemia, Myeloid, Acute - genetics | Fluorescence | DNA polymerases | Enzymes | Genetic aspects | Chromosomes | Analysis | Index Medicus
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8. Full Text Structural evidence for an in trans base selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction
by Loc'h, Jerome and Gerodimos, Christina A and Rosario, Sandrine and Tekpinar, Mustafa and Lieber, Michael R and Delarue, Marc
The Journal of biological chemistry, ISSN 0021-9258, 07/2019, Volume 294, Issue 27, pp. 10579 - 10595
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | DNA Nucleotidylexotransferase - genetics | Catalytic Domain - genetics | Substrate Specificity | DNA Nucleotidylexotransferase - metabolism | DNA - metabolism | DNA-Directed DNA Polymerase - chemistry | Recombinant Fusion Proteins - chemistry | DNA Breaks, Double-Stranded | DNA Nucleotidylexotransferase - chemistry | Isomerism | DNA-Directed DNA Polymerase - genetics | DNA - chemistry | Sequence Alignment | Animals | DNA End-Joining Repair | Recombinant Fusion Proteins - genetics | Mice | DNA-Directed DNA Polymerase - metabolism | Index Medicus | Life Sciences | Biomolecules | Cristallography | Biochemistry, Molecular Biology | Chemical Sciences | DNA and Chromosomes | DNA polymerase | DNA synapsis | DNA damage | DNA bridging | V(D)J recombination | non-homologous DNA end joining | DNA polymerase Pol X family | junctional diversity | DNA repair | X-ray crystallography | ternary complex | double-strand break | Pol μ catalytic cycle | structural biology
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9. Full Text Amplified Analysis of DNA or Proteins by TdT-generated DNAzyme
by Liu, Zhuoliang and Liu, Tianxiong and Tao, Cheng-An and Chen, Xianzhe and Huang, Jian and Wang, Fang and Wang, Jianfang
Analytical sciences, ISSN 0910-6340, 07/2020, Volume 36, Issue 7, pp. 835 - 840
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | DNA, Catalytic - chemistry | Proteins - metabolism | DNA - analysis | Humans | DNA - biosynthesis | DNA Nucleotidylexotransferase - metabolism | Proteins - analysis | DNA, Catalytic - metabolism | DNA Nucleotidylexotransferase - chemistry | Nucleic Acid Amplification Techniques | Nicking endonuclease | Fragments | Thrombin | Colorimetry | Nucleic acids | Guanine | DNA nucleotidylexotransferase | Proteins | Amplification | Hemin | Signal processing | Biomarkers | Cleavage | Biomolecules | Peroxidase | Biosensors | Endonuclease | Deoxyribonucleic acid--DNA | Target detection | Prolongation | Index Medicus
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10. Full Text Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase
by Fowler, Jason D and Suo, Zucai
Chemical reviews, ISSN 0009-2665, 06/2006, Volume 106, Issue 6, pp. 2092 - 2110
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Catalytic Domain | DNA Nucleotidylexotransferase - genetics | Immune System - enzymology | Humans | Molecular Conformation | DNA Nucleotidylexotransferase - classification | DNA Nucleotidylexotransferase - metabolism | DNA Nucleotidylexotransferase - chemistry | Animals | Recombination, Genetic | Molecular Structure | Enzyme Activation | Kinetics | Mutation | Methylation | Enzymes | Genetics | Biochemistry | DNA polymerase | DNA repair | Immune system | Index Medicus
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