Annual Review of Physical Chemistry, ISSN 0066-426X, 4/2015, Volume 66, Issue 1, pp. 497 - 519
Ultraviolet (UV) radiation is a leading external hazard to the integrity of DNA. Exposure to UV radiation triggers a cascade of chemical reactions, and many...
dimeric photoproducts | UV-induced photolesions | DNA photochemistry | charge transfer excited states | CPD formation | ultrafast spectroscopy | THYMINE DIMER FORMATION | MOLECULAR-DYNAMICS | TRIPLET-STATE | CHEMISTRY, PHYSICAL | UV-INDUCED FORMATION | EXCITED-STATE DYNAMICS | RESOLVED INFRARED-SPECTROSCOPY | CYCLOBUTANE PYRIMIDINE DIMERS | ULTRAFAST INTERNAL-CONVERSION | ENERGY-TRANSFER | SPORE-PHOTOPRODUCT FORMATION | DNA - genetics | DNA - chemistry | Animals | Ultraviolet Rays | Humans | Models, Molecular | Nucleic Acid Conformation - radiation effects | DNA Damage - radiation effects | Photochemical Processes | Ultraviolet radiation | Identification and classification | Health aspects | DNA damage | Spectrum analysis | Methods
dimeric photoproducts | UV-induced photolesions | DNA photochemistry | charge transfer excited states | CPD formation | ultrafast spectroscopy | THYMINE DIMER FORMATION | MOLECULAR-DYNAMICS | TRIPLET-STATE | CHEMISTRY, PHYSICAL | UV-INDUCED FORMATION | EXCITED-STATE DYNAMICS | RESOLVED INFRARED-SPECTROSCOPY | CYCLOBUTANE PYRIMIDINE DIMERS | ULTRAFAST INTERNAL-CONVERSION | ENERGY-TRANSFER | SPORE-PHOTOPRODUCT FORMATION | DNA - genetics | DNA - chemistry | Animals | Ultraviolet Rays | Humans | Models, Molecular | Nucleic Acid Conformation - radiation effects | DNA Damage - radiation effects | Photochemical Processes | Ultraviolet radiation | Identification and classification | Health aspects | DNA damage | Spectrum analysis | Methods
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2008, Volume 58, Issue 5, pp. S139 - S148
It is well established that ultraviolet (UV) radiation from sunlight damages skin cells' DNA. Wavelengths in the UVB range are absorbed by DNA and can induce...
Dermatology | IN-VITRO | CYCLOBUTANE PYRIMIDINE DIMERS | THYMINE DIMERS | ACTION SPECTRA | PHOTOPROTECTION ASSESSMENT | HUMAN MELANOCYTES | MAMMALIAN-CELLS | ULTRAVIOLET-B RADIATION | HUMAN KERATINOCYTES | IRRADIATED MICE | DERMATOLOGY | Photosensitivity Disorders - chemically induced | Immune Tolerance - physiology | Humans | Oxidative Stress - physiology | Comet Assay | Ultraviolet Rays - adverse effects | Tumor Suppressor Protein p53 - physiology | Sunlight - adverse effects | Animals | DNA Damage - physiology | Skin - radiation effects | DNA Repair | Cell Cycle - physiology | Apoptosis - physiology | DNA | Index Medicus
Dermatology | IN-VITRO | CYCLOBUTANE PYRIMIDINE DIMERS | THYMINE DIMERS | ACTION SPECTRA | PHOTOPROTECTION ASSESSMENT | HUMAN MELANOCYTES | MAMMALIAN-CELLS | ULTRAVIOLET-B RADIATION | HUMAN KERATINOCYTES | IRRADIATED MICE | DERMATOLOGY | Photosensitivity Disorders - chemically induced | Immune Tolerance - physiology | Humans | Oxidative Stress - physiology | Comet Assay | Ultraviolet Rays - adverse effects | Tumor Suppressor Protein p53 - physiology | Sunlight - adverse effects | Animals | DNA Damage - physiology | Skin - radiation effects | DNA Repair | Cell Cycle - physiology | Apoptosis - physiology | DNA | Index Medicus
Journal Article
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Photodamage to isolated mononucleotides - Photodissociation spectra and fragment channels
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2009, Volume 11, Issue 11, pp. 1740 - 1751
UV excitation of isolated singly-charged deprotonated mononucleotide anions in the gas phase can lead to their dissociation. We present mass spectrometry...
LOW-ENERGY ELECTRONS | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | GAS-PHASE ACIDITIES | ISOLATED DNA BASES | SINGLE DNA | COLLISION-INDUCED DISSOCIATION | THEORETICAL ESTIMATIONS | EXCITED-STATE DYNAMICS | PROTON-TRANSFER | RESONANT FORMATION | PHOTOELECTRON-SPECTROSCOPY | Thymine - chemistry | Spectrometry, Mass, Electrospray Ionization | Ultraviolet Rays | Guanine - chemistry | Cytosine - chemistry | Spectrum Analysis | Adenine - chemistry | Photochemistry
LOW-ENERGY ELECTRONS | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | GAS-PHASE ACIDITIES | ISOLATED DNA BASES | SINGLE DNA | COLLISION-INDUCED DISSOCIATION | THEORETICAL ESTIMATIONS | EXCITED-STATE DYNAMICS | PROTON-TRANSFER | RESONANT FORMATION | PHOTOELECTRON-SPECTROSCOPY | Thymine - chemistry | Spectrometry, Mass, Electrospray Ionization | Ultraviolet Rays | Guanine - chemistry | Cytosine - chemistry | Spectrum Analysis | Adenine - chemistry | Photochemistry
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 10/2018, Volume 179, Issue 4, pp. 940 - 950
Summary Background Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations...
Pyrimidines | Toiletries industry | Vitamin D | Analysis | DNA | Radiation | Calcifediol | Skin | Alfacalcidol | Skin cancer | Creatinine | Urine | Spectroscopy | Ultraviolet radiation | U.V. radiation | DNA damage | Children | Erythema | Cyclobutane pyrimidine dimers | Pigmentation | Index Medicus
Pyrimidines | Toiletries industry | Vitamin D | Analysis | DNA | Radiation | Calcifediol | Skin | Alfacalcidol | Skin cancer | Creatinine | Urine | Spectroscopy | Ultraviolet radiation | U.V. radiation | DNA damage | Children | Erythema | Cyclobutane pyrimidine dimers | Pigmentation | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2003, Volume 278, Issue 3, pp. 2021 - 2029
Photodynamic therapy using the photosensitizer Pc 4 and red light photochemically destroys the antiapoptotic protein Bcl-2 and induces apoptosis. To...
PROGRAMMED CELL-DEATH | OVEREXPRESSION | LOCALIZATION | ACTIVATION | PHOTODYNAMIC THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | APOPTOTIC PROTEIN BAK | MITOCHONDRIAL-MEMBRANE | MEDIATED APOPTOSIS | DNA-REPAIR | Green Fluorescent Proteins | Humans | Male | Mitochondria - metabolism | DNA Primers | Photochemotherapy | Microscopy, Confocal | Proto-Oncogene Proteins c-bcl-2 - metabolism | Singlet Oxygen - metabolism | Photosensitizing Agents - pharmacology | Luminescent Proteins - radiation effects | Base Sequence | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Membrane - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins c-bcl-2 - radiation effects | Luminescent Proteins - metabolism
PROGRAMMED CELL-DEATH | OVEREXPRESSION | LOCALIZATION | ACTIVATION | PHOTODYNAMIC THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | APOPTOTIC PROTEIN BAK | MITOCHONDRIAL-MEMBRANE | MEDIATED APOPTOSIS | DNA-REPAIR | Green Fluorescent Proteins | Humans | Male | Mitochondria - metabolism | DNA Primers | Photochemotherapy | Microscopy, Confocal | Proto-Oncogene Proteins c-bcl-2 - metabolism | Singlet Oxygen - metabolism | Photosensitizing Agents - pharmacology | Luminescent Proteins - radiation effects | Base Sequence | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Membrane - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins c-bcl-2 - radiation effects | Luminescent Proteins - metabolism
Journal Article
Photochemistry and Photobiology, ISSN 0031-8655, 09/2012, Volume 88, Issue 5, pp. 1111 - 1125
Although keratinocytes are relatively resistant to ultraviolet radiation (UVR) induced damage, repeated UVR exposure result in accumulated DNA mutations that...
INDUCED DNA-DAMAGE | IL-1-LIKE CYTOKINE IL-33 | IFN-GAMMA PRODUCTION | BIOPHYSICS | NOD-LIKE RECEPTORS | APOPTOTIC CELL-DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | REGULATORY T-CELLS | NECROSIS-FACTOR-ALPHA | HUMAN EPIDERMAL-KERATINOCYTES | ULTRAVIOLET-RADIATION | Interleukin-18 - immunology | Interleukin-1alpha - immunology | Apoptosis - radiation effects | Keratinocytes - radiation effects | Humans | DNA Repair - radiation effects | Signal Transduction - immunology | Interleukins - immunology | Signal Transduction - radiation effects | Inflammasomes - radiation effects | Interleukin-1beta - secretion | Epidermis - radiation effects | Interleukin-33 | Interleukin-1beta - immunology | Inflammation - immunology | Interleukin-1alpha - secretion | Keratinocytes - cytology | DNA - metabolism | Ultraviolet Rays - adverse effects | Apoptosis - immunology | Epidermis - immunology | Inflammasomes - immunology | DNA Repair - immunology | Immunity, Innate - radiation effects | Interleukin-18 - secretion | Epidermis - cytology | Interleukins - secretion
INDUCED DNA-DAMAGE | IL-1-LIKE CYTOKINE IL-33 | IFN-GAMMA PRODUCTION | BIOPHYSICS | NOD-LIKE RECEPTORS | APOPTOTIC CELL-DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | REGULATORY T-CELLS | NECROSIS-FACTOR-ALPHA | HUMAN EPIDERMAL-KERATINOCYTES | ULTRAVIOLET-RADIATION | Interleukin-18 - immunology | Interleukin-1alpha - immunology | Apoptosis - radiation effects | Keratinocytes - radiation effects | Humans | DNA Repair - radiation effects | Signal Transduction - immunology | Interleukins - immunology | Signal Transduction - radiation effects | Inflammasomes - radiation effects | Interleukin-1beta - secretion | Epidermis - radiation effects | Interleukin-33 | Interleukin-1beta - immunology | Inflammation - immunology | Interleukin-1alpha - secretion | Keratinocytes - cytology | DNA - metabolism | Ultraviolet Rays - adverse effects | Apoptosis - immunology | Epidermis - immunology | Inflammasomes - immunology | DNA Repair - immunology | Immunity, Innate - radiation effects | Interleukin-18 - secretion | Epidermis - cytology | Interleukins - secretion
Journal Article
Photochemistry and Photobiology, ISSN 0031-8655, 09/2014, Volume 90, Issue 5, pp. 1211 - 1213
When the initial effect of photodynamic therapy (PDT) involves mitochondrial photodamage, an early effect is loss of the mitochondrial membrane potential...
CYTOCHROME-C | APOPTOSIS | CELLS | BIOPHYSICS | PHOTODYNAMIC THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CANCER | Cell Survival - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | Membrane Potential, Mitochondrial - radiation effects | Mitochondria, Liver - metabolism | Mitochondria, Liver - radiation effects | Spectrometry, Fluorescence | Hepatocytes - metabolism | Porphyrins - pharmacology | Membrane Potential, Mitochondrial - drug effects | Cell Survival - radiation effects | Hepatocytes - radiation effects | Mitochondria, Liver - drug effects | Xanthenes | Photosensitizing Agents - pharmacology | Animals | Light | Cell Line, Tumor | Mice | Dose-Response Relationship, Radiation | Fluorescent Dyes | Hepatocytes - drug effects | Analysis | Mitochondrial DNA
CYTOCHROME-C | APOPTOSIS | CELLS | BIOPHYSICS | PHOTODYNAMIC THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CANCER | Cell Survival - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | Membrane Potential, Mitochondrial - radiation effects | Mitochondria, Liver - metabolism | Mitochondria, Liver - radiation effects | Spectrometry, Fluorescence | Hepatocytes - metabolism | Porphyrins - pharmacology | Membrane Potential, Mitochondrial - drug effects | Cell Survival - radiation effects | Hepatocytes - radiation effects | Mitochondria, Liver - drug effects | Xanthenes | Photosensitizing Agents - pharmacology | Animals | Light | Cell Line, Tumor | Mice | Dose-Response Relationship, Radiation | Fluorescent Dyes | Hepatocytes - drug effects | Analysis | Mitochondrial DNA
Journal Article
Photochemistry and Photobiology, ISSN 0031-8655, 09/2007, Volume 83, Issue 5, pp. 1024 - 1028
ABSTRACT Photodynamic therapy (PDT) can cause lethal photodamage by both direct and indirect mechanisms. Direct modes of cell death relate to nonspecific...
BCL-2 | BIOPHYSICS | PHOTODYNAMIC THERAPY | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE-3 | CALCIUM | BAX | STARVATION | PROTEINS | THERAPY-INDUCED DEATH | CELL-DEATH | Dose-Response Relationship, Drug | Animals | Apoptosis - drug effects | Endoplasmic Reticulum - drug effects | Photosensitizing Agents - toxicity | Cell Line, Tumor | Mesoporphyrins - pharmacology | Mice | Mitochondria - drug effects | Porphyrins - pharmacology | Photochemotherapy | Autophagy - drug effects | Photodynamic therapy | Purchasing | Protease inhibitors | Medical treatment | Amino acids | Mitochondrial DNA | Cells | Apoptosis
BCL-2 | BIOPHYSICS | PHOTODYNAMIC THERAPY | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE-3 | CALCIUM | BAX | STARVATION | PROTEINS | THERAPY-INDUCED DEATH | CELL-DEATH | Dose-Response Relationship, Drug | Animals | Apoptosis - drug effects | Endoplasmic Reticulum - drug effects | Photosensitizing Agents - toxicity | Cell Line, Tumor | Mesoporphyrins - pharmacology | Mice | Mitochondria - drug effects | Porphyrins - pharmacology | Photochemotherapy | Autophagy - drug effects | Photodynamic therapy | Purchasing | Protease inhibitors | Medical treatment | Amino acids | Mitochondrial DNA | Cells | Apoptosis
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2008, Volume 130, Issue 15, pp. 5131 - 5139
Ultraviolet irradiation of DNA produces electronic excited states that predominantly eliminate the excitation energy by returning to the ground state...
NUCLEIC-ACID BASES | WAVELENGTH-RESOLVED FLUORESCENCE | RESONANCE RAMAN-SPECTROSCOPY | GAS-PHASE | FLUORESCENCE UP-CONVERSION | ULTRAFAST INTERNAL-CONVERSION | ELECTRONIC GROUND-STATE | AROMATIC CARBONYL-COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY | EXCITED SINGLET CYTOSINE | AQUEOUS-SOLUTION | Thymine - chemistry | DNA - chemistry | Pyrimidine Dimers - radiation effects | Time Factors | Pyrimidine Dimers - chemistry | Spectrum Analysis | DNA Damage - radiation effects | Photochemistry | Fluorescence spectroscopy | Ultraviolet radiation | Research | Analysis | DNA | Index Medicus
NUCLEIC-ACID BASES | WAVELENGTH-RESOLVED FLUORESCENCE | RESONANCE RAMAN-SPECTROSCOPY | GAS-PHASE | FLUORESCENCE UP-CONVERSION | ULTRAFAST INTERNAL-CONVERSION | ELECTRONIC GROUND-STATE | AROMATIC CARBONYL-COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY | EXCITED SINGLET CYTOSINE | AQUEOUS-SOLUTION | Thymine - chemistry | DNA - chemistry | Pyrimidine Dimers - radiation effects | Time Factors | Pyrimidine Dimers - chemistry | Spectrum Analysis | DNA Damage - radiation effects | Photochemistry | Fluorescence spectroscopy | Ultraviolet radiation | Research | Analysis | DNA | Index Medicus
Journal Article