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1994, ISBN 9780120329304, Volume 29B., xvii, 315
Book
1994, ISBN 0120329298, Volume 29A., xv, 320
Book
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 09/2017, Volume 357, Issue 6358, pp. 1412 - 1416
Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc... 
REPAIR | SUMO | STRUCTURAL BASIS | TDP2 | PATHWAY | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | PHOSPHODIESTERASE | INHIBITORS | DAMAGE | COVALENT COMPLEXES | Immunoprecipitation | Humans | Gene Knockdown Techniques | HEK293 Cells | Nuclear Proteins - genetics | Recombinant Proteins - metabolism | DNA Topoisomerases, Type II - metabolism | Catalytic Domain | Biocatalysis | Small Ubiquitin-Related Modifier Proteins - metabolism | Bacterial Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Etoposide - pharmacology | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA - genetics | Transcription Factors - metabolism | Animals | DNA Repair | Saccharomyces cerevisiae Proteins - metabolism | Sumoylation | Bacterial Proteins - metabolism | DNA Topoisomerases, Type II - genetics | Luminescent Proteins - genetics | Mice | DNA Damage | Ubiquitin-Protein Ligases - genetics | Luminescent Proteins - metabolism | Proteins | Topoisomerases | Physiological aspects | Genetic research | Crosslinking | Genetic aspects | Research | Zinc finger proteins | DNA repair | Ubiquitin | Drugs | Hydrolase | Transcription | DNA damage | Genotoxicity | Phosphoesterase | Topology | Recruitment | Coordination compounds | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Phosphodiesterase
Journal Article
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 12/2010, Volume 17, Issue 35, pp. 4270 - 4290
DNA topoisomerases (topos) are essential enzymes that regulate the topological state of DNA during cellular processes such as replication, transcription, recombination, and chromatin remodeling. Topoisomerase I (Topo... 
Anticancer drugs | Topoisomerase I | Antiproliferative activity | Dual inhibitor | Topoisomerase II | RING-MODIFIED CAMPTOTHECIN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NATIONAL-CANCER-INSTITUTE | PRECLINICAL ANTITUMOR-ACTIVITY | CATALYTIC INHIBITOR | CYCLOPRODIGIOSIN HYDROCHLORIDE | NUCLEOTIDE EXCISION-REPAIR | BLOCKS NUCLEOSIDE TRANSPORT | DNA-STRAND BREAKAGE | EX-VIVO CHARACTERIZATION | PHARMACOLOGY & PHARMACY | PHASE-I | DNA Topoisomerases, Type II - metabolism | DNA Topoisomerases, Type I - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Antineoplastic Agents - chemistry | DNA - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - pharmacology | Animals | Topoisomerase II Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA topoisomerase (ATP-hydrolysing) | Enzymes | Recombination | Superhelical DNA | Transcription | Anemia | Toxicity | DNA damage | DNA topoisomerase | Chromatin remodeling | Side effects | Antitumor agents | Cell death | Replication | genomics | Cancer | Neutropenia
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2006, Volume 312, Issue 5781, pp. 1798 - 1802
Multiple enzymatic activities are required for transcriptional initiation. The enzyme DNA topoisomerase II associates with gene promoter regions and can generate breaks in double-stranded DNA (dsDNA... 
Transcriptional regulatory elements | Transcriptional activation | DNA | Genes | Histones | HeLa cells | Nucleosomes | Reports | Promoter regions | DNA breaks | Gene activation | RNA-POLYMERASE-II | POLY(ADP-RIBOSE) POLYMERASE | COACTIVATOR | CHROMATIN-STRUCTURE | NUCLEAR RECEPTORS | MULTIDISCIPLINARY SCIENCES | ESTROGEN-RECEPTOR-ALPHA | ADP-RIBOSYLATION | DEPENDENT PROTEIN-KINASE | KAPPA-B | BINDING PROTEIN
Journal Article