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1994, ISBN 9780120329304, Volume 29B., xvii, 315
Book
1994, ISBN 0120329298, Volume 29A., xv, 320
Book
Anticancer research, ISSN 0250-7005, 07/2019, Volume 39, Issue 7, pp. 3453 - 3461
To develop several new derivatives aimed to complete the studies concerning the antiproliferative profile of the oxadiazole derivative MD77. The substitution... 
DNA topoisomerase (ATP-hydrolysing) | Biotechnology | Cell lines | Tumor cell lines | Derivatives | Isomers | Viability | Cancer | Recombinant | Index Medicus
Journal Article
Genome Biology, ISSN 1474-7596, 08/2016, Volume 17, Issue 1, pp. 182 - 182
Background: Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription.... 
BioID | DNA supercoiling | Genome organization | Hi-C | Proteomics | Topological associated domains | ChIP-seq | Comparative genomics | Topoisomerase II beta | Cohesin | CTCF | ChIP-exo | DNA-DAMAGE RESPONSE | AFFINITY PURIFICATION | STRAND BREAKS | BREAST-CANCER | MODEL-BASED ANALYSIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | PROTEIN COMPLEXES | TUMOR-SUPPRESSOR | GROWTH-FACTOR | CHROMATIN INTERACTIONS | Humans | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Chromatin Immunoprecipitation | Cell Cycle Proteins - genetics | Transcription, Genetic | Binding Sites | Chromosomes | Repressor Proteins - metabolism | DNA, Ribosomal - genetics | DNA Topoisomerases, Type II - metabolism | Promoter Regions, Genetic | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Repressor Proteins - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Animals | Protein Interaction Maps - genetics | CCCTC-Binding Factor | Alleles | Protein Binding | DNA Topoisomerases, Type II - genetics | Mice | Genome | Chromatin - genetics | Deoxyribonuclease | DNA topoisomerase (ATP-hydrolysing) | Enzymes | Chromatin | Immunoprecipitation | Genomics | Genomes | Breast cancer | Regulatory sequences | Gene expression | Proteins | Nucleoli | Developmental stages | DNA methylation | Scientific imaging | Gene mapping | Protein interaction | Mass spectrometry | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
1990, Cold Spring Harbor monograph series, ISBN 9780879693480, Volume 20., ix, 480
Book
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 45, pp. E10642 - E10651
Journal Article
BMC cancer, ISSN 1471-2407, 05/2019, Volume 19, Issue 1, pp. 429 - 429
Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and... 
Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 10344 - 14
Journal Article
Nature Communications, ISSN 2041-1723, 12/2015, Volume 6, Issue 1, pp. 8962 - 8962
Journal Article
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2017, Volume 27, Issue 12, pp. 1405 - 1406
Recently, ZATT (also known as ZNF451 or Zpf451) was reported by Schellenberg et al. to aid the removal of Topoisomerase II cleavage complexes by stimulating... 
TOPOISOMERASE-II | MEDIATED DNA-DAMAGE | PHOSPHODIESTERASE | TRANSCRIPTION | CELL BIOLOGY | DNA Topoisomerases, Type II | DNA Breaks, Double-Stranded | DNA | DNA Repair | Nuclear Proteins | Poisons | DNA topoisomerase (ATP-hydrolysing) | Genomes | Deoxyribonucleic acid--DNA | Phosphodiesterase | Index Medicus | Research Highlight
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2013, Volume 23, Issue 4, pp. 934 - 938
Based on known heterocyclic topoisomerase II inhibitors and anticancer agents, various indenoindolone derivatives were predicted as potential topoisomerase... 
DNA topoisomerase (ATP-hydrolysing) | Antitumor agents | 5-Fluorouracil | Toxicity | DNA | DNA topoisomerase | Etoposide | Antitumor activity | Intercalation | oximes
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 16, pp. E934 - E943
Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here... 
Genomewide assays | Epigenetic regulation | Gene expression | Neurogenesis | METHYLATION | MULTIDISCIPLINARY SCIENCES | NEUROTROPHIN RECEPTOR P75(NTR) | ALPHA | epigenetic regulation | LYSINE-4 | HUMAN GENOME | HISTONE H3 | EMBRYONIC STEM-CELLS | neurogenesis | DNA TOPOISOMERASES | DIFFERENTIATION | EXPRESSION | gene expression | genomewide assays | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Immunoprecipitation | Oligonucleotide Array Sequence Analysis | Receptor, Nerve Growth Factor - genetics | Cell Survival - genetics | Male | Neurons - cytology | Gene Expression Profiling | Mice, 129 Strain | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | RNA Interference | Time Factors | Gene Expression Regulation, Developmental | Female | Neurons - metabolism | Neurons - drug effects | Receptor, Nerve Growth Factor - metabolism | DNA Topoisomerases, Type II - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cells, Cultured | Topoisomerase II Inhibitors - pharmacology | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Piperazines - pharmacology | Blotting, Western | Mice, Knockout | Animals | Embryonic Stem Cells - drug effects | Protein Binding | DNA Topoisomerases, Type II - genetics | Mice | Chromatin - genetics | Index Medicus | DNA topoisomerase (ATP-hydrolysing) | Chromatin | Cell survival | Transcription | Neurons | Genomes | Regulatory sequences | Longevity | Promoters | DNA biosynthesis | Lysine | Cell cycle | Stem cells | Neural stem cells | Replication | genomics | Degeneration | Differentiation | Histone H3 | Biological Sciences | PNAS Plus
Journal Article