X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (10664) 10664
Publication (1507) 1507
Book / eBook (260) 260
Book Chapter (251) 251
Book Review (237) 237
Newsletter (201) 201
Newspaper Article (96) 96
Dissertation (34) 34
Conference Proceeding (30) 30
Magazine Article (2) 2
Reference (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (5218) 5218
humans (4669) 4669
dna (2656) 2656
animals (2573) 2573
biochemistry & molecular biology (2268) 2268
microbiology (2080) 2080
deoxyribonucleic acid--dna (1781) 1781
mutation (1612) 1612
cancer (1504) 1504
research (1503) 1503
dna damage (1482) 1482
proteins (1476) 1476
dna repair (1407) 1407
cell biology (1391) 1391
pharmacology & pharmacy (1388) 1388
escherichia-coli (1311) 1311
oncology (1233) 1233
analysis (1232) 1232
genetic aspects (1214) 1214
microbial sensitivity tests (1120) 1120
anti-bacterial agents - pharmacology (1112) 1112
dna gyrase (1072) 1072
genes (1064) 1064
female (1048) 1048
genetics & heredity (961) 961
gene expression (938) 938
molecular sequence data (937) 937
research article (916) 916
male (912) 912
apoptosis (902) 902
bacteria (883) 883
multidisciplinary sciences (858) 858
dna replication (844) 844
article (823) 823
enzymes (812) 812
chemotherapy (789) 789
infectious diseases (789) 789
dna gyrase - genetics (763) 763
genomes (760) 760
drug resistance (750) 750
base sequence (721) 721
genetics (715) 715
mice (715) 715
genomics (713) 713
medicine (713) 713
genetic research (706) 706
physiological aspects (692) 692
fluoroquinolones (688) 688
biology (662) 662
escherichia coli - genetics (659) 659
life sciences (654) 654
cell cycle (653) 653
dna topoisomerase iv - genetics (644) 644
health aspects (637) 637
topoisomerase-iv (620) 620
ciprofloxacin (618) 618
antibiotics (615) 615
in-vitro (614) 614
molecular biology (612) 612
science (611) 611
chromosomes (607) 607
protein (599) 599
deoxyribonucleic acid (596) 596
dna-binding proteins - metabolism (588) 588
cell line, tumor (581) 581
bacterial proteins - genetics (579) 579
dna, bacterial - genetics (565) 565
antineoplastic agents - pharmacology (560) 560
anti-infective agents - pharmacology (545) 545
amino acid sequence (540) 540
mutations (538) 538
fluoroquinolones - pharmacology (532) 532
homologous recombination (532) 532
chemistry, medicinal (521) 521
dna - metabolism (518) 518
plasmids (516) 516
biochemistry (515) 515
expression (509) 509
resistance (500) 500
cells (499) 499
protein binding (494) 494
gene (491) 491
middle aged (487) 487
transcription (487) 487
polymerase chain reaction (482) 482
replication (473) 473
models, molecular (467) 467
adult (465) 465
dna topoisomerase iv (462) 462
drug resistance, bacterial (461) 461
care and treatment (460) 460
escherichia coli (459) 459
tumors (458) 458
dna-binding proteins - genetics (452) 452
double-strand breaks (452) 452
mechanism (448) 448
sequence analysis, dna (446) 446
biotechnology & applied microbiology (434) 434
drug resistance, bacterial - genetics (434) 434
toxicology (431) 431
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (185) 185
UofT at Mississauga - Stacks (40) 40
UofT at Scarborough - Stacks (29) 29
UTL at Downsview - May be requested (23) 23
Collection Dvlpm't (Acquisitions) - Closed Orders (22) 22
Collection Dvlpm't (Acquisitions) - Vendor file (22) 22
Earth Sciences (Noranda) - Stacks (8) 8
Online Resources - Online (8) 8
Trinity College (John W Graham) - Stacks (8) 8
St. Michael's College (John M. Kelly) - 2nd Floor (5) 5
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (4) 4
Engineering & Comp. Sci. - Stacks (3) 3
St. Michael's Hospital - Stacks (3) 3
Chemistry (A D Allen) - Stacks (2) 2
Gerstein Science - Circulation Desk (2) 2
Gerstein Science - Reference (2) 2
St. Michael's College (John M. Kelly) - Circulation Desk (2) 2
UofT at Mississauga - Reference (2) 2
UofT at Scarborough - Withdrawn (2) 2
Victoria University E.J. Pratt - Oversize (2) 2
Chemistry (A D Allen) - Withdrawn (1) 1
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Earth Sciences (Noranda) - Circulation Desk (1) 1
Earth Sciences (Noranda) - Missing (1) 1
Earth Sciences (Noranda) - Oversize (1) 1
Engineering & Comp. Sci. - Reference (1) 1
Gerstein Science - Course Reserves (1) 1
Gerstein Science - Reserve desk (1) 1
Gerstein Science - Searching (1) 1
Physics - Course Reserves (1) 1
Physics - Missing (1) 1
Physics - Storage (1) 1
Royal Ontario Museum - Stacks (1) 1
Trinity College (John W Graham) - Oversize (1) 1
UofT at Mississauga - Circulation Desk (1) 1
UofT at Mississauga - Missing (1) 1
Victoria University E.J. Pratt - Circulation Desk (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (11248) 11248
Spanish (41) 41
Japanese (27) 27
French (16) 16
Chinese (15) 15
German (12) 12
Russian (10) 10
Portuguese (8) 8
Czech (5) 5
Polish (4) 4
Turkish (3) 3
Italian (2) 2
Korean (2) 2
Arabic (1) 1
Latin (1) 1
Romanian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2017, Volume 27, Issue 15, pp. 3353 - 3358
Novel (non-fluoroquinolone) inhibitors of bacterial type II topoisomerases (NBTIs) are an emerging class of antibacterial agents. We report an optimized series... 
Topoisomerase | Antibacterial | Fluoroquinoline | Gyrase | NBTI | MRSA | BROAD-SPECTRUM | CHEMISTRY, MEDICINAL | IIA TOPOISOMERASES | TRICYCLICS E.G | CHEMISTRY, ORGANIC | RESISTANT STAPHYLOCOCCUS-AUREUS | CARDIAC INSTABILITY | GRAM-POSITIVE ACTIVITY | ACTION-POTENTIAL DURATION | SUBSTITUTED 1,5-NAPHTHYRIDINE ANALOGS | SPECTRUM ANTIBACTERIAL AGENTS | SAFETY PROFILE | DNA Topoisomerase IV - metabolism | Staphylococcus aureus - enzymology | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Structure-Activity Relationship | Quinolines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Topoisomerase Inhibitors - pharmacology | Topoisomerase Inhibitors - chemical synthesis | Topoisomerase II Inhibitors - chemistry | Anti-Bacterial Agents - chemistry | Molecular Structure | Topoisomerase II Inhibitors - chemical synthesis | Guinea Pigs | Streptococcus pyogenes - drug effects | Quinolines - chemistry | Topoisomerase II Inhibitors - pharmacology | Anti-Bacterial Agents - chemical synthesis | Quinolines - chemical synthesis | DNA Gyrase - metabolism | Animals | Streptococcus pyogenes - enzymology | DNA Topoisomerase IV - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Topoisomerase Inhibitors - chemistry | Staphylococcus aureus - drug effects | Bacterial genetics | DNA | Medical colleges | Antibacterial agents
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 06/2019, Volume 47, Issue 10, pp. 5231 - 5242
DNA topoisomerases play essential roles in chromosome organization and replication. Most bacteria possess multiple topoisomerases which have specialized... 
ESSENTIAL GENES | ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SEQUENCE | DNA GYRASE | MUTATIONS | SEGREGATION | EXPRESSION | GENOME | RNA-POLYMERASE | Molecular Biology
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2018, Volume 152, pp. 393 - 400
Journal Article
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 11/2019, Volume 58, Issue 44, pp. 4447 - 4455
Gyrase and topoisomerase IV are the targets of fluoroquinolone antibacterials. However, the rise in antimicrobial resistance has undermined the clinical use of... 
BROAD-SPECTRUM | IN-VITRO | MECHANISM | STRUCTURAL BASIS | TRICYCLICS E.G | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUINOLONE ACTION | PURIFICATION | MYCOBACTERIUM-TUBERCULOSIS GYRASE | DNA GYRASE | POTENT INHIBITORS
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2005, Volume 351, Issue 3, pp. 545 - 561
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 44, pp. 18826 - 18831
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 41, pp. 16921 - 16932
Journal Article