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Molecular cell, ISSN 1097-2765, 2017, Volume 66, Issue 2, pp. 221 - 233.e4
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease... 
R-loop | nuclease | CRISPR RNA | target DNA cleavage | CRISPR-Cas | Cpf1 | Cas12a | Cas9 | seed sequence | crRNA processing | CRISPR-CAS SYSTEMS | IMMUNITY | COMPLEX | ENDONUCLEASE | RECOGNITION | HUMAN-CELLS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CLEAVAGE | CPF1 NUCLEASES | CELL BIOLOGY | RNA Precursors - chemistry | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | RNA, Guide - chemistry | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Bacterial - metabolism | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | RNA Precursors - genetics | Endonucleases - chemistry | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Bacterial Proteins - metabolism | Protein Conformation | Gene Editing - methods | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | DNA | Crystals | Structure | Phosphates
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2011, Volume 145, Issue 1, pp. 54 - 66
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 65, Issue 2, pp. 310 - 322
C2c1 is a type V-B CRISPR-Cas system dual-RNA-guided DNA endonuclease. Here, we report the crystal structure of Alicyclobacillus acidoterrestris C2c1 in... 
crystal structure | CRISPR-Cas system | C2c1 | genome-editing | DNA endonuclease | CRISPR-CAS SYSTEMS | ADAPTIVE IMMUNITY | ENDONUCLEASE | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPF1 | TARGET DNA | CLASSIFICATION | RESOLVASE | PROKARYOTES | CELL BIOLOGY | CRISPR-Associated Proteins - chemistry | Nucleic Acid Heteroduplexes - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | DNA Breaks, Double-Stranded | Nucleic Acid Heteroduplexes - metabolism | Alicyclobacillus - enzymology | Alicyclobacillus - genetics | RNA, Guide - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats | Endodeoxyribonucleases - metabolism | RNA, Bacterial - genetics | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | RNA, Bacterial - metabolism | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | Endodeoxyribonucleases - chemistry | Nucleic Acid Heteroduplexes - chemistry | Endodeoxyribonucleases - genetics | DNA, Bacterial - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Protein Binding | Bacterial Proteins - metabolism | Nucleases | RNA | Analysis | Genomics | DNA | Crystals | Structure
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2015, Volume 54, Issue 45, pp. 13208 - 13213
Journal Article
Journal Article