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1. Full Text Fluorescence Detection of Lead(II) Ions Through Their Induced Catalytic Activity of DNAzymes
by Li, Chi-Lin and Liu, Kung-Tien and Lin, Yang-Wei and Chang, Huan-Tsung
Analytical Chemistry, ISSN 0003-2700, 01/2011, Volume 83, Issue 1, pp. 225 - 230
We have developed a fluorescence approach for the highly selective and sensitive detection of Pb2+ ions using AGRO100, a G-quadruplex DNAzyme. The sensing... 
PEROXIDASE-ACTIVITY | PB2 | CHEMISTRY, ANALYTICAL | HEMIN | FREE COLORIMETRIC DETECTION | TELOMERASE | DNA APTAMER | HYDROGEN-PEROXIDE | G-QUADRUPLEX | SELECTIVITY | BLOOD | Spectrometry, Fluorescence - methods | Oxidation-Reduction | DNA, Catalytic - genetics | Aptamers, Nucleotide - metabolism | Hydrogen Peroxide - metabolism | Aptamers, Nucleotide - genetics | Oxazines - metabolism | Biocatalysis - drug effects | Oligodeoxyribonucleotides - genetics | Base Sequence | Soil - chemistry | Lead - analysis | Biosensing Techniques - methods | Lead - pharmacology | DNA, Catalytic - metabolism | Buffers | Oligodeoxyribonucleotides - metabolism | Hydrogen-Ion Concentration | Enzymes | Composition | Analysis | Fluorescence | Lead | Atomic properties | Chemical properties | Catalysis | Research | Identification and classification | Metal ions
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2. Full Text A CRISPR-Cas9 system for genetic engineering of filamentous fungi
by Nødvig, Christina S and Nielsen, Jakob B and Kogle, Martin E and Mortensen, Uffe H
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0133085 - e0133085
The number of fully sequenced fungal genomes is rapidly increasing. Since genetic tools are poorly developed for most filamentous fungi, it is currently... 
TRANSFORMATION | EFFECTORS | ENDONUCLEASE | CRISPR/CAS9 | SPECIFICITY | ASPERGILLUS-NIDULANS | MULTIDISCIPLINARY SCIENCES | CAS SYSTEMS | SACCHAROMYCES-CEREVISIAE | EXPRESSION | GUIDE RNAS | Gene Expression Regulation, Fungal | Genetic Engineering - methods | Transformation, Genetic | Gene Targeting - methods | Aspergillus - classification | RNA, Guide - genetics | RNA, Guide - metabolism | RNA, Catalytic - metabolism | Molecular Sequence Data | Genetic Markers | Aspergillus - metabolism | Plasmids - metabolism | Mutagenesis | Escherichia coli - genetics | Base Sequence | CRISPR-Cas Systems | Escherichia coli - metabolism | Plasmids - chemistry | Aspergillus - genetics | RNA, Catalytic - genetics | Fungi | Genomes | Genetic engineering | RNA | Genomics | Genetically modified organisms | CRISPR | Biotechnology | Target recognition | Genes | Cloning | Homology | Biology | Ribonucleic acid--RNA | Publishing industry | Gene targeting | Metabolites | Mutation | Iterative methods | Deoxyribonucleic acid--DNA | Index Medicus | Ribonucleic acid | Deoxyribonucleic acid | DNA
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3. Full Text Melanoma protective antitumor immunity activated by catalytic DNA
by Cai, Hong and Cho, Eun-Ae and Li, Yue and Sockler, Jim and Parish, Christopher R and Chong, Beng H and Edwards, Jarem and Dodds, Tristan J and Ferguson, Peter M and Wilmott, James S and Scolyer, Richard A and Halliday, Gary M and Khachigian, Levon M
Oncogene, ISSN 0950-9232, 09/2018, Volume 37, Issue 37, pp. 5115 - 5126
Melanoma incidence is increasing worldwide, and although drugs such as BRAF/MEK small-molecule inhibitors and immune checkpoint antibodies improve patient... 
SURVIVAL | CD4 T-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | DNAZYME | INHIBITION | GENE | ONCOLOGY | GROWTH | MUTATION | GENETICS & HEREDITY | C-JUN | EXPRESSION | CARCINOMA | Cell Proliferation - genetics | Animals | DNA, Catalytic - genetics | Melanoma - genetics | Proto-Oncogene Proteins c-jun - genetics | Humans | Mice, Inbred C57BL | CD8 Antigens - genetics | Cell Line, Tumor | Female | Mice | CD4 Antigens - genetics | Care and treatment | Genetic aspects | Research | Gene expression | Immunity | Melanoma | Transcription factors | Immunoglobulins | CD8 antigen | Clinical trials | Antibodies | c-Jun protein | Caspase | Melanocytes | Adaptive immunity | Lymphocytes T | Metastasis | Caspase-3 | Patients | Immunosuppressive agents | Metastases | CD4 antigen | Immune checkpoint | Deoxyribonucleic acid--DNA | Tumors
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4. Full Text A microRNA-initiated DNAzyme motor operating in living cells
by Peng, Hanyong and Li, Xing-Fang and Zhang, Hongquan and Le, X. Chris
Nature Communications, ISSN 2041-1723, 03/2017, Volume 8, Issue 1, pp. 14378 - 14378
Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains... 
BREAST-CANCER | GOLD NANOPARTICLES | INTRACELLULAR-TRANSPORT | MECHANISM | WALKERS | MULTIDISCIPLINARY SCIENCES | WALKING DEVICE | DNA ENZYME | PROTEINS | NANOMACHINES | TRACK | Gold - chemistry | DNA, Catalytic - genetics | Humans | Metal Nanoparticles - chemistry | MicroRNAs - metabolism | DNA - metabolism | Manganese - chemistry | Molecular Motor Proteins - genetics | DNA - genetics | Manganese - metabolism | Cations, Divalent | MCF-7 Cells | MicroRNAs - analysis | Single-Cell Analysis - methods | Molecular Motor Proteins - metabolism | MicroRNAs - genetics | DNA, Catalytic - metabolism | Kinetics | Index Medicus
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5. Full Text Mechanistic insights into precursor messenger RNA splicing by the spliceosome
by Shi, Yigong
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 2017, Volume 18, Issue 11, pp. 655 - 670
Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of information from DNA to protein in all eukaryotes. Research over the past four... 
3-DIMENSIONAL STRUCTURE | U4/U6.U5 TRI-SNRNP | STRUCTURAL BASIS | 2ND CATALYTIC STEP | CRYSTAL-STRUCTURE | CONFORMATIONAL REARRANGEMENT | SMALL NUCLEAR RIBONUCLEOPROTEIN | CRYO-EM STRUCTURE | SACCHAROMYCES-CEREVISIAE | U6 SNRNA | CELL BIOLOGY | RNA Precursors - chemistry | Spliceosomes - genetics | Humans | RNA, Catalytic - metabolism | Crystallography, X-Ray | RNA Precursors - genetics | Spliceosomes - ultrastructure | Structure-Activity Relationship | Microscopy, Electron | RNA Splicing - physiology | Spliceosomes - metabolism | Animals | RNA Precursors - metabolism | RNA, Catalytic - genetics | RNA, Catalytic - chemistry | Spliceosomes | Messenger RNA | Research | X-ray crystallography | Eukaryotes | Biochemical analysis | Splicing | Ribonucleic acids | mRNA | Electron microscopy | Atomic structure | Crystallography | Deoxyribonucleic acid--DNA
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6. Full Text Inhibition of MIR-21 in glioma cells using catalytic nucleic acids
by Belter, Agnieszka and Rolle, Katarzyna and Piwecka, Monika and Fedoruk-Wyszomirska, Agnieszka and Naskrȩt-Barciszewska, Mirosława Z and Barciszewski, Jan
Scientific Reports, ISSN 2045-2322, 04/2016, Volume 6, Issue 1, pp. 24516 - 24516
Despite tremendous efforts worldwide, glioblastoma multiforme (GBM) remains a deadly disease for which no cure is available and prognosis is very bad.... 
MESSENGER-RNA | GENE | ENZYMES | MIRNA | MULTIDISCIPLINARY SCIENCES | HAMMERHEAD RIBOZYME | IN-VIVO | DOWN-REGULATION | EXPRESSION | CANCER | MICRORNA | Glioma - genetics | Hydrolysis | DNA, Catalytic - genetics | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - genetics | Cell Line, Tumor | MicroRNAs - genetics | RNA, Catalytic - genetics | Prognosis | Acids | Brain tumors | Brain cancer | Glioma cells | Glioblastoma | MiRNA | Ribozymes | Carcinogenesis | Glioblastoma multiforme | Tumors | Index Medicus
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7. Full Text Label free detection of lead using impedimetric sensor based on ordered mesoporous carbon–gold nanoparticles and DNAzyme catalytic beacons
by Zhou, Yaoyu and Tang, Lin and Tang, Jing and Zeng, Guangming and Zhang, Chen and Zhang, Yi and Xie, Xia and Liu, Yuanyuan and Wang, Jiajia and Deng, Yaocheng
Talanta, ISSN 0039-9140, 01/2016, Volume 146, pp. 641 - 647
A novel label-free impedimetric sensing system based on DNAzyme and ordered mesoporous carbon–gold nanoparticle (OMC–GNPs) for the determination of Pb... 
Lead | Ordered mesoporous carbon–gold nanoparticles | 8-17DNAzyme | Impedimetric sensor | Ordered mesoporous carbon-gold nanoparticles | CHEMISTRY, ANALYTICAL | SENSITIVE DETECTION | NITRIDE | PB2+ IONS | Ordered mesoporous carbon-gold nano-particles | ELECTROCHEMICAL DETECTION | AMPLIFICATION | DNA | CATECHOL | ELECTRODE | BIOSENSOR | Gold - chemistry | Limit of Detection | Nucleic Acid Hybridization | Biocatalysis | DNA, Catalytic - genetics | Metal Nanoparticles - chemistry | DNA Probes - chemistry | Electric Impedance | Carbon - chemistry | Electrodes | DNA, Catalytic - chemistry | Environmental Pollutants - chemistry | Base Sequence | DNA Probes - genetics | Electrochemistry | Lead - analysis | Biosensing Techniques - instrumentation | Biosensing Techniques - methods | DNA, Catalytic - metabolism | Porosity | Lead - chemistry | Dielectric Spectroscopy | Environmental Pollutants - analysis | Nanoparticles | Sensors | Electric properties
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8. Full Text Catalytic DNA (deoxyribozymes) for synthetic applications-current abilities and future prospects
by Silverman, Scott K
Chemical Communications, ISSN 1359-7345, 2008, Issue 30, pp. 3467 - 3485
The discovery of naturally occurring catalytic RNA (RNA enzymes, or ribozymes) in the 1980s immediately revised the view of RNA as a passive messenger that... 
CARBON BOND FORMATION | SELF-SPLICING RNA | IN-VITRO SELECTION | SYNTHESIZE BRANCHED RNA | RNA-CLEAVING DEOXYRIBOZYME | ENCODED COMBINATORIAL CHEMISTRY | TEMPLATED ORGANIC-SYNTHESIS | PHOSPHORYLATING DNA | CHEMISTRY, MULTIDISCIPLINARY | CHEMICAL LIBRARIES | NUCLEIC-ACIDS | Oligonucleotides - metabolism | DNA, Catalytic - chemistry | DNA, Catalytic - genetics | Hydroxyl Radical - chemistry | Base Sequence | DNA, Catalytic - metabolism | RNA - chemistry | RNA - metabolism
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9. Full Text Mechanistic studies reveal similar catalytic strategies for phosphodiester bond hydrolysis by protein-only and RNA-dependent ribonuclease P
by Howard, Michael J and Klemm, Bradley P and Fierke, Carol A
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 21, pp. 13454 - 13464
Ribonuclease P (RNase P) is an endonuclease that catalyzes the essential removal of the 5' end of tRNA precursors. Until recently, all identified RNase P... 
ACID-BASE CATALYSIS | PRECURSOR-TRANSFER-RNA | EVOLUTION | ACTIVE-SITE | HOLOENZYME | AFFINITY | DNA | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | METAL-IONS | CLEAVAGE | Arabidopsis Proteins - genetics | Catalytic Domain | Arabidopsis - enzymology | RNA, Catalytic - metabolism | Molecular Sequence Data | RNA Precursors - genetics | Mutation - genetics | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Hydrolysis | Ribonuclease P - genetics | Ribonuclease P - metabolism | Anisotropy | Base Sequence | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Kinetics | RNA, Catalytic - genetics | Nucleic Acid Conformation | Binding Sites | RNA, Bacterial - metabolism | Hydrogen-Ion Concentration | Metals - pharmacology | endoribonuclease | NYN | metallonuclease | precursor tRNA (pre-tRNA) | ribonuclease P (RNase P) | PRORP | metal dependence | magnesium | Enzymology | ribozyme
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10. Full Text DIRECTED EVOLUTION OF NUCLEIC ACID ENZYMES
by Joyce, Gerald F
Annual Review of Biochemistry, ISSN 0066-4154, 07/2004, Volume 73, Issue 1, pp. 791 - 836
Just as Darwinian evolution in nature has led to the development of many sophisticated enzymes, Darwinian evolution in vitro has proven to be a powerful... 
DNA enzyme | in vitro evolution | in vitro selection | combinatorial library | ribozyme | In vitro selection | Ribozyme | Combinatorial library | In vitro evolution | SELF-SPLICING RNA | CATALYTIC DNA | IMIDAZOLYL FUNCTIONALITIES | VIRUS SATELLITE RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO SELECTION | CLEAVING DNA ENZYME | MESSENGER-RNA | RNA LIGASE RIBOZYME | HAMMERHEAD RIBOZYME | SEQUENCE-SPECIFIC CLEAVAGE | Directed Molecular Evolution - methods | DNA, Catalytic - chemistry | DNA, Catalytic - genetics | RNA, Catalytic - metabolism | DNA, Catalytic - metabolism | RNA, Catalytic - genetics | RNA, Catalytic - chemistry | RNA, Catalytic - classification | Research | Nucleic acids | RNA | DNA | Enzymes | Molecules | Ribonucleic acid | Deoxyribonucleic acid | Evolution | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA
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