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PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e86358
textabstractKu70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS) to repair DNA... 
POLY(ADP-RIBOSE) POLYMERASE | CELLS | DNA-POLYMERASE BETA | BASE EXCISION-REPAIR | INTERACTS | MULTIDISCIPLINARY SCIENCES | DEFICIENT | V(D)J RECOMBINATION | XRCC1 | PROTEINS | DAMAGE | Radiation Tolerance | Male | DNA-Binding Proteins - deficiency | DNA End-Joining Repair | DNA-Activated Protein Kinase - genetics | Gene Deletion | Nuclear Proteins - deficiency | Female | Indoles - pharmacology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | Protein Subunits - genetics | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Longevity | DNA-Binding Proteins - genetics | Mice, Knockout | Point Mutation | Phenotype | Animals | Antigens, Nuclear - genetics | Ku Autoantigen | Epistasis, Genetic | Protein Subunits - deficiency | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | Mice | Apurinic Acid - genetics | Enzymes | Genetic aspects | Tumor proteins | Protein kinases | Brain | Protein kinase C | Senescence | Addition polymerization | DNA polymerase | p53 Protein | DNA damage | Science | Genomes | Biology | Epistasis | AP endonuclease | Kinases | DNA repair | Base excision repair | Defects | Proteins | Genotype & phenotype | Clonal deletion | Rodents | Deletion | Aging | Catalysis | Lesions | Repair | Public health | Deoxyribonucleic acid--DNA | Medical research | Pharmacology | Medicine | Polymerase | Life span | Protein kinase | Reagents | Non-homologous end joining | Mutation | Endonuclease | DNA-directed DNA polymerase | Cancer | Deoxyribonucleic acid | DNA
Journal Article
International Journal of Cancer, ISSN 0020-7136, 11/2012, Volume 131, Issue 10, pp. 2433 - 2444
Journal Article
Journal Article
Journal Article
Journal Article
NeuroMolecular Medicine, ISSN 1535-1084, 3/2014, Volume 16, Issue 1, pp. 161 - 174
Brain-derived neurotrophic factor (BDNF) promotes the survival and growth of neurons during brain development and mediates activity-dependent synaptic... 
Neurology | Oxidative stress | Neurosciences | Biomedicine | Exercise | Synaptic plasticity | Running | Akt kinase | Internal Medicine | Base excision repair | Alzheimer | Comet assay | NEURODEGENERATIVE DISORDERS | NEUROTROPHIC FACTOR | ALZHEIMERS-DISEASE | NEUROSCIENCES | DAMAGE | NEUROPROTECTION | CELL-DEATH | BASE EXCISION-REPAIR | TRANSCRIPTIONAL REGULATION | CEREBRAL-ISCHEMIA | BRAIN | DNA Repair - physiology | Receptor, trkB - physiology | DNA-(Apurinic or Apyrimidinic Site) Lyase - biosynthesis | Male | Cerebral Cortex - cytology | Brain-Derived Neurotrophic Factor - pharmacology | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Brain-Derived Neurotrophic Factor - physiology | RNA Interference | Receptor, trkB - antagonists & inhibitors | Enzyme Induction - drug effects | Neurons - metabolism | Neurons - drug effects | Physical Conditioning, Animal | Nerve Tissue Proteins - antagonists & inhibitors | DNA Repair - drug effects | Nerve Tissue Proteins - physiology | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Rats | Proto-Oncogene Proteins c-akt - physiology | Random Allocation | Hippocampus - cytology | Cyclic AMP Response Element-Binding Protein - physiology | Rats, Sprague-Dawley | Vitamin K 3 - pharmacology | Animals | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | Mice | Enzymes | Nucleases | Nervous system diseases | RNA | Neurons | DNA damage | Amyloid beta-protein | DNA repair | Analysis | DNA | Alzheimer's disease | Protein binding | AKT protein
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 05/2016, Volume 55, Issue 5, pp. 688 - 704
The apurinic/apyrimidinic endonuclease 1 (APE1) is a protein central to the base excision DNA repair pathway and operates in the modulation of gene expression... 
combination therapy | NPM1 | small molecule | protein/protein interaction | APE1 | Protein/protein interaction | Small molecule | Combination therapy | APE1/REF-1 | CRITICAL LYSINE RESIDUES | protein interaction | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOCELLULAR-CARCINOMA | PROTEIN INTERACTIONS | NUCLEOPHOSMIN | ONCOLOGY | protein | N-TERMINAL DOMAIN | DNA-REPAIR | EXPRESSION | Neoplasms - metabolism | Cell Survival - drug effects | Small Molecule Libraries - pharmacology | Humans | Nuclear Proteins - metabolism | High-Throughput Screening Assays | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | MCF-7 Cells | Nuclear Proteins - antagonists & inhibitors | Protein Binding - drug effects | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | HeLa Cells | Neoplasms - pathology | Proteins | Chemotherapy | Pharmacology | DNA repair | Tumors | Cell proliferation | Drugs | Surgical implants | Ovarian carcinoma | High-throughput screening | Genomes | Drug development | Assaying | Ovarian cancer | Anticancer properties | Biomedical materials | Antitumor agents | Bioactive compounds | Modulation | Biocompatibility | Localization | Deoxyribonucleic acid--DNA | Cell survival | Aggressive behavior | Preservation | Maturation | Tumor cells | rRNA | Light emitting diodes | Chemiluminescence | Gene expression | Screening | Inhibitors | Medical prognosis | Cells (biology) | Aberration | Protein interaction | Endonuclease
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2014, Volume 57, Issue 24, pp. 10241 - 10256
The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activation of... 
BASE-EXCISION-REPAIR