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eLife, ISSN 2050-084X, 12/2012, Volume 2012, Issue 1, p. e00047
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory... 
NEUTROPHIL EXTRACELLULAR TRAPS | INTRACELLULAR DNA | DAI DLM-1/ZBP1 | MAMMALIAN DNA | IN-VIVO | BIOLOGY | V(D)J RECOMBINATION | DEPENDENT PROTEIN-KINASE | CYTOSOLIC DNA | AUTOIMMUNE-DISEASE | CYTOPLASMIC DNA | Embryo, Mammalian | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | DNA-Binding Proteins - deficiency | Vaccinia virus - immunology | DNA-Activated Protein Kinase - genetics | Nuclear Proteins - deficiency | Herpesvirus 1, Human - immunology | Influenza A virus - immunology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Fibroblasts - virology | DNA-Binding Proteins - immunology | Signal Transduction | Gene Expression Regulation - immunology | Membrane Proteins - genetics | DNA, Viral - metabolism | Protein-Serine-Threonine Kinases - genetics | V(D)J Recombination | Membrane Proteins - immunology | DNA-Binding Proteins - genetics | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | DNA, Viral - immunology | Animals | DNA Repair - immunology | Interferon Type I - genetics | Fibroblasts - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Primary Cell Culture | DNA-Activated Protein Kinase - immunology | Cytokines - biosynthesis | Protein kinase C | Severe combined immunodeficiency | Transcription | Genes | Viruses | Innate immunity | Infections | Kinases | DNA repair | Proteins | Fibroblasts | Sensors | Localization | Deoxyribonucleic acid--DNA | RNA viruses | Fractionation | Statistical analysis | Cytokines | V(D)J recombination | Inflammation | RNA polymerase | Pattern recognition | DNA viruses | DNA-dependent protein kinase | Interferon regulatory factor 3 | Cytoplasm | Chemokines
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 135, Issue 6, pp. 1578 - 1588.e5
Background PRKDC encodes for DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a kinase that forms part of a complex (DNA-dependent protein kinase... 
Allergy and Immunology | autoimmunity | PRKDC | DNA-dependent protein kinase catalytic subunit | Autoimmune regulator | VDJ recombination | severe combined immunodeficiency | tolerance | recombination-activating gene | AUTOANTIBODIES | DEFECTS | HYPEREOSINOPHILIA OMENNS SYNDROME | IMMUNOLOGY | DEFICIENCY | RESPONSES | THYMUS | CALCIUM-SENSING RECEPTOR | ALLERGY | DISEASE | T-CELLS | Th1 Cells - pathology | Immunologic Deficiency Syndromes - pathology | Granuloma - metabolism | Humans | Autoimmunity - genetics | Male | Th2 Cells - immunology | Autoantibodies - biosynthesis | Th1 Cells - immunology | Th1 Cells - metabolism | Young Adult | DNA End-Joining Repair - immunology | DNA-Activated Protein Kinase - genetics | Nuclear Proteins - deficiency | Female | V(D)J Recombination - immunology | B-Lymphocytes - pathology | Immunologic Deficiency Syndromes - immunology | Nuclear Proteins - genetics | Transcription Factors - immunology | DNA-Activated Protein Kinase - deficiency | B-Lymphocytes - metabolism | Th2 Cells - pathology | Skin Neoplasms - pathology | Granuloma - genetics | Skin Neoplasms - immunology | Gene Expression Regulation | Immune Tolerance | Transcription Factors - genetics | Nuclear Proteins - immunology | Th2 Cells - metabolism | Skin Neoplasms - metabolism | Granuloma - pathology | Animals | B-Lymphocytes - immunology | Skin Neoplasms - genetics | Adolescent | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Granuloma - immunology | Mice | Mutation | DNA-Activated Protein Kinase - immunology | Autoimmunity | Genetic research | Genetic aspects | T cells | Immunodeficiency | T cell receptors | Kinases | Genes | Immune system | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2018, Volume 46, Issue 16, pp. 8326 - 8346
Abstract Chronic low levels of survival motor neuron (SMN) protein cause spinal muscular atrophy (SMA). SMN is ubiquitously expressed, but the mechanisms... 
REPAIR | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL PAUSE SITES | OCULOMOTOR APRAXIA TYPE-2 | R-LOOPS | SMN DEFICIENCY | ATAXIA | MUTATIONS | HELICASE | FINGER PROTEIN ZPR1 | RNA, Small Interfering - genetics | Spinal Muscular Atrophies of Childhood - genetics | Humans | Male | DNA Breaks, Double-Stranded | DNA-Binding Proteins - deficiency | Motor Neurons - pathology | RNA Helicases - physiology | RNA Interference | Cell Division | DNA-Activated Protein Kinase - genetics | Nuclear Proteins - deficiency | Survival of Motor Neuron 2 Protein - genetics | RNA Helicases - deficiency | Survival of Motor Neuron 1 Protein - genetics | Fibroblasts | RNA Helicases - genetics | Survival of Motor Neuron 2 Protein - deficiency | Nuclear Proteins - genetics | Nucleic Acid Conformation | DNA Helicases - genetics | DNA-Activated Protein Kinase - deficiency | Survival of Motor Neuron 1 Protein - physiology | Disease Models, Animal | DNA-Binding Proteins - physiology | RNA, Small Interfering - pharmacology | Cells, Cultured | DNA-Activated Protein Kinase - physiology | DNA Helicases - deficiency | DNA-Binding Proteins - genetics | Spinal Muscular Atrophies of Childhood - pathology | Motor Neurons - metabolism | Animals | Aged | Mice | Nuclear Proteins - physiology | DNA Damage | Nerve Degeneration | DNA Helicases - physiology | Genome Integrity, Repair and
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2015 - 11
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 05/2015, Volume 230, Issue 5, pp. 1094 - 1103
DNA‐dependent protein kinase catalytic subunit (DNA‐PKcs) plays a critical role in non‐homologous end‐joining repair of DNA double‐strand breaks (DSB) induced... 
CANCER-CELLS | MALIGNANT GLIOMA-CELLS | IN-VITRO | PHYSIOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | DEPENDENT PROTEIN-KINASE | TUMOR ANGIOGENESIS | STRESS | CONDITIONED MEDIUM | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY | DNA-Activated Protein Kinase - antagonists & inhibitors | Neovascularization, Physiologic - drug effects | Humans | Brain Neoplasms - pathology | DNA Repair - radiation effects | Culture Media, Conditioned - pharmacology | Brain Neoplasms - blood supply | Vascular Endothelial Growth Factor A - metabolism | Glioblastoma - radiotherapy | Neovascularization, Pathologic - etiology | DNA Breaks, Double-Stranded - radiation effects | Radiation Tolerance - radiation effects | DNA Breaks, Double-Stranded - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | DNA-Activated Protein Kinase - metabolism | Neovascularization, Pathologic - prevention & control | Signal Transduction - radiation effects | Brain Neoplasms - radiotherapy | Chromones - pharmacology | DNA-Activated Protein Kinase - deficiency | Radiation, Ionizing | DNA Repair - drug effects | Neoplasm Invasiveness | Morpholines - pharmacology | Endothelial Cells - radiation effects | Cell Movement - radiation effects | Radiation Tolerance - drug effects | Cell Movement - drug effects | Signal Transduction - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Endothelial Cells - pathology | Glioblastoma - blood supply | Endothelial Cells - drug effects | RNA, Small Interfering - metabolism | Genetic research | Ionizing radiation | Vascular endothelial growth factor | Glioblastoma multiforme | DNA | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e86358
textabstractKu70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS) to repair DNA... 
POLY(ADP-RIBOSE) POLYMERASE | CELLS | DNA-POLYMERASE BETA | BASE EXCISION-REPAIR | INTERACTS | MULTIDISCIPLINARY SCIENCES | DEFICIENT | V(D)J RECOMBINATION | XRCC1 | PROTEINS | DAMAGE | Radiation Tolerance | Male | DNA-Binding Proteins - deficiency | DNA End-Joining Repair | DNA-Activated Protein Kinase - genetics | Gene Deletion | Nuclear Proteins - deficiency | Female | Indoles - pharmacology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | Protein Subunits - genetics | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Longevity | DNA-Binding Proteins - genetics | Mice, Knockout | Point Mutation | Phenotype | Animals | Antigens, Nuclear - genetics | Ku Autoantigen | Epistasis, Genetic | Protein Subunits - deficiency | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | Mice | Apurinic Acid - genetics | Enzymes | Genetic aspects | Tumor proteins | Protein kinases | Brain | Protein kinase C | Senescence | Addition polymerization | DNA polymerase | p53 Protein | DNA damage | Science | Genomes | Biology | Epistasis | AP endonuclease | Kinases | DNA repair | Base excision repair | Defects | Proteins | Genotype & phenotype | Clonal deletion | Rodents | Deletion | Aging | Catalysis | Lesions | Repair | Public health | Deoxyribonucleic acid--DNA | Medical research | Pharmacology | Medicine | Polymerase | Life span | Protein kinase | Reagents | Non-homologous end joining | Mutation | Endonuclease | DNA-directed DNA polymerase | Cancer | Deoxyribonucleic acid | DNA
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2015, Volume 11, Issue 5, p. e1005239
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e113582
Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and... 
STEM-CELLS | HAMSTER ORAL PAPILLOMAVIRUS | SENCAR MICE | MULTIDISCIPLINARY SCIENCES | BASAL-CELL CARCINOMA | MICROMYS-MINUTUS | GENE-EXPRESSION | LANCEOLATE-HAIR | CERVICAL-CANCER | NUCLEOTIDE-SEQUENCE | MASTOMYS-NATALENSIS PAPILLOMAVIRUS | Skin - metabolism | Homeodomain Proteins - metabolism | Humans | DNA, Viral - analysis | Male | Gene Expression Profiling | Gene Regulatory Networks | DNA-Binding Proteins - deficiency | Papillomaviridae - genetics | DNA-Binding Proteins - metabolism | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Nuclear Proteins - deficiency | Female | Papilloma - pathology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | B-Lymphocytes - metabolism | Forkhead Transcription Factors - deficiency | Papilloma - metabolism | Skin Neoplasms - pathology | Papilloma - virology | Mice, Inbred C57BL | Gene Expression Regulation | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Homeodomain Proteins - genetics | Skin Neoplasms - metabolism | Papillomaviridae - pathogenicity | Animals | B-Lymphocytes - immunology | Mice, Nude | Skin Neoplasms - virology | Mice, Inbred NOD | T-Lymphocytes - immunology | Aged | Mice | Papillomaviruses | Infection | Squamous cell carcinoma | Analysis | Skin | T cells | Health aspects | Tropism | Carcinoma | Laboratories | Genes | Cytology | Viruses | Lymphocytes T | Infections | Immune status | Cell morphology | Connective tissues | Keratin | Inoculation | Human papillomavirus | Lymphocytes | Rodents | Endophytes | Inbreeding | Lesions | Hair | Squamous cells | Invasiveness | Vagina | Regression analysis | Mammals | Gene expression | Medicine | Lymphocytes B | Species classification | Morphology | West Nile virus | Stem cells | Papilloma | Mutation | Tumors | Cancer | Inoculum
Journal Article